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Found 5382 Enz. Inhib. hit(s) with Target = 'Platelet-derived growth factor receptor'
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research (Nibr)

Curated by ChEMBL
LigandPNGBDBM50191945(CHEMBL3904768)
Affinity DataIC50:  0.0900nMAssay Description:Inhibition of PDGFRalpha kinase domain (unknown origin) assessed as reduction in probe peptide substrate phosphorylation by capillary electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research (Nibr)

Curated by ChEMBL
LigandPNGBDBM50191977(CHEMBL3983564)
Affinity DataIC50: <0.100nMAssay Description:Inhibition of PDGFRalpha kinase domain (unknown origin) assessed as reduction in probe peptide substrate phosphorylation by capillary electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50265746(CHEMBL526507 | {4-Amino-3-[6-(4-methylpiperazinyl)...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of human recombinant PDGFRbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50265774(4-Amino-3-benzimidazol-2-yl-5-(1-methyl(3-piperidy...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of human recombinant PDGFRbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research (Nibr)

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50: <0.100nMAssay Description:Inhibition of PDGFRalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM581371(US11505527, Compound 4j)
Affinity DataIC50:  0.140nMAssay Description:An in vitro kinase assay was performed to evaluate the kinase suppression activity of the most promising cytotoxic candidates 4b, 4j against four dif...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research (Nibr)

Curated by ChEMBL
LigandPNGBDBM50191981(CHEMBL3979322)
Affinity DataIC50:  0.180nMAssay Description:Inhibition of PDGFRalpha kinase domain (unknown origin) assessed as reduction in probe peptide substrate phosphorylation by capillary electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research (Nibr)

Curated by ChEMBL
LigandPNGBDBM50191973(CHEMBL3940697)
Affinity DataIC50:  0.190nMAssay Description:Inhibition of PDGFRalpha kinase domain (unknown origin) assessed as reduction in probe peptide substrate phosphorylation by capillary electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50381946(CHEMBL2023485)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of PDGFRbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research (Nibr)

Curated by ChEMBL
LigandPNGBDBM50191978(CHEMBL3915941)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of PDGFRalpha kinase domain (unknown origin) assessed as reduction in probe peptide substrate phosphorylation by capillary electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50381945(CHEMBL2023477)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of PDGFRbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50265574(3-(1H-benzo[d]imidazol-2-yl)-4-(4-ethyl-1-methylpi...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human recombinant PDGFRbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research (Nibr)

Curated by ChEMBL
LigandPNGBDBM50336457((3S,5Z,8S,9R,11E)-8,9,16-trihydroxy-14-methoxy-3-m...)
Affinity DataIC50:  0.240nMAssay Description:Inhibition of human recombinant PDGFRalpha in cell free system after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  0.260nMAssay Description:An in vitro kinase assay was performed to evaluate the kinase suppression activity of the most promising cytotoxic candidates 4b, 4j against four dif...More data for this Ligand-Target Pair
In DepthDetails US PatentDrugBank

TargetPlatelet-derived growth factor receptor alpha [D842V](Homo sapiens (Human))
Blueprint Medicines

US Patent
LigandPNGBDBM472776(US10829493, Example 2)
Affinity DataIC50: <0.300nMAssay Description:KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor alpha [D842V](Homo sapiens (Human))
Blueprint Medicines

US Patent
LigandPNGBDBM472777(US10829493, Example 3)
Affinity DataIC50: <0.300nMAssay Description:KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor alpha [D842V](Homo sapiens (Human))
Blueprint Medicines

US Patent
LigandPNGBDBM472778(US10829493, Example 4)
Affinity DataIC50: <0.300nMAssay Description:KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor alpha [D842V](Homo sapiens (Human))
Blueprint Medicines

US Patent
LigandPNGBDBM472779(US10829493, Example 5)
Affinity DataIC50: <0.300nMAssay Description:KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor alpha [D842V](Homo sapiens (Human))
Blueprint Medicines

US Patent
LigandPNGBDBM472780(US10829493, Example 6)
Affinity DataIC50: <0.300nMAssay Description:KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor alpha [D842V](Homo sapiens (Human))
Blueprint Medicines

US Patent
LigandPNGBDBM472781(US10829493, Example 7)
Affinity DataIC50: <0.300nMAssay Description:KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor alpha [D842V](Homo sapiens (Human))
Blueprint Medicines

US Patent
LigandPNGBDBM472782(US10829493, Example 8)
Affinity DataIC50: <0.300nMAssay Description:KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor alpha [D842V](Homo sapiens (Human))
Blueprint Medicines

US Patent
LigandPNGBDBM472783(US10829493, Example 9)
Affinity DataIC50: <0.300nMAssay Description:KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor alpha [D842V](Homo sapiens (Human))
Blueprint Medicines

US Patent
LigandPNGBDBM472784(US10829493, Example 10)
Affinity DataIC50: <0.300nMAssay Description:KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor alpha [D842V](Homo sapiens (Human))
Blueprint Medicines

US Patent
LigandPNGBDBM472785(US10829493, Example 11)
Affinity DataIC50: <0.300nMAssay Description:KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor alpha [D842V](Homo sapiens (Human))
Blueprint Medicines

US Patent
LigandPNGBDBM472786(US10829493, Example 12)
Affinity DataIC50: <0.300nMAssay Description:KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor alpha [D842V](Homo sapiens (Human))
Blueprint Medicines

US Patent
LigandPNGBDBM472787(US10829493, Example 13)
Affinity DataIC50: <0.300nMAssay Description:KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor alpha [D842V](Homo sapiens (Human))
Blueprint Medicines

US Patent
LigandPNGBDBM472788(US10829493, Example 14)
Affinity DataIC50: <0.300nMAssay Description:KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor alpha [D842V](Homo sapiens (Human))
Blueprint Medicines

US Patent
LigandPNGBDBM472789(US10829493, Example 15)
Affinity DataIC50: <0.300nMAssay Description:KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor alpha [D842V](Homo sapiens (Human))
Blueprint Medicines

US Patent
LigandPNGBDBM472790(US10829493, Example 16)
Affinity DataIC50: <0.300nMAssay Description:KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor alpha [D842V](Homo sapiens (Human))
Blueprint Medicines

US Patent
LigandPNGBDBM472791(US10829493, Example 17)
Affinity DataIC50: <0.300nMAssay Description:KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor alpha [D842V](Homo sapiens (Human))
Blueprint Medicines

US Patent
LigandPNGBDBM472792(US10829493, Example 18)
Affinity DataIC50: <0.300nMAssay Description:KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor alpha [D842V](Homo sapiens (Human))
Blueprint Medicines

US Patent
LigandPNGBDBM472793(US10829493, Example 19)
Affinity DataIC50: <0.300nMAssay Description:KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor alpha [D842V](Homo sapiens (Human))
Blueprint Medicines

US Patent
LigandPNGBDBM472794(US10829493, Example 20)
Affinity DataIC50: <0.300nMAssay Description:KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor alpha [D842V](Homo sapiens (Human))
Blueprint Medicines

US Patent
LigandPNGBDBM472795(US10829493, Example 21)
Affinity DataIC50: <0.300nMAssay Description:KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor alpha [D842V](Homo sapiens (Human))
Blueprint Medicines

US Patent
LigandPNGBDBM472796(US10829493, Example 22)
Affinity DataIC50: <0.300nMAssay Description:KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor alpha [D842V](Homo sapiens (Human))
Blueprint Medicines

US Patent
LigandPNGBDBM469288(US10807985, Compound 63 | US10829493, Example 63 o...)
Affinity DataIC50: <0.300nMAssay Description:KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50265678(4-Amino-5-chloro-3-[6-(4-methylpiperazinyl)benzimi...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of human recombinant PDGFRbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50265773(4-Amino-3-benzimidazol-2-yl-5-(4-methylpiperazinyl...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of human recombinant PDGFRbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50362065(CHEMBL1940109)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of PDGFRbeta phosphorylation by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50381931(CHEMBL2023476)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of PDGFRbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha [D842V](Homo sapiens (Human))
Blueprint Medicines

US Patent
LigandPNGBDBM472775(US10829493, Example 1)
Affinity DataIC50: <0.300nMAssay Description:KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research (Nibr)

Curated by ChEMBL
LigandPNGBDBM50191974(CHEMBL3913766)
Affinity DataIC50:  0.320nMAssay Description:Inhibition of PDGFRalpha kinase domain (unknown origin) assessed as reduction in probe peptide substrate phosphorylation by capillary electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50381947(CHEMBL2023482)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of PDGFRbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50117334(4-[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-pip...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of platelet-derived growth factor receptor beta phosphorylation in MG63 cells in the absence of plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50117342(4-[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-pip...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of platelet-derived growth factor receptor beta phosphorylation in MG63 cells in the absence of plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50431812(CHEMBL2347053)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of PDGFRbeta (unknown origin) after 10 mins by mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50362089(CHEMBL1940273)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of PDGFRbeta phosphorylation by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50265750(4-Amino-7-fluoro-3-[6-(4-methylpiperazinyl)benzimi...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human recombinant PDGFRbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research (Nibr)

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  0.418nMAssay Description:Inhibition of human PDGFRalpha using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM581370(US11505527, Compound 4b)
Affinity DataIC50:  0.420nMAssay Description:An in vitro kinase assay was performed to evaluate the kinase suppression activity of the most promising cytotoxic candidates 4b, 4j against four dif...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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