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Found 112 Enz. Inhib. hit(s) with Target = 'Signal transducer and activator of transcription 6'
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50557878(CHEMBL4776801)
Affinity DataKd: >10nMAssay Description:Binding affinity to human recombinant STAT6 assessed as dissociation constant incubated for 15 mins by biolayer interferometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50401026(CHEMBL2204367)
Affinity DataKd:  656nMAssay Description:Binding affinity at human recombinant STAT6 by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50401024(CHEMBL2204366)
Affinity DataKd:  701nMAssay Description:Binding affinity at human recombinant STAT6 by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50401025(CHEMBL2203687)
Affinity DataKd:  7.40E+4nMAssay Description:Binding affinity at human recombinant STAT6 by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50197567(2-(4-hydroxyphenethylamino)-4-(benzylamino)pyrimid...)
Affinity DataIC50:  88nMAssay Description:Inhibition of STAT6 activation (unknown origin) in FW4 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50243934(2-[(4-Morpholin-4-ylphenyl)amino]-4-[(2,3,6-triflu...)
Affinity DataIC50:  88nMAssay Description:Inhibition of STAT6 activation (unknown origin) in FW4 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50243934(2-[(4-Morpholin-4-ylphenyl)amino]-4-[(2,3,6-triflu...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of STAT6 activation (unknown origin) in FW4 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50243933(2-[(4-Morpholin-4-ylphenyl)amino]-4-[(2,3,5-triflu...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of STAT6 activation (unknown origin) in FW4 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50243932(4-[(3,5-Difluorobenzyl)amino]-2-[(4-morpholin-4-yl...)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of STAT6 activation (unknown origin) in FW4 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50243885(4-[(2,6-Difluorobenzyl)amino]-2-[(4-morpholin-4-yl...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of STAT6 activation (unknown origin) in FW4 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50243884(4-[(2,5-Difluorobenzyl)amino]-2-[(4-morpholin-4-yl...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of STAT6 activation (unknown origin) in FW4 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50243883(4-[(2,4-Difluorobenzyl)amino]-2-[(4-morpholin-4-yl...)
Affinity DataIC50:  310nMAssay Description:Inhibition of STAT6 activation (unknown origin) in FW4 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50243882(4-[(2,3-Difluorobenzyl)amino]-2-[(4-morpholin-4-yl...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of STAT6 activation (unknown origin) in FW4 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50243794(4-[(3-Hydroxybenzyl)amino]-2-[(4-morpholin-4-ylphe...)
Affinity DataIC50:  19nMAssay Description:Inhibition of STAT6 activation (unknown origin) in FW4 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50243725(4-[(3-Methoxybenzyl)amino]-2-[(4-morpholin-4-ylphe...)
Affinity DataIC50:  25nMAssay Description:Inhibition of STAT6 activation (unknown origin) in FW4 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50243724(2-[(4-Morpholin-4-ylphenyl)amino]-4-[(3-trifluorom...)
Affinity DataIC50:  130nMAssay Description:Inhibition of STAT6 activation (unknown origin) in FW4 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50243723(4-[(3-Chlorobenzyl)amino]-2-[(4-morpholin-4-ylphen...)
Affinity DataIC50:  36nMAssay Description:Inhibition of STAT6 activation (unknown origin) in FW4 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50243722(4-{[2-(Methylsulfonyl)benzyl]amino}-2-[(4-morpholi...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of STAT6 activation (unknown origin) in FW4 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50244369(4-{[2-(Methylsulfanyl)benzyl]amino}-2-[(4-morpholi...)
Affinity DataIC50:  23nMAssay Description:Inhibition of STAT6 activation (unknown origin) in FW4 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50244368(4-{[2-(Acetylamino)benzyl]amino}-2-[(4-morpholin-4...)
Affinity DataIC50:  5.20E+3nMAssay Description:Inhibition of STAT6 activation (unknown origin) in FW4 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50244367(4-[(2-Aminobenzyl)amino]-2-[(4-morpholin-4-ylpheny...)
Affinity DataIC50:  310nMAssay Description:Inhibition of STAT6 activation (unknown origin) in FW4 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50244366(2-[(4-Morpholin-4-ylphenyl)amino]-4-[(2-nitrobenzy...)
Affinity DataIC50:  38nMAssay Description:Inhibition of STAT6 activation (unknown origin) in FW4 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50244332(2-[(4-Morpholin-4-ylphenyl)amino]-4-[(2-trifluorom...)
Affinity DataIC50:  25nMAssay Description:Inhibition of STAT6 activation (unknown origin) in FW4 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50244331(4-[(2-Chlorobenzyl)amino]-2-[(4-morpholin-4-ylphen...)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of STAT6 activation (unknown origin) in FW4 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50244330(4-[(2-Hydroxybenzyl)amino]-2-[(4-morpholin-4-ylphe...)
Affinity DataIC50:  22nMAssay Description:Inhibition of STAT6 activation (unknown origin) in FW4 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50244329(4-[(2-Methoxybenzyl)amino]-2-[(4-morpholin-4-ylphe...)
Affinity DataIC50:  8.20nMAssay Description:Inhibition of STAT6 activation (unknown origin) in FW4 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50244294(4-[(2-Methylbenzyl)amino]-2-[(4-morpholin-4-ylphen...)
Affinity DataIC50:  11nMAssay Description:Inhibition of STAT6 activation (unknown origin) in FW4 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50244293(4-[(4-Fluorobenzyl)amino]-2-[(4-morpholin-4-ylphen...)
Affinity DataIC50:  650nMAssay Description:Inhibition of STAT6 activation (unknown origin) in FW4 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50244292(4-[(3-Fluorobenzyl)amino]-2-[(4-morpholin-4-ylphen...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of STAT6 activation (unknown origin) in FW4 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50244291(4-[(2-Fluorobenzyl)amino]-2-[(4-morpholin-4-ylphen...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of STAT6 activation (unknown origin) in FW4 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50244259(4-Benzylamino-2-{[4-(1-methylpiperidin-4-yl)phenyl...)
Affinity DataIC50:  17nMAssay Description:Inhibition of STAT6 activation (unknown origin) in FW4 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50244258(4-(benzylamino)-2-(4-morpholinophenylamino)pyrimid...)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of STAT6 activation (unknown origin) in FW4 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50244257(4-Benzylamino-2-[(4-piperazin-1-ylphenyl)amino]-py...)
Affinity DataIC50:  7nMAssay Description:Inhibition of STAT6 activation (unknown origin) in FW4 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50244256(4-Benzylamino-2-{[4-(4-methylpiperazin-1-yl)phenyl...)
Affinity DataIC50:  6.20nMAssay Description:Inhibition of STAT6 activation (unknown origin) in FW4 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50244225(4-Benzylamino-2-[(4-piperidin-1-ylphenyl)amino]pyr...)
Affinity DataIC50:  120nMAssay Description:Inhibition of STAT6 activation (unknown origin) in FW4 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50244224(4-(Benzylamino)-2-[(4-pyrrolidine-1-ylphenyl)-amin...)
Affinity DataIC50:  650nMAssay Description:Inhibition of STAT6 activation (unknown origin) in FW4 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50244223(4-Benzylamino-2-{[4-(4-hydroxypiperidin-1-yl)pheny...)
Affinity DataIC50:  16nMAssay Description:Inhibition of STAT6 activation (unknown origin) in FW4 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50244222(4-(Benzylamino)-2-{[4-(3-hydroxypyrrolidine-1-yl)p...)
Affinity DataIC50:  98nMAssay Description:Inhibition of STAT6 activation (unknown origin) in FW4 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50244191(4-Benzylamino-2-{[4-(3-hydroxypropyl)phenyl]amino}...)
Affinity DataIC50:  81nMAssay Description:Inhibition of STAT6 activation (unknown origin) in FW4 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50244190(4-Benzylamino-2-{[4-(2-hydroxyethyl)phenyl]amino}p...)
Affinity DataIC50:  95nMAssay Description:Inhibition of STAT6 activation (unknown origin) in FW4 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50244189(4-(Benzylamino)-2-{[2-(3,5-dichloro-4-hydroxypheny...)
Affinity DataIC50:  61nMAssay Description:Inhibition of STAT6 activation (unknown origin) in FW4 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50197554(2-(3-chloro-4-hydroxyphenethylamino)-4-(benzylamin...)
Affinity DataIC50:  21nMAssay Description:Inhibition of STAT6 activation (unknown origin) in FW4 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50304425(2-(4-morpholinophenylamino)-4-(2,3,6-trifluorobenz...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50304426(7-Benzyl-N-(4-morpholin-4-ylphenyl)-6,7-dihydro-5H...)
Affinity DataIC50:  8.30E+3nMAssay Description:Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50244258(4-(benzylamino)-2-(4-morpholinophenylamino)pyrimid...)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50304427(7-(4-Fluorobenzyl)-N-(4-morpholin-4-ylphenyl)-7Hpy...)
Affinity DataIC50:  4.10E+3nMAssay Description:Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50304428(2-[4-(4-{[7-(3,5-Difluorobenzyl)-7H-pyrrolo[2,3-d]...)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50304429(2-[4-(4-{[7-(3,5-Difluorobenzyl)-7H-pyrrolo[2,3-d]...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50304430(CHEMBL595488 | [4-(4-{[7-(3,5-Difluorobenzyl)-7H-p...)
Affinity DataIC50:  26nMAssay Description:Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50304431(CHEMBL594821 | N-{4-[4-(2-Aminoethyl)piperazin-1-y...)
Affinity DataIC50:  34nMAssay Description:Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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