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Found 262 Enz. Inhib. hit(s) with Target = 'Aldehyde dehydrogenase, mitochondrial'
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM118193(US8673966, N-(4-(7-(cyclopropylethynyl)-4-oxo-4H- ...)
Affinity DataIC50:  57.7nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM118194(US8673966, N-(4-(4-oxo-7-(phenylethynyl)-4H-chrome...)
Affinity DataIC50:  329nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM153697(US10507215, Compound 14 | US9000015, 14 | US961029...)
Affinity DataIC50: >1.00E+4nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM153696(US10507215, Compound 13 | US9000015, 13 | US961029...)
Affinity DataIC50:  25nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM153695(US10507215, Compound 12 | US9000015, 12 | US961029...)
Affinity DataIC50:  304nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM153694(US10507215, Compound 11 | US9000015, 11 | US961029...)
Affinity DataIC50:  379nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM153693(US10507215, Compound 10 | US9000015, 10 | US961029...)
Affinity DataIC50:  890nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM153692(US10507215, Compound 9 | US9000015, 9 | US9610299,...)
Affinity DataIC50:  2.09E+3nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM153691(US10507215, Compound 8 | US9000015, 8 | US9610299,...)
Affinity DataIC50:  480nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM153690(US10507215, Compound 7 | US9000015, 7 | US9610299,...)
Affinity DataIC50:  464nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM118195(US8673966, N-(4-(7-(3-hydroxy-3-methylbut-1-ynyl)-...)
Affinity DataIC50:  2.18E+3nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM118196(US8673966, N-(4-(7-((1-methyl-1H-imidazol-5-yl)eth...)
Affinity DataIC50: <4.90nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM118197(US8673966, N-(4-(7-(3-methoxyprop-1-ynyl)-4-oxo-4H...)
Affinity DataIC50:  47nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM118198(US8673966, N-(4-(7-((1-hydroxycyclohexyl)ethynyl)-...)
Affinity DataIC50:  1.71E+3nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM118199(US8673966, N-(4-(7-((1-aminocyclohexyl)ethynyl)-4-...)
Affinity DataIC50:  528nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM118200(US8673966, N-(4-(4-oxo-7-(pyridin-2-ylethynyl)-4H-...)
Affinity DataIC50:  90nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM118201(US8673966, N-(4-(7-((1-hydroxycyclopentyl)ethynyl)...)
Affinity DataIC50:  386nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM118202(US8673966, N-(4-(4-oxo-7-(pyrimidin-5-ylethynyl)-4...)
Affinity DataIC50:  57nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM118203(US8673966, N-(4-(4-oxo-7-(pyridin-3-ylethynyl)-4H-...)
Affinity DataIC50:  21nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM118204(US8673966, N-(4-(7-(3-methoxyprop-1-ynyl)-4-oxo-4H...)
Affinity DataIC50:  96nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM118205(US8673966, N-(4-(7-((1-hydroxycyclopentyl)ethynyl)...)
Affinity DataIC50:  156nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM118206(US8673966, tert-butyl 4-((3-(4-(methylsulfonamido)...)
Affinity DataIC50:  86nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM118207(US8673966, tert-butyl 3-((3-(4-(methylsulfonamido)...)
Affinity DataIC50:  9nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM118208(US8673966, N-(4-(4-oxo-7-((2-oxo-1,2-dihydropyridi...)
Affinity DataIC50:  9nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM118209(US8673966, N-(4-(7-((1-(cyclopropanecarbonyl)azeti...)
Affinity DataIC50:  5nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM118210(US8673966, N-(4-(4-oxo-7-(piperidin-4-ylethynyl)-4...)
Affinity DataIC50:  174nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM118211(US8673966, N-(4-(7-((1-(cyclopropanecarbonyl)piper...)
Affinity DataIC50:  6.5nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM118212(US8673966, N-(4-(7-((1,2-dimethyl-1H-imidazol-5- y...)
Affinity DataIC50:  15nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM118213(US8673966, N-(4-(7-((1-isopropyl-1H-imidazol-5- yl...)
Affinity DataIC50:  7nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM118214(US8673966, N-(4-(7-((1-methyl-1H-imidazol-4-yl)eth...)
Affinity DataIC50:  95nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM118215(US8673966, N-(4-(7-(azetidin-3-ylethynyl)-4-oxo-4H...)
Affinity DataIC50:  266nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM118216(US8673966, cyclopentyl 3-((3-(4- (methylsulfonamid...)
Affinity DataIC50:  9nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM118217(US8673966, N-(4-(4-oxo-7-((tetrahydro-2H-pyran-4- ...)
Affinity DataIC50:  43nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM118218(US8673966, N-(4-(7-((1-isobutylazetidin-3-yl)ethyn...)
Affinity DataIC50:  109nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM118219(US8673966, N-(4-(7-((1-(3-methoxypropanoyl)azetidi...)
Affinity DataIC50:  8nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM118220(US8673966, N-(4-(7-((1-(3,3-difluorocyclobutanecar...)
Affinity DataIC50:  6nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM118221(US8673966, N-(4-(7-((1-(3-(dimethylamino)propanoyl...)
Affinity DataIC50:  64nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM118222(US8673966, N-(4-(7-((1-(2-hydroxyacetyl)azetidin-3...)
Affinity DataIC50:  15nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM118223(US8673966, N-(4-(7-((1-(3-hydroxy-3-methylcyclobut...)
Affinity DataIC50:  5nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM118224(US8673966, N-(4-(7-((1-(2-hydroxy-2-methylpropanoy...)
Affinity DataIC50:  16nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM118225(US8673966, N-(4-(7-((1-(3-methyloxetane-3- carbony...)
Affinity DataIC50:  6nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM118226(US8673966, N-(4-(7-((1-(2-hydroxypropanoyl)azetidi...)
Affinity DataIC50:  15nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM118227(US8673966, N-(4-(7-((1-(1-methylpiperidine-4- carb...)
Affinity DataIC50:  35nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM118228(US8673966, N-(4-(7-((1-(2,2-difluorocyclopropane- ...)
Affinity DataIC50:  5nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM118229(US8673966, N-(4-(7-((1-(cyclobutanecarbonyl)azetid...)
Affinity DataIC50:  4nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM118230(US8673966, N-(4-(7-((1-(1-methylcyclopropanecarbon...)
Affinity DataIC50:  6nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM118231(US8673966, tert-butyl 1-(3-((3-(4-(methylsulfonami...)
Affinity DataIC50:  6nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM118232(US8673966, tert-butyl 1-(3-((3-(4- (methylsulfonam...)
Affinity DataIC50:  5nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM118233(US8673966, tert-butyl (1-(3-((3-(4-(methylsulfonam...)
Affinity DataIC50:  2.30nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM153684(US10507215, Compound 1 | US9000015, 1 | US9610299,...)
Affinity DataIC50:  63nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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