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Found 3760 Enz. Inhib. hit(s) with Target = 'Tumor necrosis factor'
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM50373071(CHEMBL255489)
Affinity DataKd:  5.36E+3nMpH: 6.5Assay Description:Binding affinity to GST-tagged human TNF-alpha in 10 mM citrate-phosphate at pH 6.5 by fluorescence assayMore data for this Ligand-Target Pair
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM228654((E)-4-(2-(4-chloro-3-nitrophenyl)) (C87))
Affinity DataKd:  110nMpH: 7.0Assay Description:Surface plasmon resonance (SPR) assays were carried out on a BIAcore 3000 instrument (Biacore, Inc). Briefly, purified hTNFα was dissolved at 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM50103596((E)-2-hydroxy-5-((4-(N-pyridin-2-ylsulfamoyl)-phen...)
Affinity DataKd:  9.00E+3nMpH: 7.0Assay Description:Surface plasmon resonance (SPR) assays were carried out on a BIAcore 3000 instrument (Biacore, Inc). Briefly, purified hTNFα was dissolved at 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM102777(US8541572, 2207)
Affinity DataKi:  0.0300nM IC50:  260nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM102624(US8541572, 303)
Affinity DataKi:  0.0300nM IC50:  383nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM102623(US8541572, 302)
Affinity DataKi:  0.0521nM IC50:  723nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM102666(US8541572, 973)
Affinity DataKi:  0.0524nM IC50:  61nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM102663(US8541572, 970)
Affinity DataKi:  0.0556nM IC50:  65nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM102802(US8541572, 2234)
Affinity DataKi:  0.0600nM IC50:  678nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM102680(US8541572, 987)
Affinity DataKi:  0.0627nM IC50:  75.4nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM102845(US8541572, 927)
Affinity DataKi:  0.0630nM IC50:  151nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM102664(US8541572, 971)
Affinity DataKi:  0.0651nM IC50:  80.3nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM102840(US8541572, 922)
Affinity DataKi:  0.0720nM IC50:  92nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM50332292((R)-5-((4-(3-hydroxypyridin-2-yl)phenyl)ethynyl)-5...)
Affinity DataKi:  0.0740nM IC50:  117nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM102698(US8541572, 1008)
Affinity DataKi:  0.0762nM IC50:  342nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM102695(US8541572, 1002)
Affinity DataKi:  0.0770nM IC50:  119nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM102694(US8541572, 1001)
Affinity DataKi:  0.0781nM IC50:  106nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM102696(US8541572, 1003)
Affinity DataKi:  0.0826nM IC50:  124nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM102855(US8541572, 943)
Affinity DataKi:  0.0830nM IC50:  65nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM102843(US8541572, 925)
Affinity DataKi:  0.0930nM IC50:  74nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM102852(US8541572, 936)
Affinity DataKi:  0.0930nM IC50:  72.4nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM102679(US8541572, 986)
Affinity DataKi:  0.0973nM IC50:  87nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM102669(CHEMBL1288726 | US8541572, 976)
Affinity DataKi:  0.0988nM IC50:  39.8nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM102863(US8541572, 2257)
Affinity DataKi:  0.100nM IC50:  490nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM102844(US8541572, 926)
Affinity DataKi:  0.110nM IC50:  76nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM102873(US8541572, 2267)
Affinity DataKi:  0.110nM IC50:  134nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM102747(US8541572, 1918)
Affinity DataKi:  0.110nM IC50:  936nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM102681(US8541572, 988)
Affinity DataKi:  0.115nM IC50:  55.9nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM102857(US8541572, 946)
Affinity DataKi:  0.120nM IC50:  154nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM102858(US8541572, 951)
Affinity DataKi:  0.120nM IC50:  220nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM102872(US8541572, 2266)
Affinity DataKi:  0.120nM IC50:  927nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM102731(US8541572, 1902)
Affinity DataKi:  0.120nM IC50:  127nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM102853(US8541572, 941)
Affinity DataKi:  0.130nM IC50:  100nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM102730(US8541572, 1901)
Affinity DataKi:  0.130nM IC50:  113nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM102846(US8541572, 928)
Affinity DataKi:  0.150nM IC50:  278nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM102789(US8541572, 2220)
Affinity DataKi:  0.150nM IC50:  417nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM102800(US8541572, 2233)
Affinity DataKi:  0.150nM IC50:  811nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM102819(US8541572, 2252)
Affinity DataKi:  0.160nM IC50:  258nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM102834(US8541572, 911)
Affinity DataKi:  0.160nM IC50:  20nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM102835(US8541572, 912)
Affinity DataKi:  0.160nM IC50:  153nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM102784(US8541572, 2215)
Affinity DataKi:  0.160nM IC50:  229nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM102829(US8541572, 906)
Affinity DataKi:  0.170nM IC50:  382nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM102856(US8541572, 945)
Affinity DataKi:  0.170nM IC50:  86nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM102806(US8541572, 2239)
Affinity DataKi:  0.170nM IC50:  188nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM102738(US8541572, 1909)
Affinity DataKi:  0.170nM IC50:  78nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM102832(US8541572, 909)
Affinity DataKi:  0.180nM IC50:  292nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM102839(US8541572, 916)
Affinity DataKi:  0.180nM IC50:  274nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM102861(US8541572, 954)
Affinity DataKi:  0.180nM IC50:  87nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM102720(US8541572, 1311)
Affinity DataKi:  0.180nM IC50:  69nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Curated by ChEMBL
LigandPNGBDBM102736(US8541572, 1907)
Affinity DataKi:  0.180nM IC50:  86nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
In DepthDetails US Patent
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