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Found 15 hits Enz. Inhib. hit(s) with Target = 'Acetylpolyamine amidohydrolase (APAH)'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Acetylpolyamine amidohydrolase (APAH)


(Mycoplana ramosa (Gram-negative bacterium))
BDBM152730
PNG
(7-Amino-N-hydroxypentanamide (6))
Show SMILES [NH3+]CCCCCCC(=O)NO
Show InChI InChI=1S/C7H16N2O2/c8-6-4-2-1-3-5-7(10)9-11/h11H,1-6,8H2,(H,9,10)/p+1
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PubMed
n/an/a 68n/an/an/an/an/an/a



University of Pennsylvania



Assay Description
Activity assays were conducted at 25 C and contained 250 nM APAH (∼50% Zn2+ occupancy), 150 μM substrate, and 0−250 μM inhibit...


Biochemistry 54: 4692-703 (2015)

More data for this
Ligand-Target Pair
Acetylpolyamine amidohydrolase (APAH)


(Mycoplana ramosa (Gram-negative bacterium))
BDBM152729
PNG
(6-Amino-N-hydroxypentanamide (5))
Show SMILES [NH3+]CCCCCC(=O)NO
Show InChI InChI=1S/C6H14N2O2/c7-5-3-1-2-4-6(9)8-10/h10H,1-5,7H2,(H,8,9)/p+1
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n/an/a 130n/an/an/an/an/an/a



University of Pennsylvania



Assay Description
Activity assays were conducted at 25 C and contained 250 nM APAH (∼50% Zn2+ occupancy), 150 μM substrate, and 0−250 μM inhibit...


Biochemistry 54: 4692-703 (2015)

More data for this
Ligand-Target Pair
Acetylpolyamine amidohydrolase (APAH)


(Mycoplana ramosa (Gram-negative bacterium))
BDBM152731
PNG
(8-Amino-N-hydroxypentanamide (7))
Show SMILES [NH3+]CCCCCCCC(=O)NO
Show InChI InChI=1S/C8H18N2O2/c9-7-5-3-1-2-4-6-8(11)10-12/h12H,1-7,9H2,(H,10,11)/p+1
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n/an/a 150n/an/an/an/an/an/a



University of Pennsylvania



Assay Description
Activity assays were conducted at 25 C and contained 250 nM APAH (∼50% Zn2+ occupancy), 150 μM substrate, and 0−250 μM inhibit...


Biochemistry 54: 4692-703 (2015)

More data for this
Ligand-Target Pair
Acetylpolyamine amidohydrolase (APAH)


(Mycoplana ramosa (Gram-negative bacterium))
BDBM152728
PNG
(5-Amino-N-hydroxypentanamide (4))
Show SMILES [NH3+]CCCCC(=O)NO
Show InChI InChI=1S/C5H12N2O2/c6-4-2-1-3-5(8)7-9/h9H,1-4,6H2,(H,7,8)/p+1
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n/an/a 170n/an/an/an/an/an/a



University of Pennsylvania



Assay Description
Activity assays were conducted at 25 C and contained 250 nM APAH (∼50% Zn2+ occupancy), 150 μM substrate, and 0−250 μM inhibit...


Biochemistry 54: 4692-703 (2015)

More data for this
Ligand-Target Pair
Acetylpolyamine amidohydrolase (APAH)


(Mycoplana ramosa (Gram-negative bacterium))
BDBM50438390
PNG
(CHEMBL2414000)
Show SMILES NCCCNCCCCCC(=O)C(F)(F)F
Show InChI InChI=1S/C10H19F3N2O/c11-10(12,13)9(16)5-2-1-3-7-15-8-4-6-14/h15H,1-8,14H2
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n/an/a 270n/an/an/an/an/an/a



University of Pennsylvania

Curated by ChEMBL


Assay Description
Inhibition of Mycoplana ramosa APAH expressed in Escherichia coli BL21 (DE3) using BML-KI104 as substrate after 30 mins by fluorimetric assay


Bioorg Med Chem 21: 4530-40 (2013)

More data for this
Ligand-Target Pair
Acetylpolyamine amidohydrolase (APAH)


(Mycoplana ramosa (Gram-negative bacterium))
BDBM50438391
PNG
(CHEMBL2413999)
Show SMILES NCCCNCCCCCC(=O)NO
Show InChI InChI=1S/C9H21N3O2/c10-6-4-8-11-7-3-1-2-5-9(13)12-14/h11,14H,1-8,10H2,(H,12,13)
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n/an/a 390n/an/an/an/an/an/a



University of Pennsylvania

Curated by ChEMBL


Assay Description
Inhibition of Mycoplana ramosa APAH expressed in Escherichia coli BL21 (DE3) using BML-KI104 as substrate after 30 mins by fluorimetric assay


Bioorg Med Chem 21: 4530-40 (2013)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Acetylpolyamine amidohydrolase (APAH)


(Mycoplana ramosa (Gram-negative bacterium))
BDBM50438386
PNG
(CHEMBL2414004)
Show SMILES NCCCNCCCCCS
Show InChI InChI=1S/C8H20N2S/c9-5-4-7-10-6-2-1-3-8-11/h10-11H,1-9H2
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n/an/a 2.60E+4n/an/an/an/an/an/a



University of Pennsylvania

Curated by ChEMBL


Assay Description
Inhibition of Mycoplana ramosa APAH expressed in Escherichia coli BL21 (DE3) using BML-KI104 as substrate after 30 mins by fluorimetric assay


Bioorg Med Chem 21: 4530-40 (2013)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Acetylpolyamine amidohydrolase (APAH)


(Mycoplana ramosa (Gram-negative bacterium))
BDBM50438389
PNG
(CHEMBL2414001)
Show SMILES CC(=O)SCC(=O)CCCCCNCCCN
Show InChI InChI=1S/C12H24N2O2S/c1-11(15)17-10-12(16)6-3-2-4-8-14-9-5-7-13/h14H,2-10,13H2,1H3
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n/an/a 3.90E+4n/an/an/an/an/an/a



University of Pennsylvania

Curated by ChEMBL


Assay Description
Inhibition of Mycoplana ramosa APAH expressed in Escherichia coli BL21 (DE3) using BML-KI104 as substrate after 30 mins by fluorimetric assay


Bioorg Med Chem 21: 4530-40 (2013)

More data for this
Ligand-Target Pair
Acetylpolyamine amidohydrolase (APAH)


(Mycoplana ramosa (Gram-negative bacterium))
BDBM50121062
PNG
(9,9,9-TRIFLUORO-8-OXO-N-PHENYLNONANAMIDE | 9,9,9-T...)
Show SMILES FC(F)(F)C(=O)CCCCCCC(=O)Nc1ccccc1
Show InChI InChI=1S/C15H18F3NO2/c16-15(17,18)13(20)10-6-1-2-7-11-14(21)19-12-8-4-3-5-9-12/h3-5,8-9H,1-2,6-7,10-11H2,(H,19,21)
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n/an/a 1.10E+5n/an/an/an/an/an/a



Drexel University

Curated by ChEMBL


Assay Description
Inhibition of Mycoplana ramosa acetylpolyamine amidohydrolase assessed as substrate deacetylation using L-Lys(epsilon-acetyl)-coumarin as substrate p...


Bioorg Med Chem Lett 21: 5854-8 (2011)

More data for this
Ligand-Target Pair
Acetylpolyamine amidohydrolase (APAH)


(Mycoplana ramosa (Gram-negative bacterium))
BDBM50405937
PNG
(CHEMBL173782)
Show SMILES CC(=O)CCCCCNCCCN
Show InChI InChI=1S/C10H22N2O/c1-10(13)6-3-2-4-8-12-9-5-7-11/h12H,2-9,11H2,1H3
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n/an/a 1.60E+5n/an/an/an/an/an/a



University of Pennsylvania

Curated by ChEMBL


Assay Description
Inhibition of Mycoplana ramosa APAH expressed in Escherichia coli BL21 (DE3) using BML-KI104 as substrate after 30 mins by fluorimetric assay


Bioorg Med Chem 21: 4530-40 (2013)

More data for this
Ligand-Target Pair
Acetylpolyamine amidohydrolase (APAH)


(Mycoplana ramosa (Gram-negative bacterium))
BDBM50438384
PNG
(CHEMBL2414006)
Show SMILES NCCCNCCCCCB(O)O
Show InChI InChI=1S/C8H21BN2O2/c10-6-4-8-11-7-3-1-2-5-9(12)13/h11-13H,1-8,10H2
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n/an/a 2.30E+5n/an/an/an/an/an/a



University of Pennsylvania

Curated by ChEMBL


Assay Description
Inhibition of Mycoplana ramosa APAH expressed in Escherichia coli BL21 (DE3) using BML-KI104 as substrate after 30 mins by fluorimetric assay


Bioorg Med Chem 21: 4530-40 (2013)

More data for this
Ligand-Target Pair
Acetylpolyamine amidohydrolase (APAH)


(Mycoplana ramosa (Gram-negative bacterium))
BDBM50438388
PNG
(CHEMBL2414002)
Show SMILES COCC(=O)CCCCCNCCCN
Show InChI InChI=1S/C11H24N2O2/c1-15-10-11(14)6-3-2-4-8-13-9-5-7-12/h13H,2-10,12H2,1H3
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n/an/a 3.80E+5n/an/an/an/an/an/a



University of Pennsylvania

Curated by ChEMBL


Assay Description
Inhibition of Mycoplana ramosa APAH expressed in Escherichia coli BL21 (DE3) using BML-KI104 as substrate after 30 mins by fluorimetric assay


Bioorg Med Chem 21: 4530-40 (2013)

More data for this
Ligand-Target Pair
Acetylpolyamine amidohydrolase (APAH)


(Mycoplana ramosa (Gram-negative bacterium))
BDBM50438393
PNG
(CHEMBL2414007)
Show SMILES NCCCNCCCCCC(O)=O
Show InChI InChI=1S/C9H20N2O2/c10-6-4-8-11-7-3-1-2-5-9(12)13/h11H,1-8,10H2,(H,12,13)
PDB

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n/an/a 1.80E+6n/an/an/an/an/an/a



University of Pennsylvania

Curated by ChEMBL


Assay Description
Inhibition of Mycoplana ramosa APAH expressed in Escherichia coli BL21 (DE3) using BML-KI104 as substrate after 30 mins by fluorimetric assay


Bioorg Med Chem 21: 4530-40 (2013)

More data for this
Ligand-Target Pair
Acetylpolyamine amidohydrolase (APAH)


(Mycoplana ramosa (Gram-negative bacterium))
BDBM50438387
PNG
(CHEMBL2414003)
Show SMILES CC(=O)SCCCCCNCCCN
Show InChI InChI=1S/C10H22N2OS/c1-10(13)14-9-4-2-3-7-12-8-5-6-11/h12H,2-9,11H2,1H3
PDB

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n/an/a 1.90E+6n/an/an/an/an/an/a



University of Pennsylvania

Curated by ChEMBL


Assay Description
Inhibition of Mycoplana ramosa APAH expressed in Escherichia coli BL21 (DE3) using BML-KI104 as substrate after 30 mins by fluorimetric assay


Bioorg Med Chem 21: 4530-40 (2013)

More data for this
Ligand-Target Pair
Acetylpolyamine amidohydrolase (APAH)


(Mycoplana ramosa (Gram-negative bacterium))
BDBM50438385
PNG
(CHEMBL2414005)
Show SMILES CS(=O)(=O)CCCCCNCCCN
Show InChI InChI=1S/C9H22N2O2S/c1-14(12,13)9-4-2-3-7-11-8-5-6-10/h11H,2-10H2,1H3
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n/an/a 1.00E+7n/an/an/an/an/an/a



University of Pennsylvania

Curated by ChEMBL


Assay Description
Inhibition of Mycoplana ramosa APAH expressed in Escherichia coli BL21 (DE3) using BML-KI104 as substrate after 30 mins by fluorimetric assay


Bioorg Med Chem 21: 4530-40 (2013)

More data for this
Ligand-Target Pair