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Compile Data Set for Download or QSAR

Found 118 hits Enz. Inhib. hit(s) with Target = 'Acidic fibroblast growth factor'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM50374504
PNG
(CHEMBL258321)
Show SMILES CCCOC(=O)[C@H]1O[C@H](O)[C@@H](O)[C@H](O)[C@H]1O[C@@H]1O[C@@H](CO)[C@H](O[C@H]2O[C@@H]([C@H](O[C@@H]3OC[C@H](O)[C@@H](O)[C@@H]3N)[C@@H](O)[C@@H]2O)C(O)=O)[C@@H](O)[C@@H]1N
Show InChI InChI=1S/C26H44N2O20/c1-2-3-41-23(40)20-18(12(33)14(35)22(39)44-20)47-25-9(28)11(32)16(7(4-29)43-25)45-26-15(36)13(34)17(19(48-26)21(37)38)46-24-8(27)10(31)6(30)5-42-24/h6-20,22,24-26,29-36,39H,2-5,27-28H2,1H3,(H,37,38)/t6-,7-,8-,9-,10+,11-,12-,13-,14-,15-,16-,17+,18+,19-,20-,22-,24-,25-,26-/m0/s1
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n/an/a 240n/an/an/an/an/an/a



Progen Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Binding affinity at FGF1


Bioorg Med Chem Lett 18: 344-9 (2008)

More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM50374509
PNG
(CHEMBL403403)
Show SMILES CCCOC(=O)[C@H]1O[C@H](O)[C@@H](O)[C@H](O)[C@H]1O[C@@H]1O[C@@H](CO)[C@H](O[C@H]2O[C@@H]([C@H](O[C@@H]3O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]3N)[C@@H](O)[C@@H]2O)C(O)=O)[C@@H](O)[C@@H]1N
Show InChI InChI=1S/C27H46N2O21/c1-2-3-43-24(42)21-19(13(35)15(37)23(41)46-21)49-26-9(29)12(34)17(7(5-31)45-26)47-27-16(38)14(36)18(20(50-27)22(39)40)48-25-8(28)11(33)10(32)6(4-30)44-25/h6-21,23,25-27,30-38,41H,2-5,28-29H2,1H3,(H,39,40)/t6-,7-,8-,9-,10-,11-,12-,13-,14-,15-,16-,17-,18+,19+,20-,21-,23-,25-,26-,27-/m0/s1
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n/an/a 2.90E+5n/an/an/an/an/an/a



Progen Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Binding affinity at FGF1


Bioorg Med Chem Lett 18: 344-9 (2008)

More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM84561
PNG
(Linked sulfated tetracyclitol, 2)
Show SMILES [O-]S(=O)(=O)O[C@@H]1C=C[C@@H]([C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)N(CCN([C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O
Show InChI InChI=1S/C26H40N2O48S12/c29-77(30,31)65-15-5-1-11(19(69-81(41,42)43)23(15)73-85(53,54)55)27(12-2-6-16(66-78(32,33)34)24(74-86(56,57)58)20(12)70-82(44,45)46)9-10-28(13-3-7-17(67-79(35,36)37)25(75-87(59,60)61)21(13)71-83(47,48)49)14-4-8-18(68-80(38,39)40)26(76-88(62,63)64)22(14)72-84(50,51)52/h1-8,11-26H,9-10H2,(H,29,30,31)(H,32,33,34)(H,35,36,37)(H,38,39,40)(H,41,42,43)(H,44,45,46)(H,47,48,49)(H,50,51,52)(H,53,54,55)(H,56,57,58)(H,59,60,61)(H,62,63,64)/p-12/t11-,12-,13-,14-,15+,16+,17+,18+,19+,20+,21+,22+,23+,24+,25+,26+/m0/s1
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n/an/an/a 20.7n/an/an/a7.4n/a



Progen Industries Ltd.



Assay Description
Human FGF-1 and FGF-2 were purchased from R&D Systems, Inc. and supplied as protein (ug) dissolved in bovine serum albumin (BSA, 50ug). Surface plas...


Chembiochem 6: 1882-90 (2005)

Checked by Author
More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM84562
PNG
(Linked sulfated tetracyclitol, 3)
Show SMILES [O-]S(=O)(=O)O[C@@H]1C=C[C@@H]([C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)N(CCCN([C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O
Show InChI InChI=1S/C27H42N2O48S12/c30-78(31,32)66-16-6-2-12(20(70-82(42,43)44)24(16)74-86(54,55)56)28(13-3-7-17(67-79(33,34)35)25(75-87(57,58)59)21(13)71-83(45,46)47)10-1-11-29(14-4-8-18(68-80(36,37)38)26(76-88(60,61)62)22(14)72-84(48,49)50)15-5-9-19(69-81(39,40)41)27(77-89(63,64)65)23(15)73-85(51,52)53/h2-9,12-27H,1,10-11H2,(H,30,31,32)(H,33,34,35)(H,36,37,38)(H,39,40,41)(H,42,43,44)(H,45,46,47)(H,48,49,50)(H,51,52,53)(H,54,55,56)(H,57,58,59)(H,60,61,62)(H,63,64,65)/p-12/t12-,13-,14-,15-,16+,17+,18+,19+,20+,21+,22+,23+,24+,25+,26+,27+/m0/s1
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n/an/an/a 7.20n/an/an/a7.4n/a



Progen Industries Ltd.



Assay Description
Human FGF-1 and FGF-2 were purchased from R&D Systems, Inc. and supplied as protein (ug) dissolved in bovine serum albumin (BSA, 50ug). Surface plas...


Chembiochem 6: 1882-90 (2005)

Checked by Author
More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM84563
PNG
(Linked sulfated tetracyclitol, 4)
Show SMILES [O-]S(=O)(=O)O[C@@H]1C=C[C@@H]([C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)N(CCCCN([C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O
Show InChI InChI=1S/C28H44N2O48S12/c31-79(32,33)67-17-7-3-13(21(71-83(43,44)45)25(17)75-87(55,56)57)29(14-4-8-18(68-80(34,35)36)26(76-88(58,59)60)22(14)72-84(46,47)48)11-1-2-12-30(15-5-9-19(69-81(37,38)39)27(77-89(61,62)63)23(15)73-85(49,50)51)16-6-10-20(70-82(40,41)42)28(78-90(64,65)66)24(16)74-86(52,53)54/h3-10,13-28H,1-2,11-12H2,(H,31,32,33)(H,34,35,36)(H,37,38,39)(H,40,41,42)(H,43,44,45)(H,46,47,48)(H,49,50,51)(H,52,53,54)(H,55,56,57)(H,58,59,60)(H,61,62,63)(H,64,65,66)/p-12/t13-,14-,15-,16-,17+,18+,19+,20+,21+,22+,23+,24+,25+,26+,27+,28+/m0/s1
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n/an/an/a 25.4n/an/an/a7.4n/a



Progen Industries Ltd.



Assay Description
Human FGF-1 and FGF-2 were purchased from R&D Systems, Inc. and supplied as protein (ug) dissolved in bovine serum albumin (BSA, 50ug). Surface plas...


Chembiochem 6: 1882-90 (2005)

Checked by Author
More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM84564
PNG
(Linked sulfated tetracyclitol, 5)
Show SMILES [O-]S(=O)(=O)O[C@@H]1C=C[C@@H]([C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)N(CCCCCN([C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O
Show InChI InChI=1S/C29H46N2O48S12/c32-80(33,34)68-18-8-4-14(22(72-84(44,45)46)26(18)76-88(56,57)58)30(15-5-9-19(69-81(35,36)37)27(77-89(59,60)61)23(15)73-85(47,48)49)12-2-1-3-13-31(16-6-10-20(70-82(38,39)40)28(78-90(62,63)64)24(16)74-86(50,51)52)17-7-11-21(71-83(41,42)43)29(79-91(65,66)67)25(17)75-87(53,54)55/h4-11,14-29H,1-3,12-13H2,(H,32,33,34)(H,35,36,37)(H,38,39,40)(H,41,42,43)(H,44,45,46)(H,47,48,49)(H,50,51,52)(H,53,54,55)(H,56,57,58)(H,59,60,61)(H,62,63,64)(H,65,66,67)/p-12/t14-,15-,16-,17-,18+,19+,20+,21+,22+,23+,24+,25+,26+,27+,28+,29+/m0/s1
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n/an/an/a 29.8n/an/an/a7.4n/a



Progen Industries Ltd.



Assay Description
Human FGF-1 and FGF-2 were purchased from R&D Systems, Inc. and supplied as protein (ug) dissolved in bovine serum albumin (BSA, 50ug). Surface plas...


Chembiochem 6: 1882-90 (2005)

Checked by Author
More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM84565
PNG
(Linked sulfated tetracyclitol, 6)
Show SMILES [O-]S(=O)(=O)O[C@@H]1C=C[C@@H]([C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)N(CCCCCCN([C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O
Show InChI InChI=1S/C30H48N2O48S12/c33-81(34,35)69-19-9-5-15(23(73-85(45,46)47)27(19)77-89(57,58)59)31(16-6-10-20(70-82(36,37)38)28(78-90(60,61)62)24(16)74-86(48,49)50)13-3-1-2-4-14-32(17-7-11-21(71-83(39,40)41)29(79-91(63,64)65)25(17)75-87(51,52)53)18-8-12-22(72-84(42,43)44)30(80-92(66,67)68)26(18)76-88(54,55)56/h5-12,15-30H,1-4,13-14H2,(H,33,34,35)(H,36,37,38)(H,39,40,41)(H,42,43,44)(H,45,46,47)(H,48,49,50)(H,51,52,53)(H,54,55,56)(H,57,58,59)(H,60,61,62)(H,63,64,65)(H,66,67,68)/p-12/t15-,16-,17-,18-,19+,20+,21+,22+,23+,24+,25+,26+,27+,28+,29+,30+/m0/s1
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n/an/an/a 39n/an/an/a7.4n/a



Progen Industries Ltd.



Assay Description
Human FGF-1 and FGF-2 were purchased from R&D Systems, Inc. and supplied as protein (ug) dissolved in bovine serum albumin (BSA, 50ug). Surface plas...


Chembiochem 6: 1882-90 (2005)

Checked by Author
More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM84566
PNG
(Linked sulfated tetracyclitol, 7)
Show SMILES [O-]S(=O)(=O)O[C@@H]1C=C[C@@H]([C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)N(CCCCCCCN([C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O
Show InChI InChI=1S/C31H50N2O48S12/c34-82(35,36)70-20-10-6-16(24(74-86(46,47)48)28(20)78-90(58,59)60)32(17-7-11-21(71-83(37,38)39)29(79-91(61,62)63)25(17)75-87(49,50)51)14-4-2-1-3-5-15-33(18-8-12-22(72-84(40,41)42)30(80-92(64,65)66)26(18)76-88(52,53)54)19-9-13-23(73-85(43,44)45)31(81-93(67,68)69)27(19)77-89(55,56)57/h6-13,16-31H,1-5,14-15H2,(H,34,35,36)(H,37,38,39)(H,40,41,42)(H,43,44,45)(H,46,47,48)(H,49,50,51)(H,52,53,54)(H,55,56,57)(H,58,59,60)(H,61,62,63)(H,64,65,66)(H,67,68,69)/p-12/t16-,17-,18-,19-,20+,21+,22+,23+,24+,25+,26+,27+,28+,29+,30+,31+/m0/s1
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n/an/an/a 8n/an/an/a7.4n/a



Progen Industries Ltd.



Assay Description
Human FGF-1 and FGF-2 were purchased from R&D Systems, Inc. and supplied as protein (ug) dissolved in bovine serum albumin (BSA, 50ug). Surface plas...


Chembiochem 6: 1882-90 (2005)

Checked by Author
More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM84567
PNG
(Linked sulfated tetracyclitol, 8)
Show SMILES [O-]S(=O)(=O)O[C@@H]1C=C[C@@H]([C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)N(CCCCCCCCN([C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O
Show InChI InChI=1S/C32H52N2O48S12/c35-83(36,37)71-21-11-7-17(25(75-87(47,48)49)29(21)79-91(59,60)61)33(18-8-12-22(72-84(38,39)40)30(80-92(62,63)64)26(18)76-88(50,51)52)15-5-3-1-2-4-6-16-34(19-9-13-23(73-85(41,42)43)31(81-93(65,66)67)27(19)77-89(53,54)55)20-10-14-24(74-86(44,45)46)32(82-94(68,69)70)28(20)78-90(56,57)58/h7-14,17-32H,1-6,15-16H2,(H,35,36,37)(H,38,39,40)(H,41,42,43)(H,44,45,46)(H,47,48,49)(H,50,51,52)(H,53,54,55)(H,56,57,58)(H,59,60,61)(H,62,63,64)(H,65,66,67)(H,68,69,70)/p-12/t17-,18-,19-,20-,21+,22+,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+/m0/s1
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n/an/an/a 40.4n/an/an/a7.4n/a



Progen Industries Ltd.



Assay Description
Human FGF-1 and FGF-2 were purchased from R&D Systems, Inc. and supplied as protein (ug) dissolved in bovine serum albumin (BSA, 50ug). Surface plas...


Chembiochem 6: 1882-90 (2005)

Checked by Author
More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM84568
PNG
(Linked sulfated tetracyclitol, 9)
Show SMILES [O-]S(=O)(=O)O[C@@H]1C=C[C@@H]([C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)N(CCCCCCCCCN([C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O
Show InChI InChI=1S/C33H54N2O48S12/c36-84(37,38)72-22-12-8-18(26(76-88(48,49)50)30(22)80-92(60,61)62)34(19-9-13-23(73-85(39,40)41)31(81-93(63,64)65)27(19)77-89(51,52)53)16-6-4-2-1-3-5-7-17-35(20-10-14-24(74-86(42,43)44)32(82-94(66,67)68)28(20)78-90(54,55)56)21-11-15-25(75-87(45,46)47)33(83-95(69,70)71)29(21)79-91(57,58)59/h8-15,18-33H,1-7,16-17H2,(H,36,37,38)(H,39,40,41)(H,42,43,44)(H,45,46,47)(H,48,49,50)(H,51,52,53)(H,54,55,56)(H,57,58,59)(H,60,61,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)/p-12/t18-,19-,20-,21-,22+,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+/m0/s1
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n/an/an/a 119n/an/an/a7.4n/a



Progen Industries Ltd.



Assay Description
Human FGF-1 and FGF-2 were purchased from R&D Systems, Inc. and supplied as protein (ug) dissolved in bovine serum albumin (BSA, 50ug). Surface plas...


Chembiochem 6: 1882-90 (2005)

Checked by Author
More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM84569
PNG
(Linked sulfated tetracyclitol, 10)
Show SMILES [O-]S(=O)(=O)O[C@@H]1C=C[C@@H]([C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)N(CCCCCCCCCCN([C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O
Show InChI InChI=1S/C34H56N2O48S12/c37-85(38,39)73-23-13-9-19(27(77-89(49,50)51)31(23)81-93(61,62)63)35(20-10-14-24(74-86(40,41)42)32(82-94(64,65)66)28(20)78-90(52,53)54)17-7-5-3-1-2-4-6-8-18-36(21-11-15-25(75-87(43,44)45)33(83-95(67,68)69)29(21)79-91(55,56)57)22-12-16-26(76-88(46,47)48)34(84-96(70,71)72)30(22)80-92(58,59)60/h9-16,19-34H,1-8,17-18H2,(H,37,38,39)(H,40,41,42)(H,43,44,45)(H,46,47,48)(H,49,50,51)(H,52,53,54)(H,55,56,57)(H,58,59,60)(H,61,62,63)(H,64,65,66)(H,67,68,69)(H,70,71,72)/p-12/t19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+/m0/s1
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n/an/an/a 115n/an/an/a7.4n/a



Progen Industries Ltd.



Assay Description
Human FGF-1 and FGF-2 were purchased from R&D Systems, Inc. and supplied as protein (ug) dissolved in bovine serum albumin (BSA, 50ug). Surface plas...


Chembiochem 6: 1882-90 (2005)

Checked by Author
More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM84570
PNG
(Linked sulfated tetracyclitol, 11)
Show SMILES [O-]S(=O)(=O)O[C@@H]1C=C[C@@H]([C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)N([C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)c1ccc(cc1)N([C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O
Show InChI InChI=1S/C30H40N2O48S12/c33-81(34,35)69-19-9-5-15(23(73-85(45,46)47)27(19)77-89(57,58)59)31(16-6-10-20(70-82(36,37)38)28(78-90(60,61)62)24(16)74-86(48,49)50)13-1-2-14(4-3-13)32(17-7-11-21(71-83(39,40)41)29(79-91(63,64)65)25(17)75-87(51,52)53)18-8-12-22(72-84(42,43)44)30(80-92(66,67)68)26(18)76-88(54,55)56/h1-12,15-30H,(H,33,34,35)(H,36,37,38)(H,39,40,41)(H,42,43,44)(H,45,46,47)(H,48,49,50)(H,51,52,53)(H,54,55,56)(H,57,58,59)(H,60,61,62)(H,63,64,65)(H,66,67,68)/p-12/t15-,16-,17-,18-,19+,20+,21+,22+,23+,24+,25+,26+,27+,28+,29+,30+/m0/s1
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n/an/an/a 187n/an/an/a7.4n/a



Progen Industries Ltd.



Assay Description
Human FGF-1 and FGF-2 were purchased from R&D Systems, Inc. and supplied as protein (ug) dissolved in bovine serum albumin (BSA, 50ug). Surface plas...


Chembiochem 6: 1882-90 (2005)

Checked by Author
More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM84571
PNG
(Linked sulfated tetracyclitol, 12)
Show SMILES [O-]S(=O)(=O)O[C@@H]1C=CC([C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)N(CN([C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)CN([C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O
Show InChI InChI=1S/C32H51N3O60S15/c36-96(37,38)81-18-6-1-13(23(86-101(51,52)53)28(18)91-106(66,67)68)33(11-34(14-2-7-19(82-97(39,40)41)29(92-107(69,70)71)24(14)87-102(54,55)56)15-3-8-20(83-98(42,43)44)30(93-108(72,73)74)25(15)88-103(57,58)59)12-35(16-4-9-21(84-99(45,46)47)31(94-109(75,76)77)26(16)89-104(60,61)62)17-5-10-22(85-100(48,49)50)32(95-110(78,79)80)27(17)90-105(63,64)65/h1-10,13-32,102H,11-12H2,(H,36,37,38)(H,39,40,41)(H,42,43,44)(H,45,46,47)(H,48,49,50)(H,51,52,53)(H2,54,55,56)(H,57,58,59)(H,60,61,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80)/p-15/t13?,14-,15-,16-,17-,18+,19+,20+,21+,22+,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+/m0/s1
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n/an/an/a 0.400n/an/an/a7.4n/a



Progen Industries Ltd.



Assay Description
Human FGF-1 and FGF-2 were purchased from R&D Systems, Inc. and supplied as protein (ug) dissolved in bovine serum albumin (BSA, 50ug). Surface plas...


Chembiochem 6: 1882-90 (2005)

Checked by Author
More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM50017346
PNG
(CHEMBL3288258)
Show SMILES [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].CCCCCO[C@H]1O[C@H](COS([O-])(=O)=O)[C@@H](O[C@@H]2O[C@H]([C@@H](O[C@H]3O[C@H](COS([O-])(=O)=O)[C@@H](O[C@@H]4O[C@H]([C@@H](O[C@H]5O[C@H](COS([O-])(=O)=O)[C@@H](O[C@@H]6O[C@H]([C@@H](O)[C@H](O)[C@H]6OS([O-])(=O)=O)C([O-])=O)[C@H](O)[C@H]5NC(C)=O)[C@H](O)[C@H]4OS([O-])(=O)=O)C([O-])=O)[C@H](O)[C@H]3NC(C)=O)[C@H](O)[C@H]2OS([O-])(=O)=O)C([O-])=O)[C@H](O)[C@H]1NC(C)=O
Show InChI InChI=1S/C47H75N3O52S6.9Na/c1-5-6-7-8-85-42-18(48-12(2)51)21(54)28(15(89-42)9-86-103(67,68)69)93-46-35(101-107(79,80)81)26(59)31(37(98-46)40(63)64)96-44-20(50-14(4)53)23(56)30(17(91-44)11-88-105(73,74)75)94-47-36(102-108(82,83)84)27(60)32(38(99-47)41(65)66)95-43-19(49-13(3)52)22(55)29(16(90-43)10-87-104(70,71)72)92-45-34(100-106(76,77)78)25(58)24(57)33(97-45)39(61)62;;;;;;;;;/h15-38,42-47,54-60H,5-11H2,1-4H3,(H,48,51)(H,49,52)(H,50,53)(H,61,62)(H,63,64)(H,65,66)(H,67,68,69)(H,70,71,72)(H,73,74,75)(H,76,77,78)(H,79,80,81)(H,82,83,84);;;;;;;;;/q;9*+1/p-9/t15-,16-,17-,18-,19-,20-,21-,22-,23-,24+,25+,26+,27+,28-,29-,30-,31+,32+,33-,34-,35-,36-,37-,38-,42+,43-,44-,45-,46-,47-;;;;;;;;;/m1........./s1
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n/an/an/a 2.50E+7n/an/an/an/an/a



Momenta Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant FGF1 by surface plasmon resonance assay


J Med Chem 57: 4511-20 (2014)

More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM50017347
PNG
(CHEMBL3288259)
Show SMILES [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].NCCCCCO[C@H]1O[C@H](CO)[C@@H](O[C@@H]2O[C@H]([C@@H](O[C@H]3O[C@H](CO)[C@@H](O[C@@H]4O[C@H]([C@@H](O[C@H]5O[C@H](CO)[C@@H](O[C@@H]6O[C@H]([C@@H](O)[C@H](O)[C@H]6OS([O-])(=O)=O)C([O-])=O)[C@H](O)[C@H]5NS([O-])(=O)=O)[C@H](O)[C@H]4OS([O-])(=O)=O)C([O-])=O)[C@H](O)[C@H]3NS([O-])(=O)=O)[C@H](O)[C@H]2OS([O-])(=O)=O)C([O-])=O)[C@H](O)[C@H]1NS([O-])(=O)=O
Show InChI InChI=1S/C41H70N4O49S6.9Na/c42-4-2-1-3-5-80-36-12(43-95(62,63)64)15(49)22(9(6-46)81-36)85-40-29(93-99(74,75)76)20(54)25(31(90-40)34(58)59)88-38-14(45-97(68,69)70)17(51)24(11(8-48)83-38)86-41-30(94-100(77,78)79)21(55)26(32(91-41)35(60)61)87-37-13(44-96(65,66)67)16(50)23(10(7-47)82-37)84-39-28(92-98(71,72)73)19(53)18(52)27(89-39)33(56)57;;;;;;;;;/h9-32,36-41,43-55H,1-8,42H2,(H,56,57)(H,58,59)(H,60,61)(H,62,63,64)(H,65,66,67)(H,68,69,70)(H,71,72,73)(H,74,75,76)(H,77,78,79);;;;;;;;;/q;9*+1/p-9/t9-,10-,11-,12-,13-,14-,15-,16-,17-,18+,19+,20+,21+,22-,23-,24-,25+,26+,27-,28-,29-,30-,31-,32-,36+,37-,38-,39-,40-,41-;;;;;;;;;/m1........./s1
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n/an/an/a 8.00E+3n/an/an/an/an/a



Momenta Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant FGF1 by surface plasmon resonance assay


J Med Chem 57: 4511-20 (2014)

More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM50017345
PNG
(CHEMBL3288260)
Show SMILES [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].CCCCCO[C@H]1O[C@H](COS([O-])(=O)=O)[C@@H](O[C@@H]2O[C@H]([C@@H](O[C@H]3O[C@H](COS([O-])(=O)=O)[C@@H](O[C@@H]4O[C@H]([C@@H](O[C@H]5O[C@H](COS([O-])(=O)=O)[C@@H](O[C@@H]6O[C@H]([C@@H](O)[C@H](O)[C@H]6OS([O-])(=O)=O)C([O-])=O)[C@H](O)[C@H]5NC(C)=O)[C@H](O)[C@H]4OS([O-])(=O)=O)C([O-])=O)[C@H](O)[C@H]3NS([O-])(=O)=O)[C@H](O)[C@H]2O)C([O-])=O)[C@H](O)[C@H]1NC(C)=O
Show InChI InChI=1S/C45H73N3O51S6.9Na/c1-4-5-6-7-83-40-16(46-11(2)49)19(51)27(13(87-40)8-84-101(68,69)70)90-43-25(57)24(56)30(35(96-43)38(61)62)93-42-18(48-100(65,66)67)21(53)29(15(89-42)10-86-103(74,75)76)92-45-34(99-105(80,81)82)26(58)31(36(97-45)39(63)64)94-41-17(47-12(3)50)20(52)28(14(88-41)9-85-102(71,72)73)91-44-33(98-104(77,78)79)23(55)22(54)32(95-44)37(59)60;;;;;;;;;/h13-36,40-45,48,51-58H,4-10H2,1-3H3,(H,46,49)(H,47,50)(H,59,60)(H,61,62)(H,63,64)(H,65,66,67)(H,68,69,70)(H,71,72,73)(H,74,75,76)(H,77,78,79)(H,80,81,82);;;;;;;;;/q;9*+1/p-9/t13-,14-,15-,16-,17-,18-,19-,20-,21-,22+,23+,24-,25-,26+,27-,28-,29-,30+,31+,32-,33-,34-,35-,36-,40+,41-,42-,43-,44-,45-;;;;;;;;;/m1........./s1
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n/an/an/a 2.50E+7n/an/an/an/an/a



Momenta Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant FGF1 by surface plasmon resonance assay


J Med Chem 57: 4511-20 (2014)

More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM50144521
PNG
(CHEMBL408602 | Sodium sulfated glycoconjugate deri...)
Show SMILES COC1OC(COCC(=O)N(CC(=O)NC2CCCCC2)C2CCC(CC2)N(CC(=O)NC2CCCCC2)C(=O)COCC2OC(OC)C(OS([O-])(=O)=O)C(OS([O-])(=O)=O)C2OS([O-])(=O)=O)C(OS([O-])(=O)=O)C(OS([O-])(=O)=O)C1OS([O-])(=O)=O
Show InChI InChI=1S/C40H68N4O34S6/c1-67-39-37(77-83(61,62)63)35(75-81(55,56)57)33(73-79(49,50)51)27(71-39)19-69-21-31(47)43(17-29(45)41-23-9-5-3-6-10-23)25-13-15-26(16-14-25)44(18-30(46)42-24-11-7-4-8-12-24)32(48)22-70-20-28-34(74-80(52,53)54)36(76-82(58,59)60)38(40(68-2)72-28)78-84(64,65)66/h23-28,33-40H,3-22H2,1-2H3,(H,41,45)(H,42,46)(H,49,50,51)(H,52,53,54)(H,55,56,57)(H,58,59,60)(H,61,62,63)(H,64,65,66)/p-6
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n/an/an/a 3.26E+4n/an/an/an/an/a



Progen Industries Ltd

Curated by ChEMBL


Assay Description
Binding affinity for human fibroblast growth factor 1 in surface plasmon resonance (SPR) assay


Bioorg Med Chem Lett 14: 2221-6 (2004)

More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM50144520
PNG
(CHEMBL308715 | Sodium sulfated glycoconjugate deri...)
Show SMILES [O-]S(=O)(=O)OC1OC(C(OS([O-])(=O)=O)C(OS([O-])(=O)=O)C1OS([O-])(=O)=O)C(=O)N(Cc1ccccc1)C(C(=O)NC1CCCCC1)c1ccccc1
Show InChI InChI=1S/C27H34N2O19S4/c30-25(28-19-14-8-3-9-15-19)20(18-12-6-2-7-13-18)29(16-17-10-4-1-5-11-17)26(31)23-21(45-49(32,33)34)22(46-50(35,36)37)24(47-51(38,39)40)27(44-23)48-52(41,42)43/h1-2,4-7,10-13,19-24,27H,3,8-9,14-16H2,(H,28,30)(H,32,33,34)(H,35,36,37)(H,38,39,40)(H,41,42,43)/p-4
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n/an/an/a 6.25E+4n/an/an/an/an/a



Progen Industries Ltd

Curated by ChEMBL


Assay Description
Binding affinity for human fibroblast growth factor 1 in surface plasmon resonance (SPR) assay


Bioorg Med Chem Lett 14: 2221-6 (2004)

More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM50144519
PNG
(CHEMBL385967 | Sodium sulfated glycoconjugate deri...)
Show SMILES [O-]S(=O)(=O)OCC1OC(OCCNC(=O)CN(Cc2ccccc2)C(=O)COC2C(OS([O-])(=O)=O)OC(COS([O-])(=O)=O)C(OS([O-])(=O)=O)C2OS([O-])(=O)=O)C(OS([O-])(=O)=O)C(OS([O-])(=O)=O)C1OS([O-])(=O)=O
Show InChI InChI=1S/C25H38N2O38S8/c28-16(26-6-7-54-24-23(64-72(48,49)50)21(63-71(45,46)47)19(61-69(39,40)41)14(58-24)10-56-66(30,31)32)9-27(8-13-4-2-1-3-5-13)17(29)12-55-22-20(62-70(42,43)44)18(60-68(36,37)38)15(11-57-67(33,34)35)59-25(22)65-73(51,52)53/h1-5,14-15,18-25H,6-12H2,(H,26,28)(H,30,31,32)(H,33,34,35)(H,36,37,38)(H,39,40,41)(H,42,43,44)(H,45,46,47)(H,48,49,50)(H,51,52,53)/p-8
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n/an/an/a 6.36E+3n/an/an/an/an/a



Progen Industries Ltd

Curated by ChEMBL


Assay Description
Binding affinity for human fibroblast growth factor 1 in surface plasmon resonance (SPR) assay


Bioorg Med Chem Lett 14: 2221-6 (2004)

More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM50144522
PNG
(CHEMBL430983 | Sodium sulfated glycoconjugate deri...)
Show SMILES CC(=O)N(CC(=O)NCCOC1OC(COS([O-])(=O)=O)C(OS([O-])(=O)=O)C(OS([O-])(=O)=O)C1OS([O-])(=O)=O)Cc1ccccc1
Show InChI InChI=1S/C19H28N2O20S4/c1-12(22)21(9-13-5-3-2-4-6-13)10-15(23)20-7-8-36-19-18(41-45(33,34)35)17(40-44(30,31)32)16(39-43(27,28)29)14(38-19)11-37-42(24,25)26/h2-6,14,16-19H,7-11H2,1H3,(H,20,23)(H,24,25,26)(H,27,28,29)(H,30,31,32)(H,33,34,35)/p-4
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n/an/an/a 3.43E+4n/an/an/an/an/a



Progen Industries Ltd

Curated by ChEMBL


Assay Description
Binding affinity for human fibroblast growth factor 1 in surface plasmon resonance (SPR) assay


Bioorg Med Chem Lett 14: 2221-6 (2004)

More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM50144523
PNG
(CHEMBL305519 | Sodium sulfated glycoconjugate deri...)
Show SMILES [O-]S(=O)(=O)OCCN(CC(=O)NC1CCCCC1)C(=O)C1OC(OS([O-])(=O)=O)C(OS([O-])(=O)=O)C(OS([O-])(=O)=O)C1OS([O-])(=O)=O
Show InChI InChI=1S/C16H28N2O23S5/c19-10(17-9-4-2-1-3-5-9)8-18(6-7-36-42(21,22)23)15(20)13-11(38-43(24,25)26)12(39-44(27,28)29)14(40-45(30,31)32)16(37-13)41-46(33,34)35/h9,11-14,16H,1-8H2,(H,17,19)(H,21,22,23)(H,24,25,26)(H,27,28,29)(H,30,31,32)(H,33,34,35)/p-5
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n/an/an/a 2.34E+6n/an/an/an/an/a



Progen Industries Ltd

Curated by ChEMBL


Assay Description
Binding affinity for human fibroblast growth factor 1 in surface plasmon resonance (SPR) assay


Bioorg Med Chem Lett 14: 2221-6 (2004)

More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM50144524
PNG
(CHEMBL410472 | Sodium sulfated glycoconjugate deri...)
Show SMILES CC(C)(CC(=O)N(CCOC1OC(COS([O-])(=O)=O)C(OS([O-])(=O)=O)C(OS([O-])(=O)=O)C1OS([O-])(=O)=O)CC(=O)NC1CCCCC1)CC(=O)N(CCOC1OC(COS([O-])(=O)=O)C(OS([O-])(=O)=O)C(OS([O-])(=O)=O)C1OS([O-])(=O)=O)CC(=O)NC1CCCCC1
Show InChI InChI=1S/C39H68N4O40S8/c1-39(2,17-29(46)42(19-27(44)40-23-9-5-3-6-10-23)13-15-72-37-35(82-90(66,67)68)33(80-88(60,61)62)31(78-86(54,55)56)25(76-37)21-74-84(48,49)50)18-30(47)43(20-28(45)41-24-11-7-4-8-12-24)14-16-73-38-36(83-91(69,70)71)34(81-89(63,64)65)32(79-87(57,58)59)26(77-38)22-75-85(51,52)53/h23-26,31-38H,3-22H2,1-2H3,(H,40,44)(H,41,45)(H,48,49,50)(H,51,52,53)(H,54,55,56)(H,57,58,59)(H,60,61,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)/p-8
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n/an/an/a 1.00E+4n/an/an/an/an/a



Progen Industries Ltd

Curated by ChEMBL


Assay Description
Binding affinity for human fibroblast growth factor 1 in surface plasmon resonance (SPR) assay


Bioorg Med Chem Lett 14: 2221-6 (2004)

More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM50144526
PNG
(CHEMBL386607 | Sodium sulfated glycoconjugate deri...)
Show SMILES COC1OC(COCC(=O)N(CC(=O)NCCOC2OC(COS([O-])(=O)=O)C(OS([O-])(=O)=O)C(OS([O-])(=O)=O)C2OS([O-])(=O)=O)Cc2ccccc2)C(OS([O-])(=O)=O)C(OS([O-])(=O)=O)C1OS([O-])(=O)=O
Show InChI InChI=1S/C26H40N2O35S7/c1-52-25-23(62-69(46,47)48)21(60-67(40,41)42)19(58-65(34,35)36)15(56-25)11-53-13-18(30)28(9-14-5-3-2-4-6-14)10-17(29)27-7-8-54-26-24(63-70(49,50)51)22(61-68(43,44)45)20(59-66(37,38)39)16(57-26)12-55-64(31,32)33/h2-6,15-16,19-26H,7-13H2,1H3,(H,27,29)(H,31,32,33)(H,34,35,36)(H,37,38,39)(H,40,41,42)(H,43,44,45)(H,46,47,48)(H,49,50,51)/p-7
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n/an/an/a 4.84E+3n/an/an/an/an/a



Progen Industries Ltd

Curated by ChEMBL


Assay Description
Binding affinity for human fibroblast growth factor 1 in surface plasmon resonance (SPR) assay


Bioorg Med Chem Lett 14: 2221-6 (2004)

More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM50144527
PNG
(CHEMBL308220 | Sodium sulfated glycoconjugate deri...)
Show SMILES COC1OC(COCC(=O)N(CC(=O)NC2CCCCC2)Cc2ccccc2)C(OS([O-])(=O)=O)C(OS([O-])(=O)=O)C1OS([O-])(=O)=O
Show InChI InChI=1S/C24H36N2O17S3/c1-38-24-23(43-46(35,36)37)22(42-45(32,33)34)21(41-44(29,30)31)18(40-24)14-39-15-20(28)26(12-16-8-4-2-5-9-16)13-19(27)25-17-10-6-3-7-11-17/h2,4-5,8-9,17-18,21-24H,3,6-7,10-15H2,1H3,(H,25,27)(H,29,30,31)(H,32,33,34)(H,35,36,37)/p-3
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n/an/an/a 2.60E+5n/an/an/an/an/a



Progen Industries Ltd

Curated by ChEMBL


Assay Description
Binding affinity for human fibroblast growth factor 1 in surface plasmon resonance (SPR) assay


Bioorg Med Chem Lett 14: 2221-6 (2004)

More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM50144525
PNG
(CHEMBL70844 | Sodium sulfated glycoconjugate deriv...)
Show SMILES [O-]S(=O)(=O)OC1OC(C(OS([O-])(=O)=O)C(OS([O-])(=O)=O)C1OS([O-])(=O)=O)C(=O)N(CC(=O)NCc1ccccc1)Cc1ccccc1
Show InChI InChI=1S/C22H26N2O19S4/c25-16(23-11-14-7-3-1-4-8-14)13-24(12-15-9-5-2-6-10-15)21(26)19-17(40-44(27,28)29)18(41-45(30,31)32)20(42-46(33,34)35)22(39-19)43-47(36,37)38/h1-10,17-20,22H,11-13H2,(H,23,25)(H,27,28,29)(H,30,31,32)(H,33,34,35)(H,36,37,38)/p-4
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n/an/an/a 1.04E+5n/an/an/an/an/a



Progen Industries Ltd

Curated by ChEMBL


Assay Description
Binding affinity for human fibroblast growth factor 1 in surface plasmon resonance (SPR) assay


Bioorg Med Chem Lett 14: 2221-6 (2004)

More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM50143026
PNG
((6-{benzyl[(cyclohexylcarbamoyl)methyl]carbamoyl}-...)
Show SMILES [O-]S(=O)(=O)OC1OC(C(OS([O-])(=O)=O)C(OS([O-])(=O)=O)C1OS([O-])(=O)=O)C(=O)N(CC(=O)NC1CCCCC1)Cc1ccccc1
Show InChI InChI=1S/C21H30N2O19S4/c24-15(22-14-9-5-2-6-10-14)12-23(11-13-7-3-1-4-8-13)20(25)18-16(39-43(26,27)28)17(40-44(29,30)31)19(41-45(32,33)34)21(38-18)42-46(35,36)37/h1,3-4,7-8,14,16-19,21H,2,5-6,9-12H2,(H,22,24)(H,26,27,28)(H,29,30,31)(H,32,33,34)(H,35,36,37)/p-4
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n/an/an/a 1.22E+5n/an/an/an/an/a



Progen Industries Ltd

Curated by ChEMBL


Assay Description
Binding affinity for human fibroblast growth factor 1 in surface plasmon resonance (SPR) assay


Bioorg Med Chem Lett 14: 2221-6 (2004)

More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM50144529
PNG
(CHEMBL70718 | Sodium sulfated glycoconjugate deriv...)
Show SMILES OC1C(OS([O-])(=O)=O)C(OS([O-])(=O)=O)C(OS([O-])(=O)=O)OC1C(=O)N(CC(=O)NC1CCCCC1)Cc1ccccc1
Show InChI InChI=1S/C21H30N2O16S3/c24-15(22-14-9-5-2-6-10-14)12-23(11-13-7-3-1-4-8-13)20(26)18-16(25)17(37-40(27,28)29)19(38-41(30,31)32)21(36-18)39-42(33,34)35/h1,3-4,7-8,14,16-19,21,25H,2,5-6,9-12H2,(H,22,24)(H,27,28,29)(H,30,31,32)(H,33,34,35)/p-3
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n/an/an/a 5.87E+5n/an/an/an/an/a



Progen Industries Ltd

Curated by ChEMBL


Assay Description
Binding affinity for human fibroblast growth factor 1 in surface plasmon resonance (SPR) assay


Bioorg Med Chem Lett 14: 2221-6 (2004)

More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM50144528
PNG
(CHEMBL430625 | Sodium sulfated glycoconjugate deri...)
Show SMILES COC1OC(COCC(=O)N(CCS([O-])(=O)=O)CC(=O)NC2CCCCC2)C(OS([O-])(=O)=O)C(OS([O-])(=O)=O)C1OS([O-])(=O)=O
Show InChI InChI=1S/C19H34N2O20S4/c1-36-19-18(41-45(33,34)35)17(40-44(30,31)32)16(39-43(27,28)29)13(38-19)10-37-11-15(23)21(7-8-42(24,25)26)9-14(22)20-12-5-3-2-4-6-12/h12-13,16-19H,2-11H2,1H3,(H,20,22)(H,24,25,26)(H,27,28,29)(H,30,31,32)(H,33,34,35)/p-4
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n/an/an/a 2.96E+5n/an/an/an/an/a



Progen Industries Ltd

Curated by ChEMBL


Assay Description
Binding affinity for human fibroblast growth factor 1 in surface plasmon resonance (SPR) assay


Bioorg Med Chem Lett 14: 2221-6 (2004)

More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM50179253
PNG
((2R,3S,4S,5S,6R)-2-{[(2R,3S,4S,5R,6R)-2-{[(2R,3S,4...)
Show SMILES CCCCCCCCO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]1O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]4O)[C@@H]3O)[C@@H]2O)[C@@H]1O
Show InChI InChI=1S/C38H68O26/c1-2-3-4-5-6-7-8-55-38-33(25(50)20(45)15(10-40)60-38)64-37-29(54)32(23(48)18(13-43)59-37)63-36-28(53)31(22(47)17(12-42)58-36)62-35-27(52)30(21(46)16(11-41)57-35)61-34-26(51)24(49)19(44)14(9-39)56-34/h14-54H,2-13H2,1H3/t14-,15-,16-,17-,18-,19-,20-,21-,22-,23-,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34-,35-,36-,37-,38+/m1/s1
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n/an/an/a 144n/an/an/an/an/a



Progen Industries Limited

Curated by ChEMBL


Assay Description
Binding affinity for FGF1 by BIAcore solution affinity assay


J Med Chem 48: 8229-36 (2005)

More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM50179254
PNG
((2R,3S,4S,5S,6R)-2-{[(2R,3S,4S,5R,6R)-2-{[(2R,3S,4...)
Show SMILES OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](CO)O[C@H](O[C@H]3[C@H](O)[C@@H](CO)O[C@H](O[C@H]4[C@H](O)[C@@H](CO)O[C@H](O[C@H]5[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]5OCc5ccccc5)[C@H]4O)[C@H]3O)[C@H]2O)[C@@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C37H58O26/c38-6-13-18(43)23(48)25(50)33(55-13)60-29-20(45)15(8-40)56-34(26(29)51)61-30-21(46)16(9-41)57-35(27(30)52)62-31-22(47)17(10-42)58-36(28(31)53)63-32-24(49)19(44)14(7-39)59-37(32)54-11-12-4-2-1-3-5-12/h1-5,13-53H,6-11H2/t13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33-,34-,35-,36-,37+/m1/s1
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n/an/an/a 120n/an/an/an/an/a



Progen Industries Limited

Curated by ChEMBL


Assay Description
Binding affinity for FGF1 by BIAcore solution affinity assay


J Med Chem 48: 8229-36 (2005)

More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM50179256
PNG
(6-{5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d...)
Show SMILES OC[C@H]1O[C@H](NC(=O)CCCCCNC(=O)CCCC[C@@H]2SC[C@@H]3NC(=O)N[C@H]23)[C@@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O[C@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]5O)[C@@H]4O)[C@@H]3O)[C@@H]2O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C46H78N4O28S/c51-10-17-27(59)32(64)40(41(70-17)49-24(57)8-2-1-5-9-47-23(56)7-4-3-6-22-25-16(15-79-22)48-46(69)50-25)78-45-36(68)39(30(62)21(14-55)74-45)77-44-35(67)38(29(61)20(13-54)73-44)76-43-34(66)37(28(60)19(12-53)72-43)75-42-33(65)31(63)26(58)18(11-52)71-42/h16-22,25-45,51-55,58-68H,1-15H2,(H,47,56)(H,49,57)(H2,48,50,69)/t16-,17+,18+,19+,20+,21+,22-,25-,26+,27+,28+,29+,30+,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42+,43+,44+,45+/m0/s1
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n/an/an/a 390n/an/an/an/an/a



Progen Industries Limited

Curated by ChEMBL


Assay Description
Binding affinity for FGF1 by BIAcore solution affinity assay


J Med Chem 48: 8229-36 (2005)

More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM50179255
PNG
(CHEMBL265885 | N-[(2S,3S,4S,5S,6R)-3-{[(2R,3S,4S,5...)
Show SMILES OC[C@H]1O[C@H](NC(=O)COc2ccccc2)[C@@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O[C@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]5O)[C@@H]4O)[C@@H]3O)[C@@H]2O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C38H59NO27/c40-6-13-20(47)25(52)33(34(58-13)39-18(45)11-57-12-4-2-1-3-5-12)66-38-29(56)32(23(50)17(10-44)62-38)65-37-28(55)31(22(49)16(9-43)61-37)64-36-27(54)30(21(48)15(8-42)60-36)63-35-26(53)24(51)19(46)14(7-41)59-35/h1-5,13-17,19-38,40-44,46-56H,6-11H2,(H,39,45)/t13-,14-,15-,16-,17-,19-,20-,21-,22-,23-,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35-,36-,37-,38-/m1/s1
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n/an/an/a 660n/an/an/an/an/a



Progen Industries Limited

Curated by ChEMBL


Assay Description
Binding affinity for FGF1 by BIAcore solution affinity assay


J Med Chem 48: 8229-36 (2005)

More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM50097125
PNG
(2-Hydroxy-5-((4-((2-pyridinylamino)sulfonyl)phenyl...)
Show SMILES OC(=O)c1cc(ccc1O)N=Nc1ccc(cc1)S(=O)(=O)Nc1ccccn1
Show InChI InChI=1S/C18H14N4O5S/c23-16-9-6-13(11-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,23H,(H,19,22)(H,24,25)
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n/an/an/a 6.09E+5n/an/an/an/an/a



Progen Industries Limited

Curated by ChEMBL


Assay Description
Dissociation constant for Fibroblast growth factor 1


J Med Chem 47: 1683-93 (2004)

More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM50143009
PNG
(2-(azidomethyl)-3,5,6-tris(sulfonatooxy)tetrahydro...)
Show SMILES [O-]S(=O)(=O)OC1OC(CN=[N+]=[N-])C(OS([O-])(=O)=O)C(OS([O-])(=O)=O)C1OS([O-])(=O)=O
Show InChI InChI=1S/C6H11N3O17S4/c7-9-8-1-2-3(23-27(10,11)12)4(24-28(13,14)15)5(25-29(16,17)18)6(22-2)26-30(19,20)21/h2-6H,1H2,(H,10,11,12)(H,13,14,15)(H,16,17,18)(H,19,20,21)/p-4
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n/an/an/a 3.40E+5n/an/an/an/an/a



Progen Industries Limited

Curated by ChEMBL


Assay Description
Dissociation constant for Fibroblast growth factor 1


J Med Chem 47: 1683-93 (2004)

More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM50143011
PNG
((2-{[3,4-bis(sulfonatooxy)-2,5-bis[(sulfonatooxy)m...)
Show SMILES [O-]S(=O)(=O)CC1OC(OC2(COS([O-])(=O)=O)OC(COS([O-])(=O)=O)C(OS([O-])(=O)=O)C2OS([O-])(=O)=O)C(CS([O-])(=O)=O)C(OS([O-])(=O)=O)C1OS([O-])(=O)=O
Show InChI InChI=1S/C13H24O33S8/c14-47(15,16)2-5-8(43-51(26,27)28)9(44-52(29,30)31)7(3-48(17,18)19)40-12(5)42-13(4-39-50(23,24)25)11(46-54(35,36)37)10(45-53(32,33)34)6(41-13)1-38-49(20,21)22/h5-12H,1-4H2,(H,14,15,16)(H,17,18,19)(H,20,21,22)(H,23,24,25)(H,26,27,28)(H,29,30,31)(H,32,33,34)(H,35,36,37)/p-8
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n/an/an/a 740n/an/an/an/an/a



Progen Industries Limited

Curated by ChEMBL


Assay Description
Dissociation constant for Fibroblast growth factor 1


J Med Chem 47: 1683-93 (2004)

More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM50143019
PNG
(2-(benzyloxy)-3-methoxy-6,8-dioxabicyclo[3.2.1]oct...)
Show SMILES COC1C(OCc2ccccc2)C2COC(O2)C1OS([O-])(=O)=O
Show InChI InChI=1S/C14H18O8S/c1-18-12-11(19-7-9-5-3-2-4-6-9)10-8-20-14(21-10)13(12)22-23(15,16)17/h2-6,10-14H,7-8H2,1H3,(H,15,16,17)/p-1
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n/an/an/a 3.07E+5n/an/an/an/an/a



Progen Industries Limited

Curated by ChEMBL


Assay Description
Dissociation constant for Fibroblast growth factor 1


J Med Chem 47: 1683-93 (2004)

More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM50103242
PNG
(CHEMBL316894 | Naphthalene trisulfonate (NTS) | na...)
Show SMILES [O-]S(=O)(=O)c1ccc2c(cc(cc2c1)S([O-])(=O)=O)S([O-])(=O)=O
Show InChI InChI=1S/C10H8O9S3/c11-20(12,13)7-1-2-9-6(3-7)4-8(21(14,15)16)5-10(9)22(17,18)19/h1-5H,(H,11,12,13)(H,14,15,16)(H,17,18,19)/p-3
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n/an/an/a 4.74E+5n/an/an/an/an/a



Progen Industries Limited

Curated by ChEMBL


Assay Description
Dissociation constant for Fibroblast growth factor 1


J Med Chem 47: 1683-93 (2004)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM50143025
PNG
(3-(benzyloxy)-6-methoxy-2-methyl-5-(sulfonatooxy)t...)
Show SMILES COC1OC(C)C(OCc2ccccc2)C(OS([O-])(=O)=O)C1OS([O-])(=O)=O
Show InChI InChI=1S/C14H20O11S2/c1-9-11(22-8-10-6-4-3-5-7-10)12(24-26(15,16)17)13(14(21-2)23-9)25-27(18,19)20/h3-7,9,11-14H,8H2,1-2H3,(H,15,16,17)(H,18,19,20)/p-2
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n/an/an/a 3.38E+5n/an/an/an/an/a



Progen Industries Limited

Curated by ChEMBL


Assay Description
Dissociation constant for Fibroblast growth factor 1


J Med Chem 47: 1683-93 (2004)

More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM50143013
PNG
((2R,3R,4R)-4-methoxy-2-[(sulfonatooxy)methyl]tetra...)
Show SMILES CO[C@@H]1CCO[C@H](COS([O-])(=O)=O)C1OS([O-])(=O)=O
Show InChI InChI=1S/C7H14O10S2/c1-14-5-2-3-15-6(4-16-18(8,9)10)7(5)17-19(11,12)13/h5-7H,2-4H2,1H3,(H,8,9,10)(H,11,12,13)/p-2/t5-,6-,7?/m1/s1
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n/an/an/a 5.94E+6n/an/an/an/an/a



Progen Industries Limited

Curated by ChEMBL


Assay Description
Dissociation constant for Fibroblast growth factor 1


J Med Chem 47: 1683-93 (2004)

More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM50143026
PNG
((6-{benzyl[(cyclohexylcarbamoyl)methyl]carbamoyl}-...)
Show SMILES [O-]S(=O)(=O)OC1OC(C(OS([O-])(=O)=O)C(OS([O-])(=O)=O)C1OS([O-])(=O)=O)C(=O)N(CC(=O)NC1CCCCC1)Cc1ccccc1
Show InChI InChI=1S/C21H30N2O19S4/c24-15(22-14-9-5-2-6-10-14)12-23(11-13-7-3-1-4-8-13)20(25)18-16(39-43(26,27)28)17(40-44(29,30)31)19(41-45(32,33)34)21(38-18)42-46(35,36)37/h1,3-4,7-8,14,16-19,21H,2,5-6,9-12H2,(H,22,24)(H,26,27,28)(H,29,30,31)(H,32,33,34)(H,35,36,37)/p-4
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n/an/an/a 1.20E+5n/an/an/an/an/a



Progen Industries Limited

Curated by ChEMBL


Assay Description
Dissociation constant for Fibroblast growth factor 1


J Med Chem 47: 1683-93 (2004)

More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM50143027
PNG
(3-(allyloxy)-6-methoxy-2-methyl-5-(sulfonatooxy)te...)
Show SMILES COC1OC(C)C(OCC=C)C(OS([O-])(=O)=O)C1OS([O-])(=O)=O
Show InChI InChI=1S/C10H18O11S2/c1-4-5-18-7-6(2)19-10(17-3)9(21-23(14,15)16)8(7)20-22(11,12)13/h4,6-10H,1,5H2,2-3H3,(H,11,12,13)(H,14,15,16)/p-2
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n/an/an/a 1.34E+6n/an/an/an/an/a



Progen Industries Limited

Curated by ChEMBL


Assay Description
Dissociation constant for Fibroblast growth factor 1


J Med Chem 47: 1683-93 (2004)

More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM50143012
PNG
((2R,3S,4R)-4-(3-phenoxypropoxy)-2-[(sulfonatooxy)m...)
Show SMILES [O-]S(=O)(=O)OC[C@H]1OCC[C@@H](OCCCOc2ccccc2)C1OS([O-])(=O)=O
Show InChI InChI=1S/C15H22O11S2/c16-27(17,18)25-11-14-15(26-28(19,20)21)13(7-10-24-14)23-9-4-8-22-12-5-2-1-3-6-12/h1-3,5-6,13-15H,4,7-11H2,(H,16,17,18)(H,19,20,21)/p-2/t13-,14-,15?/m1/s1
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n/an/an/a 3.25E+6n/an/an/an/an/a



Progen Industries Limited

Curated by ChEMBL


Assay Description
Dissociation constant for Fibroblast growth factor 1


J Med Chem 47: 1683-93 (2004)

More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM50143018
PNG
((2R,3S,4R)-4-(benzyloxy)-2-[(sulfonatooxy)methyl]t...)
Show SMILES [O-]S(=O)(=O)OC[C@H]1OCC[C@@H](OCc2ccccc2)C1OS([O-])(=O)=O
Show InChI InChI=1S/C13H18O10S2/c14-24(15,16)22-9-12-13(23-25(17,18)19)11(6-7-20-12)21-8-10-4-2-1-3-5-10/h1-5,11-13H,6-9H2,(H,14,15,16)(H,17,18,19)/p-2/t11-,12-,13?/m1/s1
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n/an/an/a 3.41E+6n/an/an/an/an/a



Progen Industries Limited

Curated by ChEMBL


Assay Description
Dissociation constant for Fibroblast growth factor 1


J Med Chem 47: 1683-93 (2004)

More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM50374503
PNG
(CHEMBL1627089)
Show SMILES CO[C@@H]1OC[C@@H](O[C@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2OS([O-])(=O)=O)[C@H](OS([O-])(=O)=O)[C@H]1OS([O-])(=O)=O
Show InChI InChI=1S/C12H22O19S3/c1-25-11-10(31-34(22,23)24)8(29-32(16,17)18)5(3-26-11)28-12-9(30-33(19,20)21)7(15)6(14)4(2-13)27-12/h4-15H,2-3H2,1H3,(H,16,17,18)(H,19,20,21)(H,22,23,24)/p-3/t4-,5-,6+,7+,8+,9-,10-,11-,12-/m1/s1
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n/an/an/a 1.40E+6n/an/an/an/an/a



Progen Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Binding affinity at FGF1


Bioorg Med Chem Lett 18: 344-9 (2008)

More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM50374505
PNG
(CHEMBL1627091)
Show SMILES CO[C@@H]1O[C@H](COS([O-])(=O)=O)[C@@H](O[C@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2OS([O-])(=O)=O)[C@H](OS([O-])(=O)=O)[C@H]1OS([O-])(=O)=O
Show InChI InChI=1S/C13H24O23S4/c1-29-12-11(36-40(26,27)28)10(35-39(23,24)25)8(5(32-12)3-30-37(17,18)19)33-13-9(34-38(20,21)22)7(16)6(15)4(2-14)31-13/h4-16H,2-3H2,1H3,(H,17,18,19)(H,20,21,22)(H,23,24,25)(H,26,27,28)/p-4/t4-,5-,6+,7+,8-,9-,10+,11-,12-,13-/m1/s1
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n/an/an/a 7.75E+4n/an/an/an/an/a



Progen Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Binding affinity at FGF1


Bioorg Med Chem Lett 18: 344-9 (2008)

More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM50374506
PNG
(CHEMBL1627090)
Show SMILES CO[C@@H]1O[C@H](COS([O-])(=O)=O)[C@@H](O[C@H]2O[C@H](COS([O-])(=O)=O)[C@H](OC)[C@H](OC)[C@H]2OS([O-])(=O)=O)[C@H](OS([O-])(=O)=O)[C@H]1OS([O-])(=O)=O
Show InChI InChI=1S/C15H28O26S5/c1-31-8-6(4-34-42(16,17)18)37-15(12(10(8)32-2)40-45(25,26)27)38-9-7(5-35-43(19,20)21)36-14(33-3)13(41-46(28,29)30)11(9)39-44(22,23)24/h6-15H,4-5H2,1-3H3,(H,16,17,18)(H,19,20,21)(H,22,23,24)(H,25,26,27)(H,28,29,30)/p-5/t6-,7-,8+,9-,10+,11+,12-,13-,14-,15-/m1/s1
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n/an/an/a 4.79E+4n/an/an/an/an/a



Progen Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Binding affinity at FGF1


Bioorg Med Chem Lett 18: 344-9 (2008)

More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM50374507
PNG
(CHEMBL1627093)
Show SMILES COC[C@H]1O[C@H](O[C@@H]2[C@@H](COS([O-])(=O)=O)O[C@@H](OC)[C@H](OS([O-])(=O)=O)[C@H]2OS([O-])(=O)=O)[C@H](OS([O-])(=O)=O)[C@@H](OC)[C@H]1OC
Show InChI InChI=1S/C16H30O23S4/c1-29-5-7-9(30-2)11(31-3)13(38-42(23,24)25)16(35-7)36-10-8(6-33-40(17,18)19)34-15(32-4)14(39-43(26,27)28)12(10)37-41(20,21)22/h7-16H,5-6H2,1-4H3,(H,17,18,19)(H,20,21,22)(H,23,24,25)(H,26,27,28)/p-4/t7-,8-,9+,10-,11+,12+,13-,14-,15-,16-/m1/s1
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n/an/an/a 2.33E+5n/an/an/an/an/a



Progen Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Binding affinity at FGF1


Bioorg Med Chem Lett 18: 344-9 (2008)

More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM50374508
PNG
(CHEMBL1627092)
Show SMILES CO[C@@H]1O[C@H](COS([O-])(=O)=O)[C@@H](O[C@H]2O[C@H](COS([O-])(=O)=O)[C@H](O)[C@H](O)[C@H]2OS([O-])(=O)=O)[C@H](OS([O-])(=O)=O)[C@H]1OS([O-])(=O)=O
Show InChI InChI=1S/C13H24O26S5/c1-31-12-11(39-44(28,29)30)10(38-43(25,26)27)8(5(35-12)3-33-41(19,20)21)36-13-9(37-42(22,23)24)7(15)6(14)4(34-13)2-32-40(16,17)18/h4-15H,2-3H2,1H3,(H,16,17,18)(H,19,20,21)(H,22,23,24)(H,25,26,27)(H,28,29,30)/p-5/t4-,5-,6+,7+,8-,9-,10+,11-,12-,13-/m1/s1
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n/an/an/a 2.18E+4n/an/an/an/an/a



Progen Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Binding affinity at FGF1


Bioorg Med Chem Lett 18: 344-9 (2008)

More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM50378647
PNG
(CHEMBL1627122 | PI-88)
Show SMILES [O-]P([O-])(=O)OC[C@H]1O[C@H](O[C@H]2[C@H](OS([O-])(=O)=O)[C@@H](COS([O-])(=O)=O)O[C@H](O[C@H]3[C@H](OS([O-])(=O)=O)[C@@H](COS([O-])(=O)=O)O[C@H](O[C@H]4[C@H](OS([O-])(=O)=O)[C@@H](COS([O-])(=O)=O)O[C@H](O[C@@H]5[C@@H](OS([O-])(=O)=O)O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]5OS([O-])(=O)=O)[C@H]4OS([O-])(=O)=O)[C@H]3OS([O-])(=O)=O)[C@H]2OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O
Show InChI InChI=1S/C30H53O77PS16/c31-108(32,33)82-1-6-14(99-116(55,56)57)20(102-119(64,65)66)25(106-123(76,77)78)29(87-6)94-17-12(97-114(49,50)51)8(3-84-110(37,38)39)89-27(23(17)104-121(70,71)72)92-16-11(96-113(46,47)48)7(2-83-109(34,35)36)88-26(22(16)103-120(67,68)69)93-18-13(98-115(52,53)54)9(4-85-111(40,41)42)90-28(24(18)105-122(73,74)75)95-21-19(101-118(61,62)63)15(100-117(58,59)60)10(5-86-112(43,44)45)91-30(21)107-124(79,80)81/h6-30H,1-5H2,(H2,31,32,33)(H,34,35,36)(H,37,38,39)(H,40,41,42)(H,43,44,45)(H,46,47,48)(H,49,50,51)(H,52,53,54)(H,55,56,57)(H,58,59,60)(H,61,62,63)(H,64,65,66)(H,67,68,69)(H,70,71,72)(H,73,74,75)(H,76,77,78)(H,79,80,81)/p-18/t6-,7-,8-,9-,10-,11-,12-,13-,14-,15-,16+,17+,18+,19+,20+,21+,22+,23+,24+,25+,26-,27-,28-,29-,30-/m1/s1
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n/an/an/a 240n/an/an/an/an/a



Progen Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Binding affinity to FGF1 by surface plasmon-based solution affinity assay


J Med Chem 53: 1686-99 (2010)

More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM50307398
PNG
(CHEMBL603122 | Hexadecasodium [2-(benzyloxy)-3-({4...)
Show SMILES [O-]S(=O)(=O)OC[C@H]1O[C@H](OCc2ccccc2)[C@@H](O[C@H]2O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](O[C@H]3O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](O[C@H]4O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](O[C@H]5O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](OS([O-])(=O)=O)[C@@H]5OS([O-])(=O)=O)[C@@H]4OS([O-])(=O)=O)[C@@H]3OS([O-])(=O)=O)[C@@H]2OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O
Show InChI InChI=1S/C37H58O74S16/c38-112(39,40)87-7-13-18(101-117(53,54)55)23(97-35-30(109-125(77,78)79)24(19(102-118(56,57)58)14(94-35)8-88-113(41,42)43)99-37-32(111-127(83,84)85)27(107-123(71,72)73)22(105-121(65,66)67)17(96-37)11-91-116(50,51)52)29(108-124(74,75)76)34(93-13)98-25-20(103-119(59,60)61)15(9-89-114(44,45)46)95-36(31(25)110-126(80,81)82)100-28-26(106-122(68,69)70)21(104-120(62,63)64)16(10-90-115(47,48)49)92-33(28)86-6-12-4-2-1-3-5-12/h1-5,13-37H,6-11H2,(H,38,39,40)(H,41,42,43)(H,44,45,46)(H,47,48,49)(H,50,51,52)(H,53,54,55)(H,56,57,58)(H,59,60,61)(H,62,63,64)(H,65,66,67)(H,68,69,70)(H,71,72,73)(H,74,75,76)(H,77,78,79)(H,80,81,82)(H,83,84,85)/p-16/t13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34-,35-,36-,37-/m1/s1
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n/an/an/a 160n/an/an/an/an/a



Progen Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Binding affinity to FGF1 by surface plasmon-based solution affinity assay


J Med Chem 53: 1686-99 (2010)

More data for this
Ligand-Target Pair
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