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Compile Data Set for Download or QSAR

Found 1991 hits Enz. Inhib. hit(s) with Target = 'Aminopeptidase'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aminopeptidase B


(Mus musculus)
BDBM50078120
PNG
((R)-1-{[(S)-2-((S)-1-Carboxy-1-methyl-2-phenyl-eth...)
Show SMILES C[C@H]([NH3+])P(O)(=O)C[C@@H](Cc1ccccc1)C(=O)N[C@@](C)(Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C22H29N2O5P/c1-16(23)30(28,29)15-19(13-17-9-5-3-6-10-17)20(25)24-22(2,21(26)27)14-18-11-7-4-8-12-18/h3-12,16,19H,13-15,23H2,1-2H3,(H,24,25)(H,26,27)(H,28,29)/p+1/t16-,19-,22+/m1/s1
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>0.0000100n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity was measured on Aminopeptidase B using Arg p.NA as substrate


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase B


(Mus musculus)
BDBM50078122
PNG
((R)-1-{[(S)-2-((S)-1-Carboxy-1-methyl-2-phenyl-eth...)
Show SMILES C[C@@](Cc1ccccc1)(NC(=O)[C@H](Cc1ccccc1)CP(O)(=O)[C@@H]([NH3+])Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C28H33N2O5P/c1-28(27(32)33,19-23-15-9-4-10-16-23)30-26(31)24(17-21-11-5-2-6-12-21)20-36(34,35)25(29)18-22-13-7-3-8-14-22/h2-16,24-25H,17-20,29H2,1H3,(H,30,31)(H,32,33)(H,34,35)/p+1/t24-,25-,28+/m1/s1
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>0.0000100n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity was measured on Aminopeptidase B using Arg p.NA as substrate


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase A


(Sus scrofa)
BDBM50078122
PNG
((R)-1-{[(S)-2-((S)-1-Carboxy-1-methyl-2-phenyl-eth...)
Show SMILES C[C@@](Cc1ccccc1)(NC(=O)[C@H](Cc1ccccc1)CP(O)(=O)[C@@H]([NH3+])Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C28H33N2O5P/c1-28(27(32)33,19-23-15-9-4-10-16-23)30-26(31)24(17-21-11-5-2-6-12-21)20-36(34,35)25(29)18-22-13-7-3-8-14-22/h2-16,24-25H,17-20,29H2,1H3,(H,30,31)(H,32,33)(H,34,35)/p+1/t24-,25-,28+/m1/s1
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0.0000400n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity was measured on Aminopeptidase using GluNA as substrate


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50353018
PNG
(CHEMBL1821980 | CHEMBL1852660)
Show SMILES NC1CCc2c(Br)ccc(-c3ccccc3)c2CC1=O
Show InChI InChI=1S/C17H16BrNO/c18-15-8-6-12(11-4-2-1-3-5-11)14-10-17(20)16(19)9-7-13(14)15/h1-6,8,16H,7,9-10,19H2
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0.0600n/an/an/an/an/an/an/an/a



Universit£ de Haute-Alsace

Curated by ChEMBL


Assay Description
Inhibition of pig APN using L-leucine-p-nitroanilide as substrate measured every 10 mins for 2 hrs by spectriphotometric analysis


Bioorg Med Chem 21: 2135-44 (2013)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50353018
PNG
(CHEMBL1821980 | CHEMBL1852660)
Show SMILES NC1CCc2c(Br)ccc(-c3ccccc3)c2CC1=O
Show InChI InChI=1S/C17H16BrNO/c18-15-8-6-12(11-4-2-1-3-5-11)14-10-17(20)16(19)9-7-13(14)15/h1-6,8,16H,7,9-10,19H2
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0.0600n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney APN using L-leucine-p-nitroanilide as substrate after 30 mins by Dixon plot analysis


Bioorg Med Chem 19: 5716-33 (2011)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens)
BDBM50353018
PNG
(CHEMBL1821980 | CHEMBL1852660)
Show SMILES NC1CCc2c(Br)ccc(-c3ccccc3)c2CC1=O
Show InChI InChI=1S/C17H16BrNO/c18-15-8-6-12(11-4-2-1-3-5-11)14-10-17(20)16(19)9-7-13(14)15/h1-6,8,16H,7,9-10,19H2
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0.0600n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Inhibition of human APN


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens)
BDBM50078125
PNG
((1-Amino-3-phenyl-propyl)-phosphinic acid | CHEMBL...)
Show SMILES OP(O)C(=N)CCc1ccccc1
Show InChI InChI=1S/C9H12NO2P/c10-9(13(11)12)7-6-8-4-2-1-3-5-8/h1-5,10-12H,6-7H2
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0.160n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of human recombinant alanyl aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Mus musculus)
BDBM50353018
PNG
(CHEMBL1821980 | CHEMBL1852660)
Show SMILES NC1CCc2c(Br)ccc(-c3ccccc3)c2CC1=O
Show InChI InChI=1S/C17H16BrNO/c18-15-8-6-12(11-4-2-1-3-5-11)14-10-17(20)16(19)9-7-13(14)15/h1-6,8,16H,7,9-10,19H2
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0.200n/an/an/an/an/an/an/an/a



Universit£ de Haute-Alsace

Curated by ChEMBL


Assay Description
Inhibition of mouse APN using L-leucine-p-nitroanilide as substrate measured every 10 mins for 2 hrs by spectriphotometric analysis


Bioorg Med Chem 21: 2135-44 (2013)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens)
BDBM50025070
PNG
(CHEMBL3355110)
Show SMILES NCc1ccc(CC(CP(O)(=O)C(N)CCc2cccnc2)C(O)=O)cc1
Show InChI InChI=1/C19H26N3O4P/c20-11-15-5-3-14(4-6-15)10-17(19(23)24)13-27(25,26)18(21)8-7-16-2-1-9-22-12-16/h1-6,9,12,17-18H,7-8,10-11,13,20-21H2,(H,23,24)(H,25,26)
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0.210n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of human recombinant alanyl aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens)
BDBM50025048
PNG
(CHEMBL3355099)
Show SMILES N[C@@H](CCc1ccccc1)P(O)(O)=O
Show InChI InChI=1/C9H14NO3P/c10-9(14(11,12)13)7-6-8-4-2-1-3-5-8/h1-5,9H,6-7,10H2,(H2,11,12,13)/t9-/s2
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0.230n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of human recombinant alanyl aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens)
BDBM50353018
PNG
(CHEMBL1821980 | CHEMBL1852660)
Show SMILES NC1CCc2c(Br)ccc(-c3ccccc3)c2CC1=O
Show InChI InChI=1S/C17H16BrNO/c18-15-8-6-12(11-4-2-1-3-5-11)14-10-17(20)16(19)9-7-13(14)15/h1-6,8,16H,7,9-10,19H2
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0.350n/an/an/an/an/an/an/an/a



Universit£ de Haute-Alsace

Curated by ChEMBL


Assay Description
Inhibition of human APN using L-leucine-p-nitroanilide as substrate measured every 10 mins for 2 hrs by spectriphotometric analysis


Bioorg Med Chem 21: 2135-44 (2013)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM23971
PNG
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1
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0.5n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Competitive inhibition of pig APN using L-leucine-p-nitroanilide as substrate by Dixon-plot analysis


Bioorg Med Chem 20: 4942-53 (2012)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Aminopeptidase N


(Homo sapiens)
BDBM50025066
PNG
(CHEMBL3355109)
Show SMILES NCc1ccc(CC(CP(O)(=O)C(N)CCc2ccccc2)C(O)=O)cc1
Show InChI InChI=1/C20H27N2O4P/c21-13-17-8-6-16(7-9-17)12-18(20(23)24)14-27(25,26)19(22)11-10-15-4-2-1-3-5-15/h1-9,18-19H,10-14,21-22H2,(H,23,24)(H,25,26)
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0.690n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of human recombinant alanyl aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens)
BDBM50316049
PNG
(1-amino-3-phenylpropylphosphonic acid | CHEMBL1090...)
Show SMILES NC(CCc1ccccc1)P(O)(O)=O
Show InChI InChI=1S/C9H14NO3P/c10-9(14(11,12)13)7-6-8-4-2-1-3-5-8/h1-5,9H,6-7,10H2,(H2,11,12,13)
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0.790n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of human recombinant alanyl aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)

More data for this
Ligand-Target Pair
Aminopeptidase B


(Rattus norvegicus)
BDBM50017480
PNG
(5-Amino-8-guanidino-2-(4-hydroxy-benzyl)-4-oxo-oct...)
Show SMILES N[C@@H](CCCNC(N)=N)C(=O)C[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C16H24N4O4/c17-13(2-1-7-20-16(18)19)14(22)9-11(15(23)24)8-10-3-5-12(21)6-4-10/h3-6,11,13,21H,1-2,7-9,17H2,(H,23,24)(H4,18,19,20)/t11-,13+/m1/s1
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0.840n/an/an/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Inhibition of aminopeptidase B or arginyl aminopeptidase purified from rat liver


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase A


(Homo sapiens)
BDBM50083386
PNG
(1-{[1-(2,3-Dicarboxy-pyrrolidine-1-carbonyl)-2-met...)
Show SMILES CC[C@@H](C)[C@H](NC(=O)[C@H](S)[C@H]([NH3+])CCS([O-])(=O)=O)C(=O)N1CCC([C@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C17H29N3O9S2/c1-3-8(2)11(19-14(21)13(30)10(18)5-7-31(27,28)29)15(22)20-6-4-9(16(23)24)12(20)17(25)26/h8-13,30H,3-7,18H2,1-2H3,(H,19,21)(H,23,24)(H,25,26)(H,27,28,29)/t8-,9?,10-,11+,12+,13-/m1/s1
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0.873n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Binding affinity against recombinant Aminopeptidase A


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase B


(Homo sapiens)
BDBM50036831
PNG
(6-Amino-2-mercapto-hexanoic acid | CHEMBL432852)
Show SMILES NCCCCC(S)C(O)=O
Show InChI InChI=1S/C6H13NO2S/c7-4-2-1-3-5(10)6(8)9/h5,10H,1-4,7H2,(H,8,9)
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0.900n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibition of arginylaminopeptidase (aminopeptidase B)


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase B


(Rattus norvegicus)
BDBM50022743
PNG
(2,6-Diamino-hexane-1-thiol | CHEMBL68509)
Show SMILES NCCCC[C@@H](N)CS
Show InChI InChI=1S/C6H16N2S/c7-4-2-1-3-6(8)5-9/h6,9H,1-5,7-8H2/t6-/m1/s1
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0.910n/an/an/an/an/an/an/an/a



University of Wisconsin

Curated by ChEMBL


Assay Description
Inhibitory activity against aminopeptidase B


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens)
BDBM50025099
PNG
(CHEMBL3355111)
Show SMILES NCc1cccc(CC(CP(O)(=O)C(N)CCc2ccncc2)C(O)=O)c1
Show InChI InChI=1/C19H26N3O4P/c20-12-16-3-1-2-15(10-16)11-17(19(23)24)13-27(25,26)18(21)5-4-14-6-8-22-9-7-14/h1-3,6-10,17-18H,4-5,11-13,20-21H2,(H,23,24)(H,25,26)
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1.10n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of human recombinant alanyl aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50078125
PNG
((1-Amino-3-phenyl-propyl)-phosphinic acid | CHEMBL...)
Show SMILES OP(O)C(=N)CCc1ccccc1
Show InChI InChI=1S/C9H12NO2P/c10-9(13(11)12)7-6-8-4-2-1-3-5-8/h1-5,10-12H,6-7H2
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1.20n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of pig recombinant alanyl aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens)
BDBM50025041
PNG
(CHEMBL3355106)
Show SMILES NC(CCc1ccncc1)P(O)(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1/C18H23N2O4P/c19-17(7-6-14-8-10-20-11-9-14)25(23,24)13-16(18(21)22)12-15-4-2-1-3-5-15/h1-5,8-11,16-17H,6-7,12-13,19H2,(H,21,22)(H,23,24)
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1.30n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of human recombinant alanyl aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50025070
PNG
(CHEMBL3355110)
Show SMILES NCc1ccc(CC(CP(O)(=O)C(N)CCc2cccnc2)C(O)=O)cc1
Show InChI InChI=1/C19H26N3O4P/c20-11-15-5-3-14(4-6-15)10-17(19(23)24)13-27(25,26)18(21)8-7-16-2-1-9-22-12-16/h1-6,9,12,17-18H,7-8,10-11,13,20-21H2,(H,23,24)(H,25,26)
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1.5n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of pig recombinant alanyl aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50393210
PNG
(CHEMBL1235787)
Show SMILES CC(=N)P(O)(O)C[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C21H27N2O5P/c1-15(22)29(27,28)14-18(12-16-8-4-2-5-9-16)20(24)23-19(21(25)26)13-17-10-6-3-7-11-17/h2-11,18-19,22,27-29H,12-14H2,1H3,(H,23,24)(H,25,26)/t18-,19+/m1/s1
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1.5n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of porcine APN


Bioorg Med Chem Lett 26: 4122-6 (2016)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50087089
PNG
((2S)-2-[(2S)-3-{[(1S)-1-azaniumyl-2-phenylethyl](h...)
Show SMILES [NH3+][C@H](Cc1ccccc1)P(O)(=O)C[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C27H31N2O5P/c28-25(18-22-14-8-3-9-15-22)35(33,34)19-23(16-20-10-4-1-5-11-20)26(30)29-24(27(31)32)17-21-12-6-2-7-13-21/h1-15,23-25H,16-19,28H2,(H,29,30)(H,31,32)(H,33,34)/p+1/t23-,24+,25+/m1/s1
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1.5n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens)
BDBM50025043
PNG
(CHEMBL3355104)
Show SMILES NC(CCc1ccc(CO)cc1)P(O)(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1/C20H26NO5P/c21-19(11-10-15-6-8-17(13-22)9-7-15)27(25,26)14-18(20(23)24)12-16-4-2-1-3-5-16/h1-9,18-19,22H,10-14,21H2,(H,23,24)(H,25,26)
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1.70n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of human recombinant alanyl aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50087095
PNG
(1-{[3-(4-Bromo-phenyl)-2-(1-carboxy-ethylcarbamoyl...)
Show SMILES C[C@@H]([NH3+])P(O)(=O)C[C@@H](Cc1ccc(Br)cc1)C(=O)N[C@@H](C)C(O)=O
Show InChI InChI=1S/C15H22BrN2O5P/c1-9(15(20)21)18-14(19)12(8-24(22,23)10(2)17)7-11-3-5-13(16)6-4-11/h3-6,9-10,12H,7-8,17H2,1-2H3,(H,18,19)(H,20,21)(H,22,23)/p+1/t9-,10-,12+/m0/s1
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1.90n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens)
BDBM50129684
PNG
(3-[(1-amino-3-phenyl-propyl)-hydroxy-phosphinoyl]-...)
Show SMILES OC(=O)C(Cc1ccccc1)CP(O)(O)C(=N)CCc1ccccc1
Show InChI InChI=1S/C19H24NO4P/c20-18(12-11-15-7-3-1-4-8-15)25(23,24)14-17(19(21)22)13-16-9-5-2-6-10-16/h1-10,17,20,23-25H,11-14H2,(H,21,22)
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2n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of human recombinant alanyl aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50105574
PNG
(CHEMBL3597443)
Show SMILES NC1CCc2cccc(-c3ccc(Cl)cc3)c2CC1=O
Show InChI InChI=1/C17H16ClNO.ClH/c18-13-7-4-12(5-8-13)14-3-1-2-11-6-9-16(19)17(20)10-15(11)14;/h1-5,7-8,16H,6,9-10,19H2;1H
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2n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney APN assessed as decrease in p-nitroanilide release using L-leucine-p-nitroanilide as substrate by spectrophotometric ana...


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens)
BDBM50025050
PNG
(CHEMBL3355108)
Show SMILES NCc1cccc(CC(CP(O)(=O)C(N)CCc2ccccc2)C(O)=O)c1
Show InChI InChI=1/C20H27N2O4P/c21-13-17-8-4-7-16(11-17)12-18(20(23)24)14-27(25,26)19(22)10-9-15-5-2-1-3-6-15/h1-8,11,18-19H,9-10,12-14,21-22H2,(H,23,24)(H,25,26)
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2.10n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of human recombinant alanyl aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens)
BDBM50025042
PNG
(CHEMBL3355105)
Show SMILES NC(CCc1cccnc1)P(O)(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1/C18H23N2O4P/c19-17(9-8-15-7-4-10-20-12-15)25(23,24)13-16(18(21)22)11-14-5-2-1-3-6-14/h1-7,10,12,16-17H,8-9,11,13,19H2,(H,21,22)(H,23,24)
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2.10n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of human recombinant alanyl aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50087097
PNG
(1-{[2-(1-Carboxy-2-phenyl-ethylcarbamoyl)-3-phenyl...)
Show SMILES CC([NH3+])P(O)(=O)C[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C21H27N2O5P/c1-15(22)29(27,28)14-18(12-16-8-4-2-5-9-16)20(24)23-19(21(25)26)13-17-10-6-3-7-11-17/h2-11,15,18-19H,12-14,22H2,1H3,(H,23,24)(H,25,26)(H,27,28)/p+1/t15?,18-,19+/m1/s1
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2.20n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity was measured on pig kidney Aminopeptidase N (activity for A+B stereoisomer)


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens)
BDBM50393210
PNG
(CHEMBL1235787)
Show SMILES CC(=N)P(O)(O)C[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C21H27N2O5P/c1-15(22)29(27,28)14-18(12-16-8-4-2-5-9-16)20(24)23-19(21(25)26)13-17-10-6-3-7-11-17/h2-11,18-19,22,27-29H,12-14H2,1H3,(H,23,24)(H,25,26)/t18-,19+/m1/s1
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2.20n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of APN


J Med Chem 54: 5955-80 (2011)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50087097
PNG
(1-{[2-(1-Carboxy-2-phenyl-ethylcarbamoyl)-3-phenyl...)
Show SMILES CC([NH3+])P(O)(=O)C[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C21H27N2O5P/c1-15(22)29(27,28)14-18(12-16-8-4-2-5-9-16)20(24)23-19(21(25)26)13-17-10-6-3-7-11-17/h2-11,15,18-19H,12-14,22H2,1H3,(H,23,24)(H,25,26)(H,27,28)/p+1/t15?,18-,19+/m1/s1
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2.20n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50078127
PNG
(2-{3-[(1-Amino-3-phenyl-propyl)-hydroxy-phosphinoy...)
Show SMILES OC(=O)C(Cc1ccccc1)NC(=O)C(Cc1ccccc1)CP(O)(O)C(=N)CCc1ccccc1
Show InChI InChI=1S/C28H33N2O5P/c29-26(17-16-21-10-4-1-5-11-21)36(34,35)20-24(18-22-12-6-2-7-13-22)27(31)30-25(28(32)33)19-23-14-8-3-9-15-23/h1-15,24-25,29,34-36H,16-20H2,(H,30,31)(H,32,33)
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2.30n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity was measured on pig kidney Aminopeptidase N (activity for A+B stereoisomer)


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50087093
PNG
(1-{[2-(1-Carboxy-2-phenyl-ethylcarbamoyl)-3-phenyl...)
Show SMILES CCC([NH3+])P(O)(=O)C[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C22H29N2O5P/c1-2-20(23)30(28,29)15-18(13-16-9-5-3-6-10-16)21(25)24-19(22(26)27)14-17-11-7-4-8-12-17/h3-12,18-20H,2,13-15,23H2,1H3,(H,24,25)(H,26,27)(H,28,29)/p+1/t18-,19+,20?/m1/s1
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2.30n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50087084
PNG
(1-{[2-(1-Carboxy-2-phenyl-ethylcarbamoyl)-3-phenyl...)
Show SMILES [NH3+]C(CCc1ccccc1)P(O)(=O)C[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C28H33N2O5P/c29-26(17-16-21-10-4-1-5-11-21)36(34,35)20-24(18-22-12-6-2-7-13-22)27(31)30-25(28(32)33)19-23-14-8-3-9-15-23/h1-15,24-26H,16-20,29H2,(H,30,31)(H,32,33)(H,34,35)/p+1/t24-,25+,26?/m1/s1
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2.30n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50087094
PNG
((R,S,S)1-{[2-(1-Carboxy-2-phenyl-ethylcarbamoyl)-4...)
Show SMILES CC(C)C[C@H](CP(O)(=O)[C@H]([NH3+])Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C24H33N2O5P/c1-17(2)13-20(16-32(30,31)22(25)15-19-11-7-4-8-12-19)23(27)26-21(24(28)29)14-18-9-5-3-6-10-18/h3-12,17,20-22H,13-16,25H2,1-2H3,(H,26,27)(H,28,29)(H,30,31)/p+1/t20-,21+,22+/m1/s1
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2.30n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens)
BDBM50025046
PNG
(CHEMBL3355101)
Show SMILES NC(CCc1ccc(cc1)[N+]([O-])=O)P(O)(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1/C19H23N2O6P/c20-18(11-8-14-6-9-17(10-7-14)21(24)25)28(26,27)13-16(19(22)23)12-15-4-2-1-3-5-15/h1-7,9-10,16,18H,8,11-13,20H2,(H,22,23)(H,26,27)
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2.40n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of human recombinant alanyl aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)

More data for this
Ligand-Target Pair
Aminopeptidase B


(Rattus norvegicus)
BDBM50017482
PNG
(5-Amino-2-benzyl-8-guanidino-4-oxo-octanoic acid |...)
Show SMILES N[C@@H](CCCNC(N)=N)C(=O)C[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H24N4O3/c17-13(7-4-8-20-16(18)19)14(21)10-12(15(22)23)9-11-5-2-1-3-6-11/h1-3,5-6,12-13H,4,7-10,17H2,(H,22,23)(H4,18,19,20)/t12-,13+/m1/s1
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2.5n/an/an/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Inhibition of aminopeptidase B or arginyl aminopeptidase purified from rat liver


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens)
BDBM50024594
PNG
((R)-1-Ammonium-3-methyl-butane-1-phosphonic acid a...)
Show SMILES CC(C)C[C@H]([NH3+])P(O)([O-])=O
Show InChI InChI=1S/C5H14NO3P/c1-4(2)3-5(6)10(7,8)9/h4-5H,3,6H2,1-2H3,(H2,7,8,9)/t5-/m1/s1
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2.60n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of human recombinant alanyl aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50087106
PNG
((2S)-2-[(2S)-3-{[(1S)-1-azaniumylethyl](hydroxy)ph...)
Show SMILES C[C@@H]([NH3+])P(O)(=O)C[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N[C@@H](C)C(O)=O
Show InChI InChI=1S/C21H27N2O5P/c1-14(21(25)26)23-20(24)19(13-29(27,28)15(2)22)12-16-8-10-18(11-9-16)17-6-4-3-5-7-17/h3-11,14-15,19H,12-13,22H2,1-2H3,(H,23,24)(H,25,26)(H,27,28)/p+1/t14-,15-,19+/m0/s1
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2.90n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens)
BDBM50105262
PNG
(2-{3-[(1-Amino-ethyl)-hydroxy-phosphinoyl]-2-biphe...)
Show SMILES C[C@@H]([NH3+])P(O)(=O)C[C@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N[C@@H](C)C([O-])=O
Show InChI InChI=1S/C21H27N2O5P/c1-14(21(25)26)23-20(24)19(13-29(27,28)15(2)22)12-16-8-10-18(11-9-16)17-6-4-3-5-7-17/h3-11,14-15,19H,12-13,22H2,1-2H3,(H,23,24)(H,25,26)(H,27,28)/t14-,15-,19-/m0/s1
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2.90n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of enkephalin degrading enzyme, aminopeptidase N(APN)


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50405292
PNG
(CHEMBL2079630)
Show SMILES C[C@H](NC(=O)[C@H](CC(=O)NO)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C14H18N2O5/c1-9(14(19)20)15-13(18)11(8-12(17)16-21)7-10-5-3-2-4-6-10/h2-6,9,11,21H,7-8H2,1H3,(H,15,18)(H,16,17)(H,19,20)/t9-,11-/m0/s1
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2.90n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against aminopeptidase using 10 nM of [3H]Leu-enkephalin as substrate


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50078134
PNG
(2-{3-[(1-Amino-2-phenyl-ethyl)-hydroxy-phosphinoyl...)
Show SMILES OC(=O)C(Cc1ccccc1)NC(=O)C(Cc1ccccc1)CP(O)(O)C(=N)Cc1ccccc1
Show InChI InChI=1S/C27H31N2O5P/c28-25(18-22-14-8-3-9-15-22)35(33,34)19-23(16-20-10-4-1-5-11-20)26(30)29-24(27(31)32)17-21-12-6-2-7-13-21/h1-15,23-24,28,33-35H,16-19H2,(H,29,30)(H,31,32)
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2.90n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity was measured on pig kidney Aminopeptidase N (activity for A+B stereoisomer)


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50087089
PNG
((2S)-2-[(2S)-3-{[(1S)-1-azaniumyl-2-phenylethyl](h...)
Show SMILES [NH3+][C@H](Cc1ccccc1)P(O)(=O)C[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C27H31N2O5P/c28-25(18-22-14-8-3-9-15-22)35(33,34)19-23(16-20-10-4-1-5-11-20)26(30)29-24(27(31)32)17-21-12-6-2-7-13-21/h1-15,23-25H,16-19,28H2,(H,29,30)(H,31,32)(H,33,34)/p+1/t23-,24+,25+/m1/s1
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2.90n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.


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Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50105625
PNG
(CHEMBL3597456)
Show SMILES NC1CCc2cccc(-c3ccncc3)c2CC1=O
Show InChI InChI=1/C16H16N2O.ClH/c17-15-5-4-11-2-1-3-13(14(11)10-16(15)19)12-6-8-18-9-7-12;/h1-3,6-9,15H,4-5,10,17H2;1H
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3n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney APN assessed as decrease in p-nitroanilide release using L-leucine-p-nitroanilide as substrate by spectrophotometric ana...


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Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50087114
PNG
(C-{[2-(1-Carboxy-2-phenyl-ethylcarbamoyl)-3-phenyl...)
Show SMILES Cc1ccc(cc1)C([NH3+])P(O)(=O)C[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C27H31N2O5P/c1-19-12-14-22(15-13-19)25(28)35(33,34)18-23(16-20-8-4-2-5-9-20)26(30)29-24(27(31)32)17-21-10-6-3-7-11-21/h2-15,23-25H,16-18,28H2,1H3,(H,29,30)(H,31,32)(H,33,34)/p+1/t23-,24+,25?/m1/s1
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3.10n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.


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More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50087096
PNG
(1-{[2-(1-Carboxy-2-phenyl-ethylcarbamoyl)-3-phenyl...)
Show SMILES CC(C)CC([NH3+])P(O)(=O)C[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C24H33N2O5P/c1-17(2)13-22(25)32(30,31)16-20(14-18-9-5-3-6-10-18)23(27)26-21(24(28)29)15-19-11-7-4-8-12-19/h3-12,17,20-22H,13-16,25H2,1-2H3,(H,26,27)(H,28,29)(H,30,31)/p+1/t20-,21+,22?/m1/s1
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3.20n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.


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More data for this
Ligand-Target Pair
Aminopeptidase A


(Homo sapiens)
BDBM50083394
PNG
(1-{[1-(1,2-Dicarboxy-ethylcarbamoyl)-2-methyl-buty...)
Show SMILES CC[C@@H](C)[C@H](NC(=O)[C@H](S)[C@H]([NH3+])CCS([O-])(=O)=O)C(=O)N[C@@H](CC(O)=O)C(O)=O
Show InChI InChI=1S/C15H27N3O9S2/c1-3-7(2)11(13(21)17-9(15(23)24)6-10(19)20)18-14(22)12(28)8(16)4-5-29(25,26)27/h7-9,11-12,28H,3-6,16H2,1-2H3,(H,17,21)(H,18,22)(H,19,20)(H,23,24)(H,25,26,27)/t7-,8-,9+,11+,12-/m1/s1
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3.20n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Binding affinity against recombinant Aminopeptidase A


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More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50078131
PNG
(2-{3-[(1-Amino-3-methyl-butyl)-hydroxy-phosphinoyl...)
Show SMILES CC(C)CC(=N)P(O)(O)CC(Cc1ccccc1)C(=O)NC(Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C24H33N2O5P/c1-17(2)13-22(25)32(30,31)16-20(14-18-9-5-3-6-10-18)23(27)26-21(24(28)29)15-19-11-7-4-8-12-19/h3-12,17,20-21,25,30-32H,13-16H2,1-2H3,(H,26,27)(H,28,29)
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3.20n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity was measured on pig kidney Aminopeptidase N (activity for A+B stereoisomer)


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Ligand-Target Pair
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