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Found 26 hits Enz. Inhib. hit(s) with Target = 'Aurora B/Incenp'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aurora B/Incenp


(Homo sapiens (Human))
BDBM47224
PNG
(US9073917, 2-inventive)
Show SMILES CCc1[nH]cc2[C@@H](C3=C(CCCC3=O)Nc12)c1cccc(Oc2nc3ccccc3[nH]2)c1
Show InChI InChI=1S/C26H24N4O2/c1-2-18-25-17(14-27-18)23(24-21(28-25)11-6-12-22(24)31)15-7-5-8-16(13-15)32-26-29-19-9-3-4-10-20(19)30-26/h3-5,7-10,13-14,23,27-28H,2,6,11-12H2,1H3,(H,29,30)/t23-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The effect of the compounds of the invention on the activity of the enzyme PDE3 was evaluated by the company CEREP (Le bois I'Evêque, 86600 Celle...


Citation and Details
More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM50277545
PNG
(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)
Show SMILES COc1cc(Nc2ncc3CN=C(c4cc(Cl)ccc4-c3n2)c2c(F)cccc2OC)ccc1C(O)=O
Show InChI InChI=1S/C27H20ClFN4O4/c1-36-21-5-3-4-20(29)23(21)25-19-10-15(28)6-8-17(19)24-14(12-30-25)13-31-27(33-24)32-16-7-9-18(26(34)35)22(11-16)37-2/h3-11,13H,12H2,1-2H3,(H,34,35)(H,31,32,33)
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n/an/a 1.10n/an/an/an/an/an/a



University of Berne

Curated by ChEMBL


Assay Description
Inhibition of Aurora-B/INCENP (unknown origin) using biotinylated STK2 substrate incubated for 30 mins by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM50175305
PNG
(CHEMBL3600873)
Show SMILES OC(=O)[C@@]1(Cc2cccc(Nc3nccs3)n2)CC[C@@H](CC1)Oc1cccc(Cl)c1F
Show InChI InChI=1S/C22H21ClFN3O3S/c23-16-4-2-5-17(19(16)24)30-15-7-9-22(10-8-15,20(28)29)13-14-3-1-6-18(26-14)27-21-25-11-12-31-21/h1-6,11-12,15H,7-10,13H2,(H,28,29)(H,25,26,27)/t15-,22-
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n/an/a 1.5n/an/an/an/an/an/a



University of Berne

Curated by ChEMBL


Assay Description
Inhibition of Aurora-B/INCENP (unknown origin) using biotinylated STK2 substrate incubated for 30 mins by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM167515
PNG
(US9073917, 12- comparative)
Show SMILES CCOC(=O)c1[nH]cc2[C@@H](c3ccc(Sc4nc5ccccc5[nH]4)o3)C3=C(CCCC3=O)Nc12
Show InChI InChI=1S/C25H22N4O4S/c1-2-32-24(31)23-22-13(12-26-23)20(21-16(27-22)8-5-9-17(21)30)18-10-11-19(33-18)34-25-28-14-6-3-4-7-15(14)29-25/h3-4,6-7,10-12,20,26-27H,2,5,8-9H2,1H3,(H,28,29)/t20-/m0/s1
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n/an/a 3n/an/an/an/an/an/a



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US Patent


Assay Description
The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...


Citation and Details
More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM167506
PNG
(US9073917, 1-inventive)
Show SMILES CCc1[nH]cc2C(C3=C(CCCC3=O)Nc12)c1cccc(Oc2nc3ccccc3[nH]2)c1
Show InChI InChI=1S/C26H24N4O2/c1-2-18-25-17(14-27-18)23(24-21(28-25)11-6-12-22(24)31)15-7-5-8-16(13-15)32-26-29-19-9-3-4-10-20(19)30-26/h3-5,7-10,13-14,23,27-28H,2,6,11-12H2,1H3,(H,29,30)
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n/an/a 4n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...


Citation and Details
More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM167510
PNG
(US9073917, 7- comparative)
Show SMILES CCc1[nH]cc2C(C3=C(CC(C)(C)CC3=O)Nc12)c1cccc(Oc2nc3ccccc3[nH]2)c1
Show InChI InChI=1S/C28H28N4O2/c1-4-19-26-18(15-29-19)24(25-22(30-26)13-28(2,3)14-23(25)33)16-8-7-9-17(12-16)34-27-31-20-10-5-6-11-21(20)32-27/h5-12,15,24,29-30H,4,13-14H2,1-3H3,(H,31,32)
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US Patent


Assay Description
The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...


Citation and Details
More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM167507
PNG
(US9073917, 4- comparative)
Show SMILES CCc1[nH]cc2C(C3=C(CCCC3=O)Nc12)c1cccc(Sc2nc3ccccc3[nH]2)c1
Show InChI InChI=1S/C26H24N4OS/c1-2-18-25-17(14-27-18)23(24-21(28-25)11-6-12-22(24)31)15-7-5-8-16(13-15)32-26-29-19-9-3-4-10-20(19)30-26/h3-5,7-10,13-14,23,27-28H,2,6,11-12H2,1H3,(H,29,30)
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n/an/a 6n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...


Citation and Details
More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM167508
PNG
(US9073917, 5- comparative)
Show SMILES O=C1CCCC2=C1C(c1c[nH]nc1N2)c1cccc(Oc2nc3ccccc3[nH]2)c1
Show InChI InChI=1S/C23H19N5O2/c29-19-10-4-9-18-21(19)20(15-12-24-28-22(15)25-18)13-5-3-6-14(11-13)30-23-26-16-7-1-2-8-17(16)27-23/h1-3,5-8,11-12,20H,4,9-10H2,(H,26,27)(H2,24,25,28)
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n/an/a 6n/an/an/an/an/an/a



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US Patent


Assay Description
The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...


Citation and Details
More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM167512
PNG
(US9073917, 11- comparative | US9073917, 9- compara...)
Show SMILES CCc1[nH]cc2C(C3=C(CNCC3=O)Nc12)c1cccc(Sc2nc3ccccc3[nH]2)c1
Show InChI InChI=1S/C25H23N5OS/c1-2-17-24-16(11-27-17)22(23-20(28-24)12-26-13-21(23)31)14-6-5-7-15(10-14)32-25-29-18-8-3-4-9-19(18)30-25/h3-11,22,26-28H,2,12-13H2,1H3,(H,29,30)
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n/an/a 8n/an/an/an/an/an/a



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US Patent


Assay Description
The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...


Citation and Details
More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM167513
PNG
(US9073917, 10- comparative)
Show SMILES CC1(C)CC(=O)C2=C(C1)Nc1n[nH]cc1C2c1cccc(Oc2nc3ccccc3[nH]2)c1
Show InChI InChI=1S/C25H23N5O2/c1-25(2)11-19-22(20(31)12-25)21(16-13-26-30-23(16)27-19)14-6-5-7-15(10-14)32-24-28-17-8-3-4-9-18(17)29-24/h3-10,13,21H,11-12H2,1-2H3,(H,28,29)(H2,26,27,30)
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n/an/a 9n/an/an/an/an/an/a



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US Patent


Assay Description
The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...


Citation and Details
More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM167516
PNG
(US9073917, 13- comparative)
Show SMILES CCOC(=O)c1[nH]cc2C(c3ccc(Sc4nc5cccc(OC)c5[nH]4)o3)C3=C(CCCC3=O)Nc12
Show InChI InChI=1S/C26H24N4O5S/c1-3-34-25(32)24-22-13(12-27-24)20(21-14(28-22)6-4-8-16(21)31)17-10-11-19(35-17)36-26-29-15-7-5-9-18(33-2)23(15)30-26/h5,7,9-12,20,27-28H,3-4,6,8H2,1-2H3,(H,29,30)
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n/an/a 10n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...


Citation and Details
More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM167509
PNG
(US9073917, 6- comparative)
Show SMILES O=C1CNCC2=C1C(c1c[nH]nc1N2)c1cccc(Oc2nc3ccccc3[nH]2)c1
Show InChI InChI=1S/C22H18N6O2/c29-18-11-23-10-17-20(18)19(14-9-24-28-21(14)25-17)12-4-3-5-13(8-12)30-22-26-15-6-1-2-7-16(15)27-22/h1-9,19,23H,10-11H2,(H,26,27)(H2,24,25,28)
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n/an/a 13n/an/an/an/an/an/a



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US Patent


Assay Description
The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...


Citation and Details
More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM167511
PNG
(US9073917, 8- comparative)
Show SMILES CCc1[nH]cc2C(C3=C(CC(C)(C)CC3=O)Nc12)c1cccc(Sc2nc3ccccc3[nH]2)c1
Show InChI InChI=1S/C28H28N4OS/c1-4-19-26-18(15-29-19)24(25-22(30-26)13-28(2,3)14-23(25)33)16-8-7-9-17(12-16)34-27-31-20-10-5-6-11-21(20)32-27/h5-12,15,24,29-30H,4,13-14H2,1-3H3,(H,31,32)
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n/an/a 21n/an/an/an/an/an/a



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US Patent


Assay Description
The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...


Citation and Details
More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM167512
PNG
(US9073917, 11- comparative | US9073917, 9- compara...)
Show SMILES CCc1[nH]cc2C(C3=C(CNCC3=O)Nc12)c1cccc(Sc2nc3ccccc3[nH]2)c1
Show InChI InChI=1S/C25H23N5OS/c1-2-17-24-16(11-27-17)22(23-20(28-24)12-26-13-21(23)31)14-6-5-7-15(10-14)32-25-29-18-8-3-4-9-19(18)30-25/h3-11,22,26-28H,2,12-13H2,1H3,(H,29,30)
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n/an/a 107n/an/an/an/an/an/a



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US Patent


Assay Description
The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...


Citation and Details
More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM50198027
PNG
(CHEMBL3921246)
Show SMILES CCc1ccc(cc1)\N=C1/S\C(=C/c2ccnc(Nc3ccc(cn3)C(O)=O)c2)C(=O)N1C
Show InChI InChI=1S/C24H21N5O3S/c1-3-15-4-7-18(8-5-15)27-24-29(2)22(30)19(33-24)12-16-10-11-25-21(13-16)28-20-9-6-17(14-26-20)23(31)32/h4-14H,3H2,1-2H3,(H,31,32)(H,25,26,28)/b19-12-,27-24-
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n/an/a 150n/an/an/an/an/an/a



University of Berne

Curated by ChEMBL


Assay Description
Inhibition of Aurora-B/INCENP (unknown origin) using biotinylated STK2 substrate incubated for 30 mins by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM50198044
PNG
(CHEMBL3903187)
Show SMILES CCc1ccc(cc1)\N=C1/S\C(=C/c2ccnc(Nc3ccc(cc3)-c3nnn[nH]3)c2)C(=O)N1C
Show InChI InChI=1S/C25H22N8OS/c1-3-16-4-8-20(9-5-16)28-25-33(2)24(34)21(35-25)14-17-12-13-26-22(15-17)27-19-10-6-18(7-11-19)23-29-31-32-30-23/h4-15H,3H2,1-2H3,(H,26,27)(H,29,30,31,32)/b21-14-,28-25-
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n/an/a 830n/an/an/an/an/an/a



University of Berne

Curated by ChEMBL


Assay Description
Inhibition of Aurora-B/INCENP (unknown origin) using biotinylated STK2 substrate incubated for 30 mins by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM50198086
PNG
(CHEMBL3985313)
Show SMILES CCc1ccc(cc1)\N=C1/S\C(=C/c2ccnc(NC(=O)CCCC(O)=O)c2)C(=O)N1C
Show InChI InChI=1S/C23H24N4O4S/c1-3-15-7-9-17(10-8-15)25-23-27(2)22(31)18(32-23)13-16-11-12-24-19(14-16)26-20(28)5-4-6-21(29)30/h7-14H,3-6H2,1-2H3,(H,29,30)(H,24,26,28)/b18-13-,25-23-
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n/an/a 1.40E+3n/an/an/an/an/an/a



University of Berne

Curated by ChEMBL


Assay Description
Inhibition of Aurora-B/INCENP (unknown origin) using biotinylated STK2 substrate incubated for 30 mins by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM50198082
PNG
(CHEMBL3904239)
Show SMILES CCc1ccc(cc1)\N=C1/S\C(=C/c2ccnc(Nc3ccc(cc3)C(O)=O)c2)C(=O)N1C
Show InChI InChI=1S/C25H22N4O3S/c1-3-16-4-8-20(9-5-16)28-25-29(2)23(30)21(33-25)14-17-12-13-26-22(15-17)27-19-10-6-18(7-11-19)24(31)32/h4-15H,3H2,1-2H3,(H,26,27)(H,31,32)/b21-14-,28-25-
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n/an/a 1.54E+3n/an/an/an/an/an/a



University of Berne

Curated by ChEMBL


Assay Description
Inhibition of Aurora-B/INCENP (unknown origin) using biotinylated STK2 substrate incubated for 30 mins by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM50198081
PNG
(CHEMBL3915550)
Show SMILES CCc1ccc(cc1)\N=C1/S\C(=C/c2ccnc(NC(=O)CCC(O)=O)c2)C(=O)N1C
Show InChI InChI=1S/C22H22N4O4S/c1-3-14-4-6-16(7-5-14)24-22-26(2)21(30)17(31-22)12-15-10-11-23-18(13-15)25-19(27)8-9-20(28)29/h4-7,10-13H,3,8-9H2,1-2H3,(H,28,29)(H,23,25,27)/b17-12-,24-22-
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n/an/a 1.70E+3n/an/an/an/an/an/a



University of Berne

Curated by ChEMBL


Assay Description
Inhibition of Aurora-B/INCENP (unknown origin) using biotinylated STK2 substrate incubated for 30 mins by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM50198045
PNG
(CHEMBL3975102)
Show SMILES CCc1ccc(cc1)\N=C1/S\C(=C/c2ccnc(Nc3ccc(CO)cc3)c2)C(=O)N1C
Show InChI InChI=1S/C25H24N4O2S/c1-3-17-4-8-21(9-5-17)28-25-29(2)24(31)22(32-25)14-19-12-13-26-23(15-19)27-20-10-6-18(16-30)7-11-20/h4-15,30H,3,16H2,1-2H3,(H,26,27)/b22-14-,28-25-
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n/an/a 2.60E+3n/an/an/an/an/an/a



University of Berne

Curated by ChEMBL


Assay Description
Inhibition of Aurora-B/INCENP (unknown origin) using biotinylated STK2 substrate incubated for 30 mins by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM50198080
PNG
(CHEMBL3932394)
Show SMILES CCc1ccc(cc1)\N=C1/S\C(=C/c2ccnc(NC(=O)CC(O)=O)c2)C(=O)N1C
Show InChI InChI=1S/C21H20N4O4S/c1-3-13-4-6-15(7-5-13)23-21-25(2)20(29)16(30-21)10-14-8-9-22-17(11-14)24-18(26)12-19(27)28/h4-11H,3,12H2,1-2H3,(H,27,28)(H,22,24,26)/b16-10-,23-21-
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n/an/a 2.70E+3n/an/an/an/an/an/a



University of Berne

Curated by ChEMBL


Assay Description
Inhibition of Aurora-B/INCENP (unknown origin) using biotinylated STK2 substrate incubated for 30 mins by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM60452
PNG
(US9073917, 3-comparative)
Show SMILES CCc1[nH]cc2[C@H](C3=C(CCCC3=O)Nc12)c1cccc(Oc2nc3ccccc3[nH]2)c1
Show InChI InChI=1S/C26H24N4O2/c1-2-18-25-17(14-27-18)23(24-21(28-25)11-6-12-22(24)31)15-7-5-8-16(13-15)32-26-29-19-9-3-4-10-20(19)30-26/h3-5,7-10,13-14,23,27-28H,2,6,11-12H2,1H3,(H,29,30)/t23-/m1/s1
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US Patent
n/an/a 3.80E+3n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The effect of the compounds of the invention on the activity of the enzyme PDE3 was evaluated by the company CEREP (Le bois I'Evêque, 86600 Celle...


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More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM50198079
PNG
(CHEMBL3924918)
Show SMILES CCc1ccc(cc1)\N=C1/S\C(=C/c2ccnc(NC(=O)CCN)c2)C(=O)N1C
Show InChI InChI=1S/C21H23N5O2S/c1-3-14-4-6-16(7-5-14)24-21-26(2)20(28)17(29-21)12-15-9-11-23-18(13-15)25-19(27)8-10-22/h4-7,9,11-13H,3,8,10,22H2,1-2H3,(H,23,25,27)/b17-12-,24-21-
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n/an/a 1.00E+4n/an/an/an/an/an/a



University of Berne

Curated by ChEMBL


Assay Description
Inhibition of Aurora-B/INCENP (unknown origin) using biotinylated STK2 substrate incubated for 30 mins by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Aurora B/INCENP


(Homo sapiens (Human))
BDBM50419247
PNG
(CHEMBL1835071 | US8470835, 1)
Show SMILES Cc1ccc(Nc2nc(N[C@@H]3CCOC[C@@H]3N)ncc2C(N)=O)cc1
Show InChI InChI=1S/C17H22N6O2/c1-10-2-4-11(5-3-10)21-16-12(15(19)24)8-20-17(23-16)22-14-6-7-25-9-13(14)18/h2-5,8,13-14H,6-7,9,18H2,1H3,(H2,19,24)(H2,20,21,22,23)/t13-,14+/m0/s1
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n/an/a 2.00E+4n/an/an/an/an/an/a



Glaxo Group Limited

US Patent


Assay Description
Recombinant human Aurora B (2-344) was expressed as a Flag-6His-Thr-tagged protein. The activity of Aurora B was assessed using a Fluorescence Polar...


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More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM50198078
PNG
(CHEMBL3941377)
Show SMILES CCc1ccc(cc1)\N=C1/S\C(=C/c2ccnc(N)c2)C(=O)N1C
Show InChI InChI=1S/C18H18N4OS/c1-3-12-4-6-14(7-5-12)21-18-22(2)17(23)15(24-18)10-13-8-9-20-16(19)11-13/h4-11H,3H2,1-2H3,(H2,19,20)/b15-10-,21-18-
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n/an/a 2.30E+4n/an/an/an/an/an/a



University of Berne

Curated by ChEMBL


Assay Description
Inhibition of Aurora-B/INCENP (unknown origin) using biotinylated STK2 substrate incubated for 30 mins by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM50183019
PNG
(CHEMBL3819210)
Show SMILES Cc1cc(ccc1C(=O)NC1CC1)-c1cnn2c(NCC3CCOCC3)nc(Oc3ccccc3)nc12
Show InChI InChI=1S/C28H30N6O3/c1-18-15-20(7-10-23(18)26(35)31-21-8-9-21)24-17-30-34-25(24)32-28(37-22-5-3-2-4-6-22)33-27(34)29-16-19-11-13-36-14-12-19/h2-7,10,15,17,19,21H,8-9,11-14,16H2,1H3,(H,31,35)(H,29,32,33)
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n/an/a>5.00E+4n/an/an/an/an/an/a



EntreMed Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged Aurora B/full length recombinant human N-terminal GST-tagged INCENP (821-end residues) expressed in baculo...


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More data for this
Ligand-Target Pair