BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 542 hits Enz. Inhib. hit(s) with Target = 'Casein kinase I delta/epsilon'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM255164
PNG
(US9475817, 123)
Show SMILES Cn1nc(c(c1N1CCN(CC1)C(=O)CN)-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C28H26F2N10O2/c1-37-28(39-12-10-38(11-13-39)24(41)15-31)25(26(36-37)17-2-4-19(29)5-3-17)20-6-7-23-33-22(16-40(23)35-20)34-27(42)18-8-9-32-21(30)14-18/h2-9,14,16H,10-13,15,31H2,1H3,(H,34,42)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.200n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 ul prepared from 15 ul additions of enzyme, substrates (flu...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM255195
PNG
(US9475817, 154)
Show SMILES Cn1nc(c(c1C1CCN(CC1)C(=O)c1cncs1)-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C31H25F2N9O2S/c1-40-29(19-9-12-41(13-10-19)31(44)23-15-34-17-45-23)27(28(39-40)18-2-4-21(32)5-3-18)22-6-7-26-36-25(16-42(26)38-22)37-30(43)20-8-11-35-24(33)14-20/h2-8,11,14-17,19H,9-10,12-13H2,1H3,(H,37,43)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.300n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 ul prepared from 15 ul additions of enzyme, substrates (flu...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM255199
PNG
(US9475817, 158)
Show SMILES Cn1nc(c(c1C1CCN(C[C@@H](O)C(F)(F)F)CC1)-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1)-c1ccc(F)cc1
Show InChI InChI=1/C30H27F5N8O2/c1-41-28(18-9-12-42(13-10-18)15-22(44)30(33,34)35)26(27(40-41)17-2-4-20(31)5-3-17)21-6-7-25-37-24(16-43(25)39-21)38-29(45)19-8-11-36-23(32)14-19/h2-8,11,14,16,18,22,44H,9-10,12-13,15H2,1H3,(H,38,45)/t22-/s2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.300n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 ul prepared from 15 ul additions of enzyme, substrates (flu...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM255217
PNG
(US9475817, 176)
Show SMILES Cc1nc(sc1C(=O)Nc1cn2nc(ccc2n1)-c1c(nn(C)c1C1CCN(Cc2ccon2)CC1)-c1ccc(F)cc1)-c1cccnc1
Show InChI InChI=1S/C35H31FN10O2S/c1-21-33(49-35(38-21)24-4-3-14-37-18-24)34(47)40-28-20-46-29(39-28)10-9-27(41-46)30-31(22-5-7-25(36)8-6-22)42-44(2)32(30)23-11-15-45(16-12-23)19-26-13-17-48-43-26/h3-10,13-14,17-18,20,23H,11-12,15-16,19H2,1-2H3,(H,40,47)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.400n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 ul prepared from 15 ul additions of enzyme, substrates (flu...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM255204
PNG
(US9475817, 163)
Show SMILES Cn1nc(c(c1C1CCN(CC(N)=O)CC1)-c1ccc2nc(NC(=O)c3ccnc(c3)N3CCOCC3)cn2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C33H35FN10O3/c1-41-32(22-9-12-42(13-10-22)19-26(35)45)30(31(40-41)21-2-4-24(34)5-3-21)25-6-7-28-37-27(20-44(28)39-25)38-33(46)23-8-11-36-29(18-23)43-14-16-47-17-15-43/h2-8,11,18,20,22H,9-10,12-17,19H2,1H3,(H2,35,45)(H,38,46)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.600n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 ul prepared from 15 ul additions of enzyme, substrates (flu...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM255210
PNG
(US9475817, 169)
Show SMILES Cn1nc(c(c1C1CCN(Cc2ccon2)CC1)-c1ccc2nc(NC(=O)c3ccncc3)cn2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C31H28FN9O2/c1-39-30(21-10-15-40(16-11-21)18-24-12-17-43-38-24)28(29(37-39)20-2-4-23(32)5-3-20)25-6-7-27-34-26(19-41(27)36-25)35-31(42)22-8-13-33-14-9-22/h2-9,12-14,17,19,21H,10-11,15-16,18H2,1H3,(H,35,42)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.800n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 ul prepared from 15 ul additions of enzyme, substrates (flu...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM255223
PNG
(US9475817, 182)
Show SMILES Cc1nc(sc1C(=O)Nc1cn2nc(ccc2n1)-c1c(nn(C)c1C1CCN(Cc2ccon2)CC1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C35H31FN10O2S/c1-21-33(49-35(38-21)24-9-14-37-15-10-24)34(47)40-28-20-46-29(39-28)8-7-27(41-46)30-31(22-3-5-25(36)6-4-22)42-44(2)32(30)23-11-16-45(17-12-23)19-26-13-18-48-43-26/h3-10,13-15,18,20,23H,11-12,16-17,19H2,1-2H3,(H,40,47)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.900n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 ul prepared from 15 ul additions of enzyme, substrates (flu...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM255191
PNG
(US9475817, 150)
Show SMILES Cn1nc(c(c1C1CCN(Cc2ccon2)CC1)-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C31H27F2N9O2/c1-40-30(20-9-13-41(14-10-20)17-23-11-15-44-39-23)28(29(38-40)19-2-4-22(32)5-3-19)24-6-7-27-35-26(18-42(27)37-24)36-31(43)21-8-12-34-25(33)16-21/h2-8,11-12,15-16,18,20H,9-10,13-14,17H2,1H3,(H,36,43)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 ul prepared from 15 ul additions of enzyme, substrates (flu...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM207001
PNG
(US9233965, 84)
Show SMILES CC1(O)CCC(CC1)NC(=O)N1CCn2c(Cl)c(c(C(N)=O)c2C1)-c1cccc(F)c1
Show InChI InChI=1S/C22H26ClFN4O3/c1-22(31)7-5-15(6-8-22)26-21(30)27-9-10-28-16(12-27)18(20(25)29)17(19(28)23)13-3-2-4-14(24)11-13/h2-4,11,15,31H,5-10,12H2,1H3,(H2,25,29)(H,26,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
"U"-bottomed Falcon plates are prepared by placing 5 uL of solutions of the compounds according to the invention at concentrations of 10, 1, 0.1, 0.0...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM207020
PNG
(US9233965, 107)
Show SMILES CC(C)(NC(=O)N1CCn2c(C1)c(C(N)=O)c(c2C#N)-c1cccc(F)c1)C(F)(F)F
Show InChI InChI=1S/C20H19F4N5O2/c1-19(2,20(22,23)24)27-18(31)28-6-7-29-13(9-25)15(11-4-3-5-12(21)8-11)16(17(26)30)14(29)10-28/h3-5,8H,6-7,10H2,1-2H3,(H2,26,30)(H,27,31)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
"U"-bottomed Falcon plates are prepared by placing 5 uL of solutions of the compounds according to the invention at concentrations of 10, 1, 0.1, 0.0...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM207024
PNG
(US9233965, 2)
Show SMILES COc1ccc(cc1)-c1cn2CCN(Cc2c1C(N)=O)C(=O)NC(C)(C)C
Show InChI InChI=1S/C20H26N4O3/c1-20(2,3)22-19(26)24-10-9-23-11-15(17(18(21)25)16(23)12-24)13-5-7-14(27-4)8-6-13/h5-8,11H,9-10,12H2,1-4H3,(H2,21,25)(H,22,26)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
"U"-bottomed Falcon plates are prepared by placing 5 uL of solutions of the compounds according to the invention at concentrations of 10, 1, 0.1, 0.0...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM206925
PNG
(US9233965, 105)
Show SMILES CC(C)(C)NC(=O)N1CCn2c(C1)c(C(N)=O)c(c2C#N)-c1cccc(F)c1
Show InChI InChI=1S/C20H22FN5O2/c1-20(2,3)24-19(28)25-7-8-26-14(10-22)16(12-5-4-6-13(21)9-12)17(18(23)27)15(26)11-25/h4-6,9H,7-8,11H2,1-3H3,(H2,23,27)(H,24,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
"U"-bottomed Falcon plates are prepared by placing 5 uL of solutions of the compounds according to the invention at concentrations of 10, 1, 0.1, 0.0...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM207003
PNG
(US9233965, 86)
Show SMILES CON=C1CCC(CC1)NC(=O)N1CCn2c(Cl)c(c(C(N)=O)c2C1)-c1cccc(F)c1
Show InChI InChI=1S/C22H25ClFN5O3/c1-32-27-16-7-5-15(6-8-16)26-22(31)28-9-10-29-17(12-28)19(21(25)30)18(20(29)23)13-3-2-4-14(24)11-13/h2-4,11,15H,5-10,12H2,1H3,(H2,25,30)(H,26,31)/b27-16-
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
"U"-bottomed Falcon plates are prepared by placing 5 uL of solutions of the compounds according to the invention at concentrations of 10, 1, 0.1, 0.0...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM207023
PNG
(US9233965, 110)
Show SMILES NC(=O)c1c2CN(CCn2c(C#N)c1-c1cccc(F)c1)C(=O)NC1CCC(F)(F)CC1
Show InChI InChI=1S/C22H22F3N5O2/c23-14-3-1-2-13(10-14)18-16(11-26)30-9-8-29(12-17(30)19(18)20(27)31)21(32)28-15-4-6-22(24,25)7-5-15/h1-3,10,15H,4-9,12H2,(H2,27,31)(H,28,32)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
"U"-bottomed Falcon plates are prepared by placing 5 uL of solutions of the compounds according to the invention at concentrations of 10, 1, 0.1, 0.0...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM206924
PNG
(US9233965, 104)
Show SMILES CC(C)(C)NC(=O)N1CCn2c(Br)c(c(C(N)=O)c2C1)-c1cccc(F)c1
Show InChI InChI=1S/C19H22BrFN4O2/c1-19(2,3)23-18(27)24-7-8-25-13(10-24)15(17(22)26)14(16(25)20)11-5-4-6-12(21)9-11/h4-6,9H,7-8,10H2,1-3H3,(H2,22,26)(H,23,27)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
"U"-bottomed Falcon plates are prepared by placing 5 uL of solutions of the compounds according to the invention at concentrations of 10, 1, 0.1, 0.0...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM255201
PNG
(US9475817, 160)
Show SMILES Cn1nc(c(c1C1CCNCC1)-c1ccc2nc(NC(=O)c3ccnc(c3)N3CCOCC3)cn2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C31H32FN9O2/c1-39-30(21-8-11-33-12-9-21)28(29(38-39)20-2-4-23(32)5-3-20)24-6-7-26-35-25(19-41(26)37-24)36-31(42)22-10-13-34-27(18-22)40-14-16-43-17-15-40/h2-7,10,13,18-19,21,33H,8-9,11-12,14-17H2,1H3,(H,36,42)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 ul prepared from 15 ul additions of enzyme, substrates (flu...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM207015
PNG
(US9233965, 100)
Show SMILES C[C@H]1CC(C[C@@H](C)O1)NC(=O)N1CCn2c(Cl)c(c(C(N)=O)c2C1)-c1cccc(F)c1
Show InChI InChI=1/C22H26ClFN4O3/c1-12-8-16(9-13(2)31-12)26-22(30)27-6-7-28-17(11-27)19(21(25)29)18(20(28)23)14-4-3-5-15(24)10-14/h3-5,10,12-13,16H,6-9,11H2,1-2H3,(H2,25,29)(H,26,30)/t12-,13+,16?
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
"U"-bottomed Falcon plates are prepared by placing 5 uL of solutions of the compounds according to the invention at concentrations of 10, 1, 0.1, 0.0...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM206926
PNG
(US9233965, 87)
Show SMILES CC(C)(C)ON=C1CCC(CC1)NC(=O)Oc1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C17H23N3O5/c1-17(2,3)25-19-13-6-4-12(5-7-13)18-16(21)24-15-10-8-14(9-11-15)20(22)23/h8-12H,4-7H2,1-3H3,(H,18,21)/b19-13-
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
"U"-bottomed Falcon plates are prepared by placing 5 uL of solutions of the compounds according to the invention at concentrations of 10, 1, 0.1, 0.0...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM255225
PNG
(US9475817, 184)
Show SMILES Cc1nc(sc1C(=O)Nc1cn2nc(ccc2n1)-c1c(nn(C)c1C1CCN(CC(N)=O)CC1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C33H31FN10O2S/c1-19-31(47-33(37-19)22-9-13-36-14-10-22)32(46)39-26-18-44-27(38-26)8-7-24(40-44)28-29(20-3-5-23(34)6-4-20)41-42(2)30(28)21-11-15-43(16-12-21)17-25(35)45/h3-10,13-14,18,21H,11-12,15-17H2,1-2H3,(H2,35,45)(H,39,46)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.20n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 ul prepared from 15 ul additions of enzyme, substrates (flu...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM255198
PNG
(US9475817, 157)
Show SMILES Cn1nc(c(c1C1CCN(CC(N)=O)CC1)-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C29H27F2N9O2/c1-38-28(18-9-12-39(13-10-18)15-23(32)41)26(27(37-38)17-2-4-20(30)5-3-17)21-6-7-25-34-24(16-40(25)36-21)35-29(42)19-8-11-33-22(31)14-19/h2-8,11,14,16,18H,9-10,12-13,15H2,1H3,(H2,32,41)(H,35,42)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.30n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 ul prepared from 15 ul additions of enzyme, substrates (flu...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM255165
PNG
(US9475817, 124)
Show SMILES Cn1nc(c(c1N1CCN(CC(N)=O)CC1)-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C28H26F2N10O2/c1-37-28(39-12-10-38(11-13-39)15-22(31)41)25(26(36-37)17-2-4-19(29)5-3-17)20-6-7-24-33-23(16-40(24)35-20)34-27(42)18-8-9-32-21(30)14-18/h2-9,14,16H,10-13,15H2,1H3,(H2,31,41)(H,34,42)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.30n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 ul prepared from 15 ul additions of enzyme, substrates (flu...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM255219
PNG
(US9475817, 178)
Show SMILES Cc1nc(sc1C(=O)Nc1cn2nc(ccc2n1)-c1c(nn(C)c1C1CCN(CC(N)=O)CC1)-c1ccc(F)cc1)-c1cccnc1
Show InChI InChI=1S/C33H31FN10O2S/c1-19-31(47-33(37-19)22-4-3-13-36-16-22)32(46)39-26-18-44-27(38-26)10-9-24(40-44)28-29(20-5-7-23(34)8-6-20)41-42(2)30(28)21-11-14-43(15-12-21)17-25(35)45/h3-10,13,16,18,21H,11-12,14-15,17H2,1-2H3,(H2,35,45)(H,39,46)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.30n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 ul prepared from 15 ul additions of enzyme, substrates (flu...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM255200
PNG
(US9475817, 159)
Show SMILES Cn1nc(c(c1C1CCN(C[C@H](O)C(F)(F)F)CC1)-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1)-c1ccc(F)cc1
Show InChI InChI=1/C30H27F5N8O2/c1-41-28(18-9-12-42(13-10-18)15-22(44)30(33,34)35)26(27(40-41)17-2-4-20(31)5-3-17)21-6-7-25-37-24(16-43(25)39-21)38-29(45)19-8-11-36-23(32)14-19/h2-8,11,14,16,18,22,44H,9-10,12-13,15H2,1H3,(H,38,45)/t22-/s2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.40n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 ul prepared from 15 ul additions of enzyme, substrates (flu...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM255220
PNG
(US9475817, 179)
Show SMILES Cc1nc(sc1C(=O)Nc1cn2nc(ccc2n1)-c1c(nn(C)c1C1CCNCC1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C31H28FN9OS/c1-18-29(43-31(35-18)21-11-15-34-16-12-21)30(42)37-24-17-41-25(36-24)8-7-23(38-41)26-27(19-3-5-22(32)6-4-19)39-40(2)28(26)20-9-13-33-14-10-20/h3-8,11-12,15-17,20,33H,9-10,13-14H2,1-2H3,(H,37,42)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.5n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 ul prepared from 15 ul additions of enzyme, substrates (flu...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM255209
PNG
(US9475817, 168)
Show SMILES Cn1nc(c(c1C1CCN(CCO)CC1)-c1ccc2nc(NC(=O)c3ccncc3)cn2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C29H29FN8O2/c1-36-28(20-10-14-37(15-11-20)16-17-39)26(27(35-36)19-2-4-22(30)5-3-19)23-6-7-25-32-24(18-38(25)34-23)33-29(40)21-8-12-31-13-9-21/h2-9,12-13,18,20,39H,10-11,14-17H2,1H3,(H,33,40)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.5n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 ul prepared from 15 ul additions of enzyme, substrates (flu...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM206971
PNG
(US9233965, 48)
Show SMILES CSc1ccc(cc1)-c1c(C2CC2)n2CCN(Cc2c1C(N)=O)C(=O)NC(C)(C)C
Show InChI InChI=1S/C23H30N4O2S/c1-23(2,3)25-22(29)26-11-12-27-17(13-26)19(21(24)28)18(20(27)15-5-6-15)14-7-9-16(30-4)10-8-14/h7-10,15H,5-6,11-13H2,1-4H3,(H2,24,28)(H,25,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.5n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
"U"-bottomed Falcon plates are prepared by placing 5 uL of solutions of the compounds according to the invention at concentrations of 10, 1, 0.1, 0.0...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM255215
PNG
(US9475817, 174)
Show SMILES Cc1nc(sc1C(=O)Nc1cn2nc(ccc2n1)-c1c(nn(C)c1C1CCNCC1)-c1ccc(F)cc1)-c1cccnc1
Show InChI InChI=1S/C31H28FN9OS/c1-18-29(43-31(35-18)21-4-3-13-34-16-21)30(42)37-24-17-41-25(36-24)10-9-23(38-41)26-27(19-5-7-22(32)8-6-19)39-40(2)28(26)20-11-14-33-15-12-20/h3-10,13,16-17,20,33H,11-12,14-15H2,1-2H3,(H,37,42)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.80n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 ul prepared from 15 ul additions of enzyme, substrates (flu...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM255175
PNG
(US9475817, 134)
Show SMILES Cn1nc(c(c1N1CCNCC1)-c1ccc2nc(NC(=O)c3ccnc(c3)N3CCOCC3)cn2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C30H31FN10O2/c1-38-30(40-12-10-32-11-13-40)27(28(37-38)20-2-4-22(31)5-3-20)23-6-7-25-34-24(19-41(25)36-23)35-29(42)21-8-9-33-26(18-21)39-14-16-43-17-15-39/h2-9,18-19,32H,10-17H2,1H3,(H,35,42)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.80n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 ul prepared from 15 ul additions of enzyme, substrates (flu...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM255238
PNG
(US9475817, 197)
Show SMILES Cn1nc(c(c1C1CCOCC1)-c1ccc2nc(NC(=O)c3ccncc3)cn2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C27H24FN7O2/c1-34-26(18-10-14-37-15-11-18)24(25(33-34)17-2-4-20(28)5-3-17)21-6-7-23-30-22(16-35(23)32-21)31-27(36)19-8-12-29-13-9-19/h2-9,12-13,16,18H,10-11,14-15H2,1H3,(H,31,36)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.80n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 ul prepared from 15 ul additions of enzyme, substrates (flu...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM255158
PNG
(US9475817, 117)
Show SMILES Cn1nc(c(c1N1CCN(CCO)CC1)-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C28H27F2N9O2/c1-36-28(38-12-10-37(11-13-38)14-15-40)25(26(35-36)18-2-4-20(29)5-3-18)21-6-7-24-32-23(17-39(24)34-21)33-27(41)19-8-9-31-22(30)16-19/h2-9,16-17,40H,10-15H2,1H3,(H,33,41)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.80n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 ul prepared from 15 ul additions of enzyme, substrates (flu...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM255240
PNG
(US9475817, 199)
Show SMILES Cn1nc(c(c1C1CCOCC1)-c1ccc2nc(NC(=O)c3cccc(c3)-c3cccnc3)cn2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C33H28FN7O2/c1-40-32(22-13-16-43-17-14-22)30(31(39-40)21-7-9-26(34)10-8-21)27-11-12-29-36-28(20-41(29)38-27)37-33(42)24-5-2-4-23(18-24)25-6-3-15-35-19-25/h2-12,15,18-20,22H,13-14,16-17H2,1H3,(H,37,42)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.90n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 ul prepared from 15 ul additions of enzyme, substrates (flu...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM255207
PNG
(US9475817, 166)
Show SMILES Cn1nc(c(c1C1CCN(CC1)C1CC1)-c1ccc2nc(NC(=O)c3ccncc3)cn2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C30H29FN8O/c1-37-29(20-12-16-38(17-13-20)23-6-7-23)27(28(36-37)19-2-4-22(31)5-3-19)24-8-9-26-33-25(18-39(26)35-24)34-30(40)21-10-14-32-15-11-21/h2-5,8-11,14-15,18,20,23H,6-7,12-13,16-17H2,1H3,(H,34,40)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.90n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 ul prepared from 15 ul additions of enzyme, substrates (flu...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM207005
PNG
(US9233965, 89)
Show SMILES NC(=O)c1c2CN(CCn2c(Cl)c1-c1cccc(F)c1)C(=O)NC1CCC(F)(F)CC1
Show InChI InChI=1S/C21H22ClF3N4O2/c22-18-16(12-2-1-3-13(23)10-12)17(19(26)30)15-11-28(8-9-29(15)18)20(31)27-14-4-6-21(24,25)7-5-14/h1-3,10,14H,4-9,11H2,(H2,26,30)(H,27,31)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
"U"-bottomed Falcon plates are prepared by placing 5 uL of solutions of the compounds according to the invention at concentrations of 10, 1, 0.1, 0.0...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM206920
PNG
(US9233965, 64)
Show SMILES COc1ccc(cc1)-c1c(Cl)n2CCN(Cc2c1C(N)=O)C(=O)NC(C)(C)C
Show InChI InChI=1S/C20H25ClN4O3/c1-20(2,3)23-19(27)24-9-10-25-14(11-24)16(18(22)26)15(17(25)21)12-5-7-13(28-4)8-6-12/h5-8H,9-11H2,1-4H3,(H2,22,26)(H,23,27)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
"U"-bottomed Falcon plates are prepared by placing 5 uL of solutions of the compounds according to the invention at concentrations of 10, 1, 0.1, 0.0...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM255237
PNG
(US9475817, 196)
Show SMILES Cn1nc(c(c1C1CCOCC1)-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C27H23F2N7O2/c1-35-26(17-9-12-38-13-10-17)24(25(34-35)16-2-4-19(28)5-3-16)20-6-7-23-31-22(15-36(23)33-20)32-27(37)18-8-11-30-21(29)14-18/h2-8,11,14-15,17H,9-10,12-13H2,1H3,(H,32,37)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 ul prepared from 15 ul additions of enzyme, substrates (flu...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM206981
PNG
(US9233965, 62)
Show SMILES COc1cccc(c1)-c1c(Cl)n2CCN(Cc2c1C(N)=O)C(=O)NC(C)(C)C
Show InChI InChI=1S/C20H25ClN4O3/c1-20(2,3)23-19(27)24-8-9-25-14(11-24)16(18(22)26)15(17(25)21)12-6-5-7-13(10-12)28-4/h5-7,10H,8-9,11H2,1-4H3,(H2,22,26)(H,23,27)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
"U"-bottomed Falcon plates are prepared by placing 5 uL of solutions of the compounds according to the invention at concentrations of 10, 1, 0.1, 0.0...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM207002
PNG
(US9233965, 85)
Show SMILES NC(=O)c1c2CN(CCn2c(Cl)c1-c1cccc(F)c1)C(=O)NC1CCC(O)(CC1)C(F)(F)F
Show InChI InChI=1S/C22H23ClF4N4O3/c23-18-16(12-2-1-3-13(24)10-12)17(19(28)32)15-11-30(8-9-31(15)18)20(33)29-14-4-6-21(34,7-5-14)22(25,26)27/h1-3,10,14,34H,4-9,11H2,(H2,28,32)(H,29,33)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
"U"-bottomed Falcon plates are prepared by placing 5 uL of solutions of the compounds according to the invention at concentrations of 10, 1, 0.1, 0.0...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM206928
PNG
(US9233965, 4)
Show SMILES COc1ccc(cc1)-c1c(C)n2CCN(Cc2c1C(N)=O)C(=O)NC(C)(C)C
Show InChI InChI=1S/C21H28N4O3/c1-13-17(14-6-8-15(28-5)9-7-14)18(19(22)26)16-12-24(10-11-25(13)16)20(27)23-21(2,3)4/h6-9H,10-12H2,1-5H3,(H2,22,26)(H,23,27)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
"U"-bottomed Falcon plates are prepared by placing 5 uL of solutions of the compounds according to the invention at concentrations of 10, 1, 0.1, 0.0...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM207019
PNG
(US9233965, 106)
Show SMILES CC(NC(=O)N1CCn2c(C1)c(C(N)=O)c(c2C#N)-c1cccc(F)c1)C(F)(F)F
Show InChI InChI=1/C19H17F4N5O2/c1-10(19(21,22)23)26-18(30)27-5-6-28-13(8-24)15(11-3-2-4-12(20)7-11)16(17(25)29)14(28)9-27/h2-4,7,10H,5-6,9H2,1H3,(H2,25,29)(H,26,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
"U"-bottomed Falcon plates are prepared by placing 5 uL of solutions of the compounds according to the invention at concentrations of 10, 1, 0.1, 0.0...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM206915
PNG
(US9233965, 79)
Show SMILES CC(C)(NC(=O)N1CCn2c(Cl)c(c(C(N)=O)c2C1)-c1cccc(F)c1)C(F)(F)F
Show InChI InChI=1S/C19H19ClF4N4O2/c1-18(2,19(22,23)24)26-17(30)27-6-7-28-12(9-27)14(16(25)29)13(15(28)20)10-4-3-5-11(21)8-10/h3-5,8H,6-7,9H2,1-2H3,(H2,25,29)(H,26,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
"U"-bottomed Falcon plates are prepared by placing 5 uL of solutions of the compounds according to the invention at concentrations of 10, 1, 0.1, 0.0...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM255194
PNG
(US9475817, 153)
Show SMILES Cn1nc(c(c1C1CCN(CC1)C(=O)c1ccon1)-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C31H25F2N9O3/c1-40-29(19-9-13-41(14-10-19)31(44)23-11-15-45-39-23)27(28(38-40)18-2-4-21(32)5-3-18)22-6-7-26-35-25(17-42(26)37-22)36-30(43)20-8-12-34-24(33)16-20/h2-8,11-12,15-17,19H,9-10,13-14H2,1H3,(H,36,43)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.20n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 ul prepared from 15 ul additions of enzyme, substrates (flu...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM255183
PNG
(US9475817, 142)
Show SMILES Cn1nc(c(c1N1CCN(Cc2ccon2)CC1)-c1ccc2nc(NC(=O)c3ccnc(N)c3)cn2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C30H28FN11O2/c1-39-30(41-13-11-40(12-14-41)17-22-9-15-44-38-22)27(28(37-39)19-2-4-21(31)5-3-19)23-6-7-26-34-25(18-42(26)36-23)35-29(43)20-8-10-33-24(32)16-20/h2-10,15-16,18H,11-14,17H2,1H3,(H2,32,33)(H,35,43)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.20n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 ul prepared from 15 ul additions of enzyme, substrates (flu...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM255154
PNG
(US9475817, 113 | US9475817, 148)
Show SMILES Cn1nc(c(c1N1CCNCC1)-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C26H23F2N9O/c1-35-26(36-12-10-29-11-13-36)23(24(34-35)16-2-4-18(27)5-3-16)19-6-7-22-31-21(15-37(22)33-19)32-25(38)17-8-9-30-20(28)14-17/h2-9,14-15,29H,10-13H2,1H3,(H,32,38)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.30n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 ul prepared from 15 ul additions of enzyme, substrates (flu...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM255242
PNG
(US9475817, 201)
Show SMILES Cc1nc(sc1C(=O)Nc1cn2nc(ccc2n1)-c1c(nn(C)c1C1CCOCC1)-c1ccc(F)cc1)-c1cccnc1
Show InChI InChI=1S/C31H27FN8O2S/c1-18-29(43-31(34-18)21-4-3-13-33-16-21)30(41)36-24-17-40-25(35-24)10-9-23(37-40)26-27(19-5-7-22(32)8-6-19)38-39(2)28(26)20-11-14-42-15-12-20/h3-10,13,16-17,20H,11-12,14-15H2,1-2H3,(H,36,41)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.30n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 ul prepared from 15 ul additions of enzyme, substrates (flu...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM255181
PNG
(US9475817, 140)
Show SMILES Cn1nc(c(c1N1CCNCC1)-c1ccc2nc(NC(=O)c3ccnc(N)c3)cn2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C26H25FN10O/c1-35-26(36-12-10-29-11-13-36)23(24(34-35)16-2-4-18(27)5-3-16)19-6-7-22-31-21(15-37(22)33-19)32-25(38)17-8-9-30-20(28)14-17/h2-9,14-15,29H,10-13H2,1H3,(H2,28,30)(H,32,38)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.40n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 ul prepared from 15 ul additions of enzyme, substrates (flu...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM255224
PNG
(US9475817, 183)
Show SMILES Cc1nc(sc1C(=O)Nc1cn2nc(ccc2n1)-c1c(nn(C)c1C1CCN(CCC#N)CC1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C34H31FN10OS/c1-21-32(47-34(38-21)24-10-15-37-16-11-24)33(46)40-27-20-45-28(39-27)9-8-26(41-45)29-30(22-4-6-25(35)7-5-22)42-43(2)31(29)23-12-18-44(19-13-23)17-3-14-36/h4-11,15-16,20,23H,3,12-13,17-19H2,1-2H3,(H,40,46)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.40n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 ul prepared from 15 ul additions of enzyme, substrates (flu...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM255197
PNG
(US9475817, 156)
Show SMILES Cn1nc(c(c1C1CCN(CCC#N)CC1)-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C30H27F2N9O/c1-39-29(20-10-15-40(16-11-20)14-2-12-33)27(28(38-39)19-3-5-22(31)6-4-19)23-7-8-26-35-25(18-41(26)37-23)36-30(42)21-9-13-34-24(32)17-21/h3-9,13,17-18,20H,2,10-11,14-16H2,1H3,(H,36,42)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.60n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 ul prepared from 15 ul additions of enzyme, substrates (flu...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM255154
PNG
(US9475817, 113 | US9475817, 148)
Show SMILES Cn1nc(c(c1N1CCNCC1)-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C26H23F2N9O/c1-35-26(36-12-10-29-11-13-36)23(24(34-35)16-2-4-18(27)5-3-16)19-6-7-22-31-21(15-37(22)33-19)32-25(38)17-8-9-30-20(28)14-17/h2-9,14-15,29H,10-13H2,1H3,(H,32,38)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.60n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 ul prepared from 15 ul additions of enzyme, substrates (flu...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM255193
PNG
(US9475817, 152)
Show SMILES COCC(=O)N1CCC(CC1)c1c(c(nn1C)-c1ccc(F)cc1)-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1
Show InChI InChI=1S/C30H28F2N8O3/c1-38-29(19-10-13-39(14-11-19)26(41)17-43-2)27(28(37-38)18-3-5-21(31)6-4-18)22-7-8-25-34-24(16-40(25)36-22)35-30(42)20-9-12-33-23(32)15-20/h3-9,12,15-16,19H,10-11,13-14,17H2,1-2H3,(H,35,42)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.70n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 ul prepared from 15 ul additions of enzyme, substrates (flu...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM255241
PNG
(US9475817, 200)
Show SMILES Cc1nc(sc1C(=O)Nc1cn2nc(ccc2n1)-c1c(nn(C)c1C1CCOCC1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C31H27FN8O2S/c1-18-29(43-31(34-18)21-9-13-33-14-10-21)30(41)36-24-17-40-25(35-24)8-7-23(37-40)26-27(19-3-5-22(32)6-4-19)38-39(2)28(26)20-11-15-42-16-12-20/h3-10,13-14,17,20H,11-12,15-16H2,1-2H3,(H,36,41)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 ul prepared from 15 ul additions of enzyme, substrates (flu...


Citation and Details
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 542 total )  |  Next  |  Last  >>
Jump to: