BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 305 hits Enz. Inhib. hit(s) with Target = 'Cyclin-C'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclin-C


(Homo sapiens (Human))
BDBM50248627
PNG
(CHEMBL4078454)
Show SMILES OC[C@H](Nc1cncc(n1)-c1ccc(O)c(Cl)c1)c1ccccc1
Show InChI InChI=1S/C18H16ClN3O2/c19-14-8-13(6-7-17(14)24)15-9-20-10-18(21-15)22-16(11-23)12-4-2-1-3-5-12/h1-10,16,23-24H,11H2,(H,21,22)/t16-/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.200n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human His-tagged CDK8/Cyclin C expressed in baculovirus expression system using Ulight-GS peptide as substrate ...


Bioorg Med Chem 25: 2336-2350 (2017)


Article DOI: 10.1016/j.bmc.2017.02.038
BindingDB Entry DOI: 10.7270/Q21J9D6H
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50248633
PNG
(CHEMBL4083552)
Show SMILES NC(=O)c1sc(Oc2ccccc2)c-2c1CCc1cnsc-21
Show InChI InChI=1S/C16H12N2O2S2/c17-15(19)14-11-7-6-9-8-18-22-13(9)12(11)16(21-14)20-10-4-2-1-3-5-10/h1-5,8H,6-7H2,(H2,17,19)
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.340n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assay


Bioorg Med Chem 25: 2336-2350 (2017)


Article DOI: 10.1016/j.bmc.2017.02.038
BindingDB Entry DOI: 10.7270/Q21J9D6H
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50248623
PNG
(CHEMBL4096487)
Show SMILES OC[C@H](Nc1cncc(c1)-c1ccc2[nH]ncc2c1)c1ccccc1
Show InChI InChI=1S/C20H18N4O/c25-13-20(14-4-2-1-3-5-14)23-18-9-16(10-21-12-18)15-6-7-19-17(8-15)11-22-24-19/h1-12,20,23,25H,13H2,(H,22,24)/t20-/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.400n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human His-tagged CDK8/Cyclin C expressed in baculovirus expression system using Ulight-GS peptide as substrate ...


Bioorg Med Chem 25: 2336-2350 (2017)


Article DOI: 10.1016/j.bmc.2017.02.038
BindingDB Entry DOI: 10.7270/Q21J9D6H
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50248614
PNG
(CHEMBL4066819)
Show SMILES COCCNC(=O)c1ccc(Oc2sc(C(N)=O)c3CCc4cnsc4-c23)cn1
Show InChI InChI=1S/C19H18N4O4S2/c1-26-7-6-21-18(25)13-5-3-11(9-22-13)27-19-14-12(16(28-19)17(20)24)4-2-10-8-23-29-15(10)14/h3,5,8-9H,2,4,6-7H2,1H3,(H2,20,24)(H,21,25)
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.460n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assay


Bioorg Med Chem 25: 2336-2350 (2017)


Article DOI: 10.1016/j.bmc.2017.02.038
BindingDB Entry DOI: 10.7270/Q21J9D6H
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50248635
PNG
(CHEMBL4070408)
Show SMILES Cc1ncccc1Oc1sc(C(N)=O)c2CCc3cnsc3-c12
Show InChI InChI=1S/C16H13N3O2S2/c1-8-11(3-2-6-18-8)21-16-12-10(14(22-16)15(17)20)5-4-9-7-19-23-13(9)12/h2-3,6-7H,4-5H2,1H3,(H2,17,20)
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.470n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assay


Bioorg Med Chem 25: 2336-2350 (2017)


Article DOI: 10.1016/j.bmc.2017.02.038
BindingDB Entry DOI: 10.7270/Q21J9D6H
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50241875
PNG
(CHEMBL4091527)
Show SMILES O=C(Nc1ccc(CN2CCOCC2)cc1)\C=C\c1cnccc1-c1cn[nH]c1
Show InChI InChI=1S/C22H23N5O2/c28-22(6-3-18-13-23-8-7-21(18)19-14-24-25-15-19)26-20-4-1-17(2-5-20)16-27-9-11-29-12-10-27/h1-8,13-15H,9-12,16H2,(H,24,25)(H,26,28)/b6-3+
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.540n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of kinase tracer 236 binding to full length N terminal GST-tagged human CDK8 (1 to 464 end residues) /CycC ( 1 to 283 end residues) expres...


Bioorg Med Chem 25: 3018-3033 (2017)


Article DOI: 10.1016/j.bmc.2017.03.049
BindingDB Entry DOI: 10.7270/Q24X59XW
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50248656
PNG
(CHEMBL4086487)
Show SMILES CC(=O)Nc1ccc(Oc2sc(C(N)=O)c3CCc4cnsc4-c23)cn1
Show InChI InChI=1S/C17H14N4O3S2/c1-8(22)21-12-5-3-10(7-19-12)24-17-13-11(15(25-17)16(18)23)4-2-9-6-20-26-14(9)13/h3,5-7H,2,4H2,1H3,(H2,18,23)(H,19,21,22)
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.570n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assay


Bioorg Med Chem 25: 2336-2350 (2017)


Article DOI: 10.1016/j.bmc.2017.02.038
BindingDB Entry DOI: 10.7270/Q21J9D6H
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50248645
PNG
(CHEMBL4061525)
Show SMILES CNc1ccc(Oc2sc(C(N)=O)c3CCc4cnsc4-c23)cn1
Show InChI InChI=1S/C16H14N4O2S2/c1-18-11-5-3-9(7-19-11)22-16-12-10(14(23-16)15(17)21)4-2-8-6-20-24-13(8)12/h3,5-7H,2,4H2,1H3,(H2,17,21)(H,18,19)
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.590n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assay


Bioorg Med Chem 25: 2336-2350 (2017)


Article DOI: 10.1016/j.bmc.2017.02.038
BindingDB Entry DOI: 10.7270/Q21J9D6H
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50248640
PNG
(CHEMBL4074204)
Show SMILES NC(=O)c1sc(Oc2ccc(N)nc2)c-2c1CCc1cnsc-21
Show InChI InChI=1S/C15H12N4O2S2/c16-10-4-2-8(6-18-10)21-15-11-9(13(22-15)14(17)20)3-1-7-5-19-23-12(7)11/h2,4-6H,1,3H2,(H2,16,18)(H2,17,20)
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.600n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assay


Bioorg Med Chem 25: 2336-2350 (2017)


Article DOI: 10.1016/j.bmc.2017.02.038
BindingDB Entry DOI: 10.7270/Q21J9D6H
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50248690
PNG
(CHEMBL4082469)
Show SMILES CSc1sc(C(N)=O)c2CCc3cnsc3-c12
Show InChI InChI=1S/C11H10N2OS3/c1-15-11-7-6(9(16-11)10(12)14)3-2-5-4-13-17-8(5)7/h4H,2-3H2,1H3,(H2,12,14)
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.650n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assay


Bioorg Med Chem 25: 2336-2350 (2017)


Article DOI: 10.1016/j.bmc.2017.02.038
BindingDB Entry DOI: 10.7270/Q21J9D6H
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50265275
PNG
(4-(4-iodophenoxy)-2-(2H-tetrazol-5-yl)thieno[2,3-c...)
Show SMILES Ic1ccc(Oc2cncc3sc(cc23)-c2nnn[nH]2)cc1
Show InChI InChI=1S/C14H8IN5OS/c15-8-1-3-9(4-2-8)21-11-6-16-7-13-10(11)5-12(22-13)14-17-19-20-18-14/h1-7H,(H,17,18,19,20)
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.700n/an/an/an/an/an/a



Genentech Inc

Curated by ChEMBL


Assay Description
Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay


ACS Med Chem Lett 7: 223-8 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00278
BindingDB Entry DOI: 10.7270/Q29G5PPC
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50189434
PNG
(CHEMBL3828221)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1cncc2ccc(nc12)-c1nccn1C
Show InChI InChI=1S/C22H18N6/c1-27-10-9-24-22(27)20-8-7-17-11-23-13-19(21(17)26-20)16-5-3-15(4-6-16)18-12-25-28(2)14-18/h3-14H,1-2H3
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.710n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


ACS Med Chem Lett 7: 573-8 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00022
BindingDB Entry DOI: 10.7270/Q2N87CRB
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50189415
PNG
(CHEMBL3828637)
Show SMILES CNC(=O)c1ccc2cncc(-c3ccc4N(C)S(=O)(=O)Cc4c3)c2n1
Show InChI InChI=1S/C18H16N4O3S/c1-19-18(23)15-5-3-12-8-20-9-14(17(12)21-15)11-4-6-16-13(7-11)10-26(24,25)22(16)2/h3-9H,10H2,1-2H3,(H,19,23)
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
PDB
UniChem

Similars

PDB
Article
PubMed
n/an/a 0.900n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


ACS Med Chem Lett 7: 573-8 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00022
BindingDB Entry DOI: 10.7270/Q2N87CRB
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cyclin-C


(Homo sapiens (Human))
BDBM50248611
PNG
(CHEMBL4060856)
Show SMILES NC(=O)c1sc(Oc2ccc(nc2)C(N)=O)c-2c1CCc1cnsc-21
Show InChI InChI=1S/C16H12N4O3S2/c17-14(21)10-4-2-8(6-19-10)23-16-11-9(13(24-16)15(18)22)3-1-7-5-20-25-12(7)11/h2,4-6H,1,3H2,(H2,17,21)(H2,18,22)
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 0.930n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assay


Bioorg Med Chem 25: 2336-2350 (2017)


Article DOI: 10.1016/j.bmc.2017.02.038
BindingDB Entry DOI: 10.7270/Q21J9D6H
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50248638
PNG
(CHEMBL4062244)
Show SMILES Cc1ccc(Oc2sc(C(N)=O)c3CCc4cnsc4-c23)cn1
Show InChI InChI=1S/C16H13N3O2S2/c1-8-2-4-10(7-18-8)21-16-12-11(14(22-16)15(17)20)5-3-9-6-19-23-13(9)12/h2,4,6-7H,3,5H2,1H3,(H2,17,20)
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.990n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assay


Bioorg Med Chem 25: 2336-2350 (2017)


Article DOI: 10.1016/j.bmc.2017.02.038
BindingDB Entry DOI: 10.7270/Q21J9D6H
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50509567
PNG
(CHEMBL4455382)
Show SMILES CN(C)C(=O)Cn1cc(cn1)-c1ccc(cc1)-c1cncc2ccccc12
Show InChI InChI=1S/C22H20N4O/c1-25(2)22(27)15-26-14-19(12-24-26)16-7-9-17(10-8-16)21-13-23-11-18-5-3-4-6-20(18)21/h3-14H,15H2,1-2H3
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
Purchase

PC cid
PC sid
PDB
UniChem
PDB
Article
PubMed
n/an/a 1n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of CDK8/CyclinC (unknown origin)


ACS Med Chem Lett 11: 127-132 (2020)


Article DOI: 10.1021/acsmedchemlett.9b00480
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cyclin-C


(Homo sapiens (Human))
BDBM50169081
PNG
(CHEMBL3806220)
Show SMILES N#Cc1ccc(Oc2cncc3sc(cc23)-c2nnn[nH]2)cc1
Show InChI InChI=1S/C15H8N6OS/c16-6-9-1-3-10(4-2-9)22-12-7-17-8-14-11(12)5-13(23-14)15-18-20-21-19-15/h1-5,7-8H,(H,18,19,20,21)
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1n/an/an/an/an/an/a



Genentech Inc

Curated by ChEMBL


Assay Description
Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay


ACS Med Chem Lett 7: 223-8 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00278
BindingDB Entry DOI: 10.7270/Q29G5PPC
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50189428
PNG
(CHEMBL3828458)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1cncc2ccc(nc12)N1CCNC1=O
Show InChI InChI=1S/C21H18N6O/c1-26-13-17(11-24-26)14-2-4-15(5-3-14)18-12-22-10-16-6-7-19(25-20(16)18)27-9-8-23-21(27)28/h2-7,10-13H,8-9H2,1H3,(H,23,28)
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


ACS Med Chem Lett 7: 573-8 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00022
BindingDB Entry DOI: 10.7270/Q2N87CRB
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50248615
PNG
(CHEMBL4077627)
Show SMILES CCOCCNC(=O)c1ccc(Oc2sc(C(N)=O)c3CCc4cnsc4-c23)cn1
Show InChI InChI=1S/C20H20N4O4S2/c1-2-27-8-7-22-19(26)14-6-4-12(10-23-14)28-20-15-13(17(29-20)18(21)25)5-3-11-9-24-30-16(11)15/h4,6,9-10H,2-3,5,7-8H2,1H3,(H2,21,25)(H,22,26)
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.10n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assay


Bioorg Med Chem 25: 2336-2350 (2017)


Article DOI: 10.1016/j.bmc.2017.02.038
BindingDB Entry DOI: 10.7270/Q21J9D6H
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50169082
PNG
(CHEMBL3805960)
Show SMILES FC(F)(F)Oc1ccc(Oc2cncc3sc(cc23)-c2nnn[nH]2)cc1
Show InChI InChI=1S/C15H8F3N5O2S/c16-15(17,18)25-9-3-1-8(2-4-9)24-11-6-19-7-13-10(11)5-12(26-13)14-20-22-23-21-14/h1-7H,(H,20,21,22,23)
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.10n/an/an/an/an/an/a



Genentech Inc

Curated by ChEMBL


Assay Description
Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay


ACS Med Chem Lett 7: 223-8 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00278
BindingDB Entry DOI: 10.7270/Q29G5PPC
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50265311
PNG
(4-(4-chlorophenoxy)-2-(2H-tetrazol-5-yl)thieno[2,3...)
Show SMILES Clc1ccc(Oc2cncc3sc(cc23)-c2nnn[nH]2)cc1
Show InChI InChI=1S/C14H8ClN5OS/c15-8-1-3-9(4-2-8)21-11-6-16-7-13-10(11)5-12(22-13)14-17-19-20-18-14/h1-7H,(H,17,18,19,20)
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.10n/an/an/an/an/an/a



Genentech Inc

Curated by ChEMBL


Assay Description
Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay


ACS Med Chem Lett 7: 223-8 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00278
BindingDB Entry DOI: 10.7270/Q29G5PPC
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50189447
PNG
(CHEMBL3828553)
Show SMILES COC1CN(C1)C(=O)c1ccc2c(N)ncc(-c3ccc(cc3)-c3cnn(C)c3)c2n1
Show InChI InChI=1S/C23H22N6O2/c1-28-11-16(9-26-28)14-3-5-15(6-4-14)19-10-25-22(24)18-7-8-20(27-21(18)19)23(30)29-12-17(13-29)31-2/h3-11,17H,12-13H2,1-2H3,(H2,24,25)
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.10n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


ACS Med Chem Lett 7: 573-8 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00022
BindingDB Entry DOI: 10.7270/Q2N87CRB
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50191414
PNG
(CHEMBL3947140)
Show SMILES Cc1n[nH]c2ccc(nc12)C(=O)N1CCC[C@H]1c1ccc(Cl)cc1
Show InChI InChI=1S/C18H17ClN4O/c1-11-17-14(22-21-11)8-9-15(20-17)18(24)23-10-2-3-16(23)12-4-6-13(19)7-5-12/h4-9,16H,2-3,10H2,1H3,(H,21,22)/t16-/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.30n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL


Assay Description
Inhibition of Alexa647 tracer binding to full length recombinant human His-tagged CDK8/cyclin C expressed in Baculovirus expression system preincubat...


J Med Chem 59: 9337-9349 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00597
BindingDB Entry DOI: 10.7270/Q2K64M1C
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50191472
PNG
(CHEMBL3956719)
Show SMILES Cc1n[nH]c2ccc(cc12)C(=O)N1CCC[C@H]1c1ccc(Cl)cc1
Show InChI InChI=1S/C19H18ClN3O/c1-12-16-11-14(6-9-17(16)22-21-12)19(24)23-10-2-3-18(23)13-4-7-15(20)8-5-13/h4-9,11,18H,2-3,10H2,1H3,(H,21,22)/t18-/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.40n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL


Assay Description
Inhibition of Alexa647 tracer binding to full length recombinant human His-tagged CDK8/cyclin C expressed in Baculovirus expression system preincubat...


J Med Chem 59: 9337-9349 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00597
BindingDB Entry DOI: 10.7270/Q2K64M1C
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50248686
PNG
(CHEMBL4071040)
Show SMILES COCCNC(=O)c1ccc(Oc2sc(C(N)=O)c3CCc4cnsc4-c23)c(C)n1
Show InChI InChI=1S/C20H20N4O4S2/c1-10-14(6-5-13(24-10)19(26)22-7-8-27-2)28-20-15-12(17(29-20)18(21)25)4-3-11-9-23-30-16(11)15/h5-6,9H,3-4,7-8H2,1-2H3,(H2,21,25)(H,22,26)
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.40n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assay


Bioorg Med Chem 25: 2336-2350 (2017)


Article DOI: 10.1016/j.bmc.2017.02.038
BindingDB Entry DOI: 10.7270/Q21J9D6H
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50248662
PNG
(CHEMBL4091345)
Show SMILES NC(=O)c1sc(Oc2cccnc2)c-2c1CCc1cnsc-21
Show InChI InChI=1S/C15H11N3O2S2/c16-14(19)13-10-4-3-8-6-18-22-12(8)11(10)15(21-13)20-9-2-1-5-17-7-9/h1-2,5-7H,3-4H2,(H2,16,19)
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.5n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assay


Bioorg Med Chem 25: 2336-2350 (2017)


Article DOI: 10.1016/j.bmc.2017.02.038
BindingDB Entry DOI: 10.7270/Q21J9D6H
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50189417
PNG
(CHEMBL3828116)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1cncc2ccc(nc12)C(N)=O
Show InChI InChI=1S/C19H15N5O/c1-24-11-15(9-22-24)12-2-4-13(5-3-12)16-10-21-8-14-6-7-17(19(20)25)23-18(14)16/h2-11H,1H3,(H2,20,25)
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.5n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


ACS Med Chem Lett 7: 573-8 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00022
BindingDB Entry DOI: 10.7270/Q2N87CRB
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50169062
PNG
(CHEMBL3805194)
Show SMILES NC(=O)c1cc2c(Oc3ccc(Cl)cc3)cnc(N)c2s1
Show InChI InChI=1S/C14H10ClN3O2S/c15-7-1-3-8(4-2-7)20-10-6-18-13(16)12-9(10)5-11(21-12)14(17)19/h1-6H,(H2,16,18)(H2,17,19)
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.5n/an/an/an/an/an/a



Genentech Inc

Curated by ChEMBL


Assay Description
Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay


ACS Med Chem Lett 7: 223-8 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00278
BindingDB Entry DOI: 10.7270/Q29G5PPC
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50241879
PNG
(CHEMBL4082587)
Show SMILES O=C(Nc1ccc(CN2CCOCC2)cc1)\C=C\c1cnccc1-c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C26H25N5O2/c32-26(30-22-5-1-19(2-6-22)17-31-11-13-33-14-12-31)8-4-21-16-27-10-9-23(21)20-3-7-24-25(15-20)29-18-28-24/h1-10,15-16,18H,11-14,17H2,(H,28,29)(H,30,32)/b8-4+
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.5n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of kinase tracer 236 binding to full length N terminal GST-tagged human CDK8 (1 to 464 end residues) /CycC ( 1 to 283 end residues) expres...


Bioorg Med Chem 25: 3018-3033 (2017)


Article DOI: 10.1016/j.bmc.2017.03.049
BindingDB Entry DOI: 10.7270/Q24X59XW
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50529873
PNG
(CHEMBL4552616)
Show SMILES Cc1ncccc1Oc1sc(C(N)=O)c2CCc3cnn(C)c3-c12
Show InChI InChI=1S/C17H16N4O2S/c1-9-12(4-3-7-19-9)23-17-13-11(15(24-17)16(18)22)6-5-10-8-20-21(2)14(10)13/h3-4,7-8H,5-6H2,1-2H3,(H2,18,22)
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.60n/an/an/an/an/an/a



Shaoxing University

Curated by ChEMBL


Assay Description
Displacement of Kinase tracer 236 from recombinant full-length human N-terminal GST-fused CDK8 (1 to 464 residues)/cyclin C (1 to 283 residues) expre...


Eur J Med Chem 164: 77-91 (2019)


Article DOI: 10.1016/j.ejmech.2018.11.076
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50265309
PNG
(2-(2H-tetrazol-5-yl)-4-(p-tolyloxy)thieno[2,3-c]py...)
Show SMILES Cc1ccc(Oc2cncc3sc(cc23)-c2nnn[nH]2)cc1
Show InChI InChI=1S/C15H11N5OS/c1-9-2-4-10(5-3-9)21-12-7-16-8-14-11(12)6-13(22-14)15-17-19-20-18-15/h2-8H,1H3,(H,17,18,19,20)
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.60n/an/an/an/an/an/a



Genentech Inc

Curated by ChEMBL


Assay Description
Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay


ACS Med Chem Lett 7: 223-8 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00278
BindingDB Entry DOI: 10.7270/Q29G5PPC
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50529873
PNG
(CHEMBL4552616)
Show SMILES Cc1ncccc1Oc1sc(C(N)=O)c2CCc3cnn(C)c3-c12
Show InChI InChI=1S/C17H16N4O2S/c1-9-12(4-3-7-19-9)23-17-13-11(15(24-17)16(18)22)6-5-10-8-20-21(2)14(10)13/h3-4,7-8H,5-6H2,1-2H3,(H2,18,22)
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.60n/an/an/an/an/an/a



Shaoxing University

Curated by ChEMBL


Assay Description
Displacement of Kinase tracer 236 from recombinant full-length human N-terminal GST-fused CDK8 (1 to 464 residues)/cyclin C (1 to 283 residues) expre...


Eur J Med Chem 164: 77-91 (2019)


Article DOI: 10.1016/j.ejmech.2018.11.076
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50191373
PNG
(CHEMBL3966985)
Show SMILES Cc1n[nH]c2ccc(cc12)C(=O)N1CC[C@H]1c1ccc(Cl)cc1
Show InChI InChI=1S/C18H16ClN3O/c1-11-15-10-13(4-7-16(15)21-20-11)18(23)22-9-8-17(22)12-2-5-14(19)6-3-12/h2-7,10,17H,8-9H2,1H3,(H,20,21)/t17-/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.70n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL


Assay Description
Inhibition of Alexa647 tracer binding to full length recombinant human His-tagged CDK8/cyclin C expressed in Baculovirus expression system preincubat...


J Med Chem 59: 9337-9349 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00597
BindingDB Entry DOI: 10.7270/Q2K64M1C
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50189426
PNG
(CHEMBL3827944)
Show SMILES CC(=O)Nc1ccc2cncc(-c3ccc(cc3)-c3cnn(C)c3)c2n1
Show InChI InChI=1S/C20H17N5O/c1-13(26)23-19-8-7-16-9-21-11-18(20(16)24-19)15-5-3-14(4-6-15)17-10-22-25(2)12-17/h3-12H,1-2H3,(H,23,24,26)
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.80n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


ACS Med Chem Lett 7: 573-8 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00022
BindingDB Entry DOI: 10.7270/Q2N87CRB
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50248612
PNG
(CHEMBL4076395)
Show SMILES CNC(=O)c1ccc(Oc2sc(C(N)=O)c3CCc4cnsc4-c23)cn1
Show InChI InChI=1S/C17H14N4O3S2/c1-19-16(23)11-5-3-9(7-20-11)24-17-12-10(14(25-17)15(18)22)4-2-8-6-21-26-13(8)12/h3,5-7H,2,4H2,1H3,(H2,18,22)(H,19,23)
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.90n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assay


Bioorg Med Chem 25: 2336-2350 (2017)


Article DOI: 10.1016/j.bmc.2017.02.038
BindingDB Entry DOI: 10.7270/Q21J9D6H
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50154942
PNG
(CHEMBL3775076)
Show SMILES Cn1ncc2cc(Cc3n[nH]c4ccc(cc34)C(=O)N3CCC(F)(F)C3)ccc12
Show InChI InChI=1S/C21H19F2N5O/c1-27-19-5-2-13(8-15(19)11-24-27)9-18-16-10-14(3-4-17(16)25-26-18)20(29)28-7-6-21(22,23)12-28/h2-5,8,10-11H,6-7,9,12H2,1H3,(H,25,26)
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL


Assay Description
Displacement of dye-labeled ATP competitive probe from recombinant human CDK8/Cyclin C incubated for 20 mins by Alexa647 probe-based FRET assay


Bioorg Med Chem Lett 26: 1443-51 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.062
BindingDB Entry DOI: 10.7270/Q2NZ89G6
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50169080
PNG
(CHEMBL3806173)
Show SMILES CC(=O)Nc1ccc(Oc2cncc3sc(cc23)-c2nnn[nH]2)cc1
Show InChI InChI=1S/C16H12N6O2S/c1-9(23)18-10-2-4-11(5-3-10)24-13-7-17-8-15-12(13)6-14(25-15)16-19-21-22-20-16/h2-8H,1H3,(H,18,23)(H,19,20,21,22)
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2n/an/an/an/an/an/a



Genentech Inc

Curated by ChEMBL


Assay Description
Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay


ACS Med Chem Lett 7: 223-8 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00278
BindingDB Entry DOI: 10.7270/Q29G5PPC
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50154956
PNG
(CHEMBL3775317)
Show SMILES Cn1cc(cn1)-c1ccc(Cc2n[nH]c3ccc(cc23)C(=O)N2CC[C@@H](O)C2)cc1
Show InChI InChI=1S/C23H23N5O2/c1-27-13-18(12-24-27)16-4-2-15(3-5-16)10-22-20-11-17(6-7-21(20)25-26-22)23(30)28-9-8-19(29)14-28/h2-7,11-13,19,29H,8-10,14H2,1H3,(H,25,26)/t19-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL


Assay Description
Displacement of dye-labeled ATP competitive probe from recombinant human CDK8/Cyclin C incubated for 20 mins by Alexa647 probe-based FRET assay


Bioorg Med Chem Lett 26: 1443-51 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.062
BindingDB Entry DOI: 10.7270/Q2NZ89G6
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50189436
PNG
(CHEMBL3827327)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1cncc2ccc(cc12)C(=O)NC1CC1
Show InChI InChI=1S/C23H20N4O/c1-27-14-19(12-25-27)15-2-4-16(5-3-15)22-13-24-11-18-7-6-17(10-21(18)22)23(28)26-20-8-9-20/h2-7,10-14,20H,8-9H2,1H3,(H,26,28)
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.10n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


ACS Med Chem Lett 7: 573-8 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00022
BindingDB Entry DOI: 10.7270/Q2N87CRB
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50248632
PNG
(CHEMBL4069854)
Show SMILES COc1sc(C(N)=O)c2CCc3cnsc3-c12
Show InChI InChI=1S/C11H10N2O2S2/c1-15-11-7-6(9(16-11)10(12)14)3-2-5-4-13-17-8(5)7/h4H,2-3H2,1H3,(H2,12,14)
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.30n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assay


Bioorg Med Chem 25: 2336-2350 (2017)


Article DOI: 10.1016/j.bmc.2017.02.038
BindingDB Entry DOI: 10.7270/Q21J9D6H
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50248687
PNG
(CHEMBL4090775)
Show SMILES CC(C)(O)CNC(=O)c1ccc(Oc2sc(C(N)=O)c3CCc4cnsc4-c23)cn1
Show InChI InChI=1S/C20H20N4O4S2/c1-20(2,27)9-23-18(26)13-6-4-11(8-22-13)28-19-14-12(16(29-19)17(21)25)5-3-10-7-24-30-15(10)14/h4,6-8,27H,3,5,9H2,1-2H3,(H2,21,25)(H,23,26)
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.40n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assay


Bioorg Med Chem 25: 2336-2350 (2017)


Article DOI: 10.1016/j.bmc.2017.02.038
BindingDB Entry DOI: 10.7270/Q21J9D6H
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50189427
PNG
(CHEMBL3827470)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1cncc2ccc(nc12)N1CCCC1=O
Show InChI InChI=1S/C22H19N5O/c1-26-14-18(12-24-26)15-4-6-16(7-5-15)19-13-23-11-17-8-9-20(25-22(17)19)27-10-2-3-21(27)28/h4-9,11-14H,2-3,10H2,1H3
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.40n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


ACS Med Chem Lett 7: 573-8 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00022
BindingDB Entry DOI: 10.7270/Q2N87CRB
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50241862
PNG
(CHEMBL4059523)
Show SMILES FC1(F)CN(Cc2ccc(NC(=O)\C=C\c3cnccc3-c3cnn(c3)C3CC3)cc2)C1
Show InChI InChI=1S/C24H23F2N5O/c25-24(26)15-30(16-24)13-17-1-4-20(5-2-17)29-23(32)8-3-18-11-27-10-9-22(18)19-12-28-31(14-19)21-6-7-21/h1-5,8-12,14,21H,6-7,13,15-16H2,(H,29,32)/b8-3+
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.5n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of kinase tracer 236 binding to full length N terminal GST-tagged human CDK8 (1 to 464 end residues) /CycC ( 1 to 283 end residues) expres...


Bioorg Med Chem 25: 3018-3033 (2017)


Article DOI: 10.1016/j.bmc.2017.03.049
BindingDB Entry DOI: 10.7270/Q24X59XW
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50241892
PNG
(CHEMBL4072106)
Show SMILES Cn1cnc2ccc(cc12)-c1ccncc1\C=C\C(=O)Nc1ccc(CN2CCOCC2)cc1
Show InChI InChI=1S/C27H27N5O2/c1-31-19-29-25-8-4-21(16-26(25)31)24-10-11-28-17-22(24)5-9-27(33)30-23-6-2-20(3-7-23)18-32-12-14-34-15-13-32/h2-11,16-17,19H,12-15,18H2,1H3,(H,30,33)/b9-5+
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.5n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of kinase tracer 236 binding to full length N terminal GST-tagged human CDK8 (1 to 464 end residues) /CycC ( 1 to 283 end residues) expres...


Bioorg Med Chem 25: 3018-3033 (2017)


Article DOI: 10.1016/j.bmc.2017.03.049
BindingDB Entry DOI: 10.7270/Q24X59XW
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50191357
PNG
(CHEMBL3903492)
Show SMILES Cc1n[nH]c2ncc(cc12)C(=O)N1CCC[C@H]1c1ccc(Cl)cc1
Show InChI InChI=1S/C18H17ClN4O/c1-11-15-9-13(10-20-17(15)22-21-11)18(24)23-8-2-3-16(23)12-4-6-14(19)7-5-12/h4-7,9-10,16H,2-3,8H2,1H3,(H,20,21,22)/t16-/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
PDB
UniChem

Similars

PDB
Article
PubMed
n/an/a 2.60n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL


Assay Description
Inhibition of Alexa647 tracer binding to full length recombinant human His-tagged CDK8/cyclin C expressed in Baculovirus expression system preincubat...


J Med Chem 59: 9337-9349 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00597
BindingDB Entry DOI: 10.7270/Q2K64M1C
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cyclin-C


(Homo sapiens (Human))
BDBM50169078
PNG
(CHEMBL3804919)
Show SMILES OC(=O)c1cc2c(Oc3ccc(Cl)cc3)cncc2s1
Show InChI InChI=1S/C14H8ClNO3S/c15-8-1-3-9(4-2-8)19-11-6-16-7-13-10(11)5-12(20-13)14(17)18/h1-7H,(H,17,18)
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.80n/an/an/an/an/an/a



Genentech Inc

Curated by ChEMBL


Assay Description
Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay


ACS Med Chem Lett 7: 223-8 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00278
BindingDB Entry DOI: 10.7270/Q29G5PPC
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50154955
PNG
(CHEMBL3775321)
Show SMILES Cn1cc(cn1)-c1ccc(Cc2n[nH]c3ccc(cc23)C(=O)N2CC[C@H](O)C2)cc1
Show InChI InChI=1S/C23H23N5O2/c1-27-13-18(12-24-27)16-4-2-15(3-5-16)10-22-20-11-17(6-7-21(20)25-26-22)23(30)28-9-8-19(29)14-28/h2-7,11-13,19,29H,8-10,14H2,1H3,(H,25,26)/t19-/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL


Assay Description
Displacement of dye-labeled ATP competitive probe from recombinant human CDK8/Cyclin C incubated for 20 mins by Alexa647 probe-based FRET assay


Bioorg Med Chem Lett 26: 1443-51 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.062
BindingDB Entry DOI: 10.7270/Q2NZ89G6
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50264866
PNG
(4'-(2-(2H-tetrazol-5-yl)thieno[2,3-c]pyridin-4-ylo...)
Show SMILES NC(=O)c1ccc(cc1)-c1ccc(Oc2cncc3sc(cc23)-c2nnn[nH]2)cc1
Show InChI InChI=1S/C21H14N6O2S/c22-20(28)14-3-1-12(2-4-14)13-5-7-15(8-6-13)29-17-10-23-11-19-16(17)9-18(30-19)21-24-26-27-25-21/h1-11H,(H2,22,28)(H,24,25,26,27)
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3n/an/an/an/an/an/a



Genentech Inc

Curated by ChEMBL


Assay Description
Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay


ACS Med Chem Lett 7: 223-8 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00278
BindingDB Entry DOI: 10.7270/Q29G5PPC
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50191371
PNG
(CHEMBL3939280)
Show SMILES Nc1n[nH]c2ccc(cc12)C(=O)N1CCC[C@H]1c1ccc(Br)cc1
Show InChI InChI=1S/C18H17BrN4O/c19-13-6-3-11(4-7-13)16-2-1-9-23(16)18(24)12-5-8-15-14(10-12)17(20)22-21-15/h3-8,10,16H,1-2,9H2,(H3,20,21,22)/t16-/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.10n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL


Assay Description
Inhibition of Alexa647 tracer binding to full length recombinant human His-tagged CDK8/cyclin C expressed in Baculovirus expression system preincubat...


J Med Chem 59: 9337-9349 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00597
BindingDB Entry DOI: 10.7270/Q2K64M1C
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50241864
PNG
(CHEMBL4069244)
Show SMILES Cn1cc(cn1)-c1ccncc1\C=C\C(=O)Nc1ccc2CCN(CC(F)(F)F)Cc2c1
Show InChI InChI=1S/C23H22F3N5O/c1-30-13-19(12-28-30)21-6-8-27-11-17(21)3-5-22(32)29-20-4-2-16-7-9-31(14-18(16)10-20)15-23(24,25)26/h2-6,8,10-13H,7,9,14-15H2,1H3,(H,29,32)/b5-3+
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.20n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of kinase tracer 236 binding to full length N terminal GST-tagged human CDK8 (1 to 464 end residues) /CycC ( 1 to 283 end residues) expres...


Bioorg Med Chem 25: 3018-3033 (2017)


Article DOI: 10.1016/j.bmc.2017.03.049
BindingDB Entry DOI: 10.7270/Q24X59XW
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 305 total )  |  Next  |  Last  >>
Jump to: