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Compile Data Set for Download or QSAR

Found 907 hits Enz. Inhib. hit(s) with Target = 'Diacylglycerol O-acyltransferase 2'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486396
PNG
(US10947222, Example 27-A)
Show SMILES FC(F)Oc1cccc(c1)-c1cn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)N[C@H]1CCS(=O)(=O)C1
Show InChI InChI=1S/C26H21F3N2O4S/c27-18-5-7-20(8-6-18)31-14-23(16-2-1-3-21(12-16)35-26(28)29)22-9-4-17(13-24(22)31)25(32)30-19-10-11-36(33,34)15-19/h1-9,12-14,19,26H,10-11,15H2,(H,30,32)/t19-/m0/s1
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n/an/a 0.520n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM323669
PNG
((R)-(2-(3-(2- ethoxyphenoxy)piperidin- 1-yl)pyrimi...)
Show SMILES CCOc1ccccc1O[C@@H]1CCCN(C1)c1ncc(cn1)C(=O)N1CC(C1)Oc1ccccc1
Show InChI InChI=1S/C27H30N4O4/c1-2-33-24-12-6-7-13-25(24)35-22-11-8-14-30(17-22)27-28-15-20(16-29-27)26(32)31-18-23(19-31)34-21-9-4-3-5-10-21/h3-7,9-10,12-13,15-16,22-23H,2,8,11,14,17-19H2,1H3/t22-/m1/s1
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n/an/a 0.600n/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 14 o...


US Patent US10188653 (2019)


BindingDB Entry DOI: 10.7270/Q28G8NS4
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM323669
PNG
((R)-(2-(3-(2- ethoxyphenoxy)piperidin- 1-yl)pyrimi...)
Show SMILES CCOc1ccccc1O[C@@H]1CCCN(C1)c1ncc(cn1)C(=O)N1CC(C1)Oc1ccccc1
Show InChI InChI=1S/C27H30N4O4/c1-2-33-24-12-6-7-13-25(24)35-22-11-8-14-30(17-22)27-28-15-20(16-29-27)26(32)31-18-23(19-31)34-21-9-4-3-5-10-21/h3-7,9-10,12-13,15-16,22-23H,2,8,11,14,17-19H2,1H3/t22-/m1/s1
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n/an/a 0.600n/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 14 o...


US Patent US9789110 (2017)


BindingDB Entry DOI: 10.7270/Q20G3N81
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435283
PNG
(US10568876, Example 46 | ethyl 5-(2-(tert-butylcar...)
Show SMILES CCOC(=O)c1cncc(c1)-c1ccc(CNC(=O)C2C[C@H]2c2ccccc2)c2CN(CCc12)C(=O)NC(C)(C)C
Show InChI InChI=1S/C33H38N4O4/c1-5-41-31(39)24-15-23(17-34-18-24)25-12-11-22(19-35-30(38)28-16-27(28)21-9-7-6-8-10-21)29-20-37(14-13-26(25)29)32(40)36-33(2,3)4/h6-12,15,17-18,27-28H,5,13-14,16,19-20H2,1-4H3,(H,35,38)(H,36,40)/t27-,28?/m0/s1
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n/an/a 0.660n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486376
PNG
(3-(3-cyclopropylphenyl)-1-(5- fluoropyridin-2-yl)-...)
Show SMILES C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(cn(-c3ccc(F)cn3)c2c1)-c1cccc(c1)C1CC1
Show InChI InChI=1S/C28H26FN3O3S/c1-28(11-12-36(34,35)17-28)31-27(33)21-7-9-23-24(20-4-2-3-19(13-20)18-5-6-18)16-32(25(23)14-21)26-10-8-22(29)15-30-26/h2-4,7-10,13-16,18H,5-6,11-12,17H2,1H3,(H,31,33)/t28-/m0/s1
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n/an/a 0.730n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486393
PNG
(3-(5-(difluoromethoxy)pyridin- 3-yl)-1-(4-fluoroph...)
Show SMILES CC1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(cn(-c3ccc(F)cc3)c2c1)-c1cncc(OC(F)F)c1
Show InChI InChI=1S/C26H22F3N3O4S/c1-26(8-9-37(34,35)15-26)31-24(33)16-2-7-21-22(17-10-20(13-30-12-17)36-25(28)29)14-32(23(21)11-16)19-5-3-18(27)4-6-19/h2-7,10-14,25H,8-9,15H2,1H3,(H,31,33)
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n/an/a 0.770n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486375
PNG
(3-(3-cyclopropylphenyl)-1-(5- fluoropyridin-2-yl)-...)
Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(cn(-c3ccc(F)cn3)c2c1)-c1cccc(c1)C1CC1
Show InChI InChI=1S/C28H26FN3O3S/c1-28(11-12-36(34,35)17-28)31-27(33)21-7-9-23-24(20-4-2-3-19(13-20)18-5-6-18)16-32(25(23)14-21)26-10-8-22(29)15-30-26/h2-4,7-10,13-16,18H,5-6,11-12,17H2,1H3,(H,31,33)/t28-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486386
PNG
(3-(3-(difluoromethoxy)phenyl)-1-(5- fluoropyrimidi...)
Show SMILES C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(cn(-c3ncc(F)cn3)c2c1)-c1cccc(OC(F)F)c1
Show InChI InChI=1S/C25H21F3N4O4S/c1-25(7-8-37(34,35)14-25)31-22(33)16-5-6-19-20(15-3-2-4-18(9-15)36-23(27)28)13-32(21(19)10-16)24-29-11-17(26)12-30-24/h2-6,9-13,23H,7-8,14H2,1H3,(H,31,33)/t25-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486372
PNG
(3-(3-(difluoromethoxy)phenyl)-1-(5- fluoropyridin-...)
Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(cn(-c3ccc(F)cn3)c2c1)-c1cccc(OC(F)F)c1
Show InChI InChI=1S/C26H22F3N3O4S/c1-26(9-10-37(34,35)15-26)31-24(33)17-5-7-20-21(16-3-2-4-19(11-16)36-25(28)29)14-32(22(20)12-17)23-8-6-18(27)13-30-23/h2-8,11-14,25H,9-10,15H2,1H3,(H,31,33)/t26-/m1/s1
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n/an/a 0.940n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486373
PNG
(3-(3-(difluoromethoxy)phenyl)-1-(5- fluoropyridin-...)
Show SMILES C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(cn(-c3ccc(F)cn3)c2c1)-c1cccc(OC(F)F)c1
Show InChI InChI=1S/C26H22F3N3O4S/c1-26(9-10-37(34,35)15-26)31-24(33)17-5-7-20-21(16-3-2-4-19(11-16)36-25(28)29)14-32(22(20)12-17)23-8-6-18(27)13-30-23/h2-8,11-14,25H,9-10,15H2,1H3,(H,31,33)/t26-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486408
PNG
(3-[3-(difluoromethoxy)phenyl]-N- (1,1-dioxidotetra...)
Show SMILES FC(F)Oc1cccc(c1)-c1cn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)NC1CCS(=O)(=O)C1
Show InChI InChI=1S/C26H21F3N2O4S/c27-18-5-7-20(8-6-18)31-14-23(16-2-1-3-21(12-16)35-26(28)29)22-9-4-17(13-24(22)31)25(32)30-19-10-11-36(33,34)15-19/h1-9,12-14,19,26H,10-11,15H2,(H,30,32)
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n/an/a 1.10n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435291
PNG
(US10568876, Example 54 | methyl 3-(2-((1-methylcyc...)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)[C@H]2C[C@@H]2c2ccccc2)c2CN(CCc12)C(=O)NC1(C)CC1
Show InChI InChI=1S/C33H35N3O4/c1-33(14-15-33)35-32(39)36-16-13-26-25(22-9-6-10-23(17-22)31(38)40-2)12-11-24(29(26)20-36)19-34-30(37)28-18-27(28)21-7-4-3-5-8-21/h3-12,17,27-28H,13-16,18-20H2,1-2H3,(H,34,37)(H,35,39)/t27-,28+/m1/s1
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n/an/a 1.13n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM215552
PNG
(US9296745, 109-A | US9296745, 109-B | US9296745, 1...)
Show SMILES Clc1cnn(c1)C1(CC1)c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
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n/an/a 1.30n/an/an/an/an/an/a



Merck & Co. Inc

Curated by ChEMBL


Assay Description
Inhibition of human DGAT2 assessed as reduction in synthesis of triglycerol in human hepatocyte using [14C]glycerol as substrate preincubated for 20 ...


J Med Chem 61: 1767-1773 (2018)


Article DOI: 10.1021/acs.jmedchem.7b00762
BindingDB Entry DOI: 10.7270/Q2C53P79
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM323644
PNG
((R)-(2-(3-(2- ethoxyphenoxy)piperidin- 1-yl)pyrimi...)
Show SMILES CCOc1ccccc1O[C@@H]1CCCN(C1)c1ncc(cn1)C(=O)N1Cc2ccccc2C1
Show InChI InChI=1S/C26H28N4O3/c1-2-32-23-11-5-6-12-24(23)33-22-10-7-13-29(18-22)26-27-14-21(15-28-26)25(31)30-16-19-8-3-4-9-20(19)17-30/h3-6,8-9,11-12,14-15,22H,2,7,10,13,16-18H2,1H3/t22-/m1/s1
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Pfizer Inc

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 14 o...


US Patent US10188653 (2019)


BindingDB Entry DOI: 10.7270/Q28G8NS4
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM323644
PNG
((R)-(2-(3-(2- ethoxyphenoxy)piperidin- 1-yl)pyrimi...)
Show SMILES CCOc1ccccc1O[C@@H]1CCCN(C1)c1ncc(cn1)C(=O)N1Cc2ccccc2C1
Show InChI InChI=1S/C26H28N4O3/c1-2-32-23-11-5-6-12-24(23)33-22-10-7-13-29(18-22)26-27-14-21(15-28-26)25(31)30-16-19-8-3-4-9-20(19)17-30/h3-6,8-9,11-12,14-15,22H,2,7,10,13,16-18H2,1H3/t22-/m1/s1
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Pfizer Inc

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 14 o...


US Patent US9789110 (2017)


BindingDB Entry DOI: 10.7270/Q20G3N81
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM323668
PNG
(N-((S)-2,3-dihydro-1H- inden-1-yl)-2-((R)-3-(2- et...)
Show SMILES CCOc1ccccc1O[C@@H]1CCCN(C1)c1ncc(cn1)C(=O)N[C@H]1CCc2ccccc12
Show InChI InChI=1S/C27H30N4O3/c1-2-33-24-11-5-6-12-25(24)34-21-9-7-15-31(18-21)27-28-16-20(17-29-27)26(32)30-23-14-13-19-8-3-4-10-22(19)23/h3-6,8,10-12,16-17,21,23H,2,7,9,13-15,18H2,1H3,(H,30,32)/t21-,23+/m1/s1
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Pfizer Inc

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 14 o...


US Patent US9789110 (2017)


BindingDB Entry DOI: 10.7270/Q20G3N81
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM323668
PNG
(N-((S)-2,3-dihydro-1H- inden-1-yl)-2-((R)-3-(2- et...)
Show SMILES CCOc1ccccc1O[C@@H]1CCCN(C1)c1ncc(cn1)C(=O)N[C@H]1CCc2ccccc12
Show InChI InChI=1S/C27H30N4O3/c1-2-33-24-11-5-6-12-25(24)34-21-9-7-15-31(18-21)27-28-16-20(17-29-27)26(32)30-23-14-13-19-8-3-4-10-22(19)23/h3-6,8,10-12,16-17,21,23H,2,7,9,13-15,18H2,1H3,(H,30,32)/t21-,23+/m1/s1
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Pfizer Inc

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 14 o...


US Patent US10188653 (2019)


BindingDB Entry DOI: 10.7270/Q28G8NS4
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486387
PNG
(3-(3-(difluoromethoxy)phenyl)-N-(1,1- dioxidotetra...)
Show SMILES FC(F)Oc1cccc(c1)-c1cn(-c2ncc(F)cn2)c2cc(ccc12)C(=O)N[C@H]1CCS(=O)(=O)C1
Show InChI InChI=1S/C24H19F3N4O4S/c25-16-10-28-24(29-11-16)31-12-20(14-2-1-3-18(8-14)35-23(26)27)19-5-4-15(9-21(19)31)22(32)30-17-6-7-36(33,34)13-17/h1-5,8-12,17,23H,6-7,13H2,(H,30,32)/t17-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486385
PNG
(3-(3-(difluoromethoxy)phenyl)-1-(5- fluoropyrimidi...)
Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(cn(-c3ncc(F)cn3)c2c1)-c1cccc(OC(F)F)c1
Show InChI InChI=1S/C25H21F3N4O4S/c1-25(7-8-37(34,35)14-25)31-22(33)16-5-6-19-20(15-3-2-4-18(9-15)36-23(27)28)13-32(21(19)10-16)24-29-11-17(26)12-30-24/h2-6,9-13,23H,7-8,14H2,1H3,(H,31,33)/t25-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM215446
PNG
(US9296745, 1)
Show SMILES FC(F)(F)Oc1cccc(c1)-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
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n/an/a 1.70n/an/an/an/a7.425



Pfizer Inc

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM274961
PNG
(US9877957, Example 1)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CCN(CC2)c2ccc(cc2)C(F)(F)F)c2CN(CCc12)C(=O)NC(C)(C)C
Show InChI InChI=1S/C36H41F3N4O4/c1-35(2,3)41-34(46)43-19-16-30-29(24-6-5-7-25(20-24)33(45)47-4)13-8-26(31(30)22-43)21-40-32(44)23-14-17-42(18-15-23)28-11-9-27(10-12-28)36(37,38)39/h5-13,20,23H,14-19,21-22H2,1-4H3,(H,40,44)(H,41,46)
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n/an/a 1.75n/an/an/an/a7.025



Merck Sharp & Dohme Corp

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9877957 (2018)


BindingDB Entry DOI: 10.7270/Q2Z60R2C
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486377
PNG
(3-(3-(difluoromethoxy)phenyl)-N-(1,1- dioxidotetra...)
Show SMILES FC(F)Oc1cccc(c1)-c1cn(-c2ccc(F)cn2)c2cc(ccc12)C(=O)N[C@H]1CCS(=O)(=O)C1
Show InChI InChI=1S/C25H20F3N3O4S/c26-17-5-7-23(29-12-17)31-13-21(15-2-1-3-19(10-15)35-25(27)28)20-6-4-16(11-22(20)31)24(32)30-18-8-9-36(33,34)14-18/h1-7,10-13,18,25H,8-9,14H2,(H,30,32)/t18-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM50499290
PNG
(CHEMBL3734797)
Show SMILES Cc1noc(n1)[C@H]1C[C@@H]1C(=O)NCc1ccc(-c2cccc(OC(F)(F)F)c2)c2CCN(Cc12)C(=O)NC(C)(C)C
Show InChI InChI=1S/C29H32F3N5O4/c1-16-34-26(41-36-16)23-13-22(23)25(38)33-14-18-8-9-20(17-6-5-7-19(12-17)40-29(30,31)32)21-10-11-37(15-24(18)21)27(39)35-28(2,3)4/h5-9,12,22-23H,10-11,13-15H2,1-4H3,(H,33,38)(H,35,39)/t22-,23-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



Merck & Co., Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DGAT2 expressed in Sf9 cell membranes assessed as triolein formation by LC/MS/MS analysis using oleoyl-CoA as substrate


J Med Chem 58: 9345-53 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01345
BindingDB Entry DOI: 10.7270/Q28W3H9F
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486374
PNG
(3-(3-cyclopropylphenyl)-N-(1,1- dioxidotetrahydrot...)
Show SMILES Fc1ccc(nc1)-n1cc(-c2cccc(c2)C2CC2)c2ccc(cc12)C(=O)N[C@H]1CCS(=O)(=O)C1
Show InChI InChI=1S/C27H24FN3O3S/c28-21-7-9-26(29-14-21)31-15-24(19-3-1-2-18(12-19)17-4-5-17)23-8-6-20(13-25(23)31)27(32)30-22-10-11-35(33,34)16-22/h1-3,6-9,12-15,17,22H,4-5,10-11,16H2,(H,30,32)/t22-/m0/s1
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n/an/a 2.10n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM215552
PNG
(US9296745, 109-A | US9296745, 109-B | US9296745, 1...)
Show SMILES Clc1cnn(c1)C1(CC1)c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
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n/an/a 2.10n/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
For evaluation of the effects of DGAT2 inhibitors in a cell-based setting, cryopreserved human hepatocytes (Lot QOC, Celsis, Chicago, Ill.) were thaw...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486416
PNG
(3-(3-cyclopropylphenyl)-N-(1,1- dioxidotetrahydrot...)
Show SMILES Fc1ccc(cc1)-n1cc(-c2cccc(c2)C2CC2)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)C1
Show InChI InChI=1S/C28H25FN2O3S/c29-22-7-9-24(10-8-22)31-16-26(20-3-1-2-19(14-20)18-4-5-18)25-11-6-21(15-27(25)31)28(32)30-23-12-13-35(33,34)17-23/h1-3,6-11,14-16,18,23H,4-5,12-13,17H2,(H,30,32)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435252
PNG
(US10568876, Example 17 | methyl 3-(2-(tert-butylca...)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CC22CCCCC2)c2CN(CCc12)C(=O)NC(C)(C)C
Show InChI InChI=1S/C32H41N3O4/c1-31(2,3)34-30(38)35-16-13-25-24(21-9-8-10-22(17-21)29(37)39-4)12-11-23(26(25)20-35)19-33-28(36)27-18-32(27)14-6-5-7-15-32/h8-12,17,27H,5-7,13-16,18-20H2,1-4H3,(H,33,36)(H,34,38)
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n/an/a 2.20n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM323626
PNG
(US10188653, Example 15 | US9789110, 15)
Show SMILES CCOc1ccccc1O[C@@H]1CCCN(C1)c1ncc(cn1)C(=O)NCc1ccc(cc1)C(C)C(O)=O
Show InChI InChI=1S/C28H32N4O5/c1-3-36-24-8-4-5-9-25(24)37-23-7-6-14-32(18-23)28-30-16-22(17-31-28)26(33)29-15-20-10-12-21(13-11-20)19(2)27(34)35/h4-5,8-13,16-17,19,23H,3,6-7,14-15,18H2,1-2H3,(H,29,33)(H,34,35)/t19?,23-/m1/s1
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Pfizer Inc

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 14 o...


US Patent US10188653 (2019)


BindingDB Entry DOI: 10.7270/Q28G8NS4
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM323626
PNG
(US10188653, Example 15 | US9789110, 15)
Show SMILES CCOc1ccccc1O[C@@H]1CCCN(C1)c1ncc(cn1)C(=O)NCc1ccc(cc1)C(C)C(O)=O
Show InChI InChI=1S/C28H32N4O5/c1-3-36-24-8-4-5-9-25(24)37-23-7-6-14-32(18-23)28-30-16-22(17-31-28)26(33)29-15-20-10-12-21(13-11-20)19(2)27(34)35/h4-5,8-13,16-17,19,23H,3,6-7,14-15,18H2,1-2H3,(H,29,33)(H,34,35)/t19?,23-/m1/s1
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Pfizer Inc

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 14 o...


US Patent US9789110 (2017)


BindingDB Entry DOI: 10.7270/Q20G3N81
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM215661
PNG
(US9296745, 199)
Show SMILES C[C@H](c1nc2cnc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1)n1cc(Cl)cn1
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Pfizer Inc

US Patent


Assay Description
For evaluation of the effects of DGAT2 inhibitors in a cell-based setting, cryopreserved human hepatocytes (Lot QOC, Celsis, Chicago, Ill.) were thaw...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486382
PNG
(3-(3-cyclopropylphenyl)-1-(5- fluoropyrimidin-2-yl...)
Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(cn(-c3ncc(F)cn3)c2c1)-c1cccc(c1)C1CC1
Show InChI InChI=1S/C27H25FN4O3S/c1-27(9-10-36(34,35)16-27)31-25(33)20-7-8-22-23(19-4-2-3-18(11-19)17-5-6-17)15-32(24(22)12-20)26-29-13-21(28)14-30-26/h2-4,7-8,11-15,17H,5-6,9-10,16H2,1H3,(H,31,33)/t27-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM215447
PNG
(US9296745, 2)
Show SMILES CC(C)Cc1csc(n1)-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
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n/an/a 2.71n/an/an/an/a7.425



Pfizer Inc

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM215551
PNG
(US9296745, 108)
Show SMILES Clc1cnn(c1)C1(CC1)c1nc2cnc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
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Pfizer Inc

US Patent


Assay Description
For evaluation of the effects of DGAT2 inhibitors in a cell-based setting, cryopreserved human hepatocytes (Lot QOC, Celsis, Chicago, Ill.) were thaw...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486394
PNG
(US10947222, Example 26-A)
Show SMILES Fc1ccc(cc1)-n1cc(-c2cccc(c2)C2CC2)c2ccc(cc12)C(=O)N[C@H]1CCS(=O)(=O)C1
Show InChI InChI=1S/C28H25FN2O3S/c29-22-7-9-24(10-8-22)31-16-26(20-3-1-2-19(14-20)18-4-5-18)25-11-6-21(15-27(25)31)28(32)30-23-12-13-35(33,34)17-23/h1-3,6-11,14-16,18,23H,4-5,12-13,17H2,(H,30,32)/t23-/m0/s1
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n/an/a 2.90n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435246
PNG
(N-(tert-butyl)-5-(3-methoxyphenyl)-8- (((trans)-2-...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)[C@@H]2C[C@H]2c2nc(C)no2)c2CN(CCc12)C(=O)NC(C)(C)C
Show InChI InChI=1S/C29H35N5O4/c1-17-31-27(38-33-17)24-14-23(24)26(35)30-15-19-9-10-21(18-7-6-8-20(13-18)37-5)22-11-12-34(16-25(19)22)28(36)32-29(2,3)4/h6-10,13,23-24H,11-12,14-16H2,1-5H3,(H,30,35)(H,32,36)/t23-,24-/m1/s1
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n/an/a 3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM50499298
PNG
(CHEMBL3734847)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)[C@H]2C[C@@H]2c2nc(C)no2)c2CN(CCc12)C(=O)NC(C)(C)C
Show InChI InChI=1S/C29H35N5O4/c1-17-31-27(38-33-17)24-14-23(24)26(35)30-15-19-9-10-21(18-7-6-8-20(13-18)37-5)22-11-12-34(16-25(19)22)28(36)32-29(2,3)4/h6-10,13,23-24H,11-12,14-16H2,1-5H3,(H,30,35)(H,32,36)/t23-,24-/m0/s1
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Merck & Co., Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DGAT2 expressed in Sf9 cell membranes assessed as triolein formation by LC/MS/MS analysis using oleoyl-CoA as substrate


J Med Chem 58: 9345-53 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01345
BindingDB Entry DOI: 10.7270/Q28W3H9F
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM215487
PNG
(US9296745, 42)
Show SMILES CC(C)(C)c1csc(n1)-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
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n/an/a 3.18n/an/an/an/a7.425



Pfizer Inc

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486401
PNG
(US10947222, Example 32 | methyl 3-{6-[(1,1- dioxid...)
Show SMILES COC(=O)c1cccc(c1)-c1cn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)NC1CCS(=O)(=O)C1
Show InChI InChI=1S/C27H23FN2O5S/c1-35-27(32)19-4-2-3-17(13-19)24-15-30(22-8-6-20(28)7-9-22)25-14-18(5-10-23(24)25)26(31)29-21-11-12-36(33,34)16-21/h2-10,13-15,21H,11-12,16H2,1H3,(H,29,31)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486384
PNG
(3-(3-cyclopropylphenyl)-N-(1,1- dioxidotetrahydrot...)
Show SMILES Fc1cnc(nc1)-n1cc(-c2cccc(c2)C2CC2)c2ccc(cc12)C(=O)N[C@H]1CCS(=O)(=O)C1
Show InChI InChI=1S/C26H23FN4O3S/c27-20-12-28-26(29-13-20)31-14-23(18-3-1-2-17(10-18)16-4-5-16)22-7-6-19(11-24(22)31)25(32)30-21-8-9-35(33,34)15-21/h1-3,6-7,10-14,16,21H,4-5,8-9,15H2,(H,30,32)/t21-/m0/s1
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n/an/a 3.30n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM215599
PNG
(US9296745, 158)
Show SMILES O=C([C@@H]1CCCN(C1)c1ccc2nc([nH]c2n1)-c1cccc(n1)C1CC1)N1CC=CC1
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n/an/a 3.58n/an/an/an/a7.425



Pfizer Inc

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435236
PNG
(US10568876, Example 1)
Show SMILES Cc1noc(n1)C1CC1C(=O)NCc1ccc(-c2cccc(OC(F)(F)F)c2)c2CCN(Cc12)C(=O)NC(C)(C)C
Show InChI InChI=1S/C29H32F3N5O4/c1-16-34-26(41-36-16)23-13-22(23)25(38)33-14-18-8-9-20(17-6-5-7-19(12-17)40-29(30,31)32)21-10-11-37(15-24(18)21)27(39)35-28(2,3)4/h5-9,12,22-23H,10-11,13-15H2,1-4H3,(H,33,38)(H,35,39)
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n/an/a 3.60n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435247
PNG
(N-(tert-butyl)-8-(((trans)-2-(3-methyl- 1,2,4-oxad...)
Show SMILES Cc1noc(n1)[C@@H]1C[C@H]1C(=O)NCc1ccc(-c2cccc(OC(F)(F)F)c2)c2CCN(Cc12)C(=O)NC(C)(C)C
Show InChI InChI=1S/C29H32F3N5O4/c1-16-34-26(41-36-16)23-13-22(23)25(38)33-14-18-8-9-20(17-6-5-7-19(12-17)40-29(30,31)32)21-10-11-37(15-24(18)21)27(39)35-28(2,3)4/h5-9,12,22-23H,10-11,13-15H2,1-4H3,(H,33,38)(H,35,39)/t22-,23-/m1/s1
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US Patent
n/an/a 3.60n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM276763
PNG
(US10071992, Example 8)
Show SMILES CCOc1cc(F)cnc1Oc1cncc(c1)-c1ncc(cn1)C(=O)N[C@H]1CCOC1
Show InChI InChI=1S/C21H20FN5O4/c1-2-30-18-6-15(22)10-26-21(18)31-17-5-13(7-23-11-17)19-24-8-14(9-25-19)20(28)27-16-3-4-29-12-16/h5-11,16H,2-4,12H2,1H3,(H,27,28)/t16-/m0/s1
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n/an/a 3.70n/an/an/an/a7.425



Pfizer Inc

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 1 &#...


US Patent US10071992 (2018)


BindingDB Entry DOI: 10.7270/Q2RJ4MHN
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM50499292
PNG
(CHEMBL3734764)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)[C@@H]2C[C@H]2c2ccccc2)c2CN(CCc12)C(=O)NC(C)(C)C
Show InChI InChI=1S/C32H37N3O3/c1-32(2,3)34-31(37)35-16-15-26-25(22-11-8-12-24(17-22)38-4)14-13-23(29(26)20-35)19-33-30(36)28-18-27(28)21-9-6-5-7-10-21/h5-14,17,27-28H,15-16,18-20H2,1-4H3,(H,33,36)(H,34,37)/t27-,28+/m0/s1
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n/an/a 4n/an/an/an/an/an/a



Merck & Co., Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DGAT2 expressed in Sf9 cell membranes assessed as triolein formation by LC/MS/MS analysis using oleoyl-CoA as substrate


J Med Chem 58: 9345-53 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01345
BindingDB Entry DOI: 10.7270/Q28W3H9F
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM486402
PNG
(N-(1,1-dioxidotetrahydrothiophen- 3-yl)-1-(4-fluor...)
Show SMILES COc1cccc(c1)-c1cn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)NC1CCS(=O)(=O)C1
Show InChI InChI=1S/C26H23FN2O4S/c1-33-22-4-2-3-17(13-22)24-15-29(21-8-6-19(27)7-9-21)25-14-18(5-10-23(24)25)26(30)28-20-11-12-34(31,32)16-20/h2-10,13-15,20H,11-12,16H2,1H3,(H,28,30)
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US Patent
n/an/a 4n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10947222 (2021)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM323638
PNG
((R)-N-benzyl-2-(3-(2- ethoxyphenoxy)piperidin- 1-y...)
Show SMILES CCOc1ccccc1O[C@@H]1CCCN(C1)c1ncc(cn1)C(=O)NCc1ccccc1
Show InChI InChI=1S/C25H28N4O3/c1-2-31-22-12-6-7-13-23(22)32-21-11-8-14-29(18-21)25-27-16-20(17-28-25)24(30)26-15-19-9-4-3-5-10-19/h3-7,9-10,12-13,16-17,21H,2,8,11,14-15,18H2,1H3,(H,26,30)/t21-/m1/s1
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n/an/a 4.30n/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 14 o...


US Patent US9789110 (2017)


BindingDB Entry DOI: 10.7270/Q20G3N81
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM323638
PNG
((R)-N-benzyl-2-(3-(2- ethoxyphenoxy)piperidin- 1-y...)
Show SMILES CCOc1ccccc1O[C@@H]1CCCN(C1)c1ncc(cn1)C(=O)NCc1ccccc1
Show InChI InChI=1S/C25H28N4O3/c1-2-31-22-12-6-7-13-23(22)32-21-11-8-14-29(18-21)25-27-16-20(17-28-25)24(30)26-15-19-9-4-3-5-10-19/h3-7,9-10,12-13,16-17,21H,2,8,11,14-15,18H2,1H3,(H,26,30)/t21-/m1/s1
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n/an/a 4.30n/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 14 o...


US Patent US10188653 (2019)


BindingDB Entry DOI: 10.7270/Q28G8NS4
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM215486
PNG
(US9296745, 154 | US9296745, 41)
Show SMILES Clc1cccc(c1)-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
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US Patent
n/an/a 4.56n/an/an/an/a7.425



Pfizer Inc

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM215629
PNG
(US9296745, 196-A | US9296745, 196-B)
Show SMILES C[C@@H](c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1)n1cc(Cl)cn1
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n/an/a 4.60n/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
For evaluation of the effects of DGAT2 inhibitors in a cell-based setting, cryopreserved human hepatocytes (Lot QOC, Celsis, Chicago, Ill.) were thaw...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM215448
PNG
(US9296745, 3)
Show SMILES O=C([C@@H]1CCCN(C1)c1ccc2nc([nH]c2n1)-c1cccc(c1)-n1cccn1)N1CCCC1
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US Patent
n/an/a 4.82n/an/an/an/a7.425



Pfizer Inc

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
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