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Compile Data Set for Download or QSAR

Found 2699 hits Enz. Inhib. hit(s) with Target = 'Fibroblast growth factor receptor 3 '   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM286984
PNG
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCCN3CCN(CC3)C(=O)C=C)c2n1
Show InChI InChI=1S/C26H30Cl2N6O4/c1-5-20(35)33-11-9-32(10-12-33)7-6-8-34-24-16(15-30-26(29-2)31-24)13-17(25(34)36)21-22(27)18(37-3)14-19(38-4)23(21)28/h5,13-15H,1,6-12H2,2-4H3,(H,29,30,31)
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2.20n/an/an/an/an/an/an/an/a



Principia Biopharma, Inc.

Curated by ChEMBL


Assay Description
Irreversible inhibition of human FGFR3 preincubated with enzyme followed by peptide substrate addition by caliper capillary electrophoresis method


J Med Chem 60: 6516-6527 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00360
BindingDB Entry DOI: 10.7270/Q2C53P3H
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM50020310
PNG
(CHEMBL3288854)
Show SMILES CN1CCN(CCC(=O)Nc2c(C)[nH]c(\C=C3/C(=O)Nc4ccc(F)cc34)c2C)CC1
Show InChI InChI=1S/C23H28FN5O2/c1-14-20(13-18-17-12-16(24)4-5-19(17)26-23(18)31)25-15(2)22(14)27-21(30)6-7-29-10-8-28(3)9-11-29/h4-5,12-13,25H,6-11H2,1-3H3,(H,26,31)(H,27,30)/b18-13-
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89n/an/an/an/an/an/an/an/a



Qilu Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Binding affinity to FGFR3 (unknown origin)


Eur J Med Chem 82: 139-51 (2014)


Article DOI: 10.1016/j.ejmech.2014.05.051
BindingDB Entry DOI: 10.7270/Q2F1918D
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM50355491
PNG
(CHEMBL1835870)
Show SMILES Nc1nc(Nc2ccc(cc2)[C@H]2CC[C@@H](CC2)N2CCOCC2)nn1-c1ccccn1
Show InChI InChI=1/C23H29N7O/c24-22-27-23(28-30(22)21-3-1-2-12-25-21)26-19-8-4-17(5-9-19)18-6-10-20(11-7-18)29-13-15-31-16-14-29/h1-5,8-9,12,18,20H,6-7,10-11,13-16H2,(H3,24,26,27,28)/t18-,20-
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400n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibition of FGFR3


J Med Chem 55: 725-34 (2012)


Article DOI: 10.1021/jm201198w
BindingDB Entry DOI: 10.7270/Q2GQ6Z6R
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM50402020
PNG
(CHEMBL2205426)
Show SMILES CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(cc3)-c3ccncc3)n2)c(=O)c1=O
Show InChI InChI=1S/C23H22N6O2/c1-23(2,3)29-19-18(20(30)21(19)31)27-17-10-13-25-22(28-17)26-16-6-4-14(5-7-16)15-8-11-24-12-9-15/h4-13,29H,1-3H3,(H2,25,26,27,28)
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1.40E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of recombinant FGFR3 after 1 hr by scintillation counter analysis in presence of gamma-[33P]ATP


Bioorg Med Chem Lett 22: 7615-22 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.009
BindingDB Entry DOI: 10.7270/Q2XK8GQ3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM50224883
PNG
(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Show SMILES Clc1cc2NC(=O)Nc3cnc(C#N)c(OCCCCOc2cc1NCc1cncs1)n3
Show InChI InChI=1S/C20H18ClN7O3S/c21-13-5-15-17(6-14(13)24-9-12-8-23-11-32-12)30-3-1-2-4-31-19-16(7-22)25-10-18(27-19)28-20(29)26-15/h5-6,8,10-11,24H,1-4,9H2,(H2,26,27,28,29)
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>1.86E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FGFR3


Bioorg Med Chem Lett 17: 6593-601 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.063
BindingDB Entry DOI: 10.7270/Q2X067WT
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302404
PNG
(US9598416, Example 50)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCN(C)CC2)cn2ncnc(N)c12
Show InChI InChI=1S/C22H26N6OS/c1-14-8-15-10-18(30-21(15)17(9-14)29-3)19-16(11-27-6-4-26(2)5-7-27)12-28-20(19)22(23)24-13-25-28/h8-10,12-13H,4-7,11H2,1-3H3,(H2,23,24,25)
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n/an/a 0.100n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)


Article DOI: 10.1021/jm031106i
BindingDB Entry DOI: 10.7270/Q2Q2428R
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM161438
PNG
(US10124003, Ex. Compound 51 | US9108973, 51)
Show SMILES COc1cc(OC)cc(c1)C#CC1=CN(C2CN(C2)C(=O)C=C)C2N=CN=C(N)C12
Show InChI InChI=1/C22H23N5O3/c1-4-19(28)26-11-16(12-26)27-10-15(20-21(23)24-13-25-22(20)27)6-5-14-7-17(29-2)9-18(8-14)30-3/h4,7-10,13,16,20,22H,1,11-12H2,2-3H3,(H2,23,24,25)
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n/an/a 0.100n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Purified recombinant human FGFR3 protein was purchased from Carna Biosciences, Inc. When setting conditions for the measurement of the inhibitory ef...


US Patent US9108973 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HJV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM50166610
PNG
(CHEMBL3800526)
Show SMILES COc1cc(CCc2cc(Nc3ncnc4cc(ccc34)N3CCN4CCCCC4C3)n[nH]2)cc(OC)c1
Show InChI InChI=1/C29H35N7O2/c1-37-24-13-20(14-25(17-24)38-2)6-7-21-15-28(34-33-21)32-29-26-9-8-22(16-27(26)30-19-31-29)36-12-11-35-10-4-3-5-23(35)18-36/h8-9,13-17,19,23H,3-7,10-12,18H2,1-2H3,(H2,30,31,32,33,34)
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n/an/a<0.200n/an/an/an/an/an/a



Chinese Academy of Sciences (CAS)

Curated by ChEMBL


Assay Description
Inhibition of FGFR3 in human RT112 cells assessed as suppression of cell proliferation after 72 hrs by SRB/CCK-8 assay


Bioorg Med Chem Lett 26: 2594-9 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.028
BindingDB Entry DOI: 10.7270/Q20C4XNM
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302363
PNG
(N-{[4-Amino-5-(7-methoxy-5-methyl-1-benzothiophen-...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CNC(C)=O)cn2ncnc(N)c12
Show InChI InChI=1S/C19H19N5O2S/c1-10-4-12-6-15(27-18(12)14(5-10)26-3)16-13(7-21-11(2)25)8-24-17(16)19(20)22-9-23-24/h4-6,8-9H,7H2,1-3H3,(H,21,25)(H2,20,22,23)
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n/an/a 0.200n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)


Article DOI: 10.1021/jm031106i
BindingDB Entry DOI: 10.7270/Q2Q2428R
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM194899
PNG
(US9206184, 80)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCNC(=O)C2)c(Cl)n2ncnc(N)c12
Show InChI InChI=1S/C21H21ClN6O2S/c1-11-5-12-7-15(31-19(12)14(6-11)30-2)17-13(8-27-4-3-24-16(29)9-27)20(22)28-18(17)21(23)25-10-26-28/h5-7,10H,3-4,8-9H2,1-2H3,(H,24,29)(H2,23,25,26)
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n/an/a 0.200n/an/an/an/a7.022



BAYER INTELLECTUAL PROPERTY GmbH

US Patent


Assay Description
For the assay, 50 nl of each stock solution of the test compound in DMSO was pipetted into a black, low-volume 384-well microtiter plate (Greiner Bio...


US Patent US9206184 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07SH
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302362
PNG
(6-[(2-Aminoethoxy)methyl]-5-(7-methoxy-5-methyl-1-...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(COCCN)cn2ncnc(N)c12
Show InChI InChI=1S/C19H21N5O2S/c1-11-5-12-7-15(27-18(12)14(6-11)25-2)16-13(9-26-4-3-20)8-24-17(16)19(21)22-10-23-24/h5-8,10H,3-4,9,20H2,1-2H3,(H2,21,22,23)
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n/an/a 0.200n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)


Article DOI: 10.1021/jm031106i
BindingDB Entry DOI: 10.7270/Q2Q2428R
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM161392
PNG
(US10124003, Ex. Compound 5 | US9108973, 5)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn([C@H]2CCN(C2)C(=O)C#C)c2ncnc(N)c12
Show InChI InChI=1/C22H20N6O3/c1-4-19(29)27-8-7-15(12-27)28-22-20(21(23)24-13-25-22)18(26-28)6-5-14-9-16(30-2)11-17(10-14)31-3/h1,9-11,13,15H,7-8,12H2,2-3H3,(H2,23,24,25)/t15-/s2
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n/an/a 0.200n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Purified recombinant human FGFR3 protein was purchased from Carna Biosciences, Inc. When setting conditions for the measurement of the inhibitory ef...


US Patent US9108973 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HJV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302385
PNG
(4-{[4-Amino-5-(5-chloro-7-methoxy-1-benzothiophen-...)
Show SMILES COc1cc(Cl)cc2cc(sc12)-c1c(CN2CCNC(=O)C2)cn2ncnc(N)c12
Show InChI InChI=1S/C20H19ClN6O2S/c1-29-14-6-13(21)4-11-5-15(30-19(11)14)17-12(7-26-3-2-23-16(28)9-26)8-27-18(17)20(22)24-10-25-27/h4-6,8,10H,2-3,7,9H2,1H3,(H,23,28)(H2,22,24,25)
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n/an/a 0.300n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)


Article DOI: 10.1021/jm031106i
BindingDB Entry DOI: 10.7270/Q2Q2428R
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM161396
PNG
(US10124003, Ex. Compound 9 | US9108973, 9)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn(C2CN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C21H20N6O3/c1-4-18(28)26-10-14(11-26)27-21-19(20(22)23-12-24-21)17(25-27)6-5-13-7-15(29-2)9-16(8-13)30-3/h4,7-9,12,14H,1,10-11H2,2-3H3,(H2,22,23,24)
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n/an/a 0.300n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Purified recombinant human FGFR3 protein was purchased from Carna Biosciences, Inc. When setting conditions for the measurement of the inhibitory ef...


US Patent US9108973 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HJV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302379
PNG
(5-(7-Methoxy-5-methyl-1-benzothiophen-2-yl)-6-(pip...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCNCC2)cn2ncnc(N)c12
Show InChI InChI=1S/C21H24N6OS/c1-13-7-14-9-17(29-20(14)16(8-13)28-2)18-15(10-26-5-3-23-4-6-26)11-27-19(18)21(22)24-12-25-27/h7-9,11-12,23H,3-6,10H2,1-2H3,(H2,22,24,25)
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n/an/a 0.400n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)


Article DOI: 10.1021/jm031106i
BindingDB Entry DOI: 10.7270/Q2Q2428R
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302365
PNG
(4-{[4-Amino-5-(7-methoxy-5-methyl-1-benzothiophen-...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCNC(=O)C2)cn2ncnc(N)c12
Show InChI InChI=1S/C21H22N6O2S/c1-12-5-13-7-16(30-20(13)15(6-12)29-2)18-14(8-26-4-3-23-17(28)10-26)9-27-19(18)21(22)24-11-25-27/h5-7,9,11H,3-4,8,10H2,1-2H3,(H,23,28)(H2,22,24,25)
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n/an/a 0.400n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)


Article DOI: 10.1021/jm031106i
BindingDB Entry DOI: 10.7270/Q2Q2428R
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128502
PNG
(US8796244, 81)
Show SMILES CC(C)(CO)Nc1ccc(nn1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C24H24F3N7O2/c1-23(2,14-35)31-20-7-6-18(32-33-20)15-8-9-34-19(12-28-21(34)11-15)16-4-3-5-17(10-16)30-22(36)29-13-24(25,26)27/h3-12,35H,13-14H2,1-2H3,(H,31,33)(H2,29,30,36)
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n/an/a 0.447n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128624
PNG
(US8796244, 213)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(ccn12)-c1nccc(n1)-n1ccnc1
Show InChI InChI=1S/C23H17F3N8O/c24-23(25,26)13-30-22(35)31-17-3-1-2-15(10-17)18-12-29-20-11-16(5-8-34(18)20)21-28-6-4-19(32-21)33-9-7-27-14-33/h1-12,14H,13H2,(H2,30,31,35)
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n/an/a 0.460n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128551
PNG
(US8796244, 133)
Show SMILES OC1CCCN(C1)c1ccc(nn1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1/C25H24F3N7O2/c26-25(27,28)15-30-24(37)31-18-4-1-3-17(11-18)21-13-29-23-12-16(8-10-35(21)23)20-6-7-22(33-32-20)34-9-2-5-19(36)14-34/h1,3-4,6-8,10-13,19,36H,2,5,9,14-15H2,(H2,30,31,37)
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n/an/a 0.484n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM139913
PNG
(US8895745, 375)
Show SMILES Cn1cnc(c1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C20H17F3N6O/c1-28-10-16(26-12-28)13-5-6-29-17(9-24-18(29)8-13)14-3-2-4-15(7-14)27-19(30)25-11-20(21,22)23/h2-10,12H,11H2,1H3,(H2,25,27,30)
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n/an/a 0.490n/an/an/an/a7.5n/a



Astex Therapeutics Limited

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2x final concentration in 1x kinase assay buffer (as described below). Enzymes were then incubated with test ...


US Patent US8895745 (2014)


BindingDB Entry DOI: 10.7270/Q2833QQC
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302381
PNG
((3S)-3-({[4-Amino-5-(7-methoxy-5-methyl-1-benzothi...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN[C@H]2CCNC2=O)cn2ncnc(N)c12
Show InChI InChI=1/C21H22N6O2S/c1-11-5-12-7-16(30-19(12)15(6-11)29-2)17-13(8-24-14-3-4-23-21(14)28)9-27-18(17)20(22)25-10-26-27/h5-7,9-10,14,24H,3-4,8H2,1-2H3,(H,23,28)(H2,22,25,26)/t14-/s2
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n/an/a 0.5n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)


Article DOI: 10.1021/jm031106i
BindingDB Entry DOI: 10.7270/Q2Q2428R
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128659
PNG
(US8796244, 250)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(ccn12)-c1nnc(NC2CC2)s1
Show InChI InChI=1S/C21H18F3N7OS/c22-21(23,24)11-26-19(32)27-15-3-1-2-12(8-15)16-10-25-17-9-13(6-7-31(16)17)18-29-30-20(33-18)28-14-4-5-14/h1-3,6-10,14H,4-5,11H2,(H,28,30)(H2,26,27,32)
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n/an/a 0.5n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM161434
PNG
(US9108973, 47)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn([C@H]2CCN(C2)C(=O)C#CC(C)(C)O)c2ncnc(N)c12
Show InChI InChI=1/C26H27N5O4/c1-26(2,33)9-7-22(32)30-10-8-19(15-30)31-14-18(23-24(27)28-16-29-25(23)31)6-5-17-11-20(34-3)13-21(12-17)35-4/h11-14,16,19,33H,8,10,15H2,1-4H3,(H2,27,28,29)/t19-/s2
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n/an/a 0.5n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Purified recombinant human FGFR3 protein was purchased from Carna Biosciences, Inc. When setting conditions for the measurement of the inhibitory ef...


US Patent US9108973 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HJV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM161389
PNG
(US10124003, Ref. Ex. Compound 3 | US9108973, 2)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn([C@H]2CCN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1/C22H22N6O3/c1-4-19(29)27-8-7-15(12-27)28-22-20(21(23)24-13-25-22)18(26-28)6-5-14-9-16(30-2)11-17(10-14)31-3/h4,9-11,13,15H,1,7-8,12H2,2-3H3,(H2,23,24,25)/t15-/s2
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n/an/a 0.5n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Purified recombinant human FGFR3 protein was purchased from Carna Biosciences, Inc. When setting conditions for the measurement of the inhibitory ef...


US Patent US9108973 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HJV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM194900
PNG
(US9206184, 81 | US9206184, 82)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CNCC(C)(C)O)c(Cl)n2ncnc(N)c12
Show InChI InChI=1S/C21H24ClN5O2S/c1-11-5-12-7-15(30-18(12)14(6-11)29-4)16-13(8-24-9-21(2,3)28)19(22)27-17(16)20(23)25-10-26-27/h5-7,10,24,28H,8-9H2,1-4H3,(H2,23,25,26)
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n/an/a 0.5n/an/an/an/a7.022



BAYER INTELLECTUAL PROPERTY GmbH

US Patent


Assay Description
For the assay, 50 nl of each stock solution of the test compound in DMSO was pipetted into a black, low-volume 384-well microtiter plate (Greiner Bio...


US Patent US9206184 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07SH
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302420
PNG
(US9598416, Example 66)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CC[C@@H](C2)N(C)C)cn2ncnc(N)c12
Show InChI InChI=1/C23H28N6OS/c1-14-7-15-9-19(31-22(15)18(8-14)30-4)20-16(10-28-6-5-17(12-28)27(2)3)11-29-21(20)23(24)25-13-26-29/h7-9,11,13,17H,5-6,10,12H2,1-4H3,(H2,24,25,26)/t17-/s2
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n/an/a 0.5n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)


Article DOI: 10.1021/jm031106i
BindingDB Entry DOI: 10.7270/Q2Q2428R
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM339807
PNG
(US9757364, Compound 11)
Show SMILES COc1cc(OC)cc(c1)N(CCCO)c1ccc2ncc(-c3cnn(C)c3)c(Cl)c2n1
Show InChI InChI=1S/C23H24ClN5O3/c1-28-14-15(12-26-28)19-13-25-20-5-6-21(27-23(20)22(19)24)29(7-4-8-30)16-9-17(31-2)11-18(10-16)32-3/h5-6,9-14,30H,4,7-8H2,1-3H3
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n/an/a 0.501n/an/an/an/an/an/a



ASTEX THERAPEUTICS LTD

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9757364 (2017)


Article DOI: 10.1074/jbc.M512374200
BindingDB Entry DOI: 10.7270/Q2SB47VT
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128516
PNG
(US8796244, 95)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(ccn12)-c1ccc(nn1)N1CCNC(=O)C1
Show InChI InChI=1S/C24H21F3N8O2/c25-24(26,27)14-30-23(37)31-17-3-1-2-16(10-17)19-12-29-21-11-15(6-8-35(19)21)18-4-5-20(33-32-18)34-9-7-28-22(36)13-34/h1-6,8,10-12H,7,9,13-14H2,(H,28,36)(H2,30,31,37)
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n/an/a 0.530n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128496
PNG
(US8796244, 75)
Show SMILES NC1CCN(CC1)c1ccc(nn1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C25H25F3N8O/c26-25(27,28)15-31-24(37)32-19-3-1-2-17(12-19)21-14-30-23-13-16(6-11-36(21)23)20-4-5-22(34-33-20)35-9-7-18(29)8-10-35/h1-6,11-14,18H,7-10,15,29H2,(H2,31,32,37)
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n/an/a 0.535n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128668
PNG
(US8796244, 261)
Show SMILES Nc1nnc(s1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C18H14F3N7OS/c19-18(20,21)9-24-17(29)25-12-3-1-2-10(6-12)13-8-23-14-7-11(4-5-28(13)14)15-26-27-16(22)30-15/h1-8H,9H2,(H2,22,27)(H2,24,25,29)
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n/an/a 0.540n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128468
PNG
(US8796244, 47)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(ccn12)-c1cnn(c1)C1CCOC1
Show InChI InChI=1/C23H21F3N6O2/c24-23(25,26)14-28-22(33)30-18-3-1-2-16(8-18)20-11-27-21-9-15(4-6-31(20)21)17-10-29-32(12-17)19-5-7-34-13-19/h1-4,6,8-12,19H,5,7,13-14H2,(H2,28,30,33)
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n/an/a 0.542n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128427
PNG
(US8796244, 6)
Show SMILES CN1CCC(CC1)n1cc(cn1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C25H26F3N7O/c1-33-8-6-21(7-9-33)35-15-19(13-31-35)17-5-10-34-22(14-29-23(34)12-17)18-3-2-4-20(11-18)32-24(36)30-16-25(26,27)28/h2-5,10-15,21H,6-9,16H2,1H3,(H2,30,32,36)
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n/an/a 0.545n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128428
PNG
(US8796244, 7)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(ccn12)-c1ccc(nn1)N1CCCCC1
Show InChI InChI=1S/C25H24F3N7O/c26-25(27,28)16-30-24(36)31-19-6-4-5-18(13-19)21-15-29-23-14-17(9-12-35(21)23)20-7-8-22(33-32-20)34-10-2-1-3-11-34/h4-9,12-15H,1-3,10-11,16H2,(H2,30,31,36)
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n/an/a 0.550n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM339822
PNG
(US9757364, Compound 15)
Show SMILES COc1cc(OC)cc(c1)N(CCO)c1ccc2ncc(-c3cnn(C)c3)c(Cl)c2n1
Show InChI InChI=1S/C22H22ClN5O3/c1-27-13-14(11-25-27)18-12-24-19-4-5-20(26-22(19)21(18)23)28(6-7-29)15-8-16(30-2)10-17(9-15)31-3/h4-5,8-13,29H,6-7H2,1-3H3
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n/an/a 0.550n/an/an/an/an/an/a



ASTEX THERAPEUTICS LTD

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9757364 (2017)


Article DOI: 10.1074/jbc.M512374200
BindingDB Entry DOI: 10.7270/Q2SB47VT
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128561
PNG
(US8796244, 145)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(cn1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C27H26F3N7O2/c1-18(38)35-9-11-36(12-10-35)24-6-5-21(15-31-24)19-7-8-37-23(16-32-25(37)14-19)20-3-2-4-22(13-20)34-26(39)33-17-27(28,29)30/h2-8,13-16H,9-12,17H2,1H3,(H2,33,34,39)
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n/an/a 0.560n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128488
PNG
(US8796244, 67)
Show SMILES OCCNc1ccc(nn1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C22H20F3N7O2/c23-22(24,25)13-28-21(34)29-16-3-1-2-15(10-16)18-12-27-20-11-14(6-8-32(18)20)17-4-5-19(31-30-17)26-7-9-33/h1-6,8,10-12,33H,7,9,13H2,(H,26,31)(H2,28,29,34)
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n/an/a 0.569n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128425
PNG
(US8796244, 4)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(ccn12)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C24H24F3N7O/c25-24(26,27)15-30-23(35)32-19-3-1-2-17(10-19)21-13-29-22-11-16(6-9-33(21)22)18-12-31-34(14-18)20-4-7-28-8-5-20/h1-3,6,9-14,20,28H,4-5,7-8,15H2,(H2,30,32,35)
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n/an/a 0.570n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM339823
PNG
(US9757364, Compound 16)
Show SMILES COc1cc(OC)cc(c1)N(Cc1ncc[nH]1)c1ccc2ncc(-c3cnn(C)c3)c(Cl)c2n1
Show InChI InChI=1S/C24H22ClN7O2/c1-31-13-15(11-29-31)19-12-28-20-4-5-22(30-24(20)23(19)25)32(14-21-26-6-7-27-21)16-8-17(33-2)10-18(9-16)34-3/h4-13H,14H2,1-3H3,(H,26,27)
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n/an/a 0.575n/an/an/an/an/an/a



ASTEX THERAPEUTICS LTD

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9757364 (2017)


Article DOI: 10.1074/jbc.M512374200
BindingDB Entry DOI: 10.7270/Q2SB47VT
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128465
PNG
(US8796244, 44)
Show SMILES CCN1CCC(C1)N=CC(C=N)c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1/C25H28F3N7O/c1-2-34-8-7-21(15-34)30-13-19(12-29)17-6-9-35-22(14-31-23(35)11-17)18-4-3-5-20(10-18)33-24(36)32-16-25(26,27)28/h3-6,9-14,19,21,29H,2,7-8,15-16H2,1H3,(H2,32,33,36)/b29-12?,30-13+
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n/an/a 0.582n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM50065454
PNG
(CHEBI:63453 | CHEMBL3348846)
Show SMILES COc1cc(CCc2cc(NC(=O)c3ccc(cc3)N3C[C@H](C)N[C@H](C)C3)n[nH]2)cc(OC)c1
Show InChI InChI=1S/C26H33N5O3/c1-17-15-31(16-18(2)27-17)22-9-6-20(7-10-22)26(32)28-25-13-21(29-30-25)8-5-19-11-23(33-3)14-24(12-19)34-4/h6-7,9-14,17-18,27H,5,8,15-16H2,1-4H3,(H2,28,29,30,32)/t17-,18+
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PubMed
n/an/a 0.600n/an/an/an/an/an/a



Chinese Academy of Sciences (CAS)

Curated by ChEMBL


Assay Description
Inhibition of FGFR3 in human RT112 cells assessed as suppression of cell proliferation after 72 hrs by SRB/CCK-8 assay


Bioorg Med Chem Lett 26: 2594-9 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.028
BindingDB Entry DOI: 10.7270/Q20C4XNM
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302419
PNG
(US9598416, Example 65)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CC[C@H](C2)N(C)C)cn2ncnc(N)c12
Show InChI InChI=1/C23H28N6OS/c1-14-7-15-9-19(31-22(15)18(8-14)30-4)20-16(10-28-6-5-17(12-28)27(2)3)11-29-21(20)23(24)25-13-26-29/h7-9,11,13,17H,5-6,10,12H2,1-4H3,(H2,24,25,26)/t17-/s2
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n/an/a 0.600n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)


Article DOI: 10.1021/jm031106i
BindingDB Entry DOI: 10.7270/Q2Q2428R
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302421
PNG
(US9598416, Example 67)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCCC(C2)N(C)C)cn2ncnc(N)c12
Show InChI InChI=1/C24H30N6OS/c1-15-8-16-10-20(32-23(16)19(9-15)31-4)21-17(12-30-22(21)24(25)26-14-27-30)11-29-7-5-6-18(13-29)28(2)3/h8-10,12,14,18H,5-7,11,13H2,1-4H3,(H2,25,26,27)
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n/an/a 0.600n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)


Article DOI: 10.1021/jm031106i
BindingDB Entry DOI: 10.7270/Q2Q2428R
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128466
PNG
(US8796244, 45)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(ccn12)-c1cnn(c1)C1CCNC1
Show InChI InChI=1/C23H22F3N7O/c24-23(25,26)14-29-22(34)31-18-3-1-2-16(8-18)20-12-28-21-9-15(5-7-32(20)21)17-10-30-33(13-17)19-4-6-27-11-19/h1-3,5,7-10,12-13,19,27H,4,6,11,14H2,(H2,29,31,34)
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n/an/a 0.603n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128534
PNG
(US8796244, 113)
Show SMILES CN(C)c1ccc(nn1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C22H20F3N7O/c1-31(2)19-7-6-17(29-30-19)14-8-9-32-18(12-26-20(32)11-14)15-4-3-5-16(10-15)28-21(33)27-13-22(23,24)25/h3-12H,13H2,1-2H3,(H2,27,28,33)
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n/an/a 0.610n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128459
PNG
(US8796244, 38)
Show SMILES CN1CCCC(C1)N=CC(C=N)c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1/C25H28F3N7O/c1-34-8-3-6-21(15-34)30-13-19(12-29)17-7-9-35-22(14-31-23(35)11-17)18-4-2-5-20(10-18)33-24(36)32-16-25(26,27)28/h2,4-5,7,9-14,19,21,29H,3,6,8,15-16H2,1H3,(H2,32,33,36)/b29-12?,30-13+
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n/an/a 0.610n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128461
PNG
(US8796244, 40)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(ccn12)-c1cnn(c1)C1CCCNC1
Show InChI InChI=1/C24H24F3N7O/c25-24(26,27)15-30-23(35)32-19-4-1-3-17(9-19)21-13-29-22-10-16(6-8-33(21)22)18-11-31-34(14-18)20-5-2-7-28-12-20/h1,3-4,6,8-11,13-14,20,28H,2,5,7,12,15H2,(H2,30,32,35)
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n/an/a 0.612n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128453
PNG
(US8796244, 32)
Show SMILES CC(C)N1CC(C1)N=CC(C=N)c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1/C25H28F3N7O/c1-16(2)34-13-21(14-34)30-11-19(10-29)17-6-7-35-22(12-31-23(35)9-17)18-4-3-5-20(8-18)33-24(36)32-15-25(26,27)28/h3-12,16,19,21,29H,13-15H2,1-2H3,(H2,32,33,36)/b29-10?,30-11+
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n/an/a 0.613n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM339803
PNG
(US9757364, Compound 10)
Show SMILES COc1cc(OC)cc(c1)N(Cc1ncc[nH]1)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C24H23N7O2/c1-30-14-17(13-28-30)16-8-22-21(27-12-16)4-5-24(29-22)31(15-23-25-6-7-26-23)18-9-19(32-2)11-20(10-18)33-3/h4-14H,15H2,1-3H3,(H,25,26)
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n/an/a 0.631n/an/an/an/an/an/a



ASTEX THERAPEUTICS LTD

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9757364 (2017)


Article DOI: 10.1074/jbc.M512374200
BindingDB Entry DOI: 10.7270/Q2SB47VT
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM339804
PNG
(US9757364, Compound 2)
Show SMILES COc1cc(OC)cc(c1)N(CCCO)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H25N5O3/c1-27-15-17(14-25-27)16-9-22-21(24-13-16)5-6-23(26-22)28(7-4-8-29)18-10-19(30-2)12-20(11-18)31-3/h5-6,9-15,29H,4,7-8H2,1-3H3
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n/an/a 0.631n/an/an/an/an/an/a



ASTEX THERAPEUTICS LTD

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9757364 (2017)


Article DOI: 10.1074/jbc.M512374200
BindingDB Entry DOI: 10.7270/Q2SB47VT
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128436
PNG
(US8796244, 15)
Show SMILES NC(=CCC(=N)N1CCOCC1)c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C24H26F3N7O2/c25-24(26,27)15-31-23(35)32-18-3-1-2-17(12-18)20-14-30-22-13-16(6-7-34(20)22)19(28)4-5-21(29)33-8-10-36-11-9-33/h1-4,6-7,12-14,29H,5,8-11,15,28H2,(H2,31,32,35)/b19-4-,29-21?
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n/an/a 0.640n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
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