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Found 2566 hits Enz. Inhib. hit(s) with Target = 'Focal adhesion kinase 1/vascular endothelial growth factor receptor 3'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50020310
PNG
(CHEMBL3288854)
Show SMILES CN1CCN(CCC(=O)Nc2c(C)[nH]c(\C=C3/C(=O)Nc4ccc(F)cc34)c2C)CC1
Show InChI InChI=1S/C23H28FN5O2/c1-14-20(13-18-17-12-16(24)4-5-19(17)26-23(18)31)25-15(2)22(14)27-21(30)6-7-29-10-8-28(3)9-11-29/h4-5,12-13,25H,6-11H2,1-3H3,(H,26,31)(H,27,30)/b18-13-
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<0.300n/an/an/an/an/an/an/an/a



Qilu Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Binding affinity to VEGFR3 (unknown origin)


Eur J Med Chem 82: 139-51 (2014)

More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM4814
PNG
(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Show SMILES CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C
Show InChI InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12-
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17n/an/an/an/an/an/an/an/a



Qilu Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Binding affinity to VEGFR3 (unknown origin)


Eur J Med Chem 82: 139-51 (2014)

More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM50020310
PNG
(CHEMBL3288854)
Show SMILES CN1CCN(CCC(=O)Nc2c(C)[nH]c(\C=C3/C(=O)Nc4ccc(F)cc34)c2C)CC1
Show InChI InChI=1S/C23H28FN5O2/c1-14-20(13-18-17-12-16(24)4-5-19(17)26-23(18)31)25-15(2)22(14)27-21(30)6-7-29-10-8-28(3)9-11-29/h4-5,12-13,25H,6-11H2,1-3H3,(H,26,31)(H,27,30)/b18-13-
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530n/an/an/an/an/an/an/an/a



Qilu Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Binding affinity to FAK (unknown origin)


Eur J Med Chem 82: 139-51 (2014)

More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50331613
PNG
(CHEMBL1290177 | N-(4-chlorobenzyl)benzofuro[2,3-b]...)
Show SMILES Clc1ccc(CNc2ccnc3oc4ccccc4c23)cc1
Show InChI InChI=1S/C18H13ClN2O/c19-13-7-5-12(6-8-13)11-21-15-9-10-20-18-17(15)14-3-1-2-4-16(14)22-18/h1-10H,11H2,(H,20,21)
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680n/an/an/an/an/an/an/an/a



Martin Luther University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3


Bioorg Med Chem Lett 20: 6915-9 (2010)

More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM50341519
PNG
((S)-3-(4-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl...)
Show SMILES CNc1cncc(n1)-c1c[nH]c(=O)c(NC(=O)c2ccc(cc2)N2CCC[C@H]2CN2CCCC2)c1
Show InChI InChI=1S/C26H31N7O2/c1-27-24-16-28-15-23(30-24)19-13-22(26(35)29-14-19)31-25(34)18-6-8-20(9-7-18)33-12-4-5-21(33)17-32-10-2-3-11-32/h6-9,13-16,21H,2-5,10-12,17H2,1H3,(H,27,30)(H,29,35)(H,31,34)/t21-/m0/s1
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>1.00E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of FAK


J Med Chem 54: 2341-50 (2011)

More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50331618
PNG
(CHEMBL1289976 | N-benzylbenzofuro[2,3-b]pyridin-4-...)
Show SMILES C(Nc1ccnc2oc3ccccc3c12)c1ccccc1
Show InChI InChI=1S/C18H14N2O/c1-2-6-13(7-3-1)12-20-15-10-11-19-18-17(15)14-8-4-5-9-16(14)21-18/h1-11H,12H2,(H,19,20)
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1.09E+3n/an/an/an/an/an/an/an/a



Martin Luther University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3


Bioorg Med Chem Lett 20: 6915-9 (2010)

More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50331616
PNG
(CHEMBL1290071 | N-(naphthalen-1-ylmethyl)benzofuro...)
Show SMILES C(Nc1ccnc2oc3ccccc3c12)c1cccc2ccccc12
Show InChI InChI=1S/C22H16N2O/c1-2-9-17-15(6-1)7-5-8-16(17)14-24-19-12-13-23-22-21(19)18-10-3-4-11-20(18)25-22/h1-13H,14H2,(H,23,24)
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1.09E+3n/an/an/an/an/an/an/an/a



Martin Luther University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3


Bioorg Med Chem Lett 20: 6915-9 (2010)

More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50224883
PNG
(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Show SMILES Clc1cc2NC(=O)Nc3cnc(C#N)c(OCCCCOc2cc1NCc1cncs1)n3
Show InChI InChI=1S/C20H18ClN7O3S/c21-13-5-15-17(6-14(13)24-9-12-8-23-11-32-12)30-3-1-2-4-31-19-16(7-22)25-10-18(27-19)28-20(29)26-15/h5-6,8,10-11,24H,1-4,9H2,(H2,26,27,28,29)
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6.85E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT4


Bioorg Med Chem Lett 17: 6593-601 (2007)

More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50331617
PNG
(CHEMBL1289977 | N-phenethylbenzofuro[2,3-b]pyridin...)
Show SMILES C(Cc1ccccc1)Nc1ccnc2oc3ccccc3c12
Show InChI InChI=1S/C19H16N2O/c1-2-6-14(7-3-1)10-12-20-16-11-13-21-19-18(16)15-8-4-5-9-17(15)22-19/h1-9,11,13H,10,12H2,(H,20,21)
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9.39E+3n/an/an/an/an/an/an/an/a



Martin Luther University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3


Bioorg Med Chem Lett 20: 6915-9 (2010)

More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50331615
PNG
(CHEMBL1290073 | N-(3-chlorobenzyl)benzofuro[2,3-b]...)
Show SMILES Clc1cccc(CNc2ccnc3oc4ccccc4c23)c1
Show InChI InChI=1S/C18H13ClN2O/c19-13-5-3-4-12(10-13)11-21-15-8-9-20-18-17(15)14-6-1-2-7-16(14)22-18/h1-10H,11H2,(H,20,21)
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>1.00E+6n/an/an/an/an/an/an/an/a



Martin Luther University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3


Bioorg Med Chem Lett 20: 6915-9 (2010)

More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50331614
PNG
(CHEMBL1290178 | N-(pyridin-3-ylmethyl)benzofuro[2,...)
Show SMILES C(Nc1ccnc2oc3ccccc3c12)c1cccnc1
Show InChI InChI=1S/C17H13N3O/c1-2-6-15-13(5-1)16-14(7-9-19-17(16)21-15)20-11-12-4-3-8-18-10-12/h1-10H,11H2,(H,19,20)
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>1.00E+6n/an/an/an/an/an/an/an/a



Martin Luther University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3


Bioorg Med Chem Lett 20: 6915-9 (2010)

More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50331612
PNG
(CHEMBL1290072 | N-(4-methoxybenzyl)benzofuro[2,3-b...)
Show SMILES COc1ccc(CNc2ccnc3oc4ccccc4c23)cc1
Show InChI InChI=1S/C19H16N2O2/c1-22-14-8-6-13(7-9-14)12-21-16-10-11-20-19-18(16)15-4-2-3-5-17(15)23-19/h2-11H,12H2,1H3,(H,20,21)
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>1.00E+6n/an/an/an/an/an/an/an/a



Martin Luther University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3


Bioorg Med Chem Lett 20: 6915-9 (2010)

More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50206389
PNG
(CHEMBL3939307)
Show SMILES CNC(=O)c1ccccc1Sc1ccc2c(CCc3ccccn3)n[nH]c2c1
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n/an/a 0.100n/an/an/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50362065
PNG
(CHEMBL1940109)
Show SMILES COCCOc1cc2ncnc(Oc3cnn(CC(=O)Nc4cccc(OC)c4)c3)c2cc1OC
Show InChI InChI=1S/C24H25N5O6/c1-31-7-8-34-22-11-20-19(10-21(22)33-3)24(26-15-25-20)35-18-12-27-29(13-18)14-23(30)28-16-5-4-6-17(9-16)32-2/h4-6,9-13,15H,7-8,14H2,1-3H3,(H,28,30)
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n/an/a 0.200n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3 phosphorylation by cell based assay


Bioorg Med Chem Lett 22: 262-6 (2011)

More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50331095
PNG
(CHEMBL1289494 | Tivozanib)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C22H19ClN4O5/c1-12-8-21(27-32-12)26-22(28)25-16-5-4-13(9-15(16)23)31-18-6-7-24-17-11-20(30-3)19(29-2)10-14(17)18/h4-11H,1-3H3,(H2,25,26,27,28)
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n/an/a 0.240n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3


J Med Chem 55: 10797-822 (2012)

More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155552
PNG
(US9012461, 28)
Show SMILES CN1CCc2cc(Nc3ncc(c(CCc4ccccc4CC(N)=O)n3)C(F)(F)F)ccc2C1
Show InChI InChI=1S/C25H26F3N5O/c1-33-11-10-18-12-20(8-6-19(18)15-33)31-24-30-14-21(25(26,27)28)22(32-24)9-7-16-4-2-3-5-17(16)13-23(29)34/h2-6,8,12,14H,7,9-11,13,15H2,1H3,(H2,29,34)(H,30,31,32)
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US Patent
n/an/a 0.300n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
A biotin labeled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)1S...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155547
PNG
(US9012461, 23)
Show SMILES CC(=O)N1CCC(CC1)c1ccc(Nc2ncc(c(CCc3ccccc3CC(N)=O)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C28H30F3N5O2/c1-18(37)36-14-12-21(13-15-36)20-6-9-23(10-7-20)34-27-33-17-24(28(29,30)31)25(35-27)11-8-19-4-2-3-5-22(19)16-26(32)38/h2-7,9-10,17,21H,8,11-16H2,1H3,(H2,32,38)(H,33,34,35)
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n/an/a 0.390n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
A biotin labeled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)1S...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50362064
PNG
(CHEMBL1940108)
Show SMILES COc1cccc(NC(=O)Cn2cc(Oc3ncnc4cc(OC)c(OC)cc34)cn2)c1
Show InChI InChI=1S/C22H21N5O5/c1-29-15-6-4-5-14(7-15)26-21(28)12-27-11-16(10-25-27)32-22-17-8-19(30-2)20(31-3)9-18(17)23-13-24-22/h4-11,13H,12H2,1-3H3,(H,26,28)
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n/an/a 0.400n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3 phosphorylation by cell based assay


Bioorg Med Chem Lett 22: 262-6 (2011)

More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM50246239
PNG
(CHEMBL487229 | N-methyl-N-(2-((2-(1-oxoisoindolin-...)
Show SMILES CN(c1ccccc1CNc1nc(Nc2ccc3C(=O)NCc3c2)ncc1C(F)(F)F)S(C)(=O)=O
Show InChI InChI=1S/C22H21F3N6O3S/c1-31(35(2,33)34)18-6-4-3-5-13(18)10-26-19-17(22(23,24)25)12-28-21(30-19)29-15-7-8-16-14(9-15)11-27-20(16)32/h3-9,12H,10-11H2,1-2H3,(H,27,32)(H2,26,28,29,30)
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n/an/a 0.5n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged FAK (unknown origin) assessed as inhibition of poly-Glu-Tyr phosphorylation


Bioorg Med Chem Lett 18: 6071-7 (2008)

More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50336457
PNG
((3S,5Z,8S,9R,11E)-8,9,16-trihydroxy-14-methoxy-3-m...)
Show SMILES COc1cc(O)c2c(CCCC(=O)C(=O)C(=O)CCC[C@H](C)OC2=O)c1
Show InChI InChI=1S/C19H22O7/c1-11-5-3-7-14(20)18(23)15(21)8-4-6-12-9-13(25-2)10-16(22)17(12)19(24)26-11/h9-11,22H,3-8H2,1-2H3/t11-/m0/s1
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n/an/a 0.5n/an/an/an/an/an/a



National University of Ireland

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR3 in cell free system after 90 mins


Bioorg Med Chem Lett 21: 1167-70 (2011)

More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM50207351
PNG
(CHEMBL3965256)
Show SMILES CS(=O)(=O)N(CC=C)c1ncccc1CNc1nc(Nc2ccc(N3CCOCC3)c(Br)c2)ncc1C(F)(F)F
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n/an/a 0.510n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of NH2-terminal His6-tagged FAK kinase domain (410 to 689 residues) (unknown origin) expressed in baculovirus infected sf9 cells using p(G...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM50207359
PNG
(CHEMBL3892377)
Show SMILES CS(=O)(=O)N(CC=C)c1ncccc1CNc1nc(Nc2cccc(Br)c2)ncc1C(F)(F)F
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n/an/a 0.510n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of NH2-terminal His6-tagged FAK kinase domain (410 to 689 residues) (unknown origin) expressed in baculovirus infected sf9 cells using p(G...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155537
PNG
(US9012461, 13)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(Nc2ncc(c(CCc3ccccc3CC(N)=O)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C27H29F3N6O2/c1-18(37)35-12-14-36(15-13-35)22-9-7-21(8-10-22)33-26-32-17-23(27(28,29)30)24(34-26)11-6-19-4-2-3-5-20(19)16-25(31)38/h2-5,7-10,17H,6,11-16H2,1H3,(H2,31,38)(H,32,33,34)
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n/an/a 0.600n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
A biotin labeled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)1S...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155548
PNG
(US9012461, 24)
Show SMILES CC(=O)C1CCN(CC1)c1ccc(Nc2ncc(c(CCc3ccccc3CC(N)=O)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C28H30F3N5O2/c1-18(37)19-12-14-36(15-13-19)23-9-7-22(8-10-23)34-27-33-17-24(28(29,30)31)25(35-27)11-6-20-4-2-3-5-21(20)16-26(32)38/h2-5,7-10,17,19H,6,11-16H2,1H3,(H2,32,38)(H,33,34,35)
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n/an/a 0.770n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
A biotin labeled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)1S...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50321892
PNG
((Z)-5-{6-[3-(4-Methoxyphenyl)-ureido]-2-oxo-1,2-di...)
Show SMILES COc1ccc(NC(=O)Nc2ccc3\C(=C\c4[nH]cc(C(O)=O)c4C)C(=O)Nc3c2)cc1
Show InChI InChI=1S/C23H20N4O5/c1-12-18(22(29)30)11-24-19(12)10-17-16-8-5-14(9-20(16)27-21(17)28)26-23(31)25-13-3-6-15(32-2)7-4-13/h3-11,24H,1-2H3,(H,27,28)(H,29,30)(H2,25,26,31)/b17-10-
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n/an/a 0.800n/an/an/an/an/an/a



National Taiwan University

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3


Bioorg Med Chem 18: 4674-86 (2011)

More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155544
PNG
(US9012461, 20)
Show SMILES NC1CCN(CC1)c1ccc(Nc2ncc(c(CCc3ccccc3CC(N)=O)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C26H29F3N6O/c27-26(28,29)22-16-32-25(33-20-6-8-21(9-7-20)35-13-11-19(30)12-14-35)34-23(22)10-5-17-3-1-2-4-18(17)15-24(31)36/h1-4,6-9,16,19H,5,10-15,30H2,(H2,31,36)(H,32,33,34)
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n/an/a 0.810n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
A biotin labeled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)1S...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 0.900n/an/an/an/an/an/a



Southeast University

Curated by ChEMBL


Assay Description
Inhibition of FLT4 (unknown origin) incubated for 1 hr by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM50246286
PNG
(CHEMBL488247 | N-methyl-N-(2-((2-(4-(methylsulfony...)
Show SMILES CN(c1ccccc1CNc1nc(Nc2ccc(cc2)S(C)(=O)=O)ncc1C(F)(F)F)S(C)(=O)=O
Show InChI InChI=1S/C21H22F3N5O4S2/c1-29(35(3,32)33)18-7-5-4-6-14(18)12-25-19-17(21(22,23)24)13-26-20(28-19)27-15-8-10-16(11-9-15)34(2,30)31/h4-11,13H,12H2,1-3H3,(H2,25,26,27,28)
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n/an/a 0.940n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged FAK (unknown origin) assessed as inhibition of poly-Glu-Tyr phosphorylation


Bioorg Med Chem Lett 18: 6071-7 (2008)

More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50316775
PNG
(2-[5-(4-Hydroxyphenethoxy)-1-(4-methoxyphenyl)-ben...)
Show SMILES COc1ccc(cc1)-c1ccc(Cn2cc(CCN)c3cc(OCCc4ccc(O)cc4)ccc23)cc1
Show InChI InChI=1S/C32H32N2O3/c1-36-29-12-8-26(9-13-29)25-6-2-24(3-7-25)21-34-22-27(16-18-33)31-20-30(14-15-32(31)34)37-19-17-23-4-10-28(35)11-5-23/h2-15,20,22,35H,16-19,21,33H2,1H3
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n/an/a 0.960n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3 after 30 mins by chemiluminescence ELISA


Bioorg Med Chem 18: 3387-402 (2010)

More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM134114
PNG
(US8846689, 116)
Show SMILES CON1Cc2cccc(Oc3nc(Nc4cc(F)c(cc4OC)C(=O)N[C@@H]4CCCN(C)C4)ncc3C(F)(F)F)c2C1=O
Show InChI InChI=1/C28H28F4N6O5/c1-37-9-5-7-16(14-37)34-24(39)17-10-22(41-2)20(11-19(17)29)35-27-33-12-18(28(30,31)32)25(36-27)43-21-8-4-6-15-13-38(42-3)26(40)23(15)21/h4,6,8,10-12,16H,5,7,9,13-14H2,1-3H3,(H,34,39)(H,33,35,36)/t16-/s2
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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM134115
PNG
(US8846689, 117)
Show SMILES CON1Cc2cccc(Oc3nc(Nc4ccc(cc4OC)C(=O)N[C@@H]4CCCN(C)C4)ncc3C(F)(F)F)c2C1=O
Show InChI InChI=1/C28H29F3N6O5/c1-36-11-5-7-18(15-36)33-24(38)16-9-10-20(22(12-16)40-2)34-27-32-13-19(28(29,30)31)25(35-27)42-21-8-4-6-17-14-37(41-3)26(39)23(17)21/h4,6,8-10,12-13,18H,5,7,11,14-15H2,1-3H3,(H,33,38)(H,32,34,35)/t18-/s2
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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM134116
PNG
(US8846689, 118)
Show SMILES COc1cc(C(=O)NC2CCN(C)CC2)c(F)cc1Nc1ncc(c(Oc2cccc3c2C(=O)N(C)C3(C)C)n1)C(F)(F)F
Show InChI InChI=1S/C30H32F4N6O4/c1-29(2)18-7-6-8-22(24(18)27(42)40(29)4)44-26-19(30(32,33)34)15-35-28(38-26)37-21-14-20(31)17(13-23(21)43-5)25(41)36-16-9-11-39(3)12-10-16/h6-8,13-16H,9-12H2,1-5H3,(H,36,41)(H,35,37,38)
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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM134117
PNG
(US8846689, 119)
Show SMILES CO[C@H]1CN(C)CC[C@H]1NC(=O)c1cc(OC)c(Nc2ncc(c(Oc3cccc4CN(C)C(=O)c34)n2)C(F)(F)F)cc1F
Show InChI InChI=1/C29H30F4N6O5/c1-38-9-8-19(23(14-38)43-4)35-25(40)16-10-22(42-3)20(11-18(16)30)36-28-34-12-17(29(31,32)33)26(37-28)44-21-7-5-6-15-13-39(2)27(41)24(15)21/h5-7,10-12,19,23H,8-9,13-14H2,1-4H3,(H,35,40)(H,34,36,37)/t19-,23+/s2
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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM134118
PNG
(US8846689, 120)
Show SMILES COc1cc(C(=O)N[C@H]2CCN(C)C[C@H]2F)c(Cl)cc1Nc1ncc(c(Oc2cccc3c2C(=O)N(C)C3(C)C)n1)C(F)(F)F
Show InChI InChI=1/C30H31ClF4N6O4/c1-29(2)16-7-6-8-22(24(16)27(43)41(29)4)45-26-17(30(33,34)35)13-36-28(39-26)38-21-12-18(31)15(11-23(21)44-5)25(42)37-20-9-10-40(3)14-19(20)32/h6-8,11-13,19-20H,9-10,14H2,1-5H3,(H,37,42)(H,36,38,39)/t19-,20+/s2
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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM134119
PNG
(US8846689, 121)
Show SMILES CO[C@H]1CN(C)CC[C@H]1NC(=O)c1cc(OC)c(Nc2ncc(c(Oc3cccc4c3C(=O)N(C)C4(C)C)n2)C(F)(F)F)cc1Cl
Show InChI InChI=1/C31H34ClF3N6O5/c1-30(2)17-8-7-9-22(25(17)28(43)41(30)4)46-27-18(31(33,34)35)14-36-29(39-27)38-21-13-19(32)16(12-23(21)44-5)26(42)37-20-10-11-40(3)15-24(20)45-6/h7-9,12-14,20,24H,10-11,15H2,1-6H3,(H,37,42)(H,36,38,39)/t20-,24+/s2
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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM134123
PNG
(US8846689, 125)
Show SMILES COc1cc(C(=O)NCCN(C)C)c(F)cc1Nc1ncc(c(Oc2cccc3CN(C)C(=O)c23)n1)C(F)(F)F
Show InChI InChI=1S/C26H26F4N6O4/c1-35(2)9-8-31-22(37)15-10-20(39-4)18(11-17(15)27)33-25-32-12-16(26(28,29)30)23(34-25)40-19-7-5-6-14-13-36(3)24(38)21(14)19/h5-7,10-12H,8-9,13H2,1-4H3,(H,31,37)(H,32,33,34)
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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM134126
PNG
(US8846689, 128)
Show SMILES COc1cc(C(=O)NC[C@H](O)CO)c(F)cc1Nc1ncc(c(Oc2cccc3CN(C)C(=O)c23)n1)C(F)(F)F
Show InChI InChI=1/C25H23F4N5O6/c1-34-10-12-4-3-5-18(20(12)23(34)38)40-22-15(25(27,28)29)9-31-24(33-22)32-17-7-16(26)14(6-19(17)39-2)21(37)30-8-13(36)11-35/h3-7,9,13,35-36H,8,10-11H2,1-2H3,(H,30,37)(H,31,32,33)/t13-/s2
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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM134128
PNG
(US8846689, 130)
Show SMILES COc1cc(C(=O)N[C@H]2CCCN(C)C2)c(Cl)cc1Nc1ncc(c(Oc2cccc3CN(C)C(=O)c23)n1)C(F)(F)F
Show InChI InChI=1/C28H28ClF3N6O4/c1-37-9-5-7-16(14-37)34-24(39)17-10-22(41-3)20(11-19(17)29)35-27-33-12-18(28(30,31)32)25(36-27)42-21-8-4-6-15-13-38(2)26(40)23(15)21/h4,6,8,10-12,16H,5,7,9,13-14H2,1-3H3,(H,34,39)(H,33,35,36)/t16-/s2
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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM134129
PNG
(US8846689, 131)
Show SMILES COc1cc(C(=O)N[C@H]2CCN(C)C[C@H]2F)c(Cl)cc1Nc1ncc(Cl)c(Oc2cccc3CN(C)C(=O)c23)n1
Show InChI InChI=1/C27H27Cl2FN6O4/c1-35-8-7-19(18(30)13-35)32-24(37)15-9-22(39-3)20(10-16(15)28)33-27-31-11-17(29)25(34-27)40-21-6-4-5-14-12-36(2)26(38)23(14)21/h4-6,9-11,18-19H,7-8,12-13H2,1-3H3,(H,32,37)(H,31,33,34)/t18-,19+/s2
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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM134130
PNG
(US8846689, 132)
Show SMILES CO[C@H]1CN(C)CC[C@H]1NC(=O)c1cc(OC)c(Nc2ncc(Cl)c(Oc3cccc4CN(C)C(=O)c34)n2)cc1Cl
Show InChI InChI=1/C28H30Cl2N6O5/c1-35-9-8-19(23(14-35)40-4)32-25(37)16-10-22(39-3)20(11-17(16)29)33-28-31-12-18(30)26(34-28)41-21-7-5-6-15-13-36(2)27(38)24(15)21/h5-7,10-12,19,23H,8-9,13-14H2,1-4H3,(H,32,37)(H,31,33,34)/t19-,23+/s2
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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM134131
PNG
(US8846689, 133)
Show SMILES COc1cc(C(=O)NC2CCN(CC2)C2CCOCC2)c(Cl)cc1Nc1ncc(Cl)c(Oc2cccc3CN(C)C(=O)c23)n1
Show InChI InChI=1S/C31H34Cl2N6O5/c1-38-17-18-4-3-5-25(27(18)30(38)41)44-29-23(33)16-34-31(37-29)36-24-15-22(32)21(14-26(24)42-2)28(40)35-19-6-10-39(11-7-19)20-8-12-43-13-9-20/h3-5,14-16,19-20H,6-13,17H2,1-2H3,(H,35,40)(H,34,36,37)
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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM134134
PNG
(US8846689, 136)
Show SMILES COc1cc(C(=O)NC2CCCN(C)C2)c(C)cc1Nc1ncc(c(Oc2cccc3CN(C)C(=O)c23)n1)C(F)(F)F
Show InChI InChI=1/C29H31F3N6O4/c1-16-11-21(23(41-4)12-19(16)25(39)34-18-8-6-10-37(2)15-18)35-28-33-13-20(29(30,31)32)26(36-28)42-22-9-5-7-17-14-38(3)27(40)24(17)22/h5,7,9,11-13,18H,6,8,10,14-15H2,1-4H3,(H,34,39)(H,33,35,36)
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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM134135
PNG
(US8846689, 137)
Show SMILES COc1cc(C(=O)N[C@@H]2CCCN(C)C2)c(C)cc1Nc1ncc(c(Oc2cccc3CN(C)C(=O)c23)n1)C(F)(F)F
Show InChI InChI=1/C29H31F3N6O4/c1-16-11-21(23(41-4)12-19(16)25(39)34-18-8-6-10-37(2)15-18)35-28-33-13-20(29(30,31)32)26(36-28)42-22-9-5-7-17-14-38(3)27(40)24(17)22/h5,7,9,11-13,18H,6,8,10,14-15H2,1-4H3,(H,34,39)(H,33,35,36)/t18-/s2
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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM134136
PNG
(US8846689, 138)
Show SMILES COc1cc(C(=O)N[C@H]2CCCN(C)C2)c(C)cc1Nc1ncc(c(Oc2cccc3CN(C)C(=O)c23)n1)C(F)(F)F
Show InChI InChI=1/C29H31F3N6O4/c1-16-11-21(23(41-4)12-19(16)25(39)34-18-8-6-10-37(2)15-18)35-28-33-13-20(29(30,31)32)26(36-28)42-22-9-5-7-17-14-38(3)27(40)24(17)22/h5,7,9,11-13,18H,6,8,10,14-15H2,1-4H3,(H,34,39)(H,33,35,36)/t18-/s2
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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM202409
PNG
(US9238644, 16)
Show SMILES CN1CCC(CC1)c1ccc(Nc2ncc(Cl)c(CCc3ccccc3C3(CC3)C(N)=O)n2)cn1
Show InChI InChI=1S/C27H31ClN6O/c1-34-14-10-19(11-15-34)23-9-7-20(16-30-23)32-26-31-17-22(28)24(33-26)8-6-18-4-2-3-5-21(18)27(12-13-27)25(29)35/h2-5,7,9,16-17,19H,6,8,10-15H2,1H3,(H2,29,35)(H,31,32,33)
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n/an/a 1n/an/an/an/an/an/a



CANCER THERAPEUTICS CRC PTY LIMITED

US Patent


Assay Description
A biotin labelled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)....


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM134167
PNG
(US8846689, 169)
Show SMILES CO[C@H]1CN(C)CC[C@H]1NC(=O)c1cc(OC)c(Nc2ncc(Cl)c(Oc3cccc4CN(C)C(=O)c34)n2)cc1C
Show InChI InChI=1/C29H33ClN6O5/c1-16-11-21(23(39-4)12-18(16)26(37)32-20-9-10-35(2)15-24(20)40-5)33-29-31-13-19(30)27(34-29)41-22-8-6-7-17-14-36(3)28(38)25(17)22/h6-8,11-13,20,24H,9-10,14-15H2,1-5H3,(H,32,37)(H,31,33,34)/t20-,24+/s2
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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM134168
PNG
(US8846689, 170)
Show SMILES COc1cc(C(=O)N[C@H]2CCN(C)C[C@H]2F)c(C)cc1Nc1ncc(Cl)c(Oc2cccc3CN(C)C(=O)c23)n1
Show InChI InChI=1/C28H30ClFN6O4/c1-15-10-21(23(39-4)11-17(15)25(37)32-20-8-9-35(2)14-19(20)30)33-28-31-12-18(29)26(34-28)40-22-7-5-6-16-13-36(3)27(38)24(16)22/h5-7,10-12,19-20H,8-9,13-14H2,1-4H3,(H,32,37)(H,31,33,34)/t19-,20+/s2
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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM134170
PNG
(US8846689, 172)
Show SMILES CO[C@H]1CN(C)CC[C@H]1NC(=O)c1cc(OC)c(Nc2ncc(Cl)c(Oc3cccc4c3C(=O)N(C)C4(C)C)n2)cc1C
Show InChI InChI=1/C31H37ClN6O5/c1-17-13-22(24(41-6)14-18(17)27(39)34-21-11-12-37(4)16-25(21)42-7)35-30-33-15-20(32)28(36-30)43-23-10-8-9-19-26(23)29(40)38(5)31(19,2)3/h8-10,13-15,21,25H,11-12,16H2,1-7H3,(H,34,39)(H,33,35,36)/t21-,25+/s2
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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM134171
PNG
(US8846689, 173)
Show SMILES COc1cc(C(=O)N[C@H]2CCN(C)C[C@H]2F)c(C)cc1Nc1ncc(Cl)c(Oc2cccc3c2C(=O)N(C)C3(C)C)n1
Show InChI InChI=1/C30H34ClFN6O4/c1-16-12-22(24(41-6)13-17(16)26(39)34-21-10-11-37(4)15-20(21)32)35-29-33-14-19(31)27(36-29)42-23-9-7-8-18-25(23)28(40)38(5)30(18,2)3/h7-9,12-14,20-21H,10-11,15H2,1-6H3,(H,34,39)(H,33,35,36)/t20-,21+/s2
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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM134178
PNG
(US8846689, 180)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2cccc3CN(C)C(=O)c23)n1)C(F)(F)F)C(=O)NC1CCN(CCO)CC1
Show InChI InChI=1S/C29H31F3N6O5/c1-37-16-18-4-3-5-22(24(18)27(37)41)43-26-20(29(30,31)32)15-33-28(36-26)35-21-7-6-17(14-23(21)42-2)25(40)34-19-8-10-38(11-9-19)12-13-39/h3-7,14-15,19,39H,8-13,16H2,1-2H3,(H,34,40)(H,33,35,36)
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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


Citation and Details
More data for this
Ligand-Target Pair
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