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Compile Data Set for Download or QSAR

Found 453 hits Enz. Inhib. hit(s) with Target = 'Glutamate receptor AMPA 1/2'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50166288
PNG
((S)-2-Amino-3-[3-hydroxy-5-(2-methyl-2H-tetrazol-5...)
Show SMILES Cn1nnc(n1)-c1o[nH]c(=O)c1C[C@H](N)C(O)=O
Show InChI InChI=1S/C8H10N6O4/c1-14-11-6(10-13-14)5-3(7(15)12-18-5)2-4(9)8(16)17/h4H,2,9H2,1H3,(H,12,15)(H,16,17)/t4-/m0/s1
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0.00520n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat recombinant GluR1 expressed in Sf9 cells


J Med Chem 50: 2408-14 (2007)


Article DOI: 10.1021/jm061439q
BindingDB Entry DOI: 10.7270/Q2DZ0809
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50002370
PNG
((R,S)-alpha-amino-3-hydroxy-5-methyl-4-isooxazole-...)
Show SMILES Cc1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)
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0.0220n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat recombinant GluR1 expressed in Sf9 cells


J Med Chem 50: 2408-14 (2007)


Article DOI: 10.1021/jm061439q
BindingDB Entry DOI: 10.7270/Q2DZ0809
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50166286
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-ethyl-2H-5-tetrazol...)
Show SMILES CCn1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1S/C9H12N6O4/c1-2-15-12-7(11-14-15)6-4(8(16)13-19-6)3-5(10)9(17)18/h5H,2-3,10H2,1H3,(H,13,16)(H,17,18)
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0.150n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat recombinant GluR1 expressed in Sf9 cells


J Med Chem 50: 2408-14 (2007)


Article DOI: 10.1021/jm061439q
BindingDB Entry DOI: 10.7270/Q2DZ0809
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50060635
PNG
((S)-2-Amino-3-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-p...)
Show SMILES N[C@@H](Cn1cc(F)c(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C7H8FN3O4/c8-3-1-11(2-4(9)6(13)14)7(15)10-5(3)12/h1,4H,2,9H2,(H,13,14)(H,10,12,15)/t4-/m0/s1
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2.90n/an/an/an/an/an/an/an/a



European Research Centre for Drug Discovery and Development (NatSynDrugs)

Curated by ChEMBL


Assay Description
Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR1 expressed in Sf9 cells


J Med Chem 51: 6614-8 (2008)


Article DOI: 10.1021/jm800865a
BindingDB Entry DOI: 10.7270/Q261117R
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194124
PNG
((S)-N-(1-(5-(6-aminohexylamino)pentylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCCN
Show InChI InChI=1S/C24H42N4O3/c1-2-10-23(30)28-22(19-20-11-13-21(29)14-12-20)24(31)27-18-9-5-8-17-26-16-7-4-3-6-15-25/h11-14,22,26,29H,2-10,15-19,25H2,1H3,(H,27,31)(H,28,30)/t22-/m0/s1
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3n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
GRIA1


(HUMAN)
BDBM50122077
PNG
(CHEMBL153017 | N-[1-[5-(6-Amino-hexylamino)-pentyl...)
Show SMILES CCCC(=O)NC(Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCCN
Show InChI InChI=1S/C24H42N4O3/c1-2-10-23(30)28-22(19-20-11-13-21(29)14-12-20)24(31)27-18-9-5-8-17-26-16-7-4-3-6-15-25/h11-14,22,26,29H,2-10,15-19,25H2,1H3,(H,27,31)(H,28,30)
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3.30n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of the (-80 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.


J Med Chem 45: 5745-54 (2002)


Article DOI: 10.1021/jm020314s
BindingDB Entry DOI: 10.7270/Q2BP025P
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50166285
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-propyl-2H-5-tetrazo...)
Show SMILES CCCn1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1S/C10H14N6O4/c1-2-3-16-13-8(12-15-16)7-5(9(17)14-20-7)4-6(11)10(18)19/h6H,2-4,11H2,1H3,(H,14,17)(H,18,19)
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5.20n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat recombinant GluR1 expressed in Sf9 cells


J Med Chem 50: 2408-14 (2007)


Article DOI: 10.1021/jm061439q
BindingDB Entry DOI: 10.7270/Q2DZ0809
More data for this
Ligand-Target Pair
GRIA1


(HUMAN)
BDBM50166288
PNG
((S)-2-Amino-3-[3-hydroxy-5-(2-methyl-2H-tetrazol-5...)
Show SMILES Cn1nnc(n1)-c1o[nH]c(=O)c1C[C@H](N)C(O)=O
Show InChI InChI=1S/C8H10N6O4/c1-14-11-6(10-13-14)5-3(7(15)12-18-5)2-4(9)8(16)17/h4H,2,9H2,1H3,(H,12,15)(H,16,17)/t4-/m0/s1
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5.22n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Binding affinity for ionotropic Glutamate receptor AMPA 1 expressed in Sf9 cells


J Med Chem 48: 3438-42 (2005)


Article DOI: 10.1021/jm050014l
BindingDB Entry DOI: 10.7270/Q2H70FBJ
More data for this
Ligand-Target Pair
GRIA1


(HUMAN)
BDBM50060628
PNG
((S)-2-Amino-3-(6-chloro-3,5-dioxo-4,5-dihydro-3H-[...)
Show SMILES N[C@@H](Cn1nc(Cl)c(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C6H7ClN4O4/c7-3-4(12)9-6(15)11(10-3)1-2(8)5(13)14/h2H,1,8H2,(H,13,14)(H,9,12,15)/t2-/m0/s1
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7.10n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from human Ionotropic glutamate receptor AMPA 1 expressed in HEK293 cells


J Med Chem 40: 3645-50 (1997)


Article DOI: 10.1021/jm9702387
BindingDB Entry DOI: 10.7270/Q28G8MCB
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50211399
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-benzyl-2H-5-tetrazo...)
Show SMILES NC(Cc1c(o[nH]c1=O)-c1nnn(Cc2ccccc2)n1)C(O)=O
Show InChI InChI=1S/C14H14N6O4/c15-10(14(22)23)6-9-11(24-18-13(9)21)12-16-19-20(17-12)7-8-4-2-1-3-5-8/h1-5,10H,6-7,15H2,(H,18,21)(H,22,23)
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7.70n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat recombinant GluR1 expressed in Sf9 cells


J Med Chem 50: 2408-14 (2007)


Article DOI: 10.1021/jm061439q
BindingDB Entry DOI: 10.7270/Q2DZ0809
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50166287
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-isopropyl-2H-5-tetr...)
Show SMILES CC(C)n1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1S/C10H14N6O4/c1-4(2)16-13-8(12-15-16)7-5(9(17)14-20-7)3-6(11)10(18)19/h4,6H,3,11H2,1-2H3,(H,14,17)(H,18,19)
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10n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat recombinant GluR1 expressed in Sf9 cells


J Med Chem 50: 2408-14 (2007)


Article DOI: 10.1021/jm061439q
BindingDB Entry DOI: 10.7270/Q2DZ0809
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194124
PNG
((S)-N-(1-(5-(6-aminohexylamino)pentylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCCN
Show InChI InChI=1S/C24H42N4O3/c1-2-10-23(30)28-22(19-20-11-13-21(29)14-12-20)24(31)27-18-9-5-8-17-26-16-7-4-3-6-15-25/h11-14,22,26,29H,2-10,15-19,25H2,1H3,(H,27,31)(H,28,30)/t22-/m0/s1
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10n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194127
PNG
((S)-N-(1-(5-(7-aminoheptylamino)pentylamino)-3-(4-...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCCCN
Show InChI InChI=1S/C25H44N4O3/c1-2-11-24(31)29-23(20-21-12-14-22(30)15-13-21)25(32)28-19-10-6-9-18-27-17-8-5-3-4-7-16-26/h12-15,23,27,30H,2-11,16-20,26H2,1H3,(H,28,32)(H,29,31)/t23-/m0/s1
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10n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194123
PNG
((S)-N-(1-(5-(5-aminopentylamino)pentylamino)-3-(4-...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCN
Show InChI InChI=1S/C23H40N4O3/c1-2-9-22(29)27-21(18-19-10-12-20(28)13-11-19)23(30)26-17-8-4-7-16-25-15-6-3-5-14-24/h10-13,21,25,28H,2-9,14-18,24H2,1H3,(H,26,30)(H,27,29)/t21-/m0/s1
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13n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194113
PNG
((S)-N-(1-(5-(4-aminobutylamino)pentylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCN
Show InChI InChI=1S/C22H38N4O3/c1-2-8-21(28)26-20(17-18-9-11-19(27)12-10-18)22(29)25-16-6-3-5-14-24-15-7-4-13-23/h9-12,20,24,27H,2-8,13-17,23H2,1H3,(H,25,29)(H,26,28)/t20-/m0/s1
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13n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194118
PNG
((S)-N-(1-(5-(3-aminopropylamino)pentylamino)-3-(4-...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCN
Show InChI InChI=1S/C21H36N4O3/c1-2-7-20(27)25-19(16-17-8-10-18(26)11-9-17)21(28)24-15-5-3-4-13-23-14-6-12-22/h8-11,19,23,26H,2-7,12-16,22H2,1H3,(H,24,28)(H,25,27)/t19-/m0/s1
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14n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
GRIA1


(HUMAN)
BDBM50060635
PNG
((S)-2-Amino-3-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-p...)
Show SMILES N[C@@H](Cn1cc(F)c(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C7H8FN3O4/c8-3-1-11(2-4(9)6(13)14)7(15)10-5(3)12/h1,4H,2,9H2,(H,13,14)(H,10,12,15)/t4-/m0/s1
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15n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from human Ionotropic glutamate receptor AMPA 1 expressed in HEK293 cells


J Med Chem 40: 3645-50 (1997)


Article DOI: 10.1021/jm9702387
BindingDB Entry DOI: 10.7270/Q28G8MCB
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50002370
PNG
((R,S)-alpha-amino-3-hydroxy-5-methyl-4-isooxazole-...)
Show SMILES Cc1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)
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21.9n/an/an/an/an/an/an/an/a



European Research Centre for Drug Discovery and Development (NatSynDrugs)

Curated by ChEMBL


Assay Description
Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR1 expressed in Sf9 cells


J Med Chem 51: 6614-8 (2008)


Article DOI: 10.1021/jm800865a
BindingDB Entry DOI: 10.7270/Q261117R
More data for this
Ligand-Target Pair
GRIA1


(HUMAN)
BDBM17662
PNG
((2S)-2-amino-3-(3-hydroxy-5-methyl-1,2-oxazol-4-yl...)
Show SMILES Cc1o[nH]c(=O)c1C[C@H](N)C(O)=O
Show InChI InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)/t5-/m0/s1
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21.9n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Binding affinity for ionotropic Glutamate receptor AMPA 1 expressed in Sf9 cells


J Med Chem 48: 3438-42 (2005)


Article DOI: 10.1021/jm050014l
BindingDB Entry DOI: 10.7270/Q2H70FBJ
More data for this
Ligand-Target Pair
GRIA1


(HUMAN)
BDBM50002370
PNG
((R,S)-alpha-amino-3-hydroxy-5-methyl-4-isooxazole-...)
Show SMILES Cc1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)
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22n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined towards cloned Ionotropic glutamate receptor AMPA 1 (GluR1) expressed in Sf 9 insect cells


J Med Chem 46: 2246-9 (2003)


Article DOI: 10.1021/jm020588f
BindingDB Entry DOI: 10.7270/Q26T0M06
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM17662
PNG
((2S)-2-amino-3-(3-hydroxy-5-methyl-1,2-oxazol-4-yl...)
Show SMILES Cc1o[nH]c(=O)c1C[C@H](N)C(O)=O
Show InChI InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)/t5-/m0/s1
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22n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H[AMPA from rat recombinant GluA1o expressed in sS9 cells


J Med Chem 53: 8354-8361 (2010)


Article DOI: 10.1021/jm101218a
BindingDB Entry DOI: 10.7270/Q20Z73HW
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194111
PNG
((S)-N-(1-(5-(10-aminodecylamino)pentylamino)-3-(4-...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCCCCCCN
Show InChI InChI=1S/C28H50N4O3/c1-2-14-27(34)32-26(23-24-15-17-25(33)18-16-24)28(35)31-22-13-9-12-21-30-20-11-8-6-4-3-5-7-10-19-29/h15-18,26,30,33H,2-14,19-23,29H2,1H3,(H,31,35)(H,32,34)/t26-/m0/s1
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26n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
GRIA1


(HUMAN)
BDBM50060630
PNG
((S)-2-Amino-3-(6-bromo-3,5-dioxo-4,5-dihydro-3H-[1...)
Show SMILES N[C@@H](Cn1nc(Br)c(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C6H7BrN4O4/c7-3-4(12)9-6(15)11(10-3)1-2(8)5(13)14/h2H,1,8H2,(H,13,14)(H,9,12,15)/t2-/m0/s1
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29n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from human Ionotropic glutamate receptor AMPA 1 expressed in HEK293 cells


J Med Chem 40: 3645-50 (1997)


Article DOI: 10.1021/jm9702387
BindingDB Entry DOI: 10.7270/Q28G8MCB
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50252873
PNG
(2-amino-3-(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-...)
Show SMILES NC(Cn1cc(Br)c(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C7H8BrN3O4/c8-3-1-11(2-4(9)6(13)14)7(15)10-5(3)12/h1,4H,2,9H2,(H,13,14)(H,10,12,15)
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35n/an/an/an/an/an/an/an/a



European Research Centre for Drug Discovery and Development (NatSynDrugs)

Curated by ChEMBL


Assay Description
Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR1 expressed in Sf9 cells


J Med Chem 51: 6614-8 (2008)


Article DOI: 10.1021/jm800865a
BindingDB Entry DOI: 10.7270/Q261117R
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194109
PNG
((S)-N-(1-(5-(8-aminooctylamino)pentylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCCCCN
Show InChI InChI=1S/C26H46N4O3/c1-2-12-25(32)30-24(21-22-13-15-23(31)16-14-22)26(33)29-20-11-7-10-19-28-18-9-6-4-3-5-8-17-27/h13-16,24,28,31H,2-12,17-21,27H2,1H3,(H,29,33)(H,30,32)/t24-/m0/s1
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37n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194114
PNG
((S)-N-(1-(9-(6-aminohexylamino)nonylamino)-3-(4-hy...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCCCCCNCCCCCCN
Show InChI InChI=1S/C28H50N4O3/c1-2-14-27(34)32-26(23-24-15-17-25(33)18-16-24)28(35)31-22-13-8-5-3-4-7-11-20-30-21-12-9-6-10-19-29/h15-18,26,30,33H,2-14,19-23,29H2,1H3,(H,31,35)(H,32,34)/t26-/m0/s1
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37n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50060632
PNG
((S)-2-Amino-3-(5-chloro-2,4-dioxo-3,4-dihydro-2H-p...)
Show SMILES N[C@@H](Cn1cc(Cl)c(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C7H8ClN3O4/c8-3-1-11(2-4(9)6(13)14)7(15)10-5(3)12/h1,4H,2,9H2,(H,13,14)(H,10,12,15)/t4-/m0/s1
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37n/an/an/an/an/an/an/an/a



European Research Centre for Drug Discovery and Development (NatSynDrugs)

Curated by ChEMBL


Assay Description
Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR1 expressed in Sf9 cells


J Med Chem 51: 6614-8 (2008)


Article DOI: 10.1021/jm800865a
BindingDB Entry DOI: 10.7270/Q261117R
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194119
PNG
((S)-N-(1-(4-(7-aminoheptylamino)butylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCNCCCCCCCN
Show InChI InChI=1S/C24H42N4O3/c1-2-10-23(30)28-22(19-20-11-13-21(29)14-12-20)24(31)27-18-9-8-17-26-16-7-5-3-4-6-15-25/h11-14,22,26,29H,2-10,15-19,25H2,1H3,(H,27,31)(H,28,30)/t22-/m0/s1
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38n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
GRIA1


(HUMAN)
BDBM50122093
PNG
(CHEMBL152879 | N-[1-[4-(7-Amino-heptylamino)-butyl...)
Show SMILES CCCC(=O)NC(Cc1ccc(O)cc1)C(=O)NCCCCNCCCCCCCN
Show InChI InChI=1S/C24H42N4O3/c1-2-10-23(30)28-22(19-20-11-13-21(29)14-12-20)24(31)27-18-9-8-17-26-16-7-5-3-4-6-15-25/h11-14,22,26,29H,2-10,15-19,25H2,1H3,(H,27,31)(H,28,30)
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38n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of the (-80 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.


J Med Chem 45: 5745-54 (2002)


Article DOI: 10.1021/jm020314s
BindingDB Entry DOI: 10.7270/Q2BP025P
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50252922
PNG
((S)-1-(2'-Amino-2'-carboxyethyl)thieno[3,2-d]pyrim...)
Show SMILES N[C@@H](Cn1c2ccsc2c(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C9H9N3O4S/c10-4(8(14)15)3-12-5-1-2-17-6(5)7(13)11-9(12)16/h1-2,4H,3,10H2,(H,14,15)(H,11,13,16)/t4-/m0/s1
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50n/an/an/an/an/an/an/an/a



European Research Centre for Drug Discovery and Development (NatSynDrugs)

Curated by ChEMBL


Assay Description
Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR1 expressed in Sf9 cells


J Med Chem 51: 6614-8 (2008)


Article DOI: 10.1021/jm800865a
BindingDB Entry DOI: 10.7270/Q261117R
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194120
PNG
((S)-N-(1-(4-(6-aminohexylamino)butylamino)-3-(4-hy...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCNCCCCCCN
Show InChI InChI=1S/C23H40N4O3/c1-2-9-22(29)27-21(18-19-10-12-20(28)13-11-19)23(30)26-17-8-7-16-25-15-6-4-3-5-14-24/h10-13,21,25,28H,2-9,14-18,24H2,1H3,(H,26,30)(H,27,29)/t21-/m0/s1
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53n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50252920
PNG
((S)-1-[2'-Amino-2'-carboxyethyl]-5,7-dihydrothieno...)
Show SMILES N[C@@H](Cn1c2CSCc2c(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C9H11N3O4S/c10-5(8(14)15)1-12-6-3-17-2-4(6)7(13)11-9(12)16/h5H,1-3,10H2,(H,14,15)(H,11,13,16)/t5-/m0/s1
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58n/an/an/an/an/an/an/an/a



European Research Centre for Drug Discovery and Development (NatSynDrugs)

Curated by ChEMBL


Assay Description
Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR1 expressed in Sf9 cells


J Med Chem 51: 6614-8 (2008)


Article DOI: 10.1021/jm800865a
BindingDB Entry DOI: 10.7270/Q261117R
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194118
PNG
((S)-N-(1-(5-(3-aminopropylamino)pentylamino)-3-(4-...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCN
Show InChI InChI=1S/C21H36N4O3/c1-2-7-20(27)25-19(16-17-8-10-18(26)11-9-17)21(28)24-15-5-3-4-13-23-14-6-12-22/h8-11,19,23,26H,2-7,12-16,22H2,1H3,(H,24,28)(H,25,27)/t19-/m0/s1
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63n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
GRIA1


(HUMAN)
BDBM50122084
PNG
(CHEMBL153996 | N-[1-[8-(3-Amino-propylamino)-octyl...)
Show SMILES NCCCNCCCCCCCCNC(=O)C(Cc1ccc(O)cc1)NC(=O)c1ccncc1
Show InChI InChI=1S/C26H39N5O3/c27-14-7-16-28-15-5-3-1-2-4-6-17-30-26(34)24(20-21-8-10-23(32)11-9-21)31-25(33)22-12-18-29-19-13-22/h8-13,18-19,24,28,32H,1-7,14-17,20,27H2,(H,30,34)(H,31,33)
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64n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of the (-80 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.


J Med Chem 45: 5745-54 (2002)


Article DOI: 10.1021/jm020314s
BindingDB Entry DOI: 10.7270/Q2BP025P
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194117
PNG
((S)-N-(1-(5-(9-aminononylamino)pentylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCCCCCN
Show InChI InChI=1S/C27H48N4O3/c1-2-13-26(33)31-25(22-23-14-16-24(32)17-15-23)27(34)30-21-12-8-11-20-29-19-10-7-5-3-4-6-9-18-28/h14-17,25,29,32H,2-13,18-22,28H2,1H3,(H,30,34)(H,31,33)/t25-/m0/s1
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65n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194122
PNG
((S)-N-(1-(8-(3-aminopropylamino)octylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCCCCNCCCN
Show InChI InChI=1S/C24H42N4O3/c1-2-10-23(30)28-22(19-20-11-13-21(29)14-12-20)24(31)27-18-8-6-4-3-5-7-16-26-17-9-15-25/h11-14,22,26,29H,2-10,15-19,25H2,1H3,(H,27,31)(H,28,30)/t22-/m0/s1
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65n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
GRIA1


(HUMAN)
BDBM50060632
PNG
((S)-2-Amino-3-(5-chloro-2,4-dioxo-3,4-dihydro-2H-p...)
Show SMILES N[C@@H](Cn1cc(Cl)c(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C7H8ClN3O4/c8-3-1-11(2-4(9)6(13)14)7(15)10-5(3)12/h1,4H,2,9H2,(H,13,14)(H,10,12,15)/t4-/m0/s1
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65n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from human Ionotropic glutamate receptor AMPA 1 expressed in HEK293 cells


J Med Chem 40: 3645-50 (1997)


Article DOI: 10.1021/jm9702387
BindingDB Entry DOI: 10.7270/Q28G8MCB
More data for this
Ligand-Target Pair
GRIA1


(HUMAN)
BDBM50122090
PNG
(CHEMBL147182 | N-[1-[8-(3-Amino-propylamino)-octyl...)
Show SMILES CCCC(=O)NC(Cc1ccc(O)cc1)C(=O)NCCCCCCCCNCCCN
Show InChI InChI=1S/C24H42N4O3/c1-2-10-23(30)28-22(19-20-11-13-21(29)14-12-20)24(31)27-18-8-6-4-3-5-7-16-26-17-9-15-25/h11-14,22,26,29H,2-10,15-19,25H2,1H3,(H,27,31)(H,28,30)
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65n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of the (-80 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.


J Med Chem 45: 5745-54 (2002)


Article DOI: 10.1021/jm020314s
BindingDB Entry DOI: 10.7270/Q2BP025P
More data for this
Ligand-Target Pair
GRIA1


(HUMAN)
BDBM50122096
PNG
(CHEMBL152410 | Hexanoic acid [1-[8-(3-amino-propyl...)
Show SMILES CCCCCC(=O)NC(Cc1ccc(O)cc1)C(=O)NCCCCCCCCNCCCN
Show InChI InChI=1S/C26H46N4O3/c1-2-3-8-12-25(32)30-24(21-22-13-15-23(31)16-14-22)26(33)29-20-10-7-5-4-6-9-18-28-19-11-17-27/h13-16,24,28,31H,2-12,17-21,27H2,1H3,(H,29,33)(H,30,32)
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68n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of the (-80 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.


J Med Chem 45: 5745-54 (2002)


Article DOI: 10.1021/jm020314s
BindingDB Entry DOI: 10.7270/Q2BP025P
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194113
PNG
((S)-N-(1-(5-(4-aminobutylamino)pentylamino)-3-(4-h...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCN
Show InChI InChI=1S/C22H38N4O3/c1-2-8-21(28)26-20(17-18-9-11-19(27)12-10-18)22(29)25-16-6-3-5-14-24-15-7-4-13-23/h9-12,20,24,27H,2-8,13-17,23H2,1H3,(H,25,29)(H,26,28)/t20-/m0/s1
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68n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
GRIA1


(HUMAN)
BDBM50060629
PNG
((S)-2-Amino-3-(6-iodo-3,5-dioxo-4,5-dihydro-3H-[1,...)
Show SMILES N[C@@H](Cn1nc(I)c(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C6H7IN4O4/c7-3-4(12)9-6(15)11(10-3)1-2(8)5(13)14/h2H,1,8H2,(H,13,14)(H,9,12,15)/t2-/m0/s1
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74n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from human Ionotropic glutamate receptor AMPA 1 expressed in HEK293 cells


J Med Chem 40: 3645-50 (1997)


Article DOI: 10.1021/jm9702387
BindingDB Entry DOI: 10.7270/Q28G8MCB
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194126
PNG
((S)-N-(1-(8-(6-aminohexylamino)octylamino)-3-(4-hy...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCCCCNCCCCCCN
Show InChI InChI=1S/C27H48N4O3/c1-2-13-26(33)31-25(22-23-14-16-24(32)17-15-23)27(34)30-21-12-7-4-3-6-10-19-29-20-11-8-5-9-18-28/h14-17,25,29,32H,2-13,18-22,28H2,1H3,(H,30,34)(H,31,33)/t25-/m0/s1
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77n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194112
PNG
((S)-N-(1-(5-(12-aminododecylamino)pentylamino)-3-(...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCCCCCCCCN
Show InChI InChI=1S/C30H54N4O3/c1-2-16-29(36)34-28(25-26-17-19-27(35)20-18-26)30(37)33-24-15-11-14-23-32-22-13-10-8-6-4-3-5-7-9-12-21-31/h17-20,28,32,35H,2-16,21-25,31H2,1H3,(H,33,37)(H,34,36)/t28-/m0/s1
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77n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
GRIA1


(HUMAN)
BDBM50122087
PNG
(CHEMBL153995 | Cyclohexanecarboxylic acid [1-[8-(3...)
Show SMILES NCCCNCCCCCCCCNC(=O)C(Cc1ccc(O)cc1)NC(=O)C1CCCCC1
Show InChI InChI=1S/C27H46N4O3/c28-17-10-19-29-18-8-3-1-2-4-9-20-30-27(34)25(21-22-13-15-24(32)16-14-22)31-26(33)23-11-6-5-7-12-23/h13-16,23,25,29,32H,1-12,17-21,28H2,(H,30,34)(H,31,33)
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78n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of the (-80 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.


J Med Chem 45: 5745-54 (2002)


Article DOI: 10.1021/jm020314s
BindingDB Entry DOI: 10.7270/Q2BP025P
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50060627
PNG
((S)-2-Amino-3-(5-iodo-2,4-dioxo-3,4-dihydro-2H-pyr...)
Show SMILES N[C@@H](Cn1cc(I)c(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C7H8IN3O4/c8-3-1-11(2-4(9)6(13)14)7(15)10-5(3)12/h1,4H,2,9H2,(H,13,14)(H,10,12,15)/t4-/m0/s1
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83n/an/an/an/an/an/an/an/a



European Research Centre for Drug Discovery and Development (NatSynDrugs)

Curated by ChEMBL


Assay Description
Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR1 expressed in Sf9 cells


J Med Chem 51: 6614-8 (2008)


Article DOI: 10.1021/jm800865a
BindingDB Entry DOI: 10.7270/Q261117R
More data for this
Ligand-Target Pair
GRIA1


(HUMAN)
BDBM50122085
PNG
(CHEMBL152425 | N-[1-[8-(3-Amino-propylamino)-octyl...)
Show SMILES NCCCNCCCCCCCCNC(=O)C(Cc1ccc(O)cc1)NC(=O)c1cccnc1
Show InChI InChI=1S/C26H39N5O3/c27-14-8-17-28-15-5-3-1-2-4-6-18-30-26(34)24(19-21-10-12-23(32)13-11-21)31-25(33)22-9-7-16-29-20-22/h7,9-13,16,20,24,28,32H,1-6,8,14-15,17-19,27H2,(H,30,34)(H,31,33)
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88n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of the (-80 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.


J Med Chem 45: 5745-54 (2002)


Article DOI: 10.1021/jm020314s
BindingDB Entry DOI: 10.7270/Q2BP025P
More data for this
Ligand-Target Pair
GRIA1


(HUMAN)
BDBM50122086
PNG
(CHEMBL269192 | N-[1-[8-(3-Amino-propylamino)-octyl...)
Show SMILES CC(C)(C)C(=O)NC(Cc1ccc(O)cc1)C(=O)NCCCCCCCCNCCCN
Show InChI InChI=1S/C25H44N4O3/c1-25(2,3)24(32)29-22(19-20-11-13-21(30)14-12-20)23(31)28-18-9-7-5-4-6-8-16-27-17-10-15-26/h11-14,22,27,30H,4-10,15-19,26H2,1-3H3,(H,28,31)(H,29,32)
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90n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of the (-80 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.


J Med Chem 45: 5745-54 (2002)


Article DOI: 10.1021/jm020314s
BindingDB Entry DOI: 10.7270/Q2BP025P
More data for this
Ligand-Target Pair
GRIA1


(HUMAN)
BDBM50060636
PNG
((S)-2-Amino-3-(5-bromo-2,4-dioxo-3,4-dihydro-2H-py...)
Show SMILES N[C@@H](Cn1cc(Br)c(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C7H8BrN3O4/c8-3-1-11(2-4(9)6(13)14)7(15)10-5(3)12/h1,4H,2,9H2,(H,13,14)(H,10,12,15)/t4-/m0/s1
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92n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from human Ionotropic glutamate receptor AMPA 1 expressed in HEK293 cells


J Med Chem 40: 3645-50 (1997)


Article DOI: 10.1021/jm9702387
BindingDB Entry DOI: 10.7270/Q28G8MCB
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50194123
PNG
((S)-N-(1-(5-(5-aminopentylamino)pentylamino)-3-(4-...)
Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCN
Show InChI InChI=1S/C23H40N4O3/c1-2-9-22(29)27-21(18-19-10-12-20(28)13-11-19)23(30)26-17-8-4-7-16-25-15-6-3-5-14-24/h10-13,21,25,28H,2-9,14-18,24H2,1H3,(H,26,30)(H,27,29)/t21-/m0/s1
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95n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte assessed as inhibition of glutamate-induced current at holding potentia...


J Med Chem 49: 5414-23 (2006)


Article DOI: 10.1021/jm060606j
BindingDB Entry DOI: 10.7270/Q24X57FS
More data for this
Ligand-Target Pair
GRIA1


(HUMAN)
BDBM50122095
PNG
(CHEMBL355977 | N-[8-(3-Amino-propylamino)-octyl]-3...)
Show SMILES CCC(=O)NC(Cc1ccc(O)cc1)C(=O)NCCCCCCCCNCCCN
Show InChI InChI=1S/C23H40N4O3/c1-2-22(29)27-21(18-19-10-12-20(28)13-11-19)23(30)26-17-8-6-4-3-5-7-15-25-16-9-14-24/h10-13,21,25,28H,2-9,14-18,24H2,1H3,(H,26,30)(H,27,29)
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100n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of the (-80 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.


J Med Chem 45: 5745-54 (2002)


Article DOI: 10.1021/jm020314s
BindingDB Entry DOI: 10.7270/Q2BP025P
More data for this
Ligand-Target Pair
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