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Found 267 hits Enz. Inhib. hit(s) with Target = 'MALT lymphoma-associated translocation (MALT1)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355969
PNG
((S)-1-(5-chloro-6- (difluoromethoxy) pyridin-3-yl)...)
Show SMILES CO[C@@H](C)c1c(NC(=O)Nc2cnc(OC(F)F)c(Cl)c2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C16H14Cl2F2N6O3/c1-7(28-2)13-10(6-21-12-4-11(18)25-26(12)13)24-16(27)23-8-3-9(17)14(22-5-8)29-15(19)20/h3-7,15H,1-2H3,(H2,23,24,27)/t7-/m0/s1
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n/an/a 0.00100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.066
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355980
PNG
(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES Cc1cc2ncc(NC(=O)Nc3cnc(c(Cl)c3)-n3nccn3)c(n2n1)C1(C)CCCO1
Show InChI InChI=1S/C20H20ClN9O2/c1-12-8-16-22-11-15(17(29(16)28-12)20(2)4-3-7-32-20)27-19(31)26-13-9-14(21)18(23-10-13)30-24-5-6-25-30/h5-6,8-11H,3-4,7H2,1-2H3,(H2,26,27,31)
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Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.066
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355971
PNG
((S)-1-(5-chloro-6- (2H-1,2,3-triazol-2- yl)pyridin...)
Show SMILES CO[C@@H](C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(F)nn12
Show InChI InChI=1S/C17H15ClFN9O2/c1-9(30-2)15-12(8-20-14-6-13(19)26-27(14)15)25-17(29)24-10-5-11(18)16(21-7-10)28-22-3-4-23-28/h3-9H,1-2H3,(H2,24,25,29)/t9-/m0/s1
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n/an/a 0.00200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.066
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355970
PNG
((S)-1-(6-(2H-1,2,3- triazol-2-yl)-5- (trifluoromet...)
Show SMILES CO[C@@H](C)c1c(NC(=O)Nc2cnc(c(c2)C(F)(F)F)-n2nccn2)cnc2cc(F)nn12
Show InChI InChI=1S/C18H15F4N9O2/c1-9(33-2)15-12(8-23-14-6-13(19)29-30(14)15)28-17(32)27-10-5-11(18(20,21)22)16(24-7-10)31-25-3-4-26-31/h3-9H,1-2H3,(H2,27,28,32)/t9-/m0/s1
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Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.066
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355967
PNG
(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES COCC1(CCCO1)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C20H19Cl2N9O3/c1-33-11-20(3-2-6-34-20)17-14(10-23-16-8-15(22)29-30(16)17)28-19(32)27-12-7-13(21)18(24-9-12)31-25-4-5-26-31/h4-5,7-10H,2-3,6,11H2,1H3,(H2,27,28,32)
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Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.066
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355950
PNG
((S)-1-(5-chloro-6- (2H-1,2,3-triazol-2- yl)pyridin...)
Show SMILES CO[C@@H](C(C)C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C19H19Cl2N9O2/c1-10(2)17(32-3)16-13(9-22-15-7-14(21)28-29(15)16)27-19(31)26-11-6-12(20)18(23-8-11)30-24-4-5-25-30/h4-10,17H,1-3H3,(H2,26,27,31)/t17-/m0/s1
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n/an/a 0.00200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.066
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355892
PNG
(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES CC1(CC1)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C18H15Cl2N9O/c1-18(2-3-18)15-12(9-21-14-7-13(20)27-28(14)15)26-17(30)25-10-6-11(19)16(22-8-10)29-23-4-5-24-29/h4-9H,2-3H2,1H3,(H2,25,26,30)
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Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.066
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355889
PNG
((S)-methyl 3-chloro- 5-(3-(2-chloro-7-(1- methoxye...)
Show SMILES CO[C@@H](C)c1c(NC(=O)Nc2cc(Cl)cc(c2)C(=O)OC)cnc2cc(Cl)nn12
Show InChI InChI=1S/C18H17Cl2N5O4/c1-9(28-2)16-13(8-21-15-7-14(20)24-25(15)16)23-18(27)22-12-5-10(17(26)29-3)4-11(19)6-12/h4-9H,1-3H3,(H2,22,23,27)/t9-/m0/s1
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Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.066
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355886
PNG
((S)-1-(5-chloro-6- (2H-1,2,3-triazol-2- yl)pyridin...)
Show SMILES CO[C@@H](C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C17H15Cl2N9O2/c1-9(30-2)15-12(8-20-14-6-13(19)26-27(14)15)25-17(29)24-10-5-11(18)16(21-7-10)28-22-3-4-23-28/h3-9H,1-2H3,(H2,24,25,29)/t9-/m0/s1
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Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.066
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355885
PNG
((S)-1-(5-chloro-6- methoxypyridin-3- yl)-3-(2-chlo...)
Show SMILES CO[C@@H](C)c1c(NC(=O)Nc2cnc(OC)c(Cl)c2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C16H16Cl2N6O3/c1-8(26-2)14-11(7-19-13-5-12(18)23-24(13)14)22-16(25)21-9-4-10(17)15(27-3)20-6-9/h4-8H,1-3H3,(H2,21,22,25)/t8-/m0/s1
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Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.066
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM50169049
PNG
(CHEMBL3806155 | US10442808, Example 1 | US9815842,...)
Show SMILES CO[C@@H](C)c1c(NC(=O)Nc2cnc(c(c2)C(F)(F)F)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C18H15ClF3N9O2/c1-9(33-2)15-12(8-23-14-6-13(19)29-30(14)15)28-17(32)27-10-5-11(18(20,21)22)16(24-7-10)31-25-3-4-26-31/h3-9H,1-2H3,(H2,27,28,32)/t9-/m0/s1
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Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.066
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM50169049
PNG
(CHEMBL3806155 | US10442808, Example 1 | US9815842,...)
Show SMILES CO[C@@H](C)c1c(NC(=O)Nc2cnc(c(c2)C(F)(F)F)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C18H15ClF3N9O2/c1-9(33-2)15-12(8-23-14-6-13(19)29-30(14)15)28-17(32)27-10-5-11(18(20,21)22)16(24-7-10)31-25-3-4-26-31/h3-9H,1-2H3,(H2,27,28,32)/t9-/m0/s1
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n/an/a 0.00200n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MALT1 C domain (329 to 824 residues) (unknown origin) using Ac-Trp-Leu-Arg-Ser-Arg-Cys(PT14)-NH2 as substrate preincubated for 60 mins ...


ACS Med Chem Lett 7: 205-6 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00015
BindingDB Entry DOI: 10.7270/Q2K07658
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355894
PNG
(1-(5-chloro-6- methoxypyridin-3- yl)-3-(2-chloro-7...)
Show SMILES COc1ncc(NC(=O)Nc2cnc3cc(Cl)nn3c2C(C)C)cc1Cl
Show InChI InChI=1S/C16H16Cl2N6O2/c1-8(2)14-11(7-19-13-5-12(18)23-24(13)14)22-16(25)21-9-4-10(17)15(26-3)20-6-9/h4-8H,1-3H3,(H2,21,22,25)
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Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.066
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355973
PNG
((S)-1-(5-chloro-6- (difluoromethoxy)py- ridin-3-yl...)
Show SMILES COCCO[C@@H](C)c1c(NC(=O)Nc2cnc(OC(F)F)c(Cl)c2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C18H18Cl2F2N6O4/c1-9(31-4-3-30-2)15-12(8-23-14-6-13(20)27-28(14)15)26-18(29)25-10-5-11(19)16(24-7-10)32-17(21)22/h5-9,17H,3-4H2,1-2H3,(H2,25,26,29)/t9-/m0/s1
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Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.066
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355896
PNG
(1-(3-chloro-4-(2H- 1,2,3-triazol-2- yl)phenyl)-3-(...)
Show SMILES CC(C)c1c(NC(=O)Nc2ccc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C18H16Cl2N8O/c1-10(2)17-13(9-21-16-8-15(20)26-27(16)17)25-18(29)24-11-3-4-14(12(19)7-11)28-22-5-6-23-28/h3-10H,1-2H3,(H2,24,25,29)
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Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.066
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355897
PNG
(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES CC(C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C17H15Cl2N9O/c1-9(2)15-12(8-20-14-6-13(19)26-27(14)15)25-17(29)24-10-5-11(18)16(21-7-10)28-22-3-4-23-28/h3-9H,1-2H3,(H2,24,25,29)
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Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.066
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355895
PNG
(1-(2-chloro-7- isopropylpyrazolo[1, 5-a]pyrimidin-...)
Show SMILES CC(C)c1c(NC(=O)Nc2ccc(c(c2)C#N)-n2cnc(C)n2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C20H18ClN9O/c1-11(2)19-15(9-23-18-7-17(21)28-30(18)19)26-20(31)25-14-4-5-16(13(6-14)8-22)29-10-24-12(3)27-29/h4-7,9-11H,1-3H3,(H2,25,26,31)
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US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.066
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355987
PNG
((R)-1-(6-(2H-1,2,3- triazol-2-yl)-5- (trifluoromet...)
Show SMILES COC[C@H](C)c1c(NC(=O)Nc2cnc(c(c2)C(F)(F)F)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C19H17ClF3N9O2/c1-10(9-34-2)16-13(8-24-15-6-14(20)30-31(15)16)29-18(33)28-11-5-12(19(21,22)23)17(25-7-11)32-26-3-4-27-32/h3-8,10H,9H2,1-2H3,(H2,28,29,33)/t10-/m0/s1
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Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.066
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355925
PNG
(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES COC(c1ccccc1)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C22H17Cl2N9O2/c1-35-20(13-5-3-2-4-6-13)19-16(12-25-18-10-17(24)31-32(18)19)30-22(34)29-14-9-15(23)21(26-11-14)33-27-7-8-28-33/h2-12,20H,1H3,(H2,29,30,34)
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Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.066
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355948
PNG
(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES Cc1cc2ncc(NC(=O)Nc3cnc(c(Cl)c3)-n3nccn3)c(n2n1)C1(C)CC1
Show InChI InChI=1S/C19H18ClN9O/c1-11-7-15-21-10-14(16(28(15)27-11)19(2)3-4-19)26-18(30)25-12-8-13(20)17(22-9-12)29-23-5-6-24-29/h5-10H,3-4H2,1-2H3,(H2,25,26,30)
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Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.066
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355978
PNG
(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES C[C@H](OC[C@H]1CCOC1)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C21H21Cl2N9O3/c1-12(35-11-13-2-5-34-10-13)19-16(9-24-18-7-17(23)30-31(18)19)29-21(33)28-14-6-15(22)20(25-8-14)32-26-3-4-27-32/h3-4,6-9,12-13H,2,5,10-11H2,1H3,(H2,28,29,33)/t12-,13-/m0/s1
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Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.066
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355890
PNG
(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES COC(C)(C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C18H17Cl2N9O2/c1-18(2,31-3)15-12(9-21-14-7-13(20)27-28(14)15)26-17(30)25-10-6-11(19)16(22-8-10)29-23-4-5-24-29/h4-9H,1-3H3,(H2,25,26,30)
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Novartis AG

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Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.066
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355965
PNG
((S)-1-(2-chloro-7-(1- methoxyethyl)pyrazo- lo[1,5-...)
Show SMILES CO[C@@H](C)c1c(NC(=O)Nc2cnc(c(c2)C(F)F)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C18H16ClF2N9O2/c1-9(32-2)15-12(8-22-14-6-13(19)28-29(14)15)27-18(31)26-10-5-11(16(20)21)17(23-7-10)30-24-3-4-25-30/h3-9,16H,1-2H3,(H2,26,27,31)/t9-/m0/s1
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Novartis AG

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Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.066
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355921
PNG
((R)-1-(5-chloro-6- (2H-1,2,3-triazol-2- yl)pyridin...)
Show SMILES COC[C@H](C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C18H17Cl2N9O2/c1-10(9-31-2)16-13(8-21-15-6-14(20)27-28(15)16)26-18(30)25-11-5-12(19)17(22-7-11)29-23-3-4-24-29/h3-8,10H,9H2,1-2H3,(H2,25,26,30)/t10-/m0/s1
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Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.066
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355906
PNG
(1-(2-chloro-7- isopropylpyrazolo[1, 5-a]pyrimidin-...)
Show SMILES CC(C)c1c(NC(=O)Nc2cc(Cl)c(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C18H15Cl3N8O/c1-9(2)16-13(8-22-15-7-14(21)27-28(15)16)26-18(30)25-10-5-11(19)17(12(20)6-10)29-23-3-4-24-29/h3-9H,1-2H3,(H2,25,26,30)
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Novartis AG

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Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.066
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355911
PNG
(1-(7-(sec-butyl)-2- chloropyrazolo[1,5- a]pyrimidi...)
Show SMILES CCC(C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C18H17Cl2N9O/c1-3-10(2)16-13(9-21-15-7-14(20)27-28(15)16)26-18(30)25-11-6-12(19)17(22-8-11)29-23-4-5-24-29/h4-10H,3H2,1-2H3,(H2,25,26,30)
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Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.066
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355915
PNG
((S)-1-(5-chloro-6- (2H-1,2,3-triazol-2- yl)pyridin...)
Show SMILES COCCO[C@@H](C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C19H19Cl2N9O3/c1-11(33-6-5-32-2)17-14(10-22-16-8-15(21)28-29(16)17)27-19(31)26-12-7-13(20)18(23-9-12)30-24-3-4-25-30/h3-4,7-11H,5-6H2,1-2H3,(H2,26,27,31)/t11-/m0/s1
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Novartis AG

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Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.066
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM50169052
PNG
(CHEMBL3806235 | US10442808, Example 54 | US9815842...)
Show SMILES FC(F)(F)c1cc(NC(=O)Nc2cnc3cc(Cl)nn3c2C2CCCO2)cnc1-n1nccn1
Show InChI InChI=1S/C19H15ClF3N9O2/c20-14-7-15-24-9-12(16(31(15)30-14)13-2-1-5-34-13)29-18(33)28-10-6-11(19(21,22)23)17(25-8-10)32-26-3-4-27-32/h3-4,6-9,13H,1-2,5H2,(H2,28,29,33)
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Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MALT1 C domain (329 to 824 residues) (unknown origin) using Ac-Trp-Leu-Arg-Ser-Arg-Cys(PT14)-NH2 as substrate preincubated for 60 mins ...


ACS Med Chem Lett 7: 205-6 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00015
BindingDB Entry DOI: 10.7270/Q2K07658
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355920
PNG
((S)-1-(5-chloro-6- (2H-1,2,3-triazol-2- yl)pyridin...)
Show SMILES COC[C@@H](C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C18H17Cl2N9O2/c1-10(9-31-2)16-13(8-21-15-6-14(20)27-28(15)16)26-18(30)25-11-5-12(19)17(22-7-11)29-23-3-4-24-29/h3-8,10H,9H2,1-2H3,(H2,25,26,30)/t10-/m1/s1
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Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.066
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355929
PNG
(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES COc1ccccc1-c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C21H15Cl2N9O2/c1-34-16-5-3-2-4-13(16)19-15(11-24-18-9-17(23)30-31(18)19)29-21(33)28-12-8-14(22)20(25-10-12)32-26-6-7-27-32/h2-11H,1H3,(H2,28,29,33)
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Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.066
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355878
PNG
((S)-1-(2-chloro-7-(1-methoxyethyl)pyrazolo[1,5-a]p...)
Show SMILES CO[C@@H](C)c1c(NC(=O)Nc2ccnc(c2)C(F)(F)F)cnc2cc(Cl)nn12
Show InChI InChI=1S/C16H14ClF3N6O2/c1-8(28-2)14-10(7-22-13-6-12(17)25-26(13)14)24-15(27)23-9-3-4-21-11(5-9)16(18,19)20/h3-8H,1-2H3,(H2,21,23,24,27)/t8-/m0/s1
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Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.066
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355910
PNG
(1-(7-(tert-butyl)-2- chloropyrazolo[1,5- a]pyrimid...)
Show SMILES CC(C)(C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C18H17Cl2N9O/c1-18(2,3)15-12(9-21-14-7-13(20)27-28(14)15)26-17(30)25-10-6-11(19)16(22-8-10)29-23-4-5-24-29/h4-9H,1-3H3,(H2,25,26,30)
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Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.066
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM50169052
PNG
(CHEMBL3806235 | US10442808, Example 54 | US9815842...)
Show SMILES FC(F)(F)c1cc(NC(=O)Nc2cnc3cc(Cl)nn3c2C2CCCO2)cnc1-n1nccn1
Show InChI InChI=1S/C19H15ClF3N9O2/c20-14-7-15-24-9-12(16(31(15)30-14)13-2-1-5-34-13)29-18(33)28-10-6-11(19(21,22)23)17(25-8-10)32-26-3-4-27-32/h3-4,6-9,13H,1-2,5H2,(H2,28,29,33)
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Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.066
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355899
PNG
(1-(4-(2- aminopyrimidin-4- yl)-3-chlorophenyl)- 3-...)
Show SMILES CC(C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-c2ccnc(N)n2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C19H17Cl2N9O/c1-9(2)17-13(8-24-15-6-14(21)29-30(15)17)28-19(31)26-10-5-11(20)16(25-7-10)12-3-4-23-18(22)27-12/h3-9H,1-2H3,(H2,22,23,27)(H2,26,28,31)
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Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.066
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355898
PNG
(1-(5-chloro-6-(4- methyl-2H-1,2,3- triazol-2-yl)py...)
Show SMILES CC(C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2ncc(C)n2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C18H17Cl2N9O/c1-9(2)16-13(8-21-15-5-14(20)27-28(15)16)25-18(30)24-11-4-12(19)17(22-7-11)29-23-6-10(3)26-29/h4-9H,1-3H3,(H2,24,25,30)
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Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.066
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355974
PNG
(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES CO[C@H](C)[C@H](OC)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C19H19Cl2N9O3/c1-10(32-2)17(33-3)16-13(9-22-15-7-14(21)28-29(15)16)27-19(31)26-11-6-12(20)18(23-8-11)30-24-4-5-25-30/h4-10,17H,1-3H3,(H2,26,27,31)/t10-,17+/m1/s1
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Novartis AG

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Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.066
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355977
PNG
(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES C[C@H](OC1CCOC1)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C20H19Cl2N9O3/c1-11(34-13-2-5-33-10-13)18-15(9-23-17-7-16(22)29-30(17)18)28-20(32)27-12-6-14(21)19(24-8-12)31-25-3-4-26-31/h3-4,6-9,11,13H,2,5,10H2,1H3,(H2,27,28,32)/t11-,13?/m0/s1
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Novartis AG

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Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.066
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355979
PNG
(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES C[C@H](OC[C@@H]1CCOC1)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C21H21Cl2N9O3/c1-12(35-11-13-2-5-34-10-13)19-16(9-24-18-7-17(23)30-31(18)19)29-21(33)28-14-6-15(22)20(25-8-14)32-26-3-4-27-32/h3-4,6-9,12-13H,2,5,10-11H2,1H3,(H2,28,29,33)/t12-,13+/m0/s1
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Novartis AG

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Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.066
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM356002
PNG
((R)-1-(5-chloro-6-(2H-1,2,3-triazol-2-yl)pyridin-3...)
Show SMILES COC[C@H](OC)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C18H17Cl2N9O3/c1-31-9-13(32-2)16-12(8-21-15-6-14(20)27-28(15)16)26-18(30)25-10-5-11(19)17(22-7-10)29-23-3-4-24-29/h3-8,13H,9H2,1-2H3,(H2,25,26,30)/t13-/m0/s1
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Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.066
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355881
PNG
((R)-1-(5-chloro-6-(2H-1,2,3-triazol-2-yl)pyridin-3...)
Show SMILES CO[C@H](C(C)C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C19H19Cl2N9O2/c1-10(2)17(32-3)16-13(9-22-15-7-14(21)28-29(15)16)27-19(31)26-11-6-12(20)18(23-8-11)30-24-4-5-25-30/h4-10,17H,1-3H3,(H2,26,27,31)/t17-/m1/s1
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Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.066
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355891
PNG
(1-(2-chloro-7-(2- methoxypropan-2- yl)pyrazolo[1,5...)
Show SMILES COC(C)(C)c1c(NC(=O)Nc2ccnc(c2)C(F)(F)F)cnc2cc(Cl)nn12
Show InChI InChI=1S/C17H16ClF3N6O2/c1-16(2,29-3)14-10(8-23-13-7-12(18)26-27(13)14)25-15(28)24-9-4-5-22-11(6-9)17(19,20)21/h4-8H,1-3H3,(H2,22,24,25,28)
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Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.066
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355900
PNG
(1-(5-chloro-1- methyl-6-oxo-2-(1H- pyrazol-1-yl)-1...)
Show SMILES CC(C)c1c(NC(=O)Nc2cc(Cl)c(=O)n(C)c2-n2cccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C19H18Cl2N8O2/c1-10(2)16-13(9-22-15-8-14(21)26-29(15)16)25-19(31)24-12-7-11(20)18(30)27(3)17(12)28-6-4-5-23-28/h4-10H,1-3H3,(H2,24,25,31)
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Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.066
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355901
PNG
(1-(5-chloro-6- ethoxypyridin-3-yl)- 3-(2-chloro-7-...)
Show SMILES CCOc1ncc(NC(=O)Nc2cnc3cc(Cl)nn3c2C(C)C)cc1Cl
Show InChI InChI=1S/C17H18Cl2N6O2/c1-4-27-16-11(18)5-10(7-21-16)22-17(26)23-12-8-20-14-6-13(19)24-25(14)15(12)9(2)3/h5-9H,4H2,1-3H3,(H2,22,23,26)
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Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.066
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355902
PNG
(1-(5-bromopyridin-3- yl)-3-(2-chloro-7- isopropylp...)
Show SMILES CC(C)c1c(NC(=O)Nc2cncc(Br)c2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C15H14BrClN6O/c1-8(2)14-11(7-19-13-4-12(17)22-23(13)14)21-15(24)20-10-3-9(16)5-18-6-10/h3-8H,1-2H3,(H2,20,21,24)
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Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.066
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355914
PNG
(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES Clc1cc2ncc(NC(=O)Nc3cnc(c(Cl)c3)-n3nccn3)c(C3CCC3)n2n1
Show InChI InChI=1S/C18H15Cl2N9O/c19-12-6-11(8-22-17(12)29-23-4-5-24-29)25-18(30)26-13-9-21-15-7-14(20)27-28(15)16(13)10-2-1-3-10/h4-10H,1-3H2,(H2,25,26,30)
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Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.066
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355928
PNG
(1-(4-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES Clc1cc2ncc(NC(=O)Nc3cnc(c(Cl)c3)-n3nccn3)c(C3CC3)n2n1
Show InChI InChI=1S/C17H13Cl2N9O/c18-11-5-10(7-21-16(11)28-22-3-4-23-28)24-17(29)25-12-8-20-14-6-13(19)26-27(14)15(12)9-1-2-9/h3-9H,1-2H2,(H2,24,25,29)
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Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.066
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355931
PNG
(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES CC1(CCOCC1)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C20H19Cl2N9O2/c1-20(2-6-33-7-3-20)17-14(11-23-16-9-15(22)29-30(16)17)28-19(32)27-12-8-13(21)18(24-10-12)31-25-4-5-26-31/h4-5,8-11H,2-3,6-7H2,1H3,(H2,27,28,32)
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Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.066
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355932
PNG
(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES COCC(OC)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C18H17Cl2N9O3/c1-31-9-13(32-2)16-12(8-21-15-6-14(20)27-28(15)16)26-18(30)25-10-5-11(19)17(22-7-10)29-23-3-4-24-29/h3-8,13H,9H2,1-2H3,(H2,25,26,30)
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Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.066
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355947
PNG
((S)-1-(5-chloro-6- (2H-1,2,3-triazol-2- yl)pyridin...)
Show SMILES CO[C@@H](C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(C)nn12
Show InChI InChI=1S/C18H18ClN9O2/c1-10-6-15-20-9-14(16(11(2)30-3)27(15)26-10)25-18(29)24-12-7-13(19)17(21-8-12)28-22-4-5-23-28/h4-9,11H,1-3H3,(H2,24,25,29)/t11-/m0/s1
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Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.066
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355951
PNG
((S)-1-(2-chloro-7-(1- methoxy-2- methylpropyl)pyra...)
Show SMILES CO[C@@H](C(C)C)c1c(NC(=O)Nc2ccnc(c2)C(F)(F)F)cnc2cc(Cl)nn12
Show InChI InChI=1S/C18H18ClF3N6O2/c1-9(2)16(30-3)15-11(8-24-14-7-13(19)27-28(14)15)26-17(29)25-10-4-5-23-12(6-10)18(20,21)22/h4-9,16H,1-3H3,(H2,23,25,26,29)/t16-/m0/s1
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Novartis AG

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Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.066
More data for this
Ligand-Target Pair
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