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Compile Data Set for Download or QSAR

Found 298 hits Enz. Inhib. hit(s) with Target = 'Menin'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349368
PNG
(US10207991, Ex. Cpd. No. 11)
Show SMILES COc1cc2CN(Cc2cc1OC)[C@H](C)CCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H23Cl2NO2/c1-13(4-5-14-6-7-17(21)18(22)8-14)23-11-15-9-19(24-2)20(25-3)10-16(15)12-23/h6-10,13H,4-5,11-12H2,1-3H3/t13-/m1/s1
UniProtKB/SwissProt

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US Patent
0.440n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...


US Patent US10207991 (2019)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349368
PNG
(US10207991, Ex. Cpd. No. 11)
Show SMILES COc1cc2CN(Cc2cc1OC)[C@H](C)CCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H23Cl2NO2/c1-13(4-5-14-6-7-17(21)18(22)8-14)23-11-15-9-19(24-2)20(25-3)10-16(15)12-23/h6-10,13H,4-5,11-12H2,1-3H3/t13-/m1/s1
UniProtKB/SwissProt

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US Patent
0.440n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349518
PNG
(US10207991, Ex. Cpd. No. 34)
Show SMILES COc1cc2CN(Cc2cc1OC)C(C)(C)CCc1ccc(F)cc1
Show InChI InChI=1S/C21H26FNO2/c1-21(2,10-9-15-5-7-18(22)8-6-15)23-13-16-11-19(24-3)20(25-4)12-17(16)14-23/h5-8,11-12H,9-10,13-14H2,1-4H3
UniProtKB/SwissProt

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US Patent
0.530n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349518
PNG
(US10207991, Ex. Cpd. No. 34)
Show SMILES COc1cc2CN(Cc2cc1OC)C(C)(C)CCc1ccc(F)cc1
Show InChI InChI=1S/C21H26FNO2/c1-21(2,10-9-15-5-7-18(22)8-6-15)23-13-16-11-19(24-3)20(25-4)12-17(16)14-23/h5-8,11-12H,9-10,13-14H2,1-4H3
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US Patent
0.530n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...


US Patent US10207991 (2019)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349505
PNG
(US10207991, Ex. Cpd. No. 20)
Show SMILES COc1cc2CN(Cc2cc1OC)[C@@H](C)CCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H23Cl2NO2/c1-13(4-5-14-6-7-17(21)18(22)8-14)23-11-15-9-19(24-2)20(25-3)10-16(15)12-23/h6-10,13H,4-5,11-12H2,1-3H3/t13-/m0/s1
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US Patent
0.670n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349505
PNG
(US10207991, Ex. Cpd. No. 20)
Show SMILES COc1cc2CN(Cc2cc1OC)[C@@H](C)CCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H23Cl2NO2/c1-13(4-5-14-6-7-17(21)18(22)8-14)23-11-15-9-19(24-2)20(25-3)10-16(15)12-23/h6-10,13H,4-5,11-12H2,1-3H3/t13-/m0/s1
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US Patent
0.670n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...


US Patent US10207991 (2019)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349569
PNG
(US10207991, Ex. Cpd. No. 87)
Show SMILES CC(C)COc1cc(CCC(C)(C)N2Cc3ccc(cc3C2)S(C)(=O)=O)ccc1O
Show InChI InChI=1S/C24H33NO4S/c1-17(2)16-29-23-12-18(6-9-22(23)26)10-11-24(3,4)25-14-19-7-8-21(30(5,27)28)13-20(19)15-25/h6-9,12-13,17,26H,10-11,14-16H2,1-5H3
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US Patent
1.10n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349569
PNG
(US10207991, Ex. Cpd. No. 87)
Show SMILES CC(C)COc1cc(CCC(C)(C)N2Cc3ccc(cc3C2)S(C)(=O)=O)ccc1O
Show InChI InChI=1S/C24H33NO4S/c1-17(2)16-29-23-12-18(6-9-22(23)26)10-11-24(3,4)25-14-19-7-8-21(30(5,27)28)13-20(19)15-25/h6-9,12-13,17,26H,10-11,14-16H2,1-5H3
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US Patent
1.10n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...


US Patent US10207991 (2019)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349570
PNG
(US10207991, Ex. Cpd. No. 88)
Show SMILES CC(C)COc1cc(CCC(C)(C)N2Cc3cccc(F)c3C2)ccc1O
Show InChI InChI=1S/C23H30FNO2/c1-16(2)15-27-22-12-17(8-9-21(22)26)10-11-23(3,4)25-13-18-6-5-7-20(24)19(18)14-25/h5-9,12,16,26H,10-11,13-15H2,1-4H3
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US Patent
1.30n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349570
PNG
(US10207991, Ex. Cpd. No. 88)
Show SMILES CC(C)COc1cc(CCC(C)(C)N2Cc3cccc(F)c3C2)ccc1O
Show InChI InChI=1S/C23H30FNO2/c1-16(2)15-27-22-12-17(8-9-21(22)26)10-11-23(3,4)25-13-18-6-5-7-20(24)19(18)14-25/h5-9,12,16,26H,10-11,13-15H2,1-4H3
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US Patent
1.30n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...


US Patent US10207991 (2019)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349578
PNG
(US10207991, Ex. Cpd. No. 103)
Show SMILES COc1cccc(CCC(C)(C)N2Cc3ccc(cc3C2)S(C)(=O)=O)c1
Show InChI InChI=1S/C21H27NO3S/c1-21(2,11-10-16-6-5-7-19(12-16)25-3)22-14-17-8-9-20(26(4,23)24)13-18(17)15-22/h5-9,12-13H,10-11,14-15H2,1-4H3
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US Patent
1.40n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...


US Patent US10207991 (2019)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349578
PNG
(US10207991, Ex. Cpd. No. 103)
Show SMILES COc1cccc(CCC(C)(C)N2Cc3ccc(cc3C2)S(C)(=O)=O)c1
Show InChI InChI=1S/C21H27NO3S/c1-21(2,11-10-16-6-5-7-19(12-16)25-3)22-14-17-8-9-20(26(4,23)24)13-18(17)15-22/h5-9,12-13H,10-11,14-15H2,1-4H3
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US Patent
1.40n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349387
PNG
(US10207991, Ex. Cpd. No. 18)
Show SMILES C[C@H](CCc1ccc(Cl)c(Cl)c1)N1Cc2cc3ccccc3cc2C1
Show InChI InChI=1S/C22H21Cl2N/c1-15(6-7-16-8-9-21(23)22(24)10-16)25-13-19-11-17-4-2-3-5-18(17)12-20(19)14-25/h2-5,8-12,15H,6-7,13-14H2,1H3/t15-/m1/s1
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US Patent
1.5n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349387
PNG
(US10207991, Ex. Cpd. No. 18)
Show SMILES C[C@H](CCc1ccc(Cl)c(Cl)c1)N1Cc2cc3ccccc3cc2C1
Show InChI InChI=1S/C22H21Cl2N/c1-15(6-7-16-8-9-21(23)22(24)10-16)25-13-19-11-17-4-2-3-5-18(17)12-20(19)14-25/h2-5,8-12,15H,6-7,13-14H2,1H3/t15-/m1/s1
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US Patent
1.5n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...


US Patent US10207991 (2019)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM350897
PNG
(US9796672, Example Compound 19)
Show SMILES C[C@H](CCc1ccc(Cl)c(Cl)c1)N1Cc2ccc3ccccc3c2C1
Show InChI InChI=1S/C22H21Cl2N/c1-15(6-7-16-8-11-21(23)22(24)12-16)25-13-18-10-9-17-4-2-3-5-19(17)20(18)14-25/h2-5,8-12,15H,6-7,13-14H2,1H3/t15-/m1/s1
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US Patent
1.80n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349577
PNG
(US10207991, Ex. Cpd. No. 102)
Show SMILES COc1ccc(CCC(C)(C)N2Cc3ccc(cc3C2)S(C)(=O)=O)cc1
Show InChI InChI=1S/C21H27NO3S/c1-21(2,12-11-16-5-8-19(25-3)9-6-16)22-14-17-7-10-20(26(4,23)24)13-18(17)15-22/h5-10,13H,11-12,14-15H2,1-4H3
UniProtKB/SwissProt

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US Patent
1.80n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349478
PNG
(US10207991, Ex. Cpd. No. 19)
Show SMILES CC(CCc1ccc(Cl)c(Cl)c1)N1Cc2ccc3ccccc3c2C1
Show InChI InChI=1S/C22H21Cl2N/c1-15(6-7-16-8-11-21(23)22(24)12-16)25-13-18-10-9-17-4-2-3-5-19(17)20(18)14-25/h2-5,8-12,15H,6-7,13-14H2,1H3
UniProtKB/SwissProt

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US Patent
1.80n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...


US Patent US10207991 (2019)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349577
PNG
(US10207991, Ex. Cpd. No. 102)
Show SMILES COc1ccc(CCC(C)(C)N2Cc3ccc(cc3C2)S(C)(=O)=O)cc1
Show InChI InChI=1S/C21H27NO3S/c1-21(2,12-11-16-5-8-19(25-3)9-6-16)22-14-17-7-10-20(26(4,23)24)13-18(17)15-22/h5-10,13H,11-12,14-15H2,1-4H3
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US Patent
1.80n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...


US Patent US10207991 (2019)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349307
PNG
(US10207991, Ex. Cpd. No. 4)
Show SMILES C[C@H](CCc1ccc(Cl)c(Cl)c1)N1Cc2ccc(cc2C1)C(F)(F)F
Show InChI InChI=1S/C19H18Cl2F3N/c1-12(2-3-13-4-7-17(20)18(21)8-13)25-10-14-5-6-16(19(22,23)24)9-15(14)11-25/h4-9,12H,2-3,10-11H2,1H3/t12-/m1/s1
UniProtKB/SwissProt

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US Patent
2.20n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349307
PNG
(US10207991, Ex. Cpd. No. 4)
Show SMILES C[C@H](CCc1ccc(Cl)c(Cl)c1)N1Cc2ccc(cc2C1)C(F)(F)F
Show InChI InChI=1S/C19H18Cl2F3N/c1-12(2-3-13-4-7-17(20)18(21)8-13)25-10-14-5-6-16(19(22,23)24)9-15(14)11-25/h4-9,12H,2-3,10-11H2,1H3/t12-/m1/s1
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US Patent
2.20n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...


US Patent US10207991 (2019)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349559
PNG
(US10207991, Ex. Cpd. No. 76)
Show SMILES COc1cc(CCC(C)(C)N2Cc3cccc(C(=O)N4CCNCC4)c3C2)ccc1O
Show InChI InChI=1S/C25H33N3O3/c1-25(2,10-9-18-7-8-22(29)23(15-18)31-3)28-16-19-5-4-6-20(21(19)17-28)24(30)27-13-11-26-12-14-27/h4-8,15,26,29H,9-14,16-17H2,1-3H3
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US Patent
2.60n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349551
PNG
(US10207991, Ex. Cpd. No. 66)
Show SMILES CC(C)(C)Oc1cc(CCC(C)(C)N2Cc3cccc(c3C2)S(C)(=O)=O)ccc1O
Show InChI InChI=1S/C24H33NO4S/c1-23(2,3)29-21-14-17(10-11-20(21)26)12-13-24(4,5)25-15-18-8-7-9-22(19(18)16-25)30(6,27)28/h7-11,14,26H,12-13,15-16H2,1-6H3
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2.60n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349551
PNG
(US10207991, Ex. Cpd. No. 66)
Show SMILES CC(C)(C)Oc1cc(CCC(C)(C)N2Cc3cccc(c3C2)S(C)(=O)=O)ccc1O
Show InChI InChI=1S/C24H33NO4S/c1-23(2,3)29-21-14-17(10-11-20(21)26)12-13-24(4,5)25-15-18-8-7-9-22(19(18)16-25)30(6,27)28/h7-11,14,26H,12-13,15-16H2,1-6H3
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US Patent
2.60n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...


US Patent US10207991 (2019)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349559
PNG
(US10207991, Ex. Cpd. No. 76)
Show SMILES COc1cc(CCC(C)(C)N2Cc3cccc(C(=O)N4CCNCC4)c3C2)ccc1O
Show InChI InChI=1S/C25H33N3O3/c1-25(2,10-9-18-7-8-22(29)23(15-18)31-3)28-16-19-5-4-6-20(21(19)17-28)24(30)27-13-11-26-12-14-27/h4-8,15,26,29H,9-14,16-17H2,1-3H3
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US Patent
2.60n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...


US Patent US10207991 (2019)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349316
PNG
(US10207991, Ex. Cpd. No. 5)
Show SMILES C[C@H](CCc1ccc(Cl)c(Cl)c1)N1Cc2cc(Cl)c(Cl)cc2C1
Show InChI InChI=1S/C18H17Cl4N/c1-11(2-3-12-4-5-15(19)16(20)6-12)23-9-13-7-17(21)18(22)8-14(13)10-23/h4-8,11H,2-3,9-10H2,1H3/t11-/m1/s1
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US Patent
2.70n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349316
PNG
(US10207991, Ex. Cpd. No. 5)
Show SMILES C[C@H](CCc1ccc(Cl)c(Cl)c1)N1Cc2cc(Cl)c(Cl)cc2C1
Show InChI InChI=1S/C18H17Cl4N/c1-11(2-3-12-4-5-15(19)16(20)6-12)23-9-13-7-17(21)18(22)8-14(13)10-23/h4-8,11H,2-3,9-10H2,1H3/t11-/m1/s1
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US Patent
2.70n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...


US Patent US10207991 (2019)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349517
PNG
(US10207991, Ex. Cpd. No. 33)
Show SMILES CC(C)(CCc1ccc(F)cc1)N1Cc2cccc(F)c2C1
Show InChI InChI=1S/C19H21F2N/c1-19(2,11-10-14-6-8-16(20)9-7-14)22-12-15-4-3-5-18(21)17(15)13-22/h3-9H,10-13H2,1-2H3
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US Patent
3.20n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349517
PNG
(US10207991, Ex. Cpd. No. 33)
Show SMILES CC(C)(CCc1ccc(F)cc1)N1Cc2cccc(F)c2C1
Show InChI InChI=1S/C19H21F2N/c1-19(2,11-10-14-6-8-16(20)9-7-14)22-12-15-4-3-5-18(21)17(15)13-22/h3-9H,10-13H2,1-2H3
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3.20n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...


US Patent US10207991 (2019)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349519
PNG
(US10207991, Ex. Cpd. No. 35)
Show SMILES CC(C)(CCc1ccc(F)cc1)N1Cc2ccc(F)cc2C1
Show InChI InChI=1S/C19H21F2N/c1-19(2,10-9-14-3-6-17(20)7-4-14)22-12-15-5-8-18(21)11-16(15)13-22/h3-8,11H,9-10,12-13H2,1-2H3
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US Patent
3.60n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...


US Patent US10207991 (2019)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349325
PNG
(US10207991, Ex. Cpd. No. 9)
Show SMILES C[C@H](CCc1ccc(Cl)c(Cl)c1)N1Cc2cccc(F)c2C1
Show InChI InChI=1S/C18H18Cl2FN/c1-12(5-6-13-7-8-16(19)17(20)9-13)22-10-14-3-2-4-18(21)15(14)11-22/h2-4,7-9,12H,5-6,10-11H2,1H3/t12-/m1/s1
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3.60n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349519
PNG
(US10207991, Ex. Cpd. No. 35)
Show SMILES CC(C)(CCc1ccc(F)cc1)N1Cc2ccc(F)cc2C1
Show InChI InChI=1S/C19H21F2N/c1-19(2,10-9-14-3-6-17(20)7-4-14)22-12-15-5-8-18(21)11-16(15)13-22/h3-8,11H,9-10,12-13H2,1-2H3
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3.60n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349325
PNG
(US10207991, Ex. Cpd. No. 9)
Show SMILES C[C@H](CCc1ccc(Cl)c(Cl)c1)N1Cc2cccc(F)c2C1
Show InChI InChI=1S/C18H18Cl2FN/c1-12(5-6-13-7-8-16(19)17(20)9-13)22-10-14-3-2-4-18(21)15(14)11-22/h2-4,7-9,12H,5-6,10-11H2,1H3/t12-/m1/s1
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3.60n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...


US Patent US10207991 (2019)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349365
PNG
(US10207991, Ex. Cpd. No. 10)
Show SMILES C[C@H](CCc1ccc(Cl)c(Cl)c1)N1Cc2cc3OCOc3cc2C1
Show InChI InChI=1S/C19H19Cl2NO2/c1-12(2-3-13-4-5-16(20)17(21)6-13)22-9-14-7-18-19(24-11-23-18)8-15(14)10-22/h4-8,12H,2-3,9-11H2,1H3/t12-/m1/s1
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5n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...


US Patent US10207991 (2019)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349365
PNG
(US10207991, Ex. Cpd. No. 10)
Show SMILES C[C@H](CCc1ccc(Cl)c(Cl)c1)N1Cc2cc3OCOc3cc2C1
Show InChI InChI=1S/C19H19Cl2NO2/c1-12(2-3-13-4-5-16(20)17(21)6-13)22-9-14-7-18-19(24-11-23-18)8-15(14)10-22/h4-8,12H,2-3,9-11H2,1H3/t12-/m1/s1
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5n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349520
PNG
(US10207991, Ex. Cpd. No. 36)
Show SMILES CC(C)(CCc1ccc(F)cc1)N1Cc2cc3OCOc3cc2C1
Show InChI InChI=1S/C20H22FNO2/c1-20(2,8-7-14-3-5-17(21)6-4-14)22-11-15-9-18-19(24-13-23-18)10-16(15)12-22/h3-6,9-10H,7-8,11-13H2,1-2H3
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5.20n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...


US Patent US10207991 (2019)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349520
PNG
(US10207991, Ex. Cpd. No. 36)
Show SMILES CC(C)(CCc1ccc(F)cc1)N1Cc2cc3OCOc3cc2C1
Show InChI InChI=1S/C20H22FNO2/c1-20(2,8-7-14-3-5-17(21)6-4-14)22-11-15-9-18-19(24-13-23-18)10-16(15)12-22/h3-6,9-10H,7-8,11-13H2,1-2H3
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5.20n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349526
PNG
(US10207991, Ex. Cpd. No. 42)
Show SMILES CC(C)Oc1ccc(CCC(C)(C)N2Cc3ccc(F)cc3C2)cc1OC(C)C
Show InChI InChI=1S/C25H34FNO2/c1-17(2)28-23-10-7-19(13-24(23)29-18(3)4)11-12-25(5,6)27-15-20-8-9-22(26)14-21(20)16-27/h7-10,13-14,17-18H,11-12,15-16H2,1-6H3
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6.20n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349526
PNG
(US10207991, Ex. Cpd. No. 42)
Show SMILES CC(C)Oc1ccc(CCC(C)(C)N2Cc3ccc(F)cc3C2)cc1OC(C)C
Show InChI InChI=1S/C25H34FNO2/c1-17(2)28-23-10-7-19(13-24(23)29-18(3)4)11-12-25(5,6)27-15-20-8-9-22(26)14-21(20)16-27/h7-10,13-14,17-18H,11-12,15-16H2,1-6H3
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6.20n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...


US Patent US10207991 (2019)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349572
PNG
(US10207991, Ex. Cpd. No. 96)
Show SMILES CC(=O)Oc1ccc(CCC(C)(C)N2Cc3ccc(cc3C2)S(C)(=O)=O)cc1OC(C)(C)C
Show InChI InChI=1S/C26H35NO5S/c1-18(28)31-23-11-8-19(14-24(23)32-25(2,3)4)12-13-26(5,6)27-16-20-9-10-22(33(7,29)30)15-21(20)17-27/h8-11,14-15H,12-13,16-17H2,1-7H3
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6.60n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...


US Patent US10207991 (2019)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349572
PNG
(US10207991, Ex. Cpd. No. 96)
Show SMILES CC(=O)Oc1ccc(CCC(C)(C)N2Cc3ccc(cc3C2)S(C)(=O)=O)cc1OC(C)(C)C
Show InChI InChI=1S/C26H35NO5S/c1-18(28)31-23-11-8-19(14-24(23)32-25(2,3)4)12-13-26(5,6)27-16-20-9-10-22(33(7,29)30)15-21(20)17-27/h8-11,14-15H,12-13,16-17H2,1-7H3
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6.60n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349546
PNG
(US10207991, Ex. Cpd. No. 61)
Show SMILES CC(C)(CCc1ccc(O)c(OC(F)(F)F)c1)N1Cc2ccc(cc2C1)S(C)(=O)=O
Show InChI InChI=1S/C21H24F3NO4S/c1-20(2,9-8-14-4-7-18(26)19(10-14)29-21(22,23)24)25-12-15-5-6-17(30(3,27)28)11-16(15)13-25/h4-7,10-11,26H,8-9,12-13H2,1-3H3
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6.90n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...


US Patent US10207991 (2019)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349546
PNG
(US10207991, Ex. Cpd. No. 61)
Show SMILES CC(C)(CCc1ccc(O)c(OC(F)(F)F)c1)N1Cc2ccc(cc2C1)S(C)(=O)=O
Show InChI InChI=1S/C21H24F3NO4S/c1-20(2,9-8-14-4-7-18(26)19(10-14)29-21(22,23)24)25-12-15-5-6-17(30(3,27)28)11-16(15)13-25/h4-7,10-11,26H,8-9,12-13H2,1-3H3
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6.90n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349552
PNG
(US10207991, Ex. Cpd. No. 67)
Show SMILES CC(C)(CCc1ccc(O)c(OC(F)(F)F)c1)N1Cc2cccc(c2C1)S(C)(=O)=O
Show InChI InChI=1S/C21H24F3NO4S/c1-20(2,10-9-14-7-8-17(26)18(11-14)29-21(22,23)24)25-12-15-5-4-6-19(16(15)13-25)30(3,27)28/h4-8,11,26H,9-10,12-13H2,1-3H3
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8.10n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349552
PNG
(US10207991, Ex. Cpd. No. 67)
Show SMILES CC(C)(CCc1ccc(O)c(OC(F)(F)F)c1)N1Cc2cccc(c2C1)S(C)(=O)=O
Show InChI InChI=1S/C21H24F3NO4S/c1-20(2,10-9-14-7-8-17(26)18(11-14)29-21(22,23)24)25-12-15-5-4-6-19(16(15)13-25)30(3,27)28/h4-8,11,26H,9-10,12-13H2,1-3H3
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8.10n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...


US Patent US10207991 (2019)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349547
PNG
(US10207991, Ex. Cpd. No. 62)
Show SMILES CC(C)(C)Oc1cc(CCC(C)(C)N2Cc3ccc(cc3C2)S(C)(=O)=O)ccc1O
Show InChI InChI=1S/C24H33NO4S/c1-23(2,3)29-22-13-17(7-10-21(22)26)11-12-24(4,5)25-15-18-8-9-20(30(6,27)28)14-19(18)16-25/h7-10,13-14,26H,11-12,15-16H2,1-6H3
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8.5n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...


US Patent US10207991 (2019)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349547
PNG
(US10207991, Ex. Cpd. No. 62)
Show SMILES CC(C)(C)Oc1cc(CCC(C)(C)N2Cc3ccc(cc3C2)S(C)(=O)=O)ccc1O
Show InChI InChI=1S/C24H33NO4S/c1-23(2,3)29-22-13-17(7-10-21(22)26)11-12-24(4,5)25-15-18-8-9-20(30(6,27)28)14-19(18)16-25/h7-10,13-14,26H,11-12,15-16H2,1-6H3
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8.5n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349549
PNG
(US10207991, Ex. Cpd. No. 64)
Show SMILES COc1cc(CCC(C)(C)N2Cc3cccc(c3C2)S(C)(=O)=O)ccc1O
Show InChI InChI=1S/C21H27NO4S/c1-21(2,11-10-15-8-9-18(23)19(12-15)26-3)22-13-16-6-5-7-20(17(16)14-22)27(4,24)25/h5-9,12,23H,10-11,13-14H2,1-4H3
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8.60n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349549
PNG
(US10207991, Ex. Cpd. No. 64)
Show SMILES COc1cc(CCC(C)(C)N2Cc3cccc(c3C2)S(C)(=O)=O)ccc1O
Show InChI InChI=1S/C21H27NO4S/c1-21(2,11-10-15-8-9-18(23)19(12-15)26-3)22-13-16-6-5-7-20(17(16)14-22)27(4,24)25/h5-9,12,23H,10-11,13-14H2,1-4H3
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8.60n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...


US Patent US10207991 (2019)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349524
PNG
(US10207991, Ex. Cpd. No. 40)
Show SMILES CC(C)Oc1ccc(CC[C@@H](C)N2Cc3cc4OCOc4cc3C2)cc1OC(C)C
Show InChI InChI=1S/C25H33NO4/c1-16(2)29-22-9-8-19(10-25(22)30-17(3)4)7-6-18(5)26-13-20-11-23-24(28-15-27-23)12-21(20)14-26/h8-12,16-18H,6-7,13-15H2,1-5H3/t18-/m1/s1
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8.90n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...


US Patent US10207991 (2019)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349524
PNG
(US10207991, Ex. Cpd. No. 40)
Show SMILES CC(C)Oc1ccc(CC[C@@H](C)N2Cc3cc4OCOc4cc3C2)cc1OC(C)C
Show InChI InChI=1S/C25H33NO4/c1-16(2)29-22-9-8-19(10-25(22)30-17(3)4)7-6-18(5)26-13-20-11-23-24(28-15-27-23)12-21(20)14-26/h8-12,16-18H,6-7,13-15H2,1-5H3/t18-/m1/s1
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8.90n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
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