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Compile Data Set for Download or QSAR

Found 64 hits Enz. Inhib. hit(s) with Target = 'Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM214726
PNG
(Cyanines, 9)
Show SMILES C1CC[n+]2c(\C=C\C=C3/Sc4ccccc4N3CCCC[n+]3c(\C=C\C=C4/Sc5ccccc5N4C1)sc1ccccc31)sc1ccccc21
Show InChI InChI=1S/C42H38N4S4/c1-5-19-35-31(15-1)43-27-9-10-28-44-32-16-2-6-20-36(32)49-41(44)25-14-26-42-46(34-18-4-8-22-38(34)50-42)30-12-11-29-45-33-17-3-7-21-37(33)48-40(45)24-13-23-39(43)47-35/h1-8,13-26H,9-12,27-30H2/q+2
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n/an/a 120n/an/an/an/an/an/a



The Ohio State University



Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM214733
PNG
(Rhodanines, 21A)
Show SMILES [O-]C(=O)CCN1C(=S)S\C(=C/c2ccc(o2)-c2ccc(cc2)-c2ccc(o2)C([O-])=O)C1=O
Show InChI InChI=1S/C22H15NO7S2/c24-19(25)9-10-23-20(26)18(32-22(23)31)11-14-5-6-15(29-14)12-1-3-13(4-2-12)16-7-8-17(30-16)21(27)28/h1-8,11H,9-10H2,(H,24,25)(H,27,28)/p-2/b18-11-
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The Ohio State University



Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM214732
PNG
(Rhodanines, 20A)
Show SMILES [O-]C(=O)CCN1C(=S)S\C(=C/c2ccc(o2)-c2ccc(cc2)-c2ccccc2)C1=O
Show InChI InChI=1S/C23H17NO4S2/c25-21(26)12-13-24-22(27)20(30-23(24)29)14-18-10-11-19(28-18)17-8-6-16(7-9-17)15-4-2-1-3-5-15/h1-11,14H,12-13H2,(H,25,26)/p-1/b20-14-
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The Ohio State University



Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM214734
PNG
(Rhodanines, 22A)
Show SMILES [O-]C(=O)CCCCN1C(=S)S\C(=C/c2ccc(o2)-c2ccc(cc2)-n2cccc2)C1=O
Show InChI InChI=1S/C23H20N2O4S2/c26-21(27)5-1-2-14-25-22(28)20(31-23(25)30)15-18-10-11-19(29-18)16-6-8-17(9-7-16)24-12-3-4-13-24/h3-4,6-13,15H,1-2,5,14H2,(H,26,27)/p-1/b20-15-
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The Ohio State University



Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM214735
PNG
(Rhodanines, 23A)
Show SMILES [O-]C(=O)CCCN1C(=S)S\C(=C/c2ccc(o2)-c2ccc(cc2)-n2cccc2)C1=O
Show InChI InChI=1S/C22H18N2O4S2/c25-20(26)4-3-13-24-21(27)19(30-22(24)29)14-17-9-10-18(28-17)15-5-7-16(8-6-15)23-11-1-2-12-23/h1-2,5-12,14H,3-4,13H2,(H,25,26)/p-1/b19-14-
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The Ohio State University



Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM214736
PNG
(Rhodanines, 24A)
Show SMILES [O-]C(=O)CCN1C(=S)S\C(=C/c2ccc(o2)-c2ccc(cc2)-n2cccc2)C1=O
Show InChI InChI=1S/C21H16N2O4S2/c24-19(25)9-12-23-20(26)18(29-21(23)28)13-16-7-8-17(27-16)14-3-5-15(6-4-14)22-10-1-2-11-22/h1-8,10-11,13H,9,12H2,(H,24,25)/p-1/b18-13-
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The Ohio State University



Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM214737
PNG
(Rhodanines, 25A)
Show SMILES [O-]C(=O)CCCCN1C(=S)S\C(=C/c2ccc(o2)-c2ccc(cc2)-c2ccccc2)C1=O
Show InChI InChI=1S/C25H21NO4S2/c27-23(28)8-4-5-15-26-24(29)22(32-25(26)31)16-20-13-14-21(30-20)19-11-9-18(10-12-19)17-6-2-1-3-7-17/h1-3,6-7,9-14,16H,4-5,8,15H2,(H,27,28)/p-1/b22-16-
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The Ohio State University



Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM214738
PNG
(Rhodanines, 26A)
Show SMILES [O-]C(=O)CCCCN1C(=S)S\C(=C/c2ccc(o2)-c2ccc(cc2)-c2ccc(o2)C([O-])=O)C1=O
Show InChI InChI=1S/C24H19NO7S2/c26-21(27)3-1-2-12-25-22(28)20(34-24(25)33)13-16-8-9-17(31-16)14-4-6-15(7-5-14)18-10-11-19(32-18)23(29)30/h4-11,13H,1-3,12H2,(H,26,27)(H,29,30)/p-2/b20-13-
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The Ohio State University



Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM32329
PNG
((2Z)-3-ethyl-2-[(E)-3-(3-ethyl-1,3-benzothiazol-3-...)
Show SMILES CCN1\C(Sc2ccccc12)=C\C(\C)=C\c1sc2ccccc2[n+]1CC
Show InChI InChI=1S/C22H23N2S2/c1-4-23-17-10-6-8-12-19(17)25-21(23)14-16(3)15-22-24(5-2)18-11-7-9-13-20(18)26-22/h6-15H,4-5H2,1-3H3/q+1
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The Ohio State University



Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM32299
PNG
(2-[(2Z)-2-[(2E)-2-[[3-(2-hydroxyethyl)-5-methoxy-1...)
Show SMILES CC\C(=C/c1sc2ccc(OC)cc2[n+]1CCO)\C=C1/Sc2ccc(OC)cc2N1CCO
Show InChI InChI=1S/C25H29N2O4S2/c1-4-17(13-24-26(9-11-28)20-15-18(30-2)5-7-22(20)32-24)14-25-27(10-12-29)21-16-19(31-3)6-8-23(21)33-25/h5-8,13-16,28-29H,4,9-12H2,1-3H3/q+1
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The Ohio State University



Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM214739
PNG
(Rhodanines, 27A)
Show SMILES [O-]C(=O)CC(N1C(=S)S\C(=C/c2ccc(o2)-c2cccc(Cl)c2)C1=O)C([O-])=O
Show InChI InChI=1/C18H12ClNO6S2/c19-10-3-1-2-9(6-10)13-5-4-11(26-13)7-14-16(23)20(18(27)28-14)12(17(24)25)8-15(21)22/h1-7,12H,8H2,(H,21,22)(H,24,25)/p-2/b14-7-
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The Ohio State University



Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM214740
PNG
(Rhodanines, 28A)
Show SMILES [O-]C(=O)CCN1C(=S)S\C(=C/c2ccc(o2)-c2cccc(Cl)c2)C1=O
Show InChI InChI=1S/C17H12ClNO4S2/c18-11-3-1-2-10(8-11)13-5-4-12(23-13)9-14-16(22)19(17(24)25-14)7-6-15(20)21/h1-5,8-9H,6-7H2,(H,20,21)/p-1/b14-9-
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Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM50052802
PNG
(CHEBI:77181 | CRYSTAL VIOLET | Crystal violet (15)...)
Show SMILES CN(C)c1ccc(cc1)C(=C1C=CC(C=C1)=[N+](C)C)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C25H30N3/c1-26(2)22-13-7-19(8-14-22)25(20-9-15-23(16-10-20)27(3)4)21-11-17-24(18-12-21)28(5)6/h7-18H,1-6H3/q+1
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The Ohio State University



Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM214729
PNG
(Malachite green (16))
Show SMILES CN(C)c1ccc(cc1)C(=C1C=CC(C=C1)=[N+](C)C)c1ccccc1
Show InChI InChI=1S/C23H25N2/c1-24(2)21-14-10-19(11-15-21)23(18-8-6-5-7-9-18)20-12-16-22(17-13-20)25(3)4/h5-17H,1-4H3/q+1
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The Ohio State University



Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM214741
PNG
(Rhodanines, 29A)
Show SMILES O=C1N(Cc2nc3ccccc3[nH]2)C(=S)S\C1=C/c1ccc(o1)-c1ccc(cc1)-n1cccc1
Show InChI InChI=1S/C26H18N4O2S2/c31-25-23(34-26(33)30(25)16-24-27-20-5-1-2-6-21(20)28-24)15-19-11-12-22(32-19)17-7-9-18(10-8-17)29-13-3-4-14-29/h1-15H,16H2,(H,27,28)/b23-15-
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The Ohio State University



Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM214742
PNG
(Rhodanines, 30A)
Show SMILES [O-]C(=O)Cc1ccc(CN2C(=S)S\C(=C/c3ccc(o3)-c3ccc(cc3)-c3ccc(o3)C([O-])=O)C2=O)cc1
Show InChI InChI=1S/C28H19NO7S2/c30-25(31)13-16-1-3-17(4-2-16)15-29-26(32)24(38-28(29)37)14-20-9-10-21(35-20)18-5-7-19(8-6-18)22-11-12-23(36-22)27(33)34/h1-12,14H,13,15H2,(H,30,31)(H,33,34)/p-2/b24-14-
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Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM50241461
PNG
(3,7-bis(dimethylamino)phenothiazin-5-ium chloride ...)
Show SMILES CN(C)c1ccc2nc3ccc(cc3sc2c1)=[N+](C)C
Show InChI InChI=1S/C16H18N3S/c1-18(2)11-5-7-13-15(9-11)20-16-10-12(19(3)4)6-8-14(16)17-13/h5-10H,1-4H3/q+1
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Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM214743
PNG
(Rhodanines, 31A)
Show SMILES [O-]C(=O)CCN1C(=S)S\C(=C/c2ccc(o2)-c2ccccc2Cl)C1=O
Show InChI InChI=1S/C17H12ClNO4S2/c18-12-4-2-1-3-11(12)13-6-5-10(23-13)9-14-16(22)19(17(24)25-14)8-7-15(20)21/h1-6,9H,7-8H2,(H,20,21)/p-1/b14-9-
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Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM214744
PNG
(Rhodanines, 32A)
Show SMILES Clc1cccc(c1)-c1ccc(\C=C2/SC(=S)N(Cc3nc4ccccc4[nH]3)C2=O)o1
Show InChI InChI=1S/C22H14ClN3O2S2/c23-14-5-3-4-13(10-14)18-9-8-15(28-18)11-19-21(27)26(22(29)30-19)12-20-24-16-6-1-2-7-17(16)25-20/h1-11H,12H2,(H,24,25)/b19-11-
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Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM214745
PNG
(Rhodanines, 33A)
Show SMILES [O-]C(=O)Cc1ccc(CN2C(=S)S\C(=C/c3ccc(o3)-c3ccc(cc3)-c3ccccc3)C2=O)cc1
Show InChI InChI=1S/C29H21NO4S2/c31-27(32)16-19-6-8-20(9-7-19)18-30-28(33)26(36-29(30)35)17-24-14-15-25(34-24)23-12-10-22(11-13-23)21-4-2-1-3-5-21/h1-15,17H,16,18H2,(H,31,32)/p-1/b26-17-
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Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM214746
PNG
(Rhodanines, 34A)
Show SMILES [O-]C(=O)c1ccc(o1)-c1ccc(cc1)-c1ccc(\C=C2/SC(=S)N(CCc3c[nH]cn3)C2=O)o1
Show InChI InChI=1S/C24H17N3O5S2/c28-22-21(34-24(33)27(22)10-9-16-12-25-13-26-16)11-17-5-6-18(31-17)14-1-3-15(4-2-14)19-7-8-20(32-19)23(29)30/h1-8,11-13H,9-10H2,(H,25,26)(H,29,30)/p-1/b21-11-
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The Ohio State University



Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM214747
PNG
(Rhodanines, 35A)
Show SMILES [O-]C(=O)Cc1ccc(CN2C(=S)S\C(=C/c3ccc(o3)-c3ccc(cc3)-n3cccc3)C2=O)cc1
Show InChI InChI=1S/C27H20N2O4S2/c30-25(31)15-18-3-5-19(6-4-18)17-29-26(32)24(35-27(29)34)16-22-11-12-23(33-22)20-7-9-21(10-8-20)28-13-1-2-14-28/h1-14,16H,15,17H2,(H,30,31)/p-1/b24-16-
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The Ohio State University



Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM214748
PNG
(Rhodanines, 36A)
Show SMILES [O-]C(=O)CN1C(=S)S\C(=C/c2ccc(o2)-c2cccc(Cl)c2)C1=O
Show InChI InChI=1S/C16H10ClNO4S2/c17-10-3-1-2-9(6-10)12-5-4-11(22-12)7-13-15(21)18(8-14(19)20)16(23)24-13/h1-7H,8H2,(H,19,20)/p-1/b13-7-
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Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM214723
PNG
(Cyanines, 3)
Show SMILES CCN1\C(=C\C=C\c2ccc3ccccc3[n+]2CC)C=Cc2ccccc12
Show InChI InChI=1S/C25H25N2/c1-3-26-22(18-16-20-10-5-7-14-24(20)26)12-9-13-23-19-17-21-11-6-8-15-25(21)27(23)4-2/h5-19H,3-4H2,1-2H3/q+1
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Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM214749
PNG
(Rhodanines, 37A)
Show SMILES [O-]C(=O)CCCN1C(=S)S\C(=C/c2ccc(o2)-c2ccc(cc2)-c2ccccc2)C1=O
Show InChI InChI=1S/C24H19NO4S2/c26-22(27)7-4-14-25-23(28)21(31-24(25)30)15-19-12-13-20(29-19)18-10-8-17(9-11-18)16-5-2-1-3-6-16/h1-3,5-6,8-13,15H,4,7,14H2,(H,26,27)/p-1/b21-15-
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Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM75309
PNG
((2Z)-3-ethyl-2-[(E)-3-(3-ethyl-1,3-benzothiazol-3-...)
Show SMILES CCN1\C(Sc2ccccc12)=C\C=C\c1sc2ccccc2[n+]1CC
Show InChI InChI=1S/C21H21N2S2/c1-3-22-16-10-5-7-12-18(16)24-20(22)14-9-15-21-23(4-2)17-11-6-8-13-19(17)25-21/h5-15H,3-4H2,1-2H3/q+1
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Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM214750
PNG
(Rhodanines, 38A)
Show SMILES [O-]C(=O)CCN1C(=S)S\C(=C/c2ccc(s2)-c2cccc(Cl)c2)C1=O
Show InChI InChI=1S/C17H12ClNO3S3/c18-11-3-1-2-10(8-11)13-5-4-12(24-13)9-14-16(22)19(17(23)25-14)7-6-15(20)21/h1-5,8-9H,6-7H2,(H,20,21)/p-1/b14-9-
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Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM50387480
PNG
(CHEMBL467894 | Cyanines, 5)
Show SMILES CCN1\C(=C\C=C\C2=[N+](CC)c3ccccc3C2(C)C)C(C)(C)c2ccccc12
Show InChI InChI=1S/C27H33N2/c1-7-28-22-16-11-9-14-20(22)26(3,4)24(28)18-13-19-25-27(5,6)21-15-10-12-17-23(21)29(25)8-2/h9-19H,7-8H2,1-6H3/q+1
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Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM214751
PNG
(Rhodanines, 39A)
Show SMILES Clc1cccc(c1)-c1ccc(\C=C2/SC(=S)N(CCc3c[nH]cn3)C2=O)o1
Show InChI InChI=1S/C19H14ClN3O2S2/c20-13-3-1-2-12(8-13)16-5-4-15(25-16)9-17-18(24)23(19(26)27-17)7-6-14-10-21-11-22-14/h1-5,8-11H,6-7H2,(H,21,22)/b17-9-
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Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM214731
PNG
(Bindschedler's green (19))
Show SMILES CN(C)c1ccc(cc1)N=C1C=CC(C=C1)=[N+](C)C
Show InChI InChI=1S/C16H20N3/c1-18(2)15-9-5-13(6-10-15)17-14-7-11-16(12-8-14)19(3)4/h5-12H,1-4H3/q+1
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Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM214752
PNG
(Rhodanines, 40A)
Show SMILES [O-]C(=O)CCCN1C(=S)S\C(=C/c2ccc(o2)-c2cccc(Cl)c2)C1=O
Show InChI InChI=1S/C18H14ClNO4S2/c19-12-4-1-3-11(9-12)14-7-6-13(24-14)10-15-17(23)20(18(25)26-15)8-2-5-16(21)22/h1,3-4,6-7,9-10H,2,5,8H2,(H,21,22)/p-1/b15-10-
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The Ohio State University



Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM214727
PNG
(Azure B (11))
Show SMILES CNc1ccc2nc3ccc(cc3sc2c1)=[N+](C)C
Show InChI InChI=1S/C15H15N3S/c1-16-10-4-6-12-14(8-10)19-15-9-11(18(2)3)5-7-13(15)17-12/h4-9H,1-3H3/p+1
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Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM214753
PNG
(Rhodanines, 41A)
Show SMILES O=C1N(Cc2nc3ccccc3[nH]2)C(=S)S\C1=C/c1ccc(o1)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C28H19N3O2S2/c32-27-25(35-28(34)31(27)17-26-29-22-8-4-5-9-23(22)30-26)16-21-14-15-24(33-21)20-12-10-19(11-13-20)18-6-2-1-3-7-18/h1-16H,17H2,(H,29,30)/b25-16-
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Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM214754
PNG
(Rhodanines, 42A | Rhodanines, 50A)
Show SMILES CC(N1C(=S)S\C(=C/c2ccc(o2)-c2cccc(Cl)c2)C1=O)C([O-])=O
Show InChI InChI=1/C17H12ClNO4S2/c1-9(16(21)22)19-15(20)14(25-17(19)24)8-12-5-6-13(23-12)10-3-2-4-11(18)7-10/h2-9H,1H3,(H,21,22)/p-1/b14-8-
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Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM214755
PNG
(Rhodanines, 43A)
Show SMILES O=C1N(CCc2c[nH]cn2)C(=S)S\C1=C/c1ccc(o1)-c1ccc(cc1)-n1cccc1
Show InChI InChI=1S/C23H18N4O2S2/c28-22-21(31-23(30)27(22)12-9-17-14-24-15-25-17)13-19-7-8-20(29-19)16-3-5-18(6-4-16)26-10-1-2-11-26/h1-8,10-11,13-15H,9,12H2,(H,24,25)/b21-13-
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Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM214756
PNG
(Rhodanines, 44A)
Show SMILES [O-]C(=O)Cc1ccc(CN2C(=S)S\C(=C/c3ccc(o3)-c3cccc(Cl)c3)C2=O)cc1
Show InChI InChI=1S/C23H16ClNO4S2/c24-17-3-1-2-16(11-17)19-9-8-18(29-19)12-20-22(28)25(23(30)31-20)13-15-6-4-14(5-7-15)10-21(26)27/h1-9,11-12H,10,13H2,(H,26,27)/p-1/b20-12-
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n/an/a 1.97E+3n/an/an/an/an/an/a



The Ohio State University



Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM214757
PNG
(Rhodanines, 45A)
Show SMILES CCOC(=O)CN1C(=O)O\C(=C/c2ccc(o2)-c2cccc(Cl)c2)C1=O
Show InChI InChI=1S/C18H14ClNO6/c1-2-24-16(21)10-20-17(22)15(26-18(20)23)9-13-6-7-14(25-13)11-4-3-5-12(19)8-11/h3-9H,2,10H2,1H3/b15-9-
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n/an/a 2.56E+3n/an/an/an/an/an/a



The Ohio State University



Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM214724
PNG
(Cyanines, 6)
Show SMILES CCCN1\C(=C\C=C\C2=[N+](CCC)c3ccccc3C2(C)C)C(C)(C)c2ccccc12
Show InChI InChI=1S/C29H37N2/c1-7-20-30-24-16-11-9-14-22(24)28(3,4)26(30)18-13-19-27-29(5,6)23-15-10-12-17-25(23)31(27)21-8-2/h9-19H,7-8,20-21H2,1-6H3/q+1
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The Ohio State University



Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM214758
PNG
(Rhodanines, 46A)
Show SMILES [O-]C(=O)CN1C(=S)O\C(=C/c2ccc(o2)-c2cccc(Cl)c2)C1=O
Show InChI InChI=1S/C16H10ClNO5S/c17-10-3-1-2-9(6-10)12-5-4-11(22-12)7-13-15(21)18(8-14(19)20)16(24)23-13/h1-7H,8H2,(H,19,20)/p-1/b13-7-
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The Ohio State University



Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM214759
PNG
(Rhodanines, 47A)
Show SMILES CCOC(=O)CN1C(=S)N\C(=C/c2ccc(o2)-c2cccc(Cl)c2)C1=O
Show InChI InChI=1S/C18H15ClN2O4S/c1-2-24-16(22)10-21-17(23)14(20-18(21)26)9-13-6-7-15(25-13)11-4-3-5-12(19)8-11/h3-9H,2,10H2,1H3,(H,20,26)/b14-9-
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n/an/a 3.29E+3n/an/an/an/an/an/a



The Ohio State University



Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM214760
PNG
(Rhodanines, 48A)
Show SMILES [O-]C(=O)CN1C(=O)O\C(=C/c2ccc(o2)-c2cccc(Cl)c2)C1=O
Show InChI InChI=1S/C16H10ClNO6/c17-10-3-1-2-9(6-10)12-5-4-11(23-12)7-13-15(21)18(8-14(19)20)16(22)24-13/h1-7H,8H2,(H,19,20)/p-1/b13-7-
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Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM214761
PNG
(Rhodanines, 49A)
Show SMILES CC(N1C(=S)N\C(=C/c2ccc(o2)-c2cccc(Cl)c2)C1=O)C([O-])=O
Show InChI InChI=1/C17H13ClN2O4S/c1-9(16(22)23)20-15(21)13(19-17(20)25)8-12-5-6-14(24-12)10-3-2-4-11(18)7-10/h2-9H,1H3,(H,19,25)(H,22,23)/p-1/b13-8-
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n/an/a 3.79E+3n/an/an/an/an/an/a



The Ohio State University



Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM214754
PNG
(Rhodanines, 42A | Rhodanines, 50A)
Show SMILES CC(N1C(=S)S\C(=C/c2ccc(o2)-c2cccc(Cl)c2)C1=O)C([O-])=O
Show InChI InChI=1/C17H12ClNO4S2/c1-9(16(21)22)19-15(20)14(25-17(19)24)8-12-5-6-13(23-12)10-3-2-4-11(18)7-10/h2-9H,1H3,(H,21,22)/p-1/b14-8-
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Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM214763
PNG
(Rhodanines, 51B)
Show SMILES [O-]C(=O)CCCN1C(=S)S\C(=C/c2cccc(n2)-c2ccc(cc2)-c2ccccc2)C1=O
Show InChI InChI=1S/C25H20N2O3S2/c28-23(29)10-5-15-27-24(30)22(32-25(27)31)16-20-8-4-9-21(26-20)19-13-11-18(12-14-19)17-6-2-1-3-7-17/h1-4,6-9,11-14,16H,5,10,15H2,(H,28,29)/p-1/b22-16-
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n/an/a 5.03E+3n/an/an/an/an/an/a



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Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM214764
PNG
(Rhodanines, 52B)
Show SMILES [O-]C(=O)CCCCN1C(=S)S\C(=C/c2cccc(n2)-c2ccc(cc2)-c2ccccc2)C1=O
Show InChI InChI=1S/C26H22N2O3S2/c29-24(30)11-4-5-16-28-25(31)23(33-26(28)32)17-21-9-6-10-22(27-21)20-14-12-19(13-15-20)18-7-2-1-3-8-18/h1-3,6-10,12-15,17H,4-5,11,16H2,(H,29,30)/p-1/b23-17-
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n/an/a 5.03E+3n/an/an/an/an/an/a



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Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM214765
PNG
(Rhodanines, 53A)
Show SMILES [O-]C(=O)CN1C(=S)N\C(=C/c2ccc(o2)-c2cccc(Cl)c2)C1=O
Show InChI InChI=1S/C16H11ClN2O4S/c17-10-3-1-2-9(6-10)13-5-4-11(23-13)7-12-15(22)19(8-14(20)21)16(24)18-12/h1-7H,8H2,(H,18,24)(H,20,21)/p-1/b12-7-
PDB

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 6.10E+3n/an/an/an/an/an/a



The Ohio State University



Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM214766
PNG
(Rhodanines, 54A)
Show SMILES O=C1N(CCc2c[nH]cn2)C(=S)S\C1=C/c1ccc(o1)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C25H19N3O2S2/c29-24-23(32-25(31)28(24)13-12-20-15-26-16-27-20)14-21-10-11-22(30-21)19-8-6-18(7-9-19)17-4-2-1-3-5-17/h1-11,14-16H,12-13H2,(H,26,27)/b23-14-
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 7.70E+3n/an/an/an/an/an/a



The Ohio State University



Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM214767
PNG
(Rhodanines, 55A)
Show SMILES [O-]C(=O)CCN1C(=S)S\C(=C/c2ccc(c2)-c2ccc(cc2)-c2ccccc2)C1=O
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 7.92E+3n/an/an/an/an/an/a



The Ohio State University



Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM214768
PNG
(Rhodanines, 56A)
Show SMILES CCOC(=O)CN1C(=S)O\C(=C/c2ccc(o2)-c2cccc(Cl)c2)C1=O
Show InChI InChI=1S/C18H14ClNO5S/c1-2-23-16(21)10-20-17(22)15(25-18(20)26)9-13-6-7-14(24-13)11-4-3-5-12(19)8-11/h3-9H,2,10H2,1H3/b15-9-
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 8.94E+3n/an/an/an/an/an/a



The Ohio State University



Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R)


(Homo sapiens (Human))
BDBM214769
PNG
(Rhodanines, 57B)
Show SMILES O=C1N(CCc2c[nH]cn2)C(=S)S\C1=C/c1cccc(c1)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C27H21N3OS2/c31-26-25(33-27(32)30(26)14-13-24-17-28-18-29-24)16-19-5-4-8-23(15-19)22-11-9-21(10-12-22)20-6-2-1-3-7-20/h1-12,15-18H,13-14H2,(H,28,29)/b25-16-
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 9.38E+3n/an/an/an/an/an/a



The Ohio State University



Assay Description
The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...


J Biol Chem 288: 32599-611 (2013)

More data for this
Ligand-Target Pair
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