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Found 3209 hits Enz. Inhib. hit(s) with Target = 'Non-receptor tyrosine-protein kinase TYK2'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM350094
PNG
(US10208040, Example 1-2)
Show SMILES CCc1cc(O)c(F)cc1-c1ccc2c(n[nH]c2c1)-c1nc2CC(NCc2[nH]1)C(=O)N1CCN(CC1)C(C)C
Show InChI InChI=1S/C29H32FN7O2/c1-4-17-12-26(38)21(30)13-20(17)18-5-6-19-22(11-18)34-35-27(19)28-32-23-14-24(31-15-25(23)33-28)29(39)37-9-7-36(8-10-37)16(2)3/h5-6,11-13,16,24,31,38H,4,7-10,14-15H2,1-3H3/b28-27-
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0.0800n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10208040 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM277400
PNG
(1-(((1R,3s,5S)-3-((7-((5-methyl-1H-pyrazol-3-yl)am...)
Show SMILES Cc1cc(Nc2cc3ncccc3c(N[C@H]3C[C@@H]4CCC[C@H](C3)N4S(=O)(=O)N3CC(C3)C#N)n2)n[nH]1
Show InChI InChI=1S/C24H29N9O2S/c1-15-8-23(31-30-15)28-22-11-21-20(6-3-7-26-21)24(29-22)27-17-9-18-4-2-5-19(10-17)33(18)36(34,35)32-13-16(12-25)14-32/h3,6-8,11,16-19H,2,4-5,9-10,13-14H2,1H3,(H3,27,28,29,30,31)/t17-,18-,19+
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<0.100n/an/an/an/an/an/a7.5n/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10072026 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM350089
PNG
(((S)-2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-in...)
Show SMILES CCCN1Cc2[nH]c(nc2C[C@H]1C(=O)N1C[C@@H]2C[C@H]1CN2C)-c1n[nH]c2cc(ccc12)-c1cc(F)c(O)cc1CC
Show InChI InChI=1S/C31H34FN7O2/c1-4-8-38-16-26-25(13-27(38)31(41)39-15-19-11-20(39)14-37(19)3)33-30(34-26)29-21-7-6-18(9-24(21)35-36-29)22-12-23(32)28(40)10-17(22)5-2/h6-7,9-10,12,19-20,27,40H,4-5,8,11,13-16H2,1-3H3/b30-29-/t19-,20-,27-/m0/s1
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0.25n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10208040 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM350095
PNG
(US10208040, Example 1-12)
Show SMILES CCc1cc(O)c(F)cc1-c1ccc2c(n[nH]c2c1)-c1nc2C[C@H](N(C)Cc2[nH]1)C(=O)N1CCN(CC1)C(C)C
Show InChI InChI=1S/C30H34FN7O2/c1-5-18-13-27(39)22(31)14-21(18)19-6-7-20-23(12-19)34-35-28(20)29-32-24-15-26(36(4)16-25(24)33-29)30(40)38-10-8-37(9-11-38)17(2)3/h6-7,12-14,17,26,39H,5,8-11,15-16H2,1-4H3/b29-28-/t26-/m0/s1
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0.25n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10208040 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM120141
PNG
(US8697708, 224)
Show SMILES Nc1cc(Nc2ncc(C#N)c3nc(sc23)-c2c(F)cccc2[N+]#[C-])ncn1
Show InChI InChI=1S/C18H9FN8S/c1-22-11-4-2-3-10(19)14(11)18-27-15-9(6-20)7-23-17(16(15)28-18)26-13-5-12(21)24-8-25-13/h2-5,7-8H,(H3,21,23,24,25,26)
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0.300 -53.8n/an/an/an/an/a7.222



F. Hoffmann-La Roche AG

US Patent


Assay Description
To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...


US Patent US8697708 (2014)


BindingDB Entry DOI: 10.7270/Q2J38R6F
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM120132
PNG
(US8697708, 18)
Show SMILES OCc1ccnc(Nc2nccc3nc(sc23)-c2c(Cl)cccc2Cl)c1
Show InChI InChI=1S/C18H12Cl2N4OS/c19-11-2-1-3-12(20)15(11)18-23-13-5-7-22-17(16(13)26-18)24-14-8-10(9-25)4-6-21-14/h1-8,25H,9H2,(H,21,22,24)
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0.300 -53.8n/an/an/an/an/a7.222



F. Hoffmann-La Roche AG

US Patent


Assay Description
To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...


US Patent US8697708 (2014)


BindingDB Entry DOI: 10.7270/Q2J38R6F
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM333120
PNG
((S)-(3-(dimethylamino)azetidin-1-yl)(2-(6-(2-ethyl...)
Show SMILES CCc1cc(O)c(F)cc1-c1ccc2c(n[nH]c2c1)-c1nc2C[C@H](N(Cc2[nH]1)C(C)C)C(=O)N1CC(C1)N(C)C
Show InChI InChI=1S/C30H34FN7O2/c1-6-17-10-27(39)22(31)11-21(17)18-7-8-20-23(9-18)34-35-28(20)29-32-24-12-26(38(16(2)3)15-25(24)33-29)30(40)37-13-19(14-37)36(4)5/h7-11,16,19,26,39H,6,12-15H2,1-5H3/b29-28-/t26-/m0/s1
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0.320n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10196393 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM350090
PNG
(((S)-3-(dimethylamino)pyrrolidin-1-yl)((S)-5-ethyl...)
Show SMILES CCc1cc(O)c(F)cc1-c1ccc2c(n[nH]c2c1)-c1nc2C[C@H](N(Cc2[nH]1)C(C)C)C(=O)N1CC[C@@H](C1)N(C)C
Show InChI InChI=1S/C31H36FN7O2/c1-6-18-12-28(40)23(32)13-22(18)19-7-8-21-24(11-19)35-36-29(21)30-33-25-14-27(39(17(2)3)16-26(25)34-30)31(41)38-10-9-20(15-38)37(4)5/h7-8,11-13,17,20,27,40H,6,9-10,14-16H2,1-5H3/b30-29-/t20-,27-/m0/s1
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0.400n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10208040 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM333122
PNG
((S)-(3-(dimethylamino)-3-methylazetidin-1-yl)(2-(6...)
Show SMILES CCCN1Cc2[nH]c(nc2C[C@H]1C(=O)N1CC(C)(C1)N(C)C)-c1n[nH]c2cc(ccc12)-c1cc(F)c(O)cc1CC
Show InChI InChI=1S/C31H36FN7O2/c1-6-10-38-15-25-24(14-26(38)30(41)39-16-31(3,17-39)37(4)5)33-29(34-25)28-20-9-8-19(11-23(20)35-36-28)21-13-22(32)27(40)12-18(21)7-2/h8-9,11-13,26,40H,6-7,10,14-17H2,1-5H3/b29-28-/t26-/m0/s1
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0.400n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10196393 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM120140
PNG
(US8697708, 223)
Show SMILES Nc1cc(Nc2ncc(C#N)c3nc(sc23)-c2c(F)cccc2Cl)ncn1
Show InChI InChI=1S/C17H9ClFN7S/c18-9-2-1-3-10(19)13(9)17-26-14-8(5-20)6-22-16(15(14)27-17)25-12-4-11(21)23-7-24-12/h1-4,6-7H,(H3,21,22,23,24,25)
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0.400 -53.1n/an/an/an/an/a7.222



F. Hoffmann-La Roche AG

US Patent


Assay Description
To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...


US Patent US8697708 (2014)


BindingDB Entry DOI: 10.7270/Q2J38R6F
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM120143
PNG
(US8697708, 236)
Show SMILES Cc1nc(CO)cc(Nc2nccc3nc(sc23)-c2c(Cl)cccc2[N+]#[C-])n1
Show InChI InChI=1S/C19H13ClN6OS/c1-10-23-11(9-27)8-15(24-10)26-18-17-14(6-7-22-18)25-19(28-17)16-12(20)4-3-5-13(16)21-2/h3-8,27H,9H2,1H3,(H,22,23,24,26)
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0.5 -52.6n/an/an/an/an/a7.222



F. Hoffmann-La Roche AG

US Patent


Assay Description
To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...


US Patent US8697708 (2014)


BindingDB Entry DOI: 10.7270/Q2J38R6F
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM120128
PNG
(US8697708, 2)
Show SMILES Clc1cccc(Cl)c1-c1nc2ccnc(NC(=O)C3CC3)c2s1
Show InChI InChI=1S/C16H11Cl2N3OS/c17-9-2-1-3-10(18)12(9)16-20-11-6-7-19-14(13(11)23-16)21-15(22)8-4-5-8/h1-3,6-8H,4-5H2,(H,19,21,22)
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0.5 -52.6n/an/an/an/an/a7.222



F. Hoffmann-La Roche AG

US Patent


Assay Description
To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...


US Patent US8697708 (2014)


BindingDB Entry DOI: 10.7270/Q2J38R6F
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM50355501
PNG
(INCB-018424 | RUXOLITINIB | RUXOLITINIB PHOSPHATE ...)
Show SMILES N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/m1/s1
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0.5n/an/an/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of TYK2 kinase domain using N-terminal 5-carboxyfluorescein-tagged Val-Ala-Leu-Val-Asp-Gly-Tyr-Phe-Arg-Leu-Thr-Thr as substrate after 30 m...


J Med Chem 55: 6176-93 (2012)


Article DOI: 10.1021/jm300628c
BindingDB Entry DOI: 10.7270/Q25Q4X6S
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM277491
PNG
(US10072026, Example 2-27)
Show SMILES Cc1cc(Nc2cc3ncccc3c(N[C@H]3C[C@@H]4CCC[C@H](C3)N4C(=O)CCCC#N)n2)n[nH]1
Show InChI InChI=1S/C25H30N8O/c1-16-12-23(32-31-16)29-22-15-21-20(8-5-11-27-21)25(30-22)28-17-13-18-6-4-7-19(14-17)33(18)24(34)9-2-3-10-26/h5,8,11-12,15,17-19H,2-4,6-7,9,13-14H2,1H3,(H3,28,29,30,31,32)/t17-,18-,19+
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0.550n/an/an/an/an/an/a7.5n/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10072026 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM277492
PNG
(US10072026, Example 2-28)
Show SMILES Cc1cc(Nc2cc3ncccc3c(N[C@H]3C[C@@H]4CCC[C@H](C3)N4C(=O)c3ccc(nc3)C#N)n2)n[nH]1
Show InChI InChI=1S/C27H27N9O/c1-16-10-25(35-34-16)32-24-13-23-22(6-3-9-29-23)26(33-24)31-19-11-20-4-2-5-21(12-19)36(20)27(37)17-7-8-18(14-28)30-15-17/h3,6-10,13,15,19-21H,2,4-5,11-12H2,1H3,(H3,31,32,33,34,35)/t19-,20-,21+
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0.550n/an/an/an/an/an/a7.5n/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10072026 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM277493
PNG
(US10072026, Example 2-29)
Show SMILES CC(CC#N)C(=O)N1[C@H]2CCC[C@@H]1C[C@H](C2)Nc1nc(Nc2cc(C)[nH]n2)cc2ncccc12
Show InChI InChI=1S/C25H30N8O/c1-15(8-9-26)25(34)33-18-5-3-6-19(33)13-17(12-18)28-24-20-7-4-10-27-21(20)14-22(30-24)29-23-11-16(2)31-32-23/h4,7,10-11,14-15,17-19H,3,5-6,8,12-13H2,1-2H3,(H3,28,29,30,31,32)/t15?,17-,18-,19+
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0.550n/an/an/an/an/an/a7.5n/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10072026 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM277398
PNG
(N7-(5-methyl-1H-pyrazol-3-yl)-N5-((1R,3s,5S)-9-(ph...)
Show SMILES Cc1cc(Nc2cc3ncccc3c(N[C@H]3C[C@@H]4CCC[C@H](C3)N4S(=O)(=O)c3ccccc3)n2)n[nH]1
Show InChI InChI=1S/C26H29N7O2S/c1-17-13-25(32-31-17)29-24-16-23-22(11-6-12-27-23)26(30-24)28-18-14-19-7-5-8-20(15-18)33(19)36(34,35)21-9-3-2-4-10-21/h2-4,6,9-13,16,18-20H,5,7-8,14-15H2,1H3,(H3,28,29,30,31,32)/t18-,19-,20+
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0.550n/an/an/an/an/an/a7.5n/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10072026 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM277399
PNG
(N5-((1R,3s,5S)-9-(ethylsulfonyl)-9-azabicyclo[3.3....)
Show SMILES CCS(=O)(=O)N1[C@H]2CCC[C@@H]1C[C@H](C2)Nc1nc(Nc2cc(C)[nH]n2)cc2ncccc12
Show InChI InChI=1S/C22H29N7O2S/c1-3-32(30,31)29-16-6-4-7-17(29)12-15(11-16)24-22-18-8-5-9-23-19(18)13-20(26-22)25-21-10-14(2)27-28-21/h5,8-10,13,15-17H,3-4,6-7,11-12H2,1-2H3,(H3,24,25,26,27,28)/t15-,16-,17+
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0.550n/an/an/an/an/an/a7.5n/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10072026 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM277402
PNG
(1-(((1R,3s,5S)-3-((7-((5-methyl-1H-pyrazol-3-yl)am...)
Show SMILES Cc1cc(Nc2cc3ncccc3c(N[C@H]3C[C@@H]4CC[C@H](C3)N4S(=O)(=O)N3CC(C3)C#N)n2)n[nH]1
Show InChI InChI=1S/C23H27N9O2S/c1-14-7-22(30-29-14)27-21-10-20-19(3-2-6-25-20)23(28-21)26-16-8-17-4-5-18(9-16)32(17)35(33,34)31-12-15(11-24)13-31/h2-3,6-7,10,15-18H,4-5,8-9,12-13H2,1H3,(H3,26,27,28,29,30)/t16-,17-,18+
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0.550n/an/an/an/an/an/a7.5n/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10072026 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM277403
PNG
(N5-((1R,3s,5S)-9-((5-fluoropyridin-3-yl)sulfonyl)-...)
Show SMILES Cc1cc(Nc2cc3ncccc3c(N[C@H]3C[C@@H]4CCC[C@H](C3)N4S(=O)(=O)c3cncc(F)c3)n2)n[nH]1
Show InChI InChI=1S/C25H27FN8O2S/c1-15-8-24(33-32-15)30-23-12-22-21(6-3-7-28-22)25(31-23)29-17-10-18-4-2-5-19(11-17)34(18)37(35,36)20-9-16(26)13-27-14-20/h3,6-9,12-14,17-19H,2,4-5,10-11H2,1H3,(H3,29,30,31,32,33)/t17-,18-,19+
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0.550n/an/an/an/an/an/a7.5n/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10072026 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM277599
PNG
(US10072026, Example 6-18)
Show SMILES COc1cnc2cc(Nc3cc(C)[nH]n3)nc(N[C@H]3C[C@@H]4CC[C@H](C3)N4S(C)(=O)=O)c2c1
Show InChI InChI=1S/C21H27N7O3S/c1-12-6-20(27-26-12)24-19-10-18-17(9-16(31-2)11-22-18)21(25-19)23-13-7-14-4-5-15(8-13)28(14)32(3,29)30/h6,9-11,13-15H,4-5,7-8H2,1-3H3,(H3,23,24,25,26,27)/t13-,14-,15+
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0.550n/an/an/an/an/an/a7.5n/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10072026 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM277601
PNG
(US10072026, Example 6-20)
Show SMILES COc1cnc2cc(Nc3cc(C)[nH]n3)nc(N[C@H]3C[C@@H]4CC[C@H](C3)N4S(=O)(=O)N3CC(C3)C#N)c2c1
Show InChI InChI=1S/C24H29N9O3S/c1-14-5-23(31-30-14)28-22-9-21-20(8-19(36-2)11-26-21)24(29-22)27-16-6-17-3-4-18(7-16)33(17)37(34,35)32-12-15(10-25)13-32/h5,8-9,11,15-18H,3-4,6-7,12-13H2,1-2H3,(H3,27,28,29,30,31)/t16-,17-,18+
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0.550n/an/an/an/an/an/a7.5n/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10072026 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM277602
PNG
(US10072026, Example 6-21)
Show SMILES COc1cnc2cc(Nc3cc(C)[nH]n3)nc(N[C@H]3C[C@@H]4CC[C@H](C3)N4S(=O)(=O)CCCC#N)c2c1
Show InChI InChI=1S/C24H30N8O3S/c1-15-9-23(31-30-15)28-22-13-21-20(12-19(35-2)14-26-21)24(29-22)27-16-10-17-5-6-18(11-16)32(17)36(33,34)8-4-3-7-25/h9,12-14,16-18H,3-6,8,10-11H2,1-2H3,(H3,27,28,29,30,31)/t16-,17-,18+
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0.550n/an/an/an/an/an/a7.5n/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10072026 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM277603
PNG
(US10072026, Example 6-22)
Show SMILES COc1cnc2cc(Nc3cc(C)[nH]n3)nc(N[C@H]3C[C@@H]4CC[C@H](C3)N4S(=O)(=O)CCC#N)c2c1
Show InChI InChI=1S/C23H28N8O3S/c1-14-8-22(30-29-14)27-21-12-20-19(11-18(34-2)13-25-20)23(28-21)26-15-9-16-4-5-17(10-15)31(16)35(32,33)7-3-6-24/h8,11-13,15-17H,3-5,7,9-10H2,1-2H3,(H3,26,27,28,29,30)/t15-,16-,17+
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0.550n/an/an/an/an/an/a7.5n/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10072026 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM277604
PNG
(US10072026, Example 6-23)
Show SMILES COc1cnc2cc(Nc3cc(C)[nH]n3)nc(N[C@H]3C[C@@H]4CC[C@H](C3)N4S(=O)(=O)CC3(CC3)C#N)c2c1
Show InChI InChI=1S/C25H30N8O3S/c1-15-7-23(32-31-15)29-22-11-21-20(10-19(36-2)12-27-21)24(30-22)28-16-8-17-3-4-18(9-16)33(17)37(34,35)14-25(13-26)5-6-25/h7,10-12,16-18H,3-6,8-9,14H2,1-2H3,(H3,28,29,30,31,32)/t16-,17-,18+
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0.550n/an/an/an/an/an/a7.5n/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10072026 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM277501
PNG
(US10072026, Example 3-6)
Show SMILES CCOC(=O)N1[C@H]2CCC[C@@H]1C[C@H](C2)Nc1nc(Nc2cc(C)[nH]n2)cc2ncccc12
Show InChI InChI=1S/C23H29N7O2/c1-3-32-23(31)30-16-6-4-7-17(30)12-15(11-16)25-22-18-8-5-9-24-19(18)13-20(27-22)26-21-10-14(2)28-29-21/h5,8-10,13,15-17H,3-4,6-7,11-12H2,1-2H3,(H3,25,26,27,28,29)/t15-,16-,17+
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0.550n/an/an/an/an/an/a7.5n/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10072026 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM279850
PNG
(US10028960, Example 3-5)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2C(=O)CC1CC1
Show InChI InChI=1S/C23H33N7O3/c1-29(18-10-16-4-3-5-17(11-18)30(16)22(32)8-14-6-7-14)23-25-19(12-21(26-23)33-2)24-20-9-15(13-31)27-28-20/h9,12,14,16-18,31H,3-8,10-11,13H2,1-2H3,(H2,24,25,26,27,28)/t16-,17+,18-
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0.550n/an/an/an/an/an/a7.5n/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10028960 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM279852
PNG
(US10028960, Example 3-7)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2C(=O)C1CCCC1
Show InChI InChI=1S/C24H35N7O3/c1-30(24-26-20(13-22(27-24)34-2)25-21-10-16(14-32)28-29-21)19-11-17-8-5-9-18(12-19)31(17)23(33)15-6-3-4-7-15/h10,13,15,17-19,32H,3-9,11-12,14H2,1-2H3,(H2,25,26,27,28,29)/t17-,18+,19-
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0.550n/an/an/an/an/an/a7.5n/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10028960 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM279853
PNG
(US10028960, Example 3-8)
Show SMILES COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2C(=O)C1CCC1
Show InChI InChI=1S/C23H33N7O3/c1-29(18-10-16-7-4-8-17(11-18)30(16)22(32)14-5-3-6-14)23-25-19(12-21(26-23)33-2)24-20-9-15(13-31)27-28-20/h9,12,14,16-18,31H,3-8,10-11,13H2,1-2H3,(H2,24,25,26,27,28)/t16-,17+,18-
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0.550n/an/an/an/an/an/a7.5n/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10028960 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM277505
PNG
(US10072026, Example 3-10)
Show SMILES CCCCOC(=O)N1[C@H]2CCC[C@@H]1C[C@H](C2)Nc1nc(Nc2cc(C)[nH]n2)cc2ncccc12
Show InChI InChI=1S/C25H33N7O2/c1-3-4-11-34-25(33)32-18-7-5-8-19(32)14-17(13-18)27-24-20-9-6-10-26-21(20)15-22(29-24)28-23-12-16(2)30-31-23/h6,9-10,12,15,17-19H,3-5,7-8,11,13-14H2,1-2H3,(H3,27,28,29,30,31)/t17-,18-,19+
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0.550n/an/an/an/an/an/a7.5n/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10072026 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM277510
PNG
(US10072026, Example 4-1)
Show SMILES Cc1cc(Nc2cc3ncccc3c(N[C@H]3C[C@@H]4CC[C@H](C3)N4S(C)(=O)=O)n2)n[nH]1
Show InChI InChI=1S/C20H25N7O2S/c1-12-8-19(26-25-12)23-18-11-17-16(4-3-7-21-17)20(24-18)22-13-9-14-5-6-15(10-13)27(14)30(2,28)29/h3-4,7-8,11,13-15H,5-6,9-10H2,1-2H3,(H3,22,23,24,25,26)/t13-,14-,15+
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0.550n/an/an/an/an/an/a7.5n/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10072026 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM277512
PNG
(US10072026, Example 4-3)
Show SMILES CC(C)CS(=O)(=O)N1[C@H]2CC[C@@H]1C[C@H](C2)Nc1nc(Nc2cc(C)[nH]n2)cc2ncccc12
Show InChI InChI=1S/C23H31N7O2S/c1-14(2)13-33(31,32)30-17-6-7-18(30)11-16(10-17)25-23-19-5-4-8-24-20(19)12-21(27-23)26-22-9-15(3)28-29-22/h4-5,8-9,12,14,16-18H,6-7,10-11,13H2,1-3H3,(H3,25,26,27,28,29)/t16-,17-,18+
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0.550n/an/an/an/an/an/a7.5n/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10072026 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM277516
PNG
(US10072026, Example 4-7)
Show SMILES Cc1cc(Nc2cc3ncccc3c(N[C@H]3C[C@@H]4CC[C@H](C3)N4S(=O)(=O)C3(C)CC3)n2)n[nH]1
Show InChI InChI=1S/C23H29N7O2S/c1-14-10-21(29-28-14)26-20-13-19-18(4-3-9-24-19)22(27-20)25-15-11-16-5-6-17(12-15)30(16)33(31,32)23(2)7-8-23/h3-4,9-10,13,15-17H,5-8,11-12H2,1-2H3,(H3,25,26,27,28,29)/t15-,16-,17+
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0.550n/an/an/an/an/an/a7.5n/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10072026 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM277517
PNG
(US10072026, Example 4-8)
Show SMILES CCC1(CC1)S(=O)(=O)N1[C@H]2CC[C@@H]1C[C@H](C2)Nc1nc(Nc2cc(C)[nH]n2)cc2ncccc12
Show InChI InChI=1S/C24H31N7O2S/c1-3-24(8-9-24)34(32,33)31-17-6-7-18(31)13-16(12-17)26-23-19-5-4-10-25-20(19)14-21(28-23)27-22-11-15(2)29-30-22/h4-5,10-11,14,16-18H,3,6-9,12-13H2,1-2H3,(H3,26,27,28,29,30)/t16-,17-,18+
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0.550n/an/an/an/an/an/a7.5n/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10072026 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM277525
PNG
(US10072026, Example 4-16)
Show SMILES Cc1cc(Nc2cc3ncccc3c(N[C@H]3C[C@@H]4CCC[C@H](C3)N4S(C)(=O)=O)n2)n[nH]1
Show InChI InChI=1S/C21H27N7O2S/c1-13-9-20(27-26-13)24-19-12-18-17(7-4-8-22-18)21(25-19)23-14-10-15-5-3-6-16(11-14)28(15)31(2,29)30/h4,7-9,12,14-16H,3,5-6,10-11H2,1-2H3,(H3,23,24,25,26,27)/t14-,15-,16+
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0.550n/an/an/an/an/an/a7.5n/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10072026 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM277526
PNG
(US10072026, Example 4-17)
Show SMILES CC(C)CS(=O)(=O)N1[C@H]2CCC[C@@H]1C[C@H](C2)Nc1nc(Nc2cc(C)[nH]n2)cc2ncccc12
Show InChI InChI=1S/C24H33N7O2S/c1-15(2)14-34(32,33)31-18-6-4-7-19(31)12-17(11-18)26-24-20-8-5-9-25-21(20)13-22(28-24)27-23-10-16(3)29-30-23/h5,8-10,13,15,17-19H,4,6-7,11-12,14H2,1-3H3,(H3,26,27,28,29,30)/t17-,18-,19+
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0.550n/an/an/an/an/an/a7.5n/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10072026 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM277527
PNG
(US10072026, Example 4-18)
Show SMILES Cc1cc(Nc2cc3ncccc3c(N[C@H]3C[C@@H]4CCC[C@H](C3)N4S(=O)(=O)C3CC3)n2)n[nH]1
Show InChI InChI=1S/C23H29N7O2S/c1-14-10-22(29-28-14)26-21-13-20-19(6-3-9-24-20)23(27-21)25-15-11-16-4-2-5-17(12-15)30(16)33(31,32)18-7-8-18/h3,6,9-10,13,15-18H,2,4-5,7-8,11-12H2,1H3,(H3,25,26,27,28,29)/t15-,16-,17+
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0.550n/an/an/an/an/an/a7.5n/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10072026 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM277528
PNG
(US10072026, Example 4-19)
Show SMILES COCCS(=O)(=O)N1[C@H]2CCC[C@@H]1C[C@H](C2)Nc1nc(Nc2cc(C)[nH]n2)cc2ncccc12
Show InChI InChI=1S/C23H31N7O3S/c1-15-11-22(29-28-15)26-21-14-20-19(7-4-8-24-20)23(27-21)25-16-12-17-5-3-6-18(13-16)30(17)34(31,32)10-9-33-2/h4,7-8,11,14,16-18H,3,5-6,9-10,12-13H2,1-2H3,(H3,25,26,27,28,29)/t16-,17-,18+
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0.550n/an/an/an/an/an/a7.5n/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10072026 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM277529
PNG
(US10072026, Example 4-20)
Show SMILES CCC1(CC1)S(=O)(=O)N1[C@H]2CCC[C@@H]1C[C@H](C2)Nc1nc(Nc2cc(C)[nH]n2)cc2ncccc12
Show InChI InChI=1S/C25H33N7O2S/c1-3-25(9-10-25)35(33,34)32-18-6-4-7-19(32)14-17(13-18)27-24-20-8-5-11-26-21(20)15-22(29-24)28-23-12-16(2)30-31-23/h5,8,11-12,15,17-19H,3-4,6-7,9-10,13-14H2,1-2H3,(H3,27,28,29,30,31)/t17-,18-,19+
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0.550n/an/an/an/an/an/a7.5n/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10072026 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM277530
PNG
(US10072026, Example 4-21)
Show SMILES Cc1cc(Nc2cc3ncccc3c(N[C@H]3C[C@@H]4CCC[C@H](C3)N4S(=O)(=O)C3CNC3)n2)n[nH]1
Show InChI InChI=1S/C23H30N8O2S/c1-14-8-22(30-29-14)27-21-11-20-19(6-3-7-25-20)23(28-21)26-15-9-16-4-2-5-17(10-15)31(16)34(32,33)18-12-24-13-18/h3,6-8,11,15-18,24H,2,4-5,9-10,12-13H2,1H3,(H3,26,27,28,29,30)/t15-,16-,17+
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0.550n/an/an/an/an/an/a7.5n/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10072026 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM277531
PNG
(US10072026, Example 4-22)
Show SMILES Cc1cc(Nc2cc3ncccc3c(N[C@H]3C[C@@H]4CCC[C@H](C3)N4S(=O)(=O)CC=C)n2)n[nH]1
Show InChI InChI=1S/C23H29N7O2S/c1-3-10-33(31,32)30-17-6-4-7-18(30)13-16(12-17)25-23-19-8-5-9-24-20(19)14-21(27-23)26-22-11-15(2)28-29-22/h3,5,8-9,11,14,16-18H,1,4,6-7,10,12-13H2,2H3,(H3,25,26,27,28,29)/t16-,17-,18+
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0.550n/an/an/an/an/an/a7.5n/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10072026 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM277532
PNG
(US10072026, Example 4-23)
Show SMILES Cc1cc(Nc2cc3ncccc3c(N[C@H]3C[C@@H]4CCC[C@H](C3)N4S(=O)(=O)CC3CC3)n2)n[nH]1
Show InChI InChI=1S/C24H31N7O2S/c1-15-10-23(30-29-15)27-22-13-21-20(6-3-9-25-21)24(28-22)26-17-11-18-4-2-5-19(12-17)31(18)34(32,33)14-16-7-8-16/h3,6,9-10,13,16-19H,2,4-5,7-8,11-12,14H2,1H3,(H3,26,27,28,29,30)/t17-,18-,19+
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0.550n/an/an/an/an/an/a7.5n/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10072026 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM277536
PNG
(US10072026, Example 4-27)
Show SMILES Cc1cc(Nc2cc3ncccc3c(N[C@H]3C[C@@H]4CCC[C@H](C3)N4S(=O)(=O)N3CCCC3)n2)n[nH]1
Show InChI InChI=1S/C24H32N8O2S/c1-16-12-23(30-29-16)27-22-15-21-20(8-5-9-25-21)24(28-22)26-17-13-18-6-4-7-19(14-17)32(18)35(33,34)31-10-2-3-11-31/h5,8-9,12,15,17-19H,2-4,6-7,10-11,13-14H2,1H3,(H3,26,27,28,29,30)/t17-,18-,19+
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0.550n/an/an/an/an/an/a7.5n/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10072026 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM277537
PNG
(US10072026, Example 4-28)
Show SMILES CCCC1CCCN1S(=O)(=O)N1[C@H]2CCC[C@@H]1C[C@H](C2)Nc1nc(Nc2cc(C)[nH]n2)cc2ncccc12
Show InChI InChI=1S/C27H38N8O2S/c1-3-7-20-10-6-13-34(20)38(36,37)35-21-8-4-9-22(35)16-19(15-21)29-27-23-11-5-12-28-24(23)17-25(31-27)30-26-14-18(2)32-33-26/h5,11-12,14,17,19-22H,3-4,6-10,13,15-16H2,1-2H3,(H3,29,30,31,32,33)/t19-,20?,21-,22+
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0.550n/an/an/an/an/an/a7.5n/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10072026 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM277538
PNG
(US10072026, Example 4-29)
Show SMILES Cc1cc(Nc2cc3ncccc3c(N[C@H]3C[C@@H]4CCC[C@H](C3)N4S(=O)(=O)N3CCC3)n2)n[nH]1
Show InChI InChI=1S/C23H30N8O2S/c1-15-11-22(29-28-15)26-21-14-20-19(7-3-8-24-20)23(27-21)25-16-12-17-5-2-6-18(13-16)31(17)34(32,33)30-9-4-10-30/h3,7-8,11,14,16-18H,2,4-6,9-10,12-13H2,1H3,(H3,25,26,27,28,29)/t16-,17-,18+
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0.550n/an/an/an/an/an/a7.5n/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10072026 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM277539
PNG
(US10072026, Example 5-1)
Show SMILES COc1ccc2c(N[C@H]3C[C@@H]4CC[C@H](C3)N4CC(F)(F)F)nc(Nc3cc(C)[nH]n3)cc2n1
Show InChI InChI=1S/C22H26F3N7O/c1-12-7-19(31-30-12)28-18-10-17-16(5-6-20(27-17)33-2)21(29-18)26-13-8-14-3-4-15(9-13)32(14)11-22(23,24)25/h5-7,10,13-15H,3-4,8-9,11H2,1-2H3,(H3,26,28,29,30,31)/t13-,14-,15+
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0.550n/an/an/an/an/an/a7.5n/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10072026 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM277546
PNG
(US10072026, Example 5-8)
Show SMILES COc1ccc2c(N[C@H]3C[C@@H]4CC[C@H](C3)N4CCC#N)nc(Nc3cc(C)[nH]n3)cc2n1
Show InChI InChI=1S/C23H28N8O/c1-14-10-21(30-29-14)27-20-13-19-18(6-7-22(26-19)32-2)23(28-20)25-15-11-16-4-5-17(12-15)31(16)9-3-8-24/h6-7,10,13,15-17H,3-5,9,11-12H2,1-2H3,(H3,25,27,28,29,30)/t15-,16-,17+
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0.550n/an/an/an/an/an/a7.5n/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10072026 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM277547
PNG
(US10072026, Example 5-9)
Show SMILES COc1ccc2c(N[C@H]3C[C@@H]4CC[C@H](C3)N4S(C)(=O)=O)nc(Nc3cc(C)[nH]n3)cc2n1
Show InChI InChI=1S/C21H27N7O3S/c1-12-8-19(27-26-12)24-18-11-17-16(6-7-20(23-17)31-2)21(25-18)22-13-9-14-4-5-15(10-13)28(14)32(3,29)30/h6-8,11,13-15H,4-5,9-10H2,1-3H3,(H3,22,24,25,26,27)/t13-,14-,15+
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0.550n/an/an/an/an/an/a7.5n/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10072026 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM277548
PNG
(US10072026, Example 5-10)
Show SMILES COc1ccc2c(N[C@H]3C[C@@H]4CCC[C@H](C3)N4CCC#N)nc(Nc3cc(C)[nH]n3)cc2n1
Show InChI InChI=1S/C24H30N8O/c1-15-11-22(31-30-15)28-21-14-20-19(7-8-23(27-20)33-2)24(29-21)26-16-12-17-5-3-6-18(13-16)32(17)10-4-9-25/h7-8,11,14,16-18H,3-6,10,12-13H2,1-2H3,(H3,26,28,29,30,31)/t16-,17-,18+
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0.550n/an/an/an/an/an/a7.5n/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10072026 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM277549
PNG
(US10072026, Example 5-11)
Show SMILES Cc1cc(Nc2cc3nc(CO)ccc3c(N[C@H]3C[C@@H]4CC[C@H](C3)N4CC#N)n2)n[nH]1
Show InChI InChI=1S/C22H26N8O/c1-13-8-21(29-28-13)26-20-11-19-18(5-2-14(12-31)24-19)22(27-20)25-15-9-16-3-4-17(10-15)30(16)7-6-23/h2,5,8,11,15-17,31H,3-4,7,9-10,12H2,1H3,(H3,25,26,27,28,29)/t15-,16-,17+
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0.550n/an/an/an/an/an/a7.5n/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10072026 (2018)

More data for this
Ligand-Target Pair
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