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Compile Data Set for Download or QSAR

Found 2298 hits Enz. Inhib. hit(s) with Target = 'S-adenosylmethionine synthase isoform type-2'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
S-adenosylmethionine synthase isoform type-2


(Rattus norvegicus)
BDBM18134
PNG
(({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-...)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)NP(O)(O)=O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C10H17N6O12P3/c11-8-5-9(13-2-12-8)16(3-14-5)10-7(18)6(17)4(27-10)1-26-31(24,25)28-30(22,23)15-29(19,20)21/h2-4,6-7,10,17-18H,1H2,(H,24,25)(H2,11,12,13)(H4,15,19,20,21,22,23)/t4-,6-,7-,10-/m1/s1
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5.50E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory constant against rat kidney Methionine adenosyltransferase II


J Med Chem 29: 318-22 (1986)


Article DOI: 10.1021/jm00153a003
BindingDB Entry DOI: 10.7270/Q2DF6RSH
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Rattus norvegicus)
BDBM85447
PNG
(Epoxy analogue, I(a))
Show SMILES N[C@@H](C[C@H]1CO1)C(O)=O
Show InChI InChI=1S/C5H9NO3/c6-4(5(7)8)1-3-2-9-3/h3-4H,1-2,6H2,(H,7,8)/t3-,4-/m0/s1
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7.00E+3 -30.6 5.00E+4n/an/an/an/a7.537



Laboratoire de chimie bioorganique



Assay Description
AdoMet synthetase activity was measured by a radioactive assay using (14C-methyl)-L-methionine as described by Sullivan and Hoffman with minor modifi...


J Enzym Inhib 13: 361-7 (1998)


Article DOI: 10.3109/14756369809021481
BindingDB Entry DOI: 10.7270/Q2668BQ4
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
S-adenosylmethionine synthase isoform type-2


(Rattus norvegicus)
BDBM50367328
PNG
(CHEMBL1791415)
Show SMILES NC(CCSC(CP(O)(=O)OP(O)(=O)NP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C15H26N7O13P3S/c16-6(15(25)26)1-2-39-7(3-36(27,28)35-38(32,33)21-37(29,30)31)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-11,14,23-24H,1-3,16H2,(H,25,26)(H,27,28)(H2,17,18,19)(H4,21,29,30,31,32,33)/t6?,7?,9-,10+,11+,14+/m0/s1
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1.60E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition constant was evaluated with kidney Methionine adenosyltransferase II form of rat methionine adenosyltransferase, when ATP was the variable...


J Med Chem 29: 1030-8 (1986)


Article DOI: 10.1021/jm00156a022
BindingDB Entry DOI: 10.7270/Q2CF9QN4
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Rattus norvegicus)
BDBM50367329
PNG
(CHEMBL1791416)
Show SMILES NC(CCSC(CP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C15H25N6O14P3S/c16-6(15(24)25)1-2-39-7(3-36(26,27)34-38(31,32)35-37(28,29)30)11-9(22)10(23)14(33-11)21-5-20-8-12(17)18-4-19-13(8)21/h4-7,9-11,14,22-23H,1-3,16H2,(H,24,25)(H,26,27)(H,31,32)(H2,17,18,19)(H2,28,29,30)/t6?,7?,9-,10+,11+,14+/m0/s1
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3.90E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition constant was evaluated with kidney Methionine adenosyltransferase II form of rat methionine adenosyltransferase, when ATP was the variable...


J Med Chem 29: 1030-8 (1986)


Article DOI: 10.1021/jm00156a022
BindingDB Entry DOI: 10.7270/Q2CF9QN4
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Rattus norvegicus)
BDBM50452293
PNG
(CHEMBL2092766)
Show SMILES CCC[C@]1(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C13H22N5O13P3/c1-2-3-13(4-28-33(24,25)31-34(26,27)30-32(21,22)23)9(20)8(19)12(29-13)18-6-17-7-10(14)15-5-16-11(7)18/h5-6,8-9,12,19-20H,2-4H2,1H3,(H,24,25)(H,26,27)(H2,14,15,16)(H2,21,22,23)/t8-,9+,12-,13-/m1/s1
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4.80E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition constant was evaluated with kidney Methionine adenosyltransferase II form of rat methionine adenosyltransferase, when ATP was the variable...


J Med Chem 29: 1030-8 (1986)


Article DOI: 10.1021/jm00156a022
BindingDB Entry DOI: 10.7270/Q2CF9QN4
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Rattus norvegicus)
BDBM50367301
PNG
(CHEMBL1791432)
Show SMILES CCCC(OP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C13H22N5O13P3/c1-2-3-6(29-33(24,25)31-34(26,27)30-32(21,22)23)10-8(19)9(20)13(28-10)18-5-17-7-11(14)15-4-16-12(7)18/h4-6,8-10,13,19-20H,2-3H2,1H3,(H,24,25)(H,26,27)(H2,14,15,16)(H2,21,22,23)/t6?,8-,9+,10+,13+/m0/s1
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4.80E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory constant against rat kidney Methionine adenosyltransferase II, activity expressed as Ki


J Med Chem 29: 318-22 (1986)


Article DOI: 10.1021/jm00153a003
BindingDB Entry DOI: 10.7270/Q2DF6RSH
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Rattus norvegicus)
BDBM85448
PNG
(Epoxy analogue, I(b))
Show SMILES C[C@H]1O[C@H]1C[C@H](N)C(O)=O
Show InChI InChI=1S/C6H11NO3/c1-3-5(10-3)2-4(7)6(8)9/h3-5H,2,7H2,1H3,(H,8,9)/t3-,4+,5+/m1/s1
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6.10E+4 -25.0 1.00E+5n/an/an/an/a7.537



Laboratoire de chimie bioorganique



Assay Description
AdoMet synthetase activity was measured by a radioactive assay using (14C-methyl)-L-methionine as described by Sullivan and Hoffman with minor modifi...


J Enzym Inhib 13: 361-7 (1998)


Article DOI: 10.3109/14756369809021481
BindingDB Entry DOI: 10.7270/Q2668BQ4
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Rattus norvegicus)
BDBM50367042
PNG
(CHEMBL606221)
Show SMILES Nc1ncnc2n(cnc12)C1O[C@H](CCOP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C11H18N5O13P3/c12-9-6-10(14-3-13-9)16(4-15-6)11-8(18)7(17)5(27-11)1-2-26-31(22,23)29-32(24,25)28-30(19,20)21/h3-5,7-8,11,17-18H,1-2H2,(H,22,23)(H,24,25)(H2,12,13,14)(H2,19,20,21)/t5-,7-,8-,11?/m1/s1
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7.50E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory constant against rat kidney Methionine adenosyltransferase II


J Med Chem 29: 318-22 (1986)


Article DOI: 10.1021/jm00153a003
BindingDB Entry DOI: 10.7270/Q2DF6RSH
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Rattus norvegicus)
BDBM85450
PNG
(Epithioamino acid analogue, II(a))
Show SMILES N[C@@H](C[C@@H]1CS1)C(O)=O
Show InChI InChI=1S/C5H9NO2S/c6-4(5(7)8)1-3-2-9-3/h3-4H,1-2,6H2,(H,7,8)/t3-,4+/m1/s1
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1.00E+5 -23.7 1.40E+5n/an/an/an/a7.537



Laboratoire de chimie bioorganique



Assay Description
AdoMet synthetase activity was measured by a radioactive assay using (14C-methyl)-L-methionine as described by Sullivan and Hoffman with minor modifi...


J Enzym Inhib 13: 361-7 (1998)


Article DOI: 10.3109/14756369809021481
BindingDB Entry DOI: 10.7270/Q2668BQ4
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Rattus norvegicus)
BDBM85449
PNG
(Epoxy analogue, I(c))
Show SMILES C[C@@H]1O[C@H]1C[C@H](N)C(O)=O
Show InChI InChI=1S/C6H11NO3/c1-3-5(10-3)2-4(7)6(8)9/h3-5H,2,7H2,1H3,(H,8,9)/t3-,4-,5-/m0/s1
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1.05E+5 -23.6 1.10E+5n/an/an/an/a7.537



Laboratoire de chimie bioorganique



Assay Description
AdoMet synthetase activity was measured by a radioactive assay using (14C-methyl)-L-methionine as described by Sullivan and Hoffman with minor modifi...


J Enzym Inhib 13: 361-7 (1998)


Article DOI: 10.3109/14756369809021481
BindingDB Entry DOI: 10.7270/Q2668BQ4
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Rattus norvegicus)
BDBM85451
PNG
(Epithioamino acid analogue, II(b))
Show SMILES C[C@H]1S[C@@H]1C[C@H](N)C(O)=O
Show InChI InChI=1S/C6H11NO2S/c1-3-5(10-3)2-4(7)6(8)9/h3-5H,2,7H2,1H3,(H,8,9)/t3-,4+,5-/m1/s1
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1.40E+5 -22.9 3.00E+5n/an/an/an/a7.537



Laboratoire de chimie bioorganique



Assay Description
AdoMet synthetase activity was measured by a radioactive assay using (14C-methyl)-L-methionine as described by Sullivan and Hoffman with minor modifi...


J Enzym Inhib 13: 361-7 (1998)


Article DOI: 10.3109/14756369809021481
BindingDB Entry DOI: 10.7270/Q2668BQ4
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Rattus norvegicus)
BDBM85452
PNG
(Epithioamino acid analogue, II(c))
Show SMILES C[C@@H]1S[C@@H]1C[C@H](N)C(O)=O
Show InChI InChI=1S/C6H11NO2S/c1-3-5(10-3)2-4(7)6(8)9/h3-5H,2,7H2,1H3,(H,8,9)/t3-,4-,5+/m0/s1
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1.40E+5 -22.9 4.00E+5n/an/an/an/a7.537



Laboratoire de chimie bioorganique



Assay Description
AdoMet synthetase activity was measured by a radioactive assay using (14C-methyl)-L-methionine as described by Sullivan and Hoffman with minor modifi...


J Enzym Inhib 13: 361-7 (1998)


Article DOI: 10.3109/14756369809021481
BindingDB Entry DOI: 10.7270/Q2668BQ4
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Rattus norvegicus)
BDBM50026197
PNG
(Adenosine 5'-triphosphate derivative | CHEMBL31428...)
Show SMILES CO[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1n1cnc2c(N)ncnc12
Show InChI InChI=1S/C11H18N5O13P3/c1-25-8-7(17)5(2-26-31(21,22)29-32(23,24)28-30(18,19)20)27-11(8)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17H,2H2,1H3,(H,21,22)(H,23,24)(H2,12,13,14)(H2,18,19,20)
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1.40E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory constant against rat kidney Methionine adenosyltransferase II, activity expressed as Ki


J Med Chem 29: 318-22 (1986)


Article DOI: 10.1021/jm00153a003
BindingDB Entry DOI: 10.7270/Q2DF6RSH
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Rattus norvegicus)
BDBM50367331
PNG
(CHEMBL1791417)
Show SMILES NC(CCS(=O)C(CP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C15H25N6O15P3S/c16-6(15(24)25)1-2-40(33)7(3-37(26,27)35-39(31,32)36-38(28,29)30)11-9(22)10(23)14(34-11)21-5-20-8-12(17)18-4-19-13(8)21/h4-7,9-11,14,22-23H,1-3,16H2,(H,24,25)(H,26,27)(H,31,32)(H2,17,18,19)(H2,28,29,30)/t6?,7?,9-,10+,11+,14+,40?/m0/s1
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1.40E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition constant was evaluated with kidney Methionine adenosyltransferase II form of rat methionine adenosyltransferase, when ATP was the variable...


J Med Chem 29: 1030-8 (1986)


Article DOI: 10.1021/jm00156a022
BindingDB Entry DOI: 10.7270/Q2CF9QN4
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Rattus norvegicus)
BDBM50026193
PNG
(Adenosine 5'-triphosphate derivative | CHEMBL31428...)
Show SMILES CO[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C11H18N5O13P3/c1-25-8-5(2-26-31(21,22)29-32(23,24)28-30(18,19)20)27-11(7(8)17)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17H,2H2,1H3,(H,21,22)(H,23,24)(H2,12,13,14)(H2,18,19,20)
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1.70E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory constant against rat kidney Methionine adenosyltransferase II, activity expressed as Ki


J Med Chem 29: 318-22 (1986)


Article DOI: 10.1021/jm00153a003
BindingDB Entry DOI: 10.7270/Q2DF6RSH
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Rattus norvegicus)
BDBM50367329
PNG
(CHEMBL1791416)
Show SMILES NC(CCSC(CP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C15H25N6O14P3S/c16-6(15(24)25)1-2-39-7(3-36(26,27)34-38(31,32)35-37(28,29)30)11-9(22)10(23)14(33-11)21-5-20-8-12(17)18-4-19-13(8)21/h4-7,9-11,14,22-23H,1-3,16H2,(H,24,25)(H,26,27)(H,31,32)(H2,17,18,19)(H2,28,29,30)/t6?,7?,9-,10+,11+,14+/m0/s1
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1.80E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition constant was evaluated with kidney Methionine adenosyltransferase II form of rat methionine adenosyltransferase, when ATP was the variable...


J Med Chem 29: 1030-8 (1986)


Article DOI: 10.1021/jm00156a022
BindingDB Entry DOI: 10.7270/Q2CF9QN4
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Rattus norvegicus)
BDBM50367305
PNG
(CHEMBL1791430)
Show SMILES CC(OP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C11H18N5O13P3/c1-4(27-31(22,23)29-32(24,25)28-30(19,20)21)8-6(17)7(18)11(26-8)16-3-15-5-9(12)13-2-14-10(5)16/h2-4,6-8,11,17-18H,1H3,(H,22,23)(H,24,25)(H2,12,13,14)(H2,19,20,21)/t4?,6-,7+,8+,11+/m0/s1
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1.90E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory constant against rat kidney Methionine adenosyltransferase II, activity expressed as Ki


J Med Chem 29: 318-22 (1986)


Article DOI: 10.1021/jm00153a003
BindingDB Entry DOI: 10.7270/Q2DF6RSH
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Rattus norvegicus)
BDBM50452293
PNG
(CHEMBL2092766)
Show SMILES CCC[C@]1(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C13H22N5O13P3/c1-2-3-13(4-28-33(24,25)31-34(26,27)30-32(21,22)23)9(20)8(19)12(29-13)18-6-17-7-10(14)15-5-16-11(7)18/h5-6,8-9,12,19-20H,2-4H2,1H3,(H,24,25)(H,26,27)(H2,14,15,16)(H2,21,22,23)/t8-,9+,12-,13-/m1/s1
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2.70E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition constant was evaluated with kidney Methionine adenosyltransferase II form of rat methionine adenosyltransferase, when ATP was the variable...


J Med Chem 29: 1030-8 (1986)


Article DOI: 10.1021/jm00156a022
BindingDB Entry DOI: 10.7270/Q2CF9QN4
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Rattus norvegicus)
BDBM50367307
PNG
(CHEMBL1791431)
Show SMILES CCCSC(OP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C13H22N5O13P3S/c1-2-3-35-13(29-33(24,25)31-34(26,27)30-32(21,22)23)9-7(19)8(20)12(28-9)18-5-17-6-10(14)15-4-16-11(6)18/h4-5,7-9,12-13,19-20H,2-3H2,1H3,(H,24,25)(H,26,27)(H2,14,15,16)(H2,21,22,23)/t7-,8+,9-,12+,13?/m0/s1
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2.70E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory constant against rat kidney Methionine adenosyltransferase II, activity expressed as Ki


J Med Chem 29: 318-22 (1986)


Article DOI: 10.1021/jm00153a003
BindingDB Entry DOI: 10.7270/Q2DF6RSH
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Rattus norvegicus)
BDBM50118221
PNG
(9H-purine derivative | CHEMBL132722 | DIPHOSPHOMET...)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)CP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C11H18N5O12P3/c12-9-6-10(14-2-13-9)16(3-15-6)11-8(18)7(17)5(27-11)1-26-29(19,20)4-30(21,22)28-31(23,24)25/h2-3,5,7-8,11,17-18H,1,4H2,(H,19,20)(H,21,22)(H2,12,13,14)(H2,23,24,25)/t5-,7-,8-,11-/m1/s1
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3.00E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory constant against rat kidney Methionine adenosyltransferase II


J Med Chem 29: 318-22 (1986)


Article DOI: 10.1021/jm00153a003
BindingDB Entry DOI: 10.7270/Q2DF6RSH
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Rattus norvegicus)
BDBM50367300
PNG
(CHEMBL610977)
Show SMILES CCCCSc1ncnc2n(cnc12)C1O[C@H](OP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C13H21N4O13P3S/c1-2-3-4-34-11-7-10(14-5-15-11)17(6-16-7)12-8(18)9(19)13(27-12)28-32(23,24)30-33(25,26)29-31(20,21)22/h5-6,8-9,12-13,18-19H,2-4H2,1H3,(H,23,24)(H,25,26)(H2,20,21,22)/t8-,9+,12?,13-/m1/s1
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3.10E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory constant against rat kidney Methionine adenosyltransferase II, activity expressed as Ki


J Med Chem 29: 318-22 (1986)


Article DOI: 10.1021/jm00153a003
BindingDB Entry DOI: 10.7270/Q2DF6RSH
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Rattus norvegicus)
BDBM50367303
PNG
(CHEMBL1791433)
Show SMILES CSC(OP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C11H18N5O13P3S/c1-33-11(27-31(22,23)29-32(24,25)28-30(19,20)21)7-5(17)6(18)10(26-7)16-3-15-4-8(12)13-2-14-9(4)16/h2-3,5-7,10-11,17-18H,1H3,(H,22,23)(H,24,25)(H2,12,13,14)(H2,19,20,21)/t5-,6+,7-,10+,11?/m0/s1
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4.10E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory constant against rat kidney Methionine adenosyltransferase II, activity expressed as Ki


J Med Chem 29: 318-22 (1986)


Article DOI: 10.1021/jm00153a003
BindingDB Entry DOI: 10.7270/Q2DF6RSH
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Rattus norvegicus)
BDBM50025158
PNG
(2-Amino-3-methyl-4-methylsulfanyl-butyric acid | C...)
Show SMILES CSCC(C)C(N)C(O)=O
Show InChI InChI=1S/C6H13NO2S/c1-4(3-10-2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)
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5.00E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Competitive inhibitory activity against Methionine adenosyltransferase II


J Med Chem 29: 1743-8 (1986)


Article DOI: 10.1021/jm00159a030
BindingDB Entry DOI: 10.7270/Q24748V9
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Rattus norvegicus)
BDBM50367306
PNG
(CHEMBL608929)
Show SMILES NC(CCSc1nc2c(N)ncnc2n1C1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O)C(O)=O
Show InChI InChI=1S/C14H23N6O15P3S/c15-5(13(23)24)1-2-39-14-19-7-10(16)17-4-18-11(7)20(14)12-9(22)8(21)6(33-12)3-32-37(28,29)35-38(30,31)34-36(25,26)27/h4-6,8-9,12,21-22H,1-3,15H2,(H,23,24)(H,28,29)(H,30,31)(H2,16,17,18)(H2,25,26,27)/t5?,6-,8-,9-,12?/m1/s1
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5.20E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory constant against rat kidney Methionine adenosyltransferase II


J Med Chem 29: 318-22 (1986)


Article DOI: 10.1021/jm00153a003
BindingDB Entry DOI: 10.7270/Q2DF6RSH
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Rattus norvegicus)
BDBM50367304
PNG
(CHEMBL610404)
Show SMILES CCCCNc1ncnc2n(cnc12)C1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C14H24N5O13P3/c1-2-3-4-15-12-9-13(17-6-16-12)19(7-18-9)14-11(21)10(20)8(30-14)5-29-34(25,26)32-35(27,28)31-33(22,23)24/h6-8,10-11,14,20-21H,2-5H2,1H3,(H,25,26)(H,27,28)(H,15,16,17)(H2,22,23,24)/t8-,10-,11-,14?/m1/s1
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5.30E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory constant against rat kidney Methionine adenosyltransferase II


J Med Chem 29: 318-22 (1986)


Article DOI: 10.1021/jm00153a003
BindingDB Entry DOI: 10.7270/Q2DF6RSH
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Rattus norvegicus)
BDBM50118232
PNG
(2-MeSATP | ATP, 2-meS | CHEMBL336208)
Show SMILES CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1S/C11H18N5O13P3S/c1-33-11-14-8(12)5-9(15-11)16(3-13-5)10-7(18)6(17)4(27-10)2-26-31(22,23)29-32(24,25)28-30(19,20)21/h3-4,6-7,10,17-18H,2H2,1H3,(H,22,23)(H,24,25)(H2,12,14,15)(H2,19,20,21)/t4-,6-,7-,10-/m1/s1
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6.00E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory constant against rat kidney Methionine adenosyltransferase II


J Med Chem 29: 318-22 (1986)


Article DOI: 10.1021/jm00153a003
BindingDB Entry DOI: 10.7270/Q2DF6RSH
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Rattus norvegicus)
BDBM50025157
PNG
(2-Amino-2-methyl-4-methylsulfanyl-pentanoic acid |...)
Show SMILES CS[C@@H](C)C[C@](C)(N)C(O)=O
Show InChI InChI=1S/C7H15NO2S/c1-5(11-3)4-7(2,8)6(9)10/h5H,4,8H2,1-3H3,(H,9,10)/t5-,7-/m0/s1
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1.50E+6n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Competitive inhibitory activity against M-2 Methionine adenosyltransferase II


J Med Chem 29: 1743-8 (1986)


Article DOI: 10.1021/jm00159a030
BindingDB Entry DOI: 10.7270/Q24748V9
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Rattus norvegicus)
BDBM50025156
PNG
(2-Amino-4-methylsulfanyl-pentanoic acid | CHEMBL45...)
Show SMILES CSC(C)C[C@@H](N)C(O)=O
Show InChI InChI=1S/C6H13NO2S/c1-4(10-2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4?,5-/m1/s1
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2.40E+6n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Competitive inhibitory activity against Methionine adenosyltransferase II


J Med Chem 29: 1743-8 (1986)


Article DOI: 10.1021/jm00159a030
BindingDB Entry DOI: 10.7270/Q24748V9
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM50559541
PNG
(CHEMBL4746939)
Show SMILES Cn1cc2cc(ccc2n1)-n1nc2ccc(OCC(F)(F)F)nc2c(-c2ccc(OC(F)F)cc2)c1=O
Show InChI InChI=1S/C24H16F5N5O3/c1-33-11-14-10-15(4-7-17(14)31-33)34-22(35)20(13-2-5-16(6-3-13)37-23(25)26)21-18(32-34)8-9-19(30-21)36-12-24(27,28)29/h2-11,23H,12H2,1H3
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n/an/a<100n/an/an/an/an/an/a



Usona Institute

Curated by ChEMBL


Assay Description
Inhibition of recombinant human MAT2A expressed in baculovirus infected Sf9 cells using L-methionine as substrate incubated for 60 mins followed by s...


ACS Med Chem Lett 12: 180-181 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM50559542
PNG
(CHEMBL4746079)
Show SMILES Cn1cc2cc(ccc2n1)-n1nc2ccc(OCC(F)(F)F)nc2c(-c2ccc(Cl)cc2)c1=O
Show InChI InChI=1S/C23H15ClF3N5O2/c1-31-11-14-10-16(6-7-17(14)29-31)32-22(33)20(13-2-4-15(24)5-3-13)21-18(30-32)8-9-19(28-21)34-12-23(25,26)27/h2-11H,12H2,1H3
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n/an/a<100n/an/an/an/an/an/a



Usona Institute

Curated by ChEMBL


Assay Description
Inhibition of recombinant human MAT2A expressed in baculovirus infected Sf9 cells using L-methionine as substrate incubated for 60 mins followed by s...


ACS Med Chem Lett 12: 180-181 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM50559543
PNG
(CHEMBL4754086)
Show SMILES Cn1cc2cc(ccc2n1)-n1nc2ccc(OCC(F)F)nc2c(-c2ccc(OC(F)F)cc2)c1=O
Show InChI InChI=1S/C24H17F4N5O3/c1-32-11-14-10-15(4-7-17(14)30-32)33-23(34)21(13-2-5-16(6-3-13)36-24(27)28)22-18(31-33)8-9-20(29-22)35-12-19(25)26/h2-11,19,24H,12H2,1H3
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n/an/a<100n/an/an/an/an/an/a



Usona Institute

Curated by ChEMBL


Assay Description
Inhibition of recombinant human MAT2A expressed in baculovirus infected Sf9 cells using L-methionine as substrate incubated for 60 mins followed by s...


ACS Med Chem Lett 12: 180-181 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM50559544
PNG
(CHEMBL4751206)
Show SMILES COc1ccc(cn1)-c1c2nc(OCC(F)F)ccc2nn(-c2ccc3nn(C)cc3c2)c1=O
Show InChI InChI=1S/C23H18F2N6O3/c1-30-11-14-9-15(4-5-16(14)28-30)31-23(32)21(13-3-7-19(33-2)26-10-13)22-17(29-31)6-8-20(27-22)34-12-18(24)25/h3-11,18H,12H2,1-2H3
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n/an/a<100n/an/an/an/an/an/a



Usona Institute

Curated by ChEMBL


Assay Description
Inhibition of recombinant human MAT2A expressed in baculovirus infected Sf9 cells using L-methionine as substrate incubated for 60 mins followed by s...


ACS Med Chem Lett 12: 180-181 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM50559545
PNG
(CHEMBL4762089)
Show SMILES Cn1cc2cc(ccc2n1)-n1nc2ccc(OCCC(F)(F)F)nc2c(-c2ccc(OC(F)F)cc2)c1=O
Show InChI InChI=1S/C25H18F5N5O3/c1-34-13-15-12-16(4-7-18(15)32-34)35-23(36)21(14-2-5-17(6-3-14)38-24(26)27)22-19(33-35)8-9-20(31-22)37-11-10-25(28,29)30/h2-9,12-13,24H,10-11H2,1H3
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n/an/a<100n/an/an/an/an/an/a



Usona Institute

Curated by ChEMBL


Assay Description
Inhibition of recombinant human MAT2A expressed in baculovirus infected Sf9 cells using L-methionine as substrate incubated for 60 mins followed by s...


ACS Med Chem Lett 12: 180-181 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM50559546
PNG
(CHEMBL4760483)
Show SMILES Cn1cc2cc(ccc2n1)-n1nc2ccc(SCC(F)(F)F)nc2c(-c2ccc(OC(F)F)cc2)c1=O
Show InChI InChI=1S/C24H16F5N5O2S/c1-33-11-14-10-15(4-7-17(14)31-33)34-22(35)20(13-2-5-16(6-3-13)36-23(25)26)21-18(32-34)8-9-19(30-21)37-12-24(27,28)29/h2-11,23H,12H2,1H3
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n/an/a<100n/an/an/an/an/an/a



Usona Institute

Curated by ChEMBL


Assay Description
Inhibition of recombinant human MAT2A expressed in baculovirus infected Sf9 cells using L-methionine as substrate incubated for 60 mins followed by s...


ACS Med Chem Lett 12: 180-181 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM50559547
PNG
(CHEMBL4754303)
Show SMILES FC(F)COc1ccc2nn(-c3ccc4ncsc4c3)c(=O)c(-c3ccc(OC(F)F)cc3)c2n1
Show InChI InChI=1S/C23H14F4N4O3S/c24-18(25)10-33-19-8-7-16-21(29-19)20(12-1-4-14(5-2-12)34-23(26)27)22(32)31(30-16)13-3-6-15-17(9-13)35-11-28-15/h1-9,11,18,23H,10H2
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n/an/a<100n/an/an/an/an/an/a



Usona Institute

Curated by ChEMBL


Assay Description
Inhibition of recombinant human MAT2A expressed in baculovirus infected Sf9 cells using L-methionine as substrate incubated for 60 mins followed by s...


ACS Med Chem Lett 12: 180-181 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM50559548
PNG
(CHEMBL4741054)
Show SMILES [2H]C([2H])([2H])Oc1n(C)nc2ccc(cc12)-n1nc2ccc(OCC(F)F)nc2c(-c2ccc(OC(F)F)cc2)c1=O
Show InChI InChI=1S/C25H19F4N5O4/c1-33-24(36-2)16-11-14(5-8-17(16)31-33)34-23(35)21(13-3-6-15(7-4-13)38-25(28)29)22-18(32-34)9-10-20(30-22)37-12-19(26)27/h3-11,19,25H,12H2,1-2H3/i2D3
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n/an/a<100n/an/an/an/an/an/a



Usona Institute

Curated by ChEMBL


Assay Description
Inhibition of recombinant human MAT2A expressed in baculovirus infected Sf9 cells using L-methionine as substrate incubated for 60 mins followed by s...


ACS Med Chem Lett 12: 180-181 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM50559549
PNG
(CHEMBL4786665)
Show SMILES FC(F)COc1ccc2nn(-c3ccc4OCCc4c3)c(=O)c(-c3ccc(OC(F)F)cc3)c2n1
Show InChI InChI=1S/C24H17F4N3O4/c25-19(26)12-34-20-8-6-17-22(29-20)21(13-1-4-16(5-2-13)35-24(27)28)23(32)31(30-17)15-3-7-18-14(11-15)9-10-33-18/h1-8,11,19,24H,9-10,12H2
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n/an/a<100n/an/an/an/an/an/a



Usona Institute

Curated by ChEMBL


Assay Description
Inhibition of recombinant human MAT2A expressed in baculovirus infected Sf9 cells using L-methionine as substrate incubated for 60 mins followed by s...


ACS Med Chem Lett 12: 180-181 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM50559549
PNG
(CHEMBL4786665)
Show SMILES FC(F)COc1ccc2nn(-c3ccc4OCCc4c3)c(=O)c(-c3ccc(OC(F)F)cc3)c2n1
Show InChI InChI=1S/C24H17F4N3O4/c25-19(26)12-34-20-8-6-17-22(29-20)21(13-1-4-16(5-2-13)35-24(27)28)23(32)31(30-17)15-3-7-18-14(11-15)9-10-33-18/h1-8,11,19,24H,9-10,12H2
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n/an/a<100n/an/an/an/an/an/a



Usona Institute

Curated by ChEMBL


Assay Description
Inhibition of MAT2A in human HCT-116 cells assessed as reduction in SAM incubated for 72 hrs by LC-MS/MS analysis


ACS Med Chem Lett 12: 180-181 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM50559548
PNG
(CHEMBL4741054)
Show SMILES [2H]C([2H])([2H])Oc1n(C)nc2ccc(cc12)-n1nc2ccc(OCC(F)F)nc2c(-c2ccc(OC(F)F)cc2)c1=O
Show InChI InChI=1S/C25H19F4N5O4/c1-33-24(36-2)16-11-14(5-8-17(16)31-33)34-23(35)21(13-3-6-15(7-4-13)38-25(28)29)22-18(32-34)9-10-20(30-22)37-12-19(26)27/h3-11,19,25H,12H2,1-2H3/i2D3
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n/an/a<100n/an/an/an/an/an/a



Usona Institute

Curated by ChEMBL


Assay Description
Inhibition of MAT2A in human HCT-116 cells assessed as reduction in SAM incubated for 72 hrs by LC-MS/MS analysis


ACS Med Chem Lett 12: 180-181 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM50559547
PNG
(CHEMBL4754303)
Show SMILES FC(F)COc1ccc2nn(-c3ccc4ncsc4c3)c(=O)c(-c3ccc(OC(F)F)cc3)c2n1
Show InChI InChI=1S/C23H14F4N4O3S/c24-18(25)10-33-19-8-7-16-21(29-19)20(12-1-4-14(5-2-12)34-23(26)27)22(32)31(30-16)13-3-6-15-17(9-13)35-11-28-15/h1-9,11,18,23H,10H2
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n/an/a<100n/an/an/an/an/an/a



Usona Institute

Curated by ChEMBL


Assay Description
Inhibition of MAT2A in human HCT-116 cells assessed as reduction in SAM incubated for 72 hrs by LC-MS/MS analysis


ACS Med Chem Lett 12: 180-181 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM50559546
PNG
(CHEMBL4760483)
Show SMILES Cn1cc2cc(ccc2n1)-n1nc2ccc(SCC(F)(F)F)nc2c(-c2ccc(OC(F)F)cc2)c1=O
Show InChI InChI=1S/C24H16F5N5O2S/c1-33-11-14-10-15(4-7-17(14)31-33)34-22(35)20(13-2-5-16(6-3-13)36-23(25)26)21-18(32-34)8-9-19(30-21)37-12-24(27,28)29/h2-11,23H,12H2,1H3
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n/an/a<100n/an/an/an/an/an/a



Usona Institute

Curated by ChEMBL


Assay Description
Inhibition of MAT2A in human HCT-116 cells assessed as reduction in SAM incubated for 72 hrs by LC-MS/MS analysis


ACS Med Chem Lett 12: 180-181 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM50559544
PNG
(CHEMBL4751206)
Show SMILES COc1ccc(cn1)-c1c2nc(OCC(F)F)ccc2nn(-c2ccc3nn(C)cc3c2)c1=O
Show InChI InChI=1S/C23H18F2N6O3/c1-30-11-14-9-15(4-5-16(14)28-30)31-23(32)21(13-3-7-19(33-2)26-10-13)22-17(29-31)6-8-20(27-22)34-12-18(24)25/h3-11,18H,12H2,1-2H3
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n/an/a<100n/an/an/an/an/an/a



Usona Institute

Curated by ChEMBL


Assay Description
Inhibition of MAT2A in human HCT-116 cells assessed as reduction in SAM incubated for 72 hrs by LC-MS/MS analysis


ACS Med Chem Lett 12: 180-181 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM50559543
PNG
(CHEMBL4754086)
Show SMILES Cn1cc2cc(ccc2n1)-n1nc2ccc(OCC(F)F)nc2c(-c2ccc(OC(F)F)cc2)c1=O
Show InChI InChI=1S/C24H17F4N5O3/c1-32-11-14-10-15(4-7-17(14)30-32)33-23(34)21(13-2-5-16(6-3-13)36-24(27)28)22-18(31-33)8-9-20(29-22)35-12-19(25)26/h2-11,19,24H,12H2,1H3
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n/an/a<100n/an/an/an/an/an/a



Usona Institute

Curated by ChEMBL


Assay Description
Inhibition of MAT2A in human HCT-116 cells assessed as reduction in SAM incubated for 72 hrs by LC-MS/MS analysis


ACS Med Chem Lett 12: 180-181 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM50559542
PNG
(CHEMBL4746079)
Show SMILES Cn1cc2cc(ccc2n1)-n1nc2ccc(OCC(F)(F)F)nc2c(-c2ccc(Cl)cc2)c1=O
Show InChI InChI=1S/C23H15ClF3N5O2/c1-31-11-14-10-16(6-7-17(14)29-31)32-22(33)20(13-2-4-15(24)5-3-13)21-18(30-32)8-9-19(28-21)34-12-23(25,26)27/h2-11H,12H2,1H3
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n/an/a<100n/an/an/an/an/an/a



Usona Institute

Curated by ChEMBL


Assay Description
Inhibition of MAT2A in human HCT-116 cells assessed as reduction in SAM incubated for 72 hrs by LC-MS/MS analysis


ACS Med Chem Lett 12: 180-181 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM50559541
PNG
(CHEMBL4746939)
Show SMILES Cn1cc2cc(ccc2n1)-n1nc2ccc(OCC(F)(F)F)nc2c(-c2ccc(OC(F)F)cc2)c1=O
Show InChI InChI=1S/C24H16F5N5O3/c1-33-11-14-10-15(4-7-17(14)31-33)34-22(35)20(13-2-5-16(6-3-13)37-23(25)26)21-18(32-34)8-9-19(30-21)36-12-24(27,28)29/h2-11,23H,12H2,1H3
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n/an/a<100n/an/an/an/an/an/a



Usona Institute

Curated by ChEMBL


Assay Description
Inhibition of MAT2A in human HCT-116 cells assessed as reduction in SAM incubated for 72 hrs by LC-MS/MS analysis


ACS Med Chem Lett 12: 180-181 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM50559540
PNG
(CHEMBL4750527)
Show SMILES CCOc1ccc2nn(-c3ccc4nn(C)cc4c3)c(=O)c(-c3ccc(OC)cc3)c2n1
Show InChI InChI=1S/C24H21N5O3/c1-4-32-21-12-11-20-23(25-21)22(15-5-8-18(31-3)9-6-15)24(30)29(27-20)17-7-10-19-16(13-17)14-28(2)26-19/h5-14H,4H2,1-3H3
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n/an/a<100n/an/an/an/an/an/a



Usona Institute

Curated by ChEMBL


Assay Description
Inhibition of MAT2A in human HCT-116 cells assessed as reduction in SAM incubated for 72 hrs by LC-MS/MS analysis


ACS Med Chem Lett 12: 180-181 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM50559540
PNG
(CHEMBL4750527)
Show SMILES CCOc1ccc2nn(-c3ccc4nn(C)cc4c3)c(=O)c(-c3ccc(OC)cc3)c2n1
Show InChI InChI=1S/C24H21N5O3/c1-4-32-21-12-11-20-23(25-21)22(15-5-8-18(31-3)9-6-15)24(30)29(27-20)17-7-10-19-16(13-17)14-28(2)26-19/h5-14H,4H2,1-3H3
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n/an/a<100n/an/an/an/an/an/a



Usona Institute

Curated by ChEMBL


Assay Description
Inhibition of recombinant human MAT2A expressed in baculovirus infected Sf9 cells using L-methionine as substrate incubated for 60 mins followed by s...


ACS Med Chem Lett 12: 180-181 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM508347
PNG
(1-(2-chlorophenyl)-7-(1,1- difluoroethyl)-4- (meth...)
Show SMILES CNc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C(C)(F)F
Show InChI InChI=1S/C17H14ClF2N3O/c1-17(19,20)10-7-8-11-14(9-10)23(16(24)22-15(11)21-2)13-6-4-3-5-12(13)18/h3-9H,1-2H3,(H,21,22,24)
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US Patent
n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM508348
PNG
(1-(3-chloropyridin-2-yl)-7-ethyl-4- (methylamino)q...)
Show SMILES CCc1ccc2c(NC)nc(=O)n(-c3ncccc3Cl)c2c1
Show InChI InChI=1S/C16H15ClN4O/c1-3-10-6-7-11-13(9-10)21(16(22)20-14(11)18-2)15-12(17)5-4-8-19-15/h4-9H,3H2,1-2H3,(H,18,20,22)
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n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM508349
PNG
(4-amino-1-(3-chloropyridin-2-yl)-7- (1,1-difluoroe...)
Show SMILES CC(F)(F)c1ccc2c(N)nc(=O)n(-c3ncccc3Cl)c2c1
Show InChI InChI=1S/C15H11ClF2N4O/c1-15(17,18)8-4-5-9-11(7-8)22(14(23)21-12(9)19)13-10(16)3-2-6-20-13/h2-7H,1H3,(H2,19,21,23)
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n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
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