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Compile Data Set for Download or QSAR

Found 176 hits Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase 17A'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM50166076
PNG
(CHEMBL3799585)
Show SMILES CCCC(=O)Nc1ccc2NC(=O)\C(=C3/Nc4ccccc4/C/3=N\O)c2c1
Show InChI InChI=1S/C20H18N4O3/c1-2-5-16(25)21-11-8-9-15-13(10-11)17(20(26)23-15)19-18(24-27)12-6-3-4-7-14(12)22-19/h3-4,6-10,22,27H,2,5H2,1H3,(H,21,25)(H,23,26)/b19-17-,24-18+
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n/an/a 12n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of DRAK1 (unknown origin)


Bioorg Med Chem Lett 26: 2719-23 (2016)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM50154342
PNG
(CHEMBL3774448)
Show SMILES O=C1NC(=S)S\C1=C/c1ccc2ncccc2c1
Show InChI InChI=1S/C13H8N2OS2/c16-12-11(18-13(17)15-12)7-8-3-4-10-9(6-8)2-1-5-14-10/h1-7H,(H,15,16,17)/b11-7-
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n/an/a 13n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Inhibition of STK17A (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM50166251
PNG
(CHEMBL3799389)
Show SMILES O\N=C1\C(\Nc2ccccc\12)=C1\C(=O)Nc2ccc(NC(=O)C3CC3)cc12
Show InChI InChI=1S/C20H16N4O3/c25-19(10-5-6-10)21-11-7-8-15-13(9-11)16(20(26)23-15)18-17(24-27)12-3-1-2-4-14(12)22-18/h1-4,7-10,22,27H,5-6H2,(H,21,25)(H,23,26)/b18-16-,24-17+
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n/an/a 21n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of DRAK1 (unknown origin)


Bioorg Med Chem Lett 26: 2719-23 (2016)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM50166271
PNG
(CHEMBL3798563)
Show SMILES O\N=C1\C(\Nc2ccccc\12)=C1\C(=O)Nc2ccc(NC(=O)c3cc(cc(c3)[N+]([O-])=O)[N+]([O-])=O)cc12
Show InChI InChI=1S/C23H14N6O7/c30-22(11-7-13(28(33)34)10-14(8-11)29(35)36)24-12-5-6-18-16(9-12)19(23(31)26-18)21-20(27-32)15-3-1-2-4-17(15)25-21/h1-10,25,32H,(H,24,30)(H,26,31)/b21-19-,27-20+
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n/an/a 24n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of DRAK1 (unknown origin)


Bioorg Med Chem Lett 26: 2719-23 (2016)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM50166260
PNG
(CHEMBL3799505)
Show SMILES CC(C)(C)CC(=O)Nc1ccc2NC(=O)\C(=C3/Nc4ccccc4/C/3=N\O)c2c1
Show InChI InChI=1S/C22H22N4O3/c1-22(2,3)11-17(27)23-12-8-9-16-14(10-12)18(21(28)25-16)20-19(26-29)13-6-4-5-7-15(13)24-20/h4-10,24,29H,11H2,1-3H3,(H,23,27)(H,25,28)/b20-18-,26-19+
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n/an/a 24n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of DRAK1 (unknown origin)


Bioorg Med Chem Lett 26: 2719-23 (2016)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM50166077
PNG
(CHEMBL513703)
Show SMILES CC(C)(C)C(=O)Nc1ccc2NC(=O)\C(=C3/Nc4ccccc4/C/3=N\O)c2c1
Show InChI InChI=1S/C21H20N4O3/c1-21(2,3)20(27)22-11-8-9-15-13(10-11)16(19(26)24-15)18-17(25-28)12-6-4-5-7-14(12)23-18/h4-10,23,28H,1-3H3,(H,22,27)(H,24,26)/b18-16-,25-17+
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n/an/a 32n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of DRAK1 (unknown origin)


Bioorg Med Chem Lett 26: 2719-23 (2016)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM50166121
PNG
(CHEMBL3797480)
Show SMILES CCCCC(=O)Nc1ccc2NC(=O)\C(=C3/Nc4ccccc4/C/3=N\O)c2c1
Show InChI InChI=1S/C21H20N4O3/c1-2-3-8-17(26)22-12-9-10-16-14(11-12)18(21(27)24-16)20-19(25-28)13-6-4-5-7-15(13)23-20/h4-7,9-11,23,28H,2-3,8H2,1H3,(H,22,26)(H,24,27)/b20-18-,25-19+
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n/an/a 51n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of DRAK1 (unknown origin)


Bioorg Med Chem Lett 26: 2719-23 (2016)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM50166211
PNG
(CHEMBL3798579)
Show SMILES O\N=C1\C(\Nc2ccccc\12)=C1\C(=O)Nc2ccc(NC(=O)C3CCCCC3)cc12
Show InChI InChI=1S/C23H22N4O3/c28-22(13-6-2-1-3-7-13)24-14-10-11-18-16(12-14)19(23(29)26-18)21-20(27-30)15-8-4-5-9-17(15)25-21/h4-5,8-13,25,30H,1-3,6-7H2,(H,24,28)(H,26,29)/b21-19-,27-20+
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n/an/a 110n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of DRAK1 (unknown origin)


Bioorg Med Chem Lett 26: 2719-23 (2016)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM103302
PNG
(SCH772984 | US8546404, 6)
Show SMILES O=C(CN1CC[C@@H](C1)C(=O)Nc1ccc2[nH]nc(-c3ccncc3)c2c1)N1CCN(CC1)c1ccc(cc1)-c1ncccn1
Show InChI InChI=1S/C33H33N9O2/c43-30(42-18-16-41(17-19-42)27-5-2-24(3-6-27)32-35-11-1-12-36-32)22-40-15-10-25(21-40)33(44)37-26-4-7-29-28(20-26)31(39-38-29)23-8-13-34-14-9-23/h1-9,11-14,20,25H,10,15-19,21-22H2,(H,37,44)(H,38,39)/t25-/m1/s1
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n/an/a 114n/an/an/an/an/an/a



George Washington University



Assay Description
The IC50 values of selected kinases were determined using either Z'LYTE, Adapta or LanthaScreen assays.


Nat Chem Biol 10: 853-860 (2014)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM50166254
PNG
(CHEMBL3797466)
Show SMILES CC(C)=CC(=O)Nc1ccc2NC(=O)\C(=C3/Nc4ccccc4/C/3=N\O)c2c1
Show InChI InChI=1S/C21H18N4O3/c1-11(2)9-17(26)22-12-7-8-16-14(10-12)18(21(27)24-16)20-19(25-28)13-5-3-4-6-15(13)23-20/h3-10,23,28H,1-2H3,(H,22,26)(H,24,27)/b20-18-,25-19+
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n/an/a 120n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of DRAK1 (unknown origin)


Bioorg Med Chem Lett 26: 2719-23 (2016)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM50166149
PNG
(CHEMBL3797817)
Show SMILES O\N=C1\C(\Nc2ccccc\12)=C1\C(=O)Nc2ccc(NC(=O)c3ccccc3F)cc12
Show InChI InChI=1S/C23H15FN4O3/c24-16-7-3-1-5-13(16)22(29)25-12-9-10-18-15(11-12)19(23(30)27-18)21-20(28-31)14-6-2-4-8-17(14)26-21/h1-11,26,31H,(H,25,29)(H,27,30)/b21-19-,28-20+
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n/an/a 250n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of DRAK1 (unknown origin)


Bioorg Med Chem Lett 26: 2719-23 (2016)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM50166268
PNG
(CHEMBL3798680)
Show SMILES O\N=C1\C(\Nc2ccccc\12)=C1\C(=O)Nc2ccc(NC(=O)c3ccccc3C(F)(F)F)cc12
Show InChI InChI=1S/C24H15F3N4O3/c25-24(26,27)16-7-3-1-5-13(16)22(32)28-12-9-10-18-15(11-12)19(23(33)30-18)21-20(31-34)14-6-2-4-8-17(14)29-21/h1-11,29,34H,(H,28,32)(H,30,33)/b21-19-,31-20+
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n/an/a 320n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of DRAK1 (unknown origin)


Bioorg Med Chem Lett 26: 2719-23 (2016)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM50166269
PNG
(CHEMBL3797582)
Show SMILES COc1ccc(cc1)C(=O)Nc1ccc2NC(=O)\C(=C3/Nc4ccccc4/C/3=N\O)c2c1
Show InChI InChI=1S/C24H18N4O4/c1-32-15-9-6-13(7-10-15)23(29)25-14-8-11-19-17(12-14)20(24(30)27-19)22-21(28-31)16-4-2-3-5-18(16)26-22/h2-12,26,31H,1H3,(H,25,29)(H,27,30)/b22-20-,28-21+
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n/an/a 360n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of DRAK1 (unknown origin)


Bioorg Med Chem Lett 26: 2719-23 (2016)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM50166163
PNG
(CHEMBL3797732)
Show SMILES O\N=C1\C(\Nc2ccccc\12)=C1\C(=O)Nc2ccc(NC(=O)c3ccccc3)cc12
Show InChI InChI=1S/C23H16N4O3/c28-22(13-6-2-1-3-7-13)24-14-10-11-18-16(12-14)19(23(29)26-18)21-20(27-30)15-8-4-5-9-17(15)25-21/h1-12,25,30H,(H,24,28)(H,26,29)/b21-19-,27-20+
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n/an/a 360n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of DRAK1 (unknown origin)


Bioorg Med Chem Lett 26: 2719-23 (2016)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM50166267
PNG
(CHEMBL3799218)
Show SMILES O\N=C1\C(\Nc2ccccc\12)=C1\C(=O)Nc2ccc(NC(=O)COc3cccc(Cl)c3)cc12
Show InChI InChI=1S/C24H17ClN4O4/c25-13-4-3-5-15(10-13)33-12-20(30)26-14-8-9-19-17(11-14)21(24(31)28-19)23-22(29-32)16-6-1-2-7-18(16)27-23/h1-11,27,32H,12H2,(H,26,30)(H,28,31)/b23-21-,29-22+
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n/an/a 460n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of DRAK1 (unknown origin)


Bioorg Med Chem Lett 26: 2719-23 (2016)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM50166138
PNG
(CHEMBL3799256)
Show SMILES O\N=C1\C(\Nc2ccccc\12)=C1\C(=O)Nc2ccc(NC(=O)c3ccc(cc3)[N+]([O-])=O)cc12
Show InChI InChI=1S/C23H15N5O5/c29-22(12-5-8-14(9-6-12)28(32)33)24-13-7-10-18-16(11-13)19(23(30)26-18)21-20(27-31)15-3-1-2-4-17(15)25-21/h1-11,25,31H,(H,24,29)(H,26,30)/b21-19-,27-20+
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n/an/a 500n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of DRAK1 (unknown origin)


Bioorg Med Chem Lett 26: 2719-23 (2016)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM50024284
PNG
(CHEMBL3334979)
Show SMILES COc1ccc(cc1OC)-c1cnc2scc(NC(=O)C3CCCCC3)c2c1
Show InChI InChI=1S/C22H24N2O3S/c1-26-19-9-8-15(11-20(19)27-2)16-10-17-18(13-28-22(17)23-12-16)24-21(25)14-6-4-3-5-7-14/h8-14H,3-7H2,1-2H3,(H,24,25)
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n/an/a 560n/an/an/an/an/an/a



KU Leuven

Curated by ChEMBL


Assay Description
Inhibition of DRAK1 (unknown origin) using 1 uM ATP by biochemical assay


J Med Chem 57: 7624-43 (2014)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM50024284
PNG
(CHEMBL3334979)
Show SMILES COc1ccc(cc1OC)-c1cnc2scc(NC(=O)C3CCCCC3)c2c1
Show InChI InChI=1S/C22H24N2O3S/c1-26-19-9-8-15(11-20(19)27-2)16-10-17-18(13-28-22(17)23-12-16)24-21(25)14-6-4-3-5-7-14/h8-14H,3-7H2,1-2H3,(H,24,25)
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n/an/a 630n/an/an/an/an/an/a



KU Leuven

Curated by ChEMBL


Assay Description
Inhibition of DRAK1 (unknown origin) using 5 uM ATP by biochemical assay


J Med Chem 57: 7624-43 (2014)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM50166265
PNG
(CHEMBL3799269)
Show SMILES O\N=C1\C(\Nc2ccccc\12)=C1\C(=O)Nc2ccc(NC(=O)c3cccc4ccccc34)cc12
Show InChI InChI=1S/C27H18N4O3/c32-26(18-10-5-7-15-6-1-2-8-17(15)18)28-16-12-13-22-20(14-16)23(27(33)30-22)25-24(31-34)19-9-3-4-11-21(19)29-25/h1-14,29,34H,(H,28,32)(H,30,33)/b25-23-,31-24+
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n/an/a 700n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of DRAK1 (unknown origin)


Bioorg Med Chem Lett 26: 2719-23 (2016)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM50024284
PNG
(CHEMBL3334979)
Show SMILES COc1ccc(cc1OC)-c1cnc2scc(NC(=O)C3CCCCC3)c2c1
Show InChI InChI=1S/C22H24N2O3S/c1-26-19-9-8-15(11-20(19)27-2)16-10-17-18(13-28-22(17)23-12-16)24-21(25)14-6-4-3-5-7-14/h8-14H,3-7H2,1-2H3,(H,24,25)
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n/an/a 710n/an/an/an/an/an/a



KU Leuven

Curated by ChEMBL


Assay Description
Inhibition of DRAK1 (unknown origin) using 10 uM ATP by biochemical assay


J Med Chem 57: 7624-43 (2014)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM50166148
PNG
(CHEMBL3798747)
Show SMILES O\N=C1\C(\Nc2ccccc\12)=C1\C(=O)Nc2ccc(NC(=O)c3ccc(F)cc3)cc12
Show InChI InChI=1S/C23H15FN4O3/c24-13-7-5-12(6-8-13)22(29)25-14-9-10-18-16(11-14)19(23(30)27-18)21-20(28-31)15-3-1-2-4-17(15)26-21/h1-11,26,31H,(H,25,29)(H,27,30)/b21-19-,28-20+
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n/an/a 780n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of DRAK1 (unknown origin)


Bioorg Med Chem Lett 26: 2719-23 (2016)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM50024284
PNG
(CHEMBL3334979)
Show SMILES COc1ccc(cc1OC)-c1cnc2scc(NC(=O)C3CCCCC3)c2c1
Show InChI InChI=1S/C22H24N2O3S/c1-26-19-9-8-15(11-20(19)27-2)16-10-17-18(13-28-22(17)23-12-16)24-21(25)14-6-4-3-5-7-14/h8-14H,3-7H2,1-2H3,(H,24,25)
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n/an/a 940n/an/an/an/an/an/a



KU Leuven

Curated by ChEMBL


Assay Description
Inhibition of DRAK1 (unknown origin) using 25 uM ATP by biochemical assay


J Med Chem 57: 7624-43 (2014)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM50166266
PNG
(CHEMBL3798736)
Show SMILES O\N=C1\C(\Nc2ccccc\12)=C1\C(=O)Nc2ccc(NC(=O)\C=C\c3ccccc3)cc12
Show InChI InChI=1S/C25H18N4O3/c30-21(13-10-15-6-2-1-3-7-15)26-16-11-12-20-18(14-16)22(25(31)28-20)24-23(29-32)17-8-4-5-9-19(17)27-24/h1-14,27,32H,(H,26,30)(H,28,31)/b13-10+,24-22-,29-23+
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n/an/a 1.10E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of DRAK1 (unknown origin)


Bioorg Med Chem Lett 26: 2719-23 (2016)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM50166270
PNG
(CHEMBL3798927)
Show SMILES Cc1ccc(cc1)C(=O)Nc1ccc2NC(=O)\C(=C3/Nc4ccccc4/C/3=N\O)c2c1
Show InChI InChI=1S/C24H18N4O3/c1-13-6-8-14(9-7-13)23(29)25-15-10-11-19-17(12-15)20(24(30)27-19)22-21(28-31)16-4-2-3-5-18(16)26-22/h2-12,26,31H,1H3,(H,25,29)(H,27,30)/b22-20-,28-21+
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n/an/a 1.30E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of DRAK1 (unknown origin)


Bioorg Med Chem Lett 26: 2719-23 (2016)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM50024284
PNG
(CHEMBL3334979)
Show SMILES COc1ccc(cc1OC)-c1cnc2scc(NC(=O)C3CCCCC3)c2c1
Show InChI InChI=1S/C22H24N2O3S/c1-26-19-9-8-15(11-20(19)27-2)16-10-17-18(13-28-22(17)23-12-16)24-21(25)14-6-4-3-5-7-14/h8-14H,3-7H2,1-2H3,(H,24,25)
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n/an/a 1.33E+3n/an/an/an/an/an/a



KU Leuven

Curated by ChEMBL


Assay Description
Inhibition of DRAK1 (unknown origin) using 50 uM ATP by biochemical assay


J Med Chem 57: 7624-43 (2014)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM50436476
PNG
(CHEMBL2397316)
Show SMILES Cc1nc(NC(=O)C(C)(C)CC(F)(F)F)sc1-c1ccc(N)nc1
Show InChI InChI=1S/C15H17F3N4OS/c1-8-11(9-4-5-10(19)20-6-9)24-13(21-8)22-12(23)14(2,3)7-15(16,17)18/h4-6H,7H2,1-3H3,(H2,19,20)(H,21,22,23)
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n/an/a 2.10E+3n/an/an/an/an/an/a



Boehringer Ingelheim (Canada) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of STK17A (unknown origin)


Bioorg Med Chem Lett 23: 3841-7 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM50024284
PNG
(CHEMBL3334979)
Show SMILES COc1ccc(cc1OC)-c1cnc2scc(NC(=O)C3CCCCC3)c2c1
Show InChI InChI=1S/C22H24N2O3S/c1-26-19-9-8-15(11-20(19)27-2)16-10-17-18(13-28-22(17)23-12-16)24-21(25)14-6-4-3-5-7-14/h8-14H,3-7H2,1-2H3,(H,24,25)
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n/an/a 2.11E+3n/an/an/an/an/an/a



KU Leuven

Curated by ChEMBL


Assay Description
Inhibition of DRAK1 (unknown origin) using 100 uM ATP by biochemical assay


J Med Chem 57: 7624-43 (2014)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM50024284
PNG
(CHEMBL3334979)
Show SMILES COc1ccc(cc1OC)-c1cnc2scc(NC(=O)C3CCCCC3)c2c1
Show InChI InChI=1S/C22H24N2O3S/c1-26-19-9-8-15(11-20(19)27-2)16-10-17-18(13-28-22(17)23-12-16)24-21(25)14-6-4-3-5-7-14/h8-14H,3-7H2,1-2H3,(H,24,25)
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n/an/a 2.25E+3n/an/an/an/an/an/a



KU Leuven

Curated by ChEMBL


Assay Description
Inhibition of DRAK1 (unknown origin) using 33P-ATP after 30 mins by Trilux scintillation counting


J Med Chem 57: 7624-43 (2014)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM50024284
PNG
(CHEMBL3334979)
Show SMILES COc1ccc(cc1OC)-c1cnc2scc(NC(=O)C3CCCCC3)c2c1
Show InChI InChI=1S/C22H24N2O3S/c1-26-19-9-8-15(11-20(19)27-2)16-10-17-18(13-28-22(17)23-12-16)24-21(25)14-6-4-3-5-7-14/h8-14H,3-7H2,1-2H3,(H,24,25)
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n/an/a 2.85E+3n/an/an/an/an/an/a



KU Leuven

Curated by ChEMBL


Assay Description
Inhibition of DRAK1 (unknown origin) using 250 uM ATP by biochemical assay


J Med Chem 57: 7624-43 (2014)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM50436478
PNG
(CHEMBL2397314)
Show SMILES C[C@H](CC(F)(F)F)C(=O)Nc1nc(C)c(s1)-c1ccc(N)nc1
Show InChI InChI=1S/C14H15F3N4OS/c1-7(5-14(15,16)17)12(22)21-13-20-8(2)11(23-13)9-3-4-10(18)19-6-9/h3-4,6-7H,5H2,1-2H3,(H2,18,19)(H,20,21,22)/t7-/m1/s1
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n/an/a 2.90E+3n/an/an/an/an/an/a



Boehringer Ingelheim (Canada) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of STK17A (unknown origin)


Bioorg Med Chem Lett 23: 3841-7 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM50166155
PNG
(CHEMBL3797619)
Show SMILES O\N=C1\C(\Nc2ccccc\12)=C1\C(=O)Nc2ccc(NC(=O)c3ccc(Cl)cc3)cc12
Show InChI InChI=1S/C23H15ClN4O3/c24-13-7-5-12(6-8-13)22(29)25-14-9-10-18-16(11-14)19(23(30)27-18)21-20(28-31)15-3-1-2-4-17(15)26-21/h1-11,26,31H,(H,25,29)(H,27,30)/b21-19-,28-20+
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n/an/a 3.00E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of DRAK1 (unknown origin)


Bioorg Med Chem Lett 26: 2719-23 (2016)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM50024285
PNG
(CHEMBL3334980)
Show SMILES COc1ccc(cc1OC)-c1cnc2scc(NC(=O)C3CCCCC3)c2n1
Show InChI InChI=1S/C21H23N3O3S/c1-26-17-9-8-14(10-18(17)27-2)15-11-22-21-19(23-15)16(12-28-21)24-20(25)13-6-4-3-5-7-13/h8-13H,3-7H2,1-2H3,(H,24,25)
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n/an/a 4.94E+3n/an/an/an/an/an/a



KU Leuven

Curated by ChEMBL


Assay Description
Inhibition of DRAK1 (unknown origin) using 33P-ATP after 30 mins by Trilux scintillation counting


J Med Chem 57: 7624-43 (2014)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM50024284
PNG
(CHEMBL3334979)
Show SMILES COc1ccc(cc1OC)-c1cnc2scc(NC(=O)C3CCCCC3)c2c1
Show InChI InChI=1S/C22H24N2O3S/c1-26-19-9-8-15(11-20(19)27-2)16-10-17-18(13-28-22(17)23-12-16)24-21(25)14-6-4-3-5-7-14/h8-14H,3-7H2,1-2H3,(H,24,25)
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n/an/a 5.91E+3n/an/an/an/an/an/a



KU Leuven

Curated by ChEMBL


Assay Description
Inhibition of DRAK1 (unknown origin) using 500 uM ATP by biochemical assay


J Med Chem 57: 7624-43 (2014)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM50135286
PNG
(CHEMBL3745885)
Show SMILES Cn1c2nc(Nc3ccc4[nH]ccc4c3)ncc2cc(c1=O)S(=O)(=O)c1ccc(F)cc1F
Show InChI InChI=1S/C22H15F2N5O3S/c1-29-20-13(9-19(21(29)30)33(31,32)18-5-2-14(23)10-16(18)24)11-26-22(28-20)27-15-3-4-17-12(8-15)6-7-25-17/h2-11,25H,1H3,(H,26,27,28)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Icahn School of Medicine at Mount Sinai

Curated by ChEMBL


Assay Description
Inhibition of human DRAK1 using [KKLNRTLSFAEPG] as substrate


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM13533
PNG
(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Ansaris

Curated by ChEMBL


Assay Description
Inhibition of DRAK1


Bioorg Med Chem Lett 21: 7155-65 (2011)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM50359359
PNG
(CHEMBL1929238)
Show SMILES CN(C)CCN1CCN(CCC1=O)C(=O)c1cc(sc1NC(=O)Nc1cccc(Cl)c1Cl)C(C)(C)C
Show InChI InChI=1S/C25H33Cl2N5O3S/c1-25(2,3)19-15-16(22(36-19)29-24(35)28-18-8-6-7-17(26)21(18)27)23(34)32-10-9-20(33)31(13-14-32)12-11-30(4)5/h6-8,15H,9-14H2,1-5H3,(H2,28,29,35)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Ansaris

Curated by ChEMBL


Assay Description
Inhibition of DRAK1


Bioorg Med Chem Lett 21: 7155-65 (2011)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM5931
PNG
(BMS-387072 | CHEMBL296468 | N-(5-{[(5-tert-butyl-1...)
Show SMILES CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1
Show InChI InChI=1S/C17H24N4O2S2/c1-17(2,3)12-8-19-13(23-12)10-24-14-9-20-16(25-14)21-15(22)11-4-6-18-7-5-11/h8-9,11,18H,4-7,10H2,1-3H3,(H,20,21,22)
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n/an/an/a 4.40E+5n/an/an/an/an/a



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM25118
PNG
((3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,...)
Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O
Show InChI InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29)
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n/an/an/a 8.30E+5n/an/an/an/an/a



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM31090
PNG
((E)-N-[4-(3-chloro-4-fluoro-anilino)-3-cyano-7-eth...)
Show SMILES CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C
Show InChI InChI=1S/C24H23ClFN5O2/c1-4-33-22-12-20-17(11-21(22)30-23(32)6-5-9-31(2)3)24(15(13-27)14-28-20)29-16-7-8-19(26)18(25)10-16/h5-8,10-12,14H,4,9H2,1-3H3,(H,28,29)(H,30,32)/b6-5+
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n/an/an/a 2.00E+5n/an/an/an/an/a



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM5447
PNG
(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)
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Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM6866
PNG
(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)
Show SMILES Nc1nc(Nc2ccc(cc2)S(N)(=O)=O)nn1C(=O)c1c(F)cccc1F
Show InChI InChI=1S/C15H12F2N6O3S/c16-10-2-1-3-11(17)12(10)13(24)23-14(18)21-15(22-23)20-8-4-6-9(7-5-8)27(19,25)26/h1-7H,(H2,19,25,26)(H3,18,20,21,22)
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n/an/an/a 5.60E+6n/an/an/an/an/a



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM31093
PNG
(4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-py...)
Show SMILES OC(=O)c1ccc(Nc2ncc3CN=C(c4cc(Cl)ccc4-c3n2)c2c(F)cccc2F)cc1
Show InChI InChI=1S/C25H15ClF2N4O2/c26-15-6-9-17-18(10-15)23(21-19(27)2-1-3-20(21)28)29-11-14-12-30-25(32-22(14)17)31-16-7-4-13(5-8-16)24(33)34/h1-10,12H,11H2,(H,33,34)(H,30,31,32)
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Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM31094
PNG
(PKC-412 | cid_24202429)
Show SMILES CO[C@H]1[C@H](C[C@@H]2O[C@@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1
Show InChI InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m0/s1
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Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM31095
PNG
(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Show SMILES Cc1[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1
Show InChI InChI=1S/C23H27FN4O4/c1-13-20(10-18-17-9-15(24)3-4-19(17)27-22(18)30)26-14(2)21(13)23(31)25-11-16(29)12-28-5-7-32-8-6-28/h3-4,9-10,16,26,29H,5-8,11-12H2,1-2H3,(H,25,31)(H,27,30)/b18-10-/t16-/m0/s1
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n/an/an/a 2.40E+4n/an/an/an/an/a



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM31096
PNG
(CHEMBL290084 | Staurosporine | cid_451705)
Show SMILES CN[C@H]1C[C@@H]2O[C@](C)([C@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m0/s1
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n/an/an/a 1.40E+4n/an/an/an/an/a



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM4814
PNG
(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Show SMILES CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C
Show InChI InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12-
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n/an/an/a 1.00E+3n/an/an/an/an/a



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM13530
PNG
(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Show SMILES CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1
Show InChI InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34)
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n/an/an/a 2.80E+3n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Average Binding Constant for STK17A; NA=Not Active at 10 uM


Nat Biotechnol 23: 329-36 (2005)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM5447
PNG
(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)
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n/an/an/a 2.90E+3n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Average Binding Constant for STK17A; NA=Not Active at 10 uM


Nat Biotechnol 23: 329-36 (2005)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM50024294
PNG
(SP-600125)
Show SMILES Oc1c2cccc3N=Nc(c23)c2ccccc12
Show InChI InChI=1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7,17H
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n/an/an/a 2.10E+3n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Average Binding Constant for STK17A; NA=Not Active at 10 uM


Nat Biotechnol 23: 329-36 (2005)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17A


(Homo sapiens)
BDBM4814
PNG
(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Show SMILES CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C
Show InChI InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12-
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n/an/an/a 21n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Average Binding Constant for STK17A; NA=Not Active at 10 uM


Nat Biotechnol 23: 329-36 (2005)

More data for this
Ligand-Target Pair
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