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Found 33 hits Enz. Inhib. hit(s) with Target = 'Serum paraoxonase/arylesterase 1'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM50139137
PNG
(CHEMBL3759162)
KEGG

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2.39E+3n/an/an/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase 1 (PON1)


(Homo sapiens (Human))
BDBM92331
PNG
(Lornoxicam)
Show SMILES CN1C(C(=O)Nc2ccccn2)=C(O)c2sc(Cl)cc2S1(=O)=O
Show InChI InChI=1S/C13H10ClN3O4S2/c1-17-10(13(19)16-9-4-2-3-5-15-9)11(18)12-7(23(17,20)21)6-8(14)22-12/h2-6,18H,1H3,(H,15,16,19)
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PubMed
9.00E+3 -28.8 1.36E+5n/an/an/an/a10.525



Atatürk University



Assay Description
The enzyme assay was based on the estimation of p-nitrophenol at 412nm. The molar extinction coefficient of p-nitrophenol was used to calculate enzy...


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase 1 (PON1)


(Homo sapiens (Human))
BDBM50316126
PNG
(Bleph-10 | Bleph-30 | Blephamide | CHEMBL455 | Cet...)
Show SMILES CC(=O)NS(=O)(=O)c1ccc(N)cc1
Show InChI InChI=1S/C8H10N2O3S/c1-6(11)10-14(12,13)8-4-2-7(9)3-5-8/h2-5H,9H2,1H3,(H,10,11)
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8.60E+4n/a 1.80E+5n/an/an/an/an/an/a



Atatürk University



Assay Description
The inhibitory effects of six sulfonamide derivatives was examined against the purified enzyme hPON1 and were tested in a triplicate experiment in fi...


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase 1 (PON1)


(Homo sapiens (Human))
BDBM17638
PNG
(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Show SMILES COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(O)=O)c2c1
Show InChI InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
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PubMed
9.70E+4 -22.9 1.95E+5n/an/an/an/a10.525



Atatürk University



Assay Description
The enzyme assay was based on the estimation of p-nitrophenol at 412nm. The molar extinction coefficient of p-nitrophenol was used to calculate enzy...


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase 1 (PON1)


(Homo sapiens (Human))
BDBM92332
PNG
(Tenoxicam)
Show SMILES CN1C(C(=O)Nc2ccccn2)=C(O)c2sccc2S1(=O)=O
Show InChI InChI=1S/C13H11N3O4S2/c1-16-10(13(18)15-9-4-2-3-6-14-9)11(17)12-8(5-7-21-12)22(16,19)20/h2-7,17H,1H3,(H,14,15,18)
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3.06E+5 -20.1 3.40E+5n/an/an/an/a10.525



Atatürk University



Assay Description
The enzyme assay was based on the estimation of p-nitrophenol at 412nm. The molar extinction coefficient of p-nitrophenol was used to calculate enzy...


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase 1 (PON1)


(Homo sapiens (Human))
BDBM10860
PNG
(4-(aminomethyl)benzene-1-sulfonamide | CHEMBL419 |...)
Show SMILES NCc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C7H10N2O2S/c8-5-6-1-3-7(4-2-6)12(9,10)11/h1-4H,5,8H2,(H2,9,10,11)
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3.40E+5n/a 1.90E+5n/an/an/an/an/an/a



Atatürk University



Assay Description
The inhibitory effects of six sulfonamide derivatives was examined against the purified enzyme hPON1 and were tested in a triplicate experiment in fi...


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase 1 (PON1)


(Homo sapiens (Human))
BDBM82185
PNG
(Sulfosalazine, 3)
Show SMILES OC(=O)c1ccc(cc1O)\N=N\c1ccc(cc1)S(=O)(=O)Nc1ccccn1
Show InChI InChI=1S/C18H14N4O5S/c23-16-11-13(6-9-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,23H,(H,19,22)(H,24,25)/b21-20+
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5.70E+5n/a 2.60E+5n/an/an/an/an/an/a



Atatürk University



Assay Description
The inhibitory effects of six sulfonamide derivatives was examined against the purified enzyme hPON1 and were tested in a triplicate experiment in fi...


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase 1 (PON1)


(Homo sapiens (Human))
BDBM25902
PNG
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
Show SMILES NS(=O)(=O)c1cc(C(O)=O)c(NCc2ccco2)cc1Cl
Show InChI InChI=1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19)
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7.02E+5n/a 3.60E+5n/an/an/an/an/an/a



Atatürk University



Assay Description
The inhibitory effects of six sulfonamide derivatives was examined against the purified enzyme hPON1 and were tested in a triplicate experiment in fi...


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase 1 (PON1)


(Homo sapiens (Human))
BDBM10880
PNG
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Show SMILES CC(=O)Nc1nnc(s1)S(N)(=O)=O
Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
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7.43E+5n/a 8.00E+5n/an/an/an/an/an/a



Atatürk University



Assay Description
The inhibitory effects of six sulfonamide derivatives was examined against the purified enzyme hPON1 and were tested in a triplicate experiment in fi...


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase 1 (PON1)


(Homo sapiens (Human))
BDBM50174201
PNG
(ARTHROTEC | DICLOFENAC SODIUM | GP 45840 | SOLARAZ...)
Show SMILES [O-]C(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl
Show InChI InChI=1S/C14H11Cl2NO2/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19/h1-7,17H,8H2,(H,18,19)/p-1
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8.05E+5 -17.7 1.64E+6n/an/an/an/a10.525



Atatürk University



Assay Description
The enzyme assay was based on the estimation of p-nitrophenol at 412nm. The molar extinction coefficient of p-nitrophenol was used to calculate enzy...


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase 1 (PON1)


(Homo sapiens (Human))
BDBM10868
PNG
(1,3,4-Thiadiazole-2-sulfonamide, 6 | 1,3,4-thiadia...)
Show SMILES Nc1nnc(s1)S(N)(=O)=O
Show InChI InChI=1S/C2H4N4O2S2/c3-1-5-6-2(9-1)10(4,7)8/h(H2,3,5)(H2,4,7,8)
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2.00E+6n/a 1.24E+6n/an/an/an/an/an/a



Atatürk University



Assay Description
The inhibitory effects of six sulfonamide derivatives was examined against the purified enzyme hPON1 and were tested in a triplicate experiment in fi...


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase 1 (PON1)


(Homo sapiens (Human))
BDBM92333
PNG
(Lincomycine)
Show SMILES CCCC1CC(N(C)C1)C(=O)NC(C(C)O)C1OC(SC)C(O)C(O)C1O
Show InChI InChI=1S/C18H34N2O6S/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25)
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1.11E+7 -11.2 1.30E+7n/an/an/an/a10.525



Atatürk University



Assay Description
The enzyme assay was based on the estimation of p-nitrophenol at 412nm. The molar extinction coefficient of p-nitrophenol was used to calculate enzy...


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase 1 (PON1)


(Homo sapiens (Human))
BDBM50022271
PNG
(2-(3-Benzoylphenyl)propionic acid | 2-(3-benzoylph...)
Show SMILES CC(C(O)=O)c1cccc(c1)C(=O)c1ccccc1
Show InChI InChI=1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19)
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PubMed
1.30E+7 -10.8 6.23E+6n/an/an/an/a10.525



Atatürk University



Assay Description
The enzyme assay was based on the estimation of p-nitrophenol at 412nm. The molar extinction coefficient of p-nitrophenol was used to calculate enzy...


Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM86068
PNG
(PPC)
Show SMILES Cc1ccc(cc1)-c1cc2cc(O)c(O)cc2oc1=O
Show InChI InChI=1S/C16H12O4/c1-9-2-4-10(5-3-9)12-6-11-7-13(17)14(18)8-15(11)20-16(12)19/h2-8,17-18H,1H3
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n/an/a 3.00E+3n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase 1 (PON1)


(Homo sapiens (Human))
BDBM50139137
PNG
(CHEMBL3759162)
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n/an/a 6.37E+3n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM50144692
PNG
(CHEMBL3759251)
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n/an/a 8.76E+3n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM50144693
PNG
(CHEMBL3758983)
KEGG

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n/an/a 1.91E+4n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase 1 (PON1)


(Homo sapiens (Human))
BDBM50139133
PNG
(CHEMBL3759178)
KEGG

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n/an/a 2.14E+4n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase 1 (PON1)


(Homo sapiens (Human))
BDBM50139135
PNG
(CHEMBL3759775)
KEGG

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n/an/a 2.37E+4n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM50144739
PNG
(CHEMBL3759516)
KEGG

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n/an/a 2.90E+4n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase 1 (PON1)


(Homo sapiens (Human))
BDBM50139132
PNG
(CHEMBL1462074)
KEGG

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n/an/a 3.14E+4n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase 1 (PON1)


(Homo sapiens (Human))
BDBM50139134
PNG
(CHEMBL3758686)
KEGG

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n/an/a 4.00E+4n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM50144690
PNG
(CHEMBL3759001)
KEGG

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n/an/a 2.38E+5n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase 1 (PON1)


(Homo sapiens (Human))
BDBM50139136
PNG
(CHEMBL3759337)
KEGG

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n/an/a 3.17E+5n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM50144740
PNG
(CHEMBL3758357)
KEGG

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n/an/a 5.64E+5n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM50144738
PNG
(CHEMBL3758838)
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n/an/a 6.26E+5n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM50144691
PNG
(CHEMBL3759697)
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n/an/a 6.27E+5n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase 1 (PON1)


(Homo sapiens (Human))
BDBM50127646
PNG
(CHEMBL42577 | Phosphoric acid 4-amino-phenyl ester...)
Show SMILES CCOP(=O)(OCC)Oc1ccc(N)cc1
Show InChI InChI=1S/C10H16NO4P/c1-3-13-16(12,14-4-2)15-10-7-5-9(11)6-8-10/h5-8H,3-4,11H2,1-2H3
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n/an/a 1.28E+6n/an/an/an/an/an/a



The University of Birmingham

Curated by ChEMBL


Assay Description
Inhibitory activity against human serum paraoxonase (PON1)


Bioorg Med Chem Lett 13: 1623-6 (2003)

More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM50144742
PNG
(CHEMBL3758332)
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n/an/a 2.06E+6n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase 1 (PON1)


(Homo sapiens (Human))
BDBM14675
PNG
(CHEMBL26128 | Fragment 5 | Phenylphosphate | pheno...)
Show SMILES OP(O)(=O)Oc1ccccc1
Show InChI InChI=1S/C6H7O4P/c7-11(8,9)10-6-4-2-1-3-5-6/h1-5H,(H2,7,8,9)
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n/an/a 3.25E+6n/an/an/an/an/an/a



The University of Birmingham

Curated by ChEMBL


Assay Description
Inhibitory activity against human serum paraoxonase (PON1)


Bioorg Med Chem Lett 13: 1623-6 (2003)

More data for this
Ligand-Target Pair
Serum paraoxonase 1 (PON1)


(Homo sapiens (Human))
BDBM50127647
PNG
(CHEMBL296745 | Phosphoric acid diethyl ester pheny...)
Show SMILES CCOP(=O)(OCC)Oc1ccccc1
Show InChI InChI=1S/C10H15O4P/c1-3-12-15(11,13-4-2)14-10-8-6-5-7-9-10/h5-9H,3-4H2,1-2H3
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n/an/a 3.27E+6n/an/an/an/an/an/a



The University of Birmingham

Curated by ChEMBL


Assay Description
Inhibitory activity against human serum paraoxonase (PON1)


Bioorg Med Chem Lett 13: 1623-6 (2003)

More data for this
Ligand-Target Pair
Serum paraoxonase/arylesterase 1


(Homo sapiens (Human))
BDBM50144741
PNG
(CHEMBL3760112)
KEGG

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n/an/a 3.33E+6n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Serum paraoxonase 1 (PON1)


(Homo sapiens (Human))
BDBM24514
PNG
(4-nitrophenoxyphosphonic acid | 4-nitrophenyl phos...)
Show SMILES OP(O)(=O)Oc1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)
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n/an/a 1.85E+7n/an/an/an/an/an/a



The University of Birmingham

Curated by ChEMBL


Assay Description
Inhibitory activity against human serum paraoxonase (PON1)


Bioorg Med Chem Lett 13: 1623-6 (2003)

More data for this
Ligand-Target Pair