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Found 673 hits Enz. Inhib. hit(s) with Target = 'Solute carrier family 22 member 12'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM26658
PNG
(2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-1-benzopy...)
Show SMILES Oc1ccc(c(O)c1)-c1oc2cc(O)cc(O)c2c(=O)c1O
Show InChI InChI=1S/C15H10O7/c16-6-1-2-8(9(18)3-6)15-14(21)13(20)12-10(19)4-7(17)5-11(12)22-15/h1-5,16-19,21H
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5.74E+3n/an/an/an/an/an/an/an/a



The Chinese University of Hong Kong

Curated by ChEMBL


Assay Description
Inhibition of human URAT1-mediated urate uptake in HEK293 cells by competitive inhibition assay


Drug Metab Dispos 35: 981-6 (2007)


Article DOI: 10.1124/dmd.106.012187
BindingDB Entry DOI: 10.7270/Q2KK9CPP
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM165874
PNG
(US9067922, 213 | US9067922, 225)
Show SMILES Fc1ccc(Oc2cc(F)c(cc2Cl)S(=O)(=O)Nc2ncccn2)cc1C#N
Show InChI InChI=1S/C17H9ClF2N4O3S/c18-12-7-16(28(25,26)24-17-22-4-1-5-23-17)14(20)8-15(12)27-11-2-3-13(19)10(6-11)9-21/h1-8H,(H,22,23,24)
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n/an/a 0n/an/an/an/a7.4n/a



Pfizer Inc

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...


US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM165905
PNG
(US9067922, 247)
Show SMILES OCc1ccc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(F)cn2)cc1Cl
Show InChI InChI=1S/C19H13ClFN3O4S/c20-17-8-15(3-1-12(17)11-25)28-18-5-4-16(7-13(18)9-22)29(26,27)24-19-6-2-14(21)10-23-19/h1-8,10,25H,11H2,(H,23,24)
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n/an/a 1n/an/an/an/a7.4n/a



Pfizer Inc

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...


US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM165898
PNG
(US9067922, 239)
Show SMILES OCc1ncc(Oc2ccc(c(F)c2)S(=O)(=O)Nc2ccc(F)cn2)cc1Cl
Show InChI InChI=1S/C17H12ClF2N3O4S/c18-13-5-12(8-21-15(13)9-24)27-11-2-3-16(14(20)6-11)28(25,26)23-17-4-1-10(19)7-22-17/h1-8,24H,9H2,(H,22,23)
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n/an/a 2n/an/an/an/a7.4n/a



Pfizer Inc

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...


US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM50239134
PNG
(CHEMBL4087516)
Show SMILES FC(F)(F)S(=O)(=O)Nc1ccncc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C13H8F3N3O2S/c14-13(15,16)22(20,21)19-12-5-6-18-8-11(12)10-3-1-9(7-17)2-4-10/h1-6,8H,(H,18,19)
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n/an/a 2n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human URAT1 expressed in HEK293T cells assessed as reduction in [14C]uric acid uptake measured after 5 mins by liquid scintillation cou...


Bioorg Med Chem Lett 27: 1919-1922 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.041
BindingDB Entry DOI: 10.7270/Q2NK3H6D
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM165900
PNG
(US9067922, 241)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3cc(Cl)c(C#N)c(Cl)c3)c(c2)C#N)nc1
Show InChI InChI=1S/C19H9Cl2FN4O3S/c20-16-6-13(7-17(21)15(16)9-24)29-18-3-2-14(5-11(18)8-23)30(27,28)26-19-4-1-12(22)10-25-19/h1-7,10H,(H,25,26)
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n/an/a 3n/an/an/an/a7.4n/a



Pfizer Inc

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...


US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM165745
PNG
(US9067922, 235 | US9067922, 79)
Show SMILES Cc1cc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(F)cn2)cc(C)c1C#N
Show InChI InChI=1S/C21H15FN4O3S/c1-13-7-17(8-14(2)19(13)11-24)29-20-5-4-18(9-15(20)10-23)30(27,28)26-21-6-3-16(22)12-25-21/h3-9,12H,1-2H3,(H,25,26)
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n/an/a 7n/an/an/an/a7.4n/a



Pfizer Inc

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...


US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM165896
PNG
(US9067922, 237)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3cc(F)c(C#N)c(Cl)c3)c(c2)C#N)nc1
Show InChI InChI=1S/C19H9ClF2N4O3S/c20-16-6-13(7-17(22)15(16)9-24)29-18-3-2-14(5-11(18)8-23)30(27,28)26-19-4-1-12(21)10-25-19/h1-7,10H,(H,25,26)
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n/an/a 8n/an/an/an/a7.4n/a



Pfizer Inc

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...


US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM290450
PNG
(2{[4-(4-Cyanonaphthalen)isoquinolin-6-yl]thio}-2-m...)
Show SMILES CC(C)(Sc1ccc2cncc(-c3ccc(C#N)c4ccccc34)c2c1)C(O)=O
Show InChI InChI=1S/C24H18N2O2S/c1-24(2,23(27)28)29-17-9-7-16-13-26-14-22(21(16)11-17)20-10-8-15(12-25)18-5-3-4-6-19(18)20/h3-11,13-14H,1-2H3,(H,27,28)
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n/an/a 8n/an/an/an/an/an/a



Shanghai Yingli Pharmaceutical Co., Ltd

US Patent


Assay Description
Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37 C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf...


US Patent US10100016 (2018)


Article DOI: 10.1021/jm0499458
BindingDB Entry DOI: 10.7270/Q2TH8PQZ
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM152051
PNG
(US8987473, 137)
Show SMILES Cc1nn(Cc2c(Cl)cccc2Cl)c2cc(Cc3n[nH]c(=S)o3)ccc12
Show InChI InChI=1S/C18H14Cl2N4OS/c1-10-12-6-5-11(8-17-21-22-18(26)25-17)7-16(12)24(23-10)9-13-14(19)3-2-4-15(13)20/h2-7H,8-9H2,1H3,(H,22,26)
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n/an/a 10n/an/an/an/an/an/a



Sato Pharmaceutical Co., Ltd.

US Patent


Assay Description
It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...


US Patent US8987473 (2015)


BindingDB Entry DOI: 10.7270/Q23F4NCB
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM290480
PNG
(US10100016, Compound 45B)
Show SMILES C[C@@H](CC(O)=O)c1cc2cncc(-c3ccc(C#N)c4ccccc34)c2s1
Show InChI InChI=1/C22H16N2O2S/c1-13(8-21(25)26)20-9-15-11-24-12-19(22(15)27-20)18-7-6-14(10-23)16-4-2-3-5-17(16)18/h2-7,9,11-13H,8H2,1H3,(H,25,26)/t13-/s2
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n/an/a 10n/an/an/an/an/an/a



Shanghai Yingli Pharmaceutical Co., Ltd

US Patent


Assay Description
Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37 C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf...


US Patent US10100016 (2018)


Article DOI: 10.1021/jm0499458
BindingDB Entry DOI: 10.7270/Q2TH8PQZ
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM50239146
PNG
(CHEMBL4088988)
Show SMILES FC(F)(F)S(=O)(=O)Nc1ccncc1-c1ccc(C#N)c2ccccc12
Show InChI InChI=1S/C17H10F3N3O2S/c18-17(19,20)26(24,25)23-16-7-8-22-10-15(16)14-6-5-11(9-21)12-3-1-2-4-13(12)14/h1-8,10H,(H,22,23)
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n/an/a 10n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human URAT1 expressed in HEK293T cells assessed as reduction in [14C]uric acid uptake measured after 5 mins by liquid scintillation cou...


Bioorg Med Chem Lett 27: 1919-1922 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.041
BindingDB Entry DOI: 10.7270/Q2NK3H6D
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM152041
PNG
(US8987473, 122)
Show SMILES Cc1nn(Cc2c(Cl)cccc2Cl)c2cc(CCC(O)=O)ccc12
Show InChI InChI=1S/C18H16Cl2N2O2/c1-11-13-7-5-12(6-8-18(23)24)9-17(13)22(21-11)10-14-15(19)3-2-4-16(14)20/h2-5,7,9H,6,8,10H2,1H3,(H,23,24)
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n/an/a 10n/an/an/an/an/an/a



Sato Pharmaceutical Co., Ltd.

US Patent


Assay Description
It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...


US Patent US8987473 (2015)


BindingDB Entry DOI: 10.7270/Q23F4NCB
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM290470
PNG
(US10100016, Compound 43A)
Show SMILES C[C@H](CC(O)=O)c1cc2c(cncc2s1)-c1ccc(C#N)c2ccccc12
Show InChI InChI=1/C22H16N2O2S/c1-13(8-22(25)26)20-9-18-19(11-24-12-21(18)27-20)17-7-6-14(10-23)15-4-2-3-5-16(15)17/h2-7,9,11-13H,8H2,1H3,(H,25,26)/t13-/s2
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n/an/a 11n/an/an/an/an/an/a



Shanghai Yingli Pharmaceutical Co., Ltd

US Patent


Assay Description
Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37 C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf...


US Patent US10100016 (2018)


Article DOI: 10.1021/jm0499458
BindingDB Entry DOI: 10.7270/Q2TH8PQZ
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM290481
PNG
(3-[4-(4-Cyanonaphthalen-1-yl)isoquinolin-6-yl]-2,2...)
Show SMILES CC(C)(Cc1ccc2cncc(-c3ccc(C#N)c4ccccc34)c2c1)C(O)=O
Show InChI InChI=1S/C25H20N2O2/c1-25(2,24(28)29)12-16-7-8-18-14-27-15-23(22(18)11-16)21-10-9-17(13-26)19-5-3-4-6-20(19)21/h3-11,14-15H,12H2,1-2H3,(H,28,29)
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n/an/a 12n/an/an/an/an/an/a



Shanghai Yingli Pharmaceutical Co., Ltd

US Patent


Assay Description
Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37 C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf...


US Patent US10100016 (2018)


Article DOI: 10.1021/jm0499458
BindingDB Entry DOI: 10.7270/Q2TH8PQZ
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM165893
PNG
(US9067922, 232)
Show SMILES Clc1ccc(NS(=O)(=O)c2ccc(Oc3ccc(C#N)c(Cl)c3)c(c2)C#N)nc1
Show InChI InChI=1S/C19H10Cl2N4O3S/c20-14-2-6-19(24-11-14)25-29(26,27)16-4-5-18(13(7-16)10-23)28-15-3-1-12(9-22)17(21)8-15/h1-8,11H,(H,24,25)
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n/an/a 12n/an/an/an/a7.4n/a



Pfizer Inc

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...


US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM318948
PNG
(2-Methyl-2-[[7-(4-nitrophenyl)benzo[d]isothiazol-6...)
Show SMILES CC(C)(Sc1ccc2cnsc2c1-c1ccc(cc1)[N+]([O-])=O)C(O)=O
Show InChI InChI=1S/C17H14N2O4S2/c1-17(2,16(20)21)24-13-8-5-11-9-18-25-15(11)14(13)10-3-6-12(7-4-10)19(22)23/h3-9H,1-2H3,(H,20,21)
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n/an/a 12n/an/an/an/an/an/a



Nippon Chemiphar Co., Ltd

US Patent


Assay Description
URAT1 stably expressed HEK293 cells (HEK-URAT1) or HEK293 cells transfected with empty vector (HEK-mock) were cultured in DMEM culture medium supplem...


US Patent US10173990 (2019)


Article DOI: 10.1021/jm060015t
BindingDB Entry DOI: 10.7270/Q2RR21BP
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM290489
PNG
(3-[4-(4-Cyanophenyl)thieno[2,3-c]pyridin-2-yl]-2,2...)
Show SMILES CC(C)(Cc1cc2c(cncc2s1)-c1ccc(cc1)C#N)C(O)=O
Show InChI InChI=1S/C19H16N2O2S/c1-19(2,18(22)23)8-14-7-15-16(10-21-11-17(15)24-14)13-5-3-12(9-20)4-6-13/h3-7,10-11H,8H2,1-2H3,(H,22,23)
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n/an/a 12n/an/an/an/an/an/a



Shanghai Yingli Pharmaceutical Co., Ltd

US Patent


Assay Description
Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37 C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf...


US Patent US10100016 (2018)


Article DOI: 10.1021/jm0499458
BindingDB Entry DOI: 10.7270/Q2TH8PQZ
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM152048
PNG
(US8987473, 134)
Show SMILES Cc1nn(Cc2c(Cl)cccc2Cl)c2cc(Cc3nnn[nH]3)ccc12
Show InChI InChI=1S/C17H14Cl2N6/c1-10-12-6-5-11(8-17-20-23-24-21-17)7-16(12)25(22-10)9-13-14(18)3-2-4-15(13)19/h2-7H,8-9H2,1H3,(H,20,21,23,24)
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n/an/a 13n/an/an/an/an/an/a



Sato Pharmaceutical Co., Ltd.

US Patent


Assay Description
It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...


US Patent US8987473 (2015)


BindingDB Entry DOI: 10.7270/Q23F4NCB
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM165745
PNG
(US9067922, 235 | US9067922, 79)
Show SMILES Cc1cc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(F)cn2)cc(C)c1C#N
Show InChI InChI=1S/C21H15FN4O3S/c1-13-7-17(8-14(2)19(13)11-24)29-20-5-4-18(9-15(20)10-23)30(27,28)26-21-6-3-16(22)12-25-21/h3-9,12H,1-2H3,(H,25,26)
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n/an/a 13n/an/an/an/a7.4n/a



Pfizer Inc

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...


US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM165667
PNG
(US9067922, 1)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3ccc(C#N)c(Cl)c3)c(c2)C#N)nc1
Show InChI InChI=1S/C19H10ClFN4O3S/c20-17-8-15(3-1-12(17)9-22)28-18-5-4-16(7-13(18)10-23)29(26,27)25-19-6-2-14(21)11-24-19/h1-8,11H,(H,24,25)
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n/an/a 13n/an/an/an/a7.4n/a



Pfizer Inc

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...


US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM377700
PNG
(US10266496, Example 27)
Show SMILES OC(=O)c1ccc(cc1O)-c1cc(cc2oc(Cl)cc12)C#N
Show InChI InChI=1S/C16H8ClNO4/c17-15-6-12-11(3-8(7-18)4-14(12)22-15)9-1-2-10(16(20)21)13(19)5-9/h1-6,19H,(H,20,21)
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n/an/a 14n/an/an/an/an/an/a



Sunshine Lake Pharma Co., Ltd

US Patent


Assay Description
a. Construction of a Cell Line Stably Expressing hURAT1hURAT1 plasmid was transfected into HEK293T cell, and a cell line stably expressing hURAT1 was...


US Patent US10266496 (2019)

More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM152079
PNG
(US8987473, 183)
Show SMILES Cc1nn(Cc2c(Cl)cccc2Cl)c2cc(ccc12)C(F)(F)C(O)=O
Show InChI InChI=1S/C17H12Cl2F2N2O2/c1-9-11-6-5-10(17(20,21)16(24)25)7-15(11)23(22-9)8-12-13(18)3-2-4-14(12)19/h2-7H,8H2,1H3,(H,24,25)
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n/an/a 15n/an/an/an/an/an/a



Sato Pharmaceutical Co., Ltd.

US Patent


Assay Description
It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...


US Patent US8987473 (2015)


BindingDB Entry DOI: 10.7270/Q23F4NCB
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM152017
PNG
(US8987473, 82)
Show SMILES Cc1cn(Cc2c(Cl)cccc2Cl)c2cc(CC(O)=O)ccc12
Show InChI InChI=1S/C18H15Cl2NO2/c1-11-9-21(10-14-15(19)3-2-4-16(14)20)17-7-12(8-18(22)23)5-6-13(11)17/h2-7,9H,8,10H2,1H3,(H,22,23)
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n/an/a 15n/an/an/an/an/an/a



Sato Pharmaceutical Co., Ltd.

US Patent


Assay Description
It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...


US Patent US8987473 (2015)


BindingDB Entry DOI: 10.7270/Q23F4NCB
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM290479
PNG
(3-[4-(4-Cyanonaphthalen-1-yl)isoquinolin-6-yl]-2-m...)
Show SMILES CC(Cc1ccc2cncc(-c3ccc(C#N)c4ccccc34)c2c1)C(O)=O
Show InChI InChI=1/C24H18N2O2/c1-15(24(27)28)10-16-6-7-18-13-26-14-23(22(18)11-16)21-9-8-17(12-25)19-4-2-3-5-20(19)21/h2-9,11,13-15H,10H2,1H3,(H,27,28)
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n/an/a 15n/an/an/an/an/an/a



Shanghai Yingli Pharmaceutical Co., Ltd

US Patent


Assay Description
Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37 C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf...


US Patent US10100016 (2018)


Article DOI: 10.1021/jm0499458
BindingDB Entry DOI: 10.7270/Q2TH8PQZ
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM377703
PNG
(US10266496, Example 30)
Show SMILES OC(=O)c1ccc(cc1O)-c1cc(cc2sc(F)cc12)C#N
Show InChI InChI=1S/C16H8FNO3S/c17-15-6-12-11(3-8(7-18)4-14(12)22-15)9-1-2-10(16(20)21)13(19)5-9/h1-6,19H,(H,20,21)
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n/an/a 15n/an/an/an/an/an/a



Sunshine Lake Pharma Co., Ltd

US Patent


Assay Description
a. Construction of a Cell Line Stably Expressing hURAT1hURAT1 plasmid was transfected into HEK293T cell, and a cell line stably expressing hURAT1 was...


US Patent US10266496 (2019)

More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM290448
PNG
(2{[4-(4-Cyanophenyl)isoquinolin-6-yl]thio-2-methyl...)
Show SMILES CC(C)(Sc1ccc2cncc(-c3ccc(cc3)C#N)c2c1)C(O)=O
Show InChI InChI=1S/C20H16N2O2S/c1-20(2,19(23)24)25-16-8-7-15-11-22-12-18(17(15)9-16)14-5-3-13(10-21)4-6-14/h3-9,11-12H,1-2H3,(H,23,24)
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n/an/a 15n/an/an/an/an/an/a



Shanghai Yingli Pharmaceutical Co., Ltd

US Patent


Assay Description
Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37 C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf...


US Patent US10100016 (2018)


Article DOI: 10.1021/jm0499458
BindingDB Entry DOI: 10.7270/Q2TH8PQZ
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM165769
PNG
(US9067922, 104)
Show SMILES Fc1ccnc(NS(=O)(=O)c2ccc(Oc3ccc(C#N)c(Cl)c3)c(c2)C#N)c1
Show InChI InChI=1S/C19H10ClFN4O3S/c20-17-9-15(2-1-12(17)10-22)28-18-4-3-16(7-13(18)11-23)29(26,27)25-19-8-14(21)5-6-24-19/h1-9H,(H,24,25)
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n/an/a 15n/an/an/an/a7.4n/a



Pfizer Inc

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...


US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM152047
PNG
(US8987473, 133)
Show SMILES Cc1nn(Cc2c(Cl)cccc2Cl)c2cc(CCCC(O)=O)ccc12
Show InChI InChI=1S/C19H18Cl2N2O2/c1-12-14-9-8-13(4-2-7-19(24)25)10-18(14)23(22-12)11-15-16(20)5-3-6-17(15)21/h3,5-6,8-10H,2,4,7,11H2,1H3,(H,24,25)
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n/an/a 16n/an/an/an/an/an/a



Sato Pharmaceutical Co., Ltd.

US Patent


Assay Description
It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...


US Patent US8987473 (2015)


BindingDB Entry DOI: 10.7270/Q23F4NCB
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM152080
PNG
(US8987473, 185)
Show SMILES Cc1nn(Cc2c(Cl)cccc2C2CC2)c2cc(CCC(O)=O)ccc12
Show InChI InChI=1S/C21H21ClN2O2/c1-13-16-9-5-14(6-10-21(25)26)11-20(16)24(23-13)12-18-17(15-7-8-15)3-2-4-19(18)22/h2-5,9,11,15H,6-8,10,12H2,1H3,(H,25,26)
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n/an/a 17n/an/an/an/an/an/a



Sato Pharmaceutical Co., Ltd.

US Patent


Assay Description
It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...


US Patent US8987473 (2015)


BindingDB Entry DOI: 10.7270/Q23F4NCB
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM152016
PNG
(US8987473, 80)
Show SMILES Cc1cccc(C)c1CN1CC(C)(C)c2ccc(CC(O)=O)cc12
Show InChI InChI=1S/C21H25NO2/c1-14-6-5-7-15(2)17(14)12-22-13-21(3,4)18-9-8-16(10-19(18)22)11-20(23)24/h5-10H,11-13H2,1-4H3,(H,23,24)
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n/an/a 18n/an/an/an/an/an/a



Sato Pharmaceutical Co., Ltd.

US Patent


Assay Description
It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...


US Patent US8987473 (2015)


BindingDB Entry DOI: 10.7270/Q23F4NCB
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM152026
PNG
(US8987473, 97)
Show SMILES Cc1nn(Cc2c(Cl)cccc2Cl)c2cc(CC(O)=O)ccc12
Show InChI InChI=1S/C17H14Cl2N2O2/c1-10-12-6-5-11(8-17(22)23)7-16(12)21(20-10)9-13-14(18)3-2-4-15(13)19/h2-7H,8-9H2,1H3,(H,22,23)
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n/an/a 18n/an/an/an/an/an/a



Sato Pharmaceutical Co., Ltd.

US Patent


Assay Description
It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...


US Patent US8987473 (2015)


BindingDB Entry DOI: 10.7270/Q23F4NCB
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM290490
PNG
(1-{[4-(4-cyanonaphthalen-1-yl)isoquinolin-6-yl]thi...)
Show SMILES OC(=O)C1(CCC1)Sc1ccc2cncc(-c3ccc(C#N)c4ccccc34)c2c1
Show InChI InChI=1S/C25H18N2O2S/c26-13-16-7-9-21(20-5-2-1-4-19(16)20)23-15-27-14-17-6-8-18(12-22(17)23)30-25(24(28)29)10-3-11-25/h1-2,4-9,12,14-15H,3,10-11H2,(H,28,29)
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n/an/a 18n/an/an/an/an/an/a



Shanghai Yingli Pharmaceutical Co., Ltd

US Patent


Assay Description
Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37 C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf...


US Patent US10100016 (2018)


Article DOI: 10.1021/jm0499458
BindingDB Entry DOI: 10.7270/Q2TH8PQZ
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM290488
PNG
(2-{[4-(2-Chloro-4-cyanophenyl)isoquinolin-6-yl]thi...)
Show SMILES CC(C)(Sc1ccc2cncc(-c3ccc(cc3Cl)C#N)c2c1)C(O)=O
Show InChI InChI=1S/C20H15ClN2O2S/c1-20(2,19(24)25)26-14-5-4-13-10-23-11-17(16(13)8-14)15-6-3-12(9-22)7-18(15)21/h3-8,10-11H,1-2H3,(H,24,25)
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n/an/a 18n/an/an/an/an/an/a



Shanghai Yingli Pharmaceutical Co., Ltd

US Patent


Assay Description
Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37 C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf...


US Patent US10100016 (2018)


Article DOI: 10.1021/jm0499458
BindingDB Entry DOI: 10.7270/Q2TH8PQZ
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM290487
PNG
(3-[4-(4-Cyanonaphthalen-1-yl)thieno[2,3-c]pyridin-...)
Show SMILES CC(C)(Cc1cc2c(cncc2s1)-c1ccc(C#N)c2ccccc12)C(O)=O
Show InChI InChI=1S/C23H18N2O2S/c1-23(2,22(26)27)10-15-9-19-20(12-25-13-21(19)28-15)18-8-7-14(11-24)16-5-3-4-6-17(16)18/h3-9,12-13H,10H2,1-2H3,(H,26,27)
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n/an/a 18n/an/an/an/an/an/a



Shanghai Yingli Pharmaceutical Co., Ltd

US Patent


Assay Description
Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37 C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf...


US Patent US10100016 (2018)


Article DOI: 10.1021/jm0499458
BindingDB Entry DOI: 10.7270/Q2TH8PQZ
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM165744
PNG
(US9067922, 78)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3ccc(F)c(Cl)c3)c(c2)C#N)nc1
Show InChI InChI=1S/C18H10ClF2N3O3S/c19-15-8-13(2-4-16(15)21)27-17-5-3-14(7-11(17)9-22)28(25,26)24-18-6-1-12(20)10-23-18/h1-8,10H,(H,23,24)
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n/an/a 19n/an/an/an/a7.4n/a



Pfizer Inc

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...


US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM377690
PNG
(US10266496, Example 2)
Show SMILES OC(=O)c1ccc(cc1O)-c1cc(cc2ccccc12)C#N
Show InChI InChI=1S/C18H11NO3/c19-10-11-7-12-3-1-2-4-14(12)16(8-11)13-5-6-15(18(21)22)17(20)9-13/h1-9,20H,(H,21,22)
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n/an/a 19n/an/an/an/an/an/a



Sunshine Lake Pharma Co., Ltd

US Patent


Assay Description
a. Construction of a Cell Line Stably Expressing hURAT1hURAT1 plasmid was transfected into HEK293T cell, and a cell line stably expressing hURAT1 was...


US Patent US10266496 (2019)

More data for this
Ligand-Target Pair
Solute carrier family 22 member 12 (URAT1)


(Homo sapiens (Human))
BDBM50134635
PNG
(CHEMBL3746329 | US9637484, 3)
Show SMILES OC(=O)C1(CCC1)Sc1ccnc2ccc(Br)cc12
Show InChI InChI=1S/C14H12BrNO2S/c15-9-2-3-11-10(8-9)12(4-7-16-11)19-14(13(17)18)5-1-6-14/h2-4,7-8H,1,5-6H2,(H,17,18)
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n/an/a 19n/an/an/an/an/an/a



Shanghai Hengrui Pharmaceutical Co., Ltd

US Patent


Assay Description
In vitro URAT1 assay can be used to identify compounds having potential activity for decreasing serum uric acid. In a suitable test, the vectors that...


US Patent US9637484 (2017)


Article DOI: 10.1016/j.bmcl.2006.07.061
BindingDB Entry DOI: 10.7270/Q2S75JD2
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM290515
PNG
(3-[4-(4-Cyanophenyl)isoquinolin-6-yl]-2,2-dimethyl...)
Show SMILES CC(C)(Cc1ccc2cncc(-c3ccc(cc3)C#N)c2c1)C(O)=O
Show InChI InChI=1S/C21H18N2O2/c1-21(2,20(24)25)10-15-5-8-17-12-23-13-19(18(17)9-15)16-6-3-14(11-22)4-7-16/h3-9,12-13H,10H2,1-2H3,(H,24,25)
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n/an/a 19n/an/an/an/an/an/a



Shanghai Yingli Pharmaceutical Co., Ltd

US Patent


Assay Description
Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37 C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf...


US Patent US10100016 (2018)


Article DOI: 10.1021/jm0499458
BindingDB Entry DOI: 10.7270/Q2TH8PQZ
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM290467
PNG
(2{[4-(5-Cyanonaphthalen-1-yl)isoquinolin-6-yl]thio...)
Show SMILES CC(C)(Sc1ccc2cncc(-c3cccc4c(cccc34)C#N)c2c1)C(O)=O
Show InChI InChI=1S/C24H18N2O2S/c1-24(2,23(27)28)29-17-10-9-16-13-26-14-22(21(16)11-17)20-8-4-6-18-15(12-25)5-3-7-19(18)20/h3-11,13-14H,1-2H3,(H,27,28)
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n/an/a 19n/an/an/an/an/an/a



Shanghai Yingli Pharmaceutical Co., Ltd

US Patent


Assay Description
Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37 C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf...


US Patent US10100016 (2018)


Article DOI: 10.1021/jm0499458
BindingDB Entry DOI: 10.7270/Q2TH8PQZ
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM60431
PNG
(US9067922, 249)
Show SMILES Cc1cc(Oc2ccc(c(F)c2)S(=O)(=O)Nc2ccc(F)cn2)cc(C)c1C#N
Show InChI InChI=1S/C20H15F2N3O3S/c1-12-7-16(8-13(2)17(12)10-23)28-15-4-5-19(18(22)9-15)29(26,27)25-20-6-3-14(21)11-24-20/h3-9,11H,1-2H3,(H,24,25)
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n/an/a 21n/an/an/an/a7.4n/a



Pfizer Inc

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...


US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM318954
PNG
(2-[[7-(4-Cyanophenyl)benzo[d]isothiazol-6-yl]thio]...)
Show SMILES CCC(CC)(Sc1ccc2cnsc2c1-c1ccc(cc1)C#N)C(O)=O
Show InChI InChI=1S/C20H18N2O2S2/c1-3-20(4-2,19(23)24)25-16-10-9-15-12-22-26-18(15)17(16)14-7-5-13(11-21)6-8-14/h5-10,12H,3-4H2,1-2H3,(H,23,24)
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n/an/a 21n/an/an/an/an/an/a



Nippon Chemiphar Co., Ltd

US Patent


Assay Description
URAT1 stably expressed HEK293 cells (HEK-URAT1) or HEK293 cells transfected with empty vector (HEK-mock) were cultured in DMEM culture medium supplem...


US Patent US10173990 (2019)


Article DOI: 10.1021/jm060015t
BindingDB Entry DOI: 10.7270/Q2RR21BP
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM318946
PNG
(1-[[7-(4-Cyanophenyl)benzo[d]isothiazol-6-yl]thio]...)
Show SMILES OC(=O)C1(CCC1)Sc1ccc2cnsc2c1-c1ccc(cc1)C#N
Show InChI InChI=1S/C19H14N2O2S2/c20-10-12-2-4-13(5-3-12)16-15(7-6-14-11-21-25-17(14)16)24-19(18(22)23)8-1-9-19/h2-7,11H,1,8-9H2,(H,22,23)
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n/an/a 21.5n/an/an/an/an/an/a



Nippon Chemiphar Co., Ltd

US Patent


Assay Description
URAT1 stably expressed HEK293 cells (HEK-URAT1) or HEK293 cells transfected with empty vector (HEK-mock) were cultured in DMEM culture medium supplem...


US Patent US10173990 (2019)


Article DOI: 10.1021/jm060015t
BindingDB Entry DOI: 10.7270/Q2RR21BP
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM152011
PNG
(US8987473, 64)
Show SMILES Cc1cn(Cc2c(C)cccc2C)c2cc(CC(O)=O)ccc12
Show InChI InChI=1S/C20H21NO2/c1-13-5-4-6-14(2)18(13)12-21-11-15(3)17-8-7-16(9-19(17)21)10-20(22)23/h4-9,11H,10,12H2,1-3H3,(H,22,23)
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n/an/a 22n/an/an/an/an/an/a



Sato Pharmaceutical Co., Ltd.

US Patent


Assay Description
It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...


US Patent US8987473 (2015)


BindingDB Entry DOI: 10.7270/Q23F4NCB
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM152023
PNG
(US8987473, 89)
Show SMILES Cc1cn(Cc2c(Cl)cccc2Cl)c2cc(CCC(O)=O)ccc12
Show InChI InChI=1S/C19H17Cl2NO2/c1-12-10-22(11-15-16(20)3-2-4-17(15)21)18-9-13(5-7-14(12)18)6-8-19(23)24/h2-5,7,9-10H,6,8,11H2,1H3,(H,23,24)
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n/an/a 23n/an/an/an/an/an/a



Sato Pharmaceutical Co., Ltd.

US Patent


Assay Description
It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...


US Patent US8987473 (2015)


BindingDB Entry DOI: 10.7270/Q23F4NCB
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM152049
PNG
(US8987473, 135)
Show SMILES Cc1nn(Cc2c(Cl)cccc2Cl)c2cc(CCc3nnn[nH]3)ccc12
Show InChI InChI=1S/C18H16Cl2N6/c1-11-13-7-5-12(6-8-18-21-24-25-22-18)9-17(13)26(23-11)10-14-15(19)3-2-4-16(14)20/h2-5,7,9H,6,8,10H2,1H3,(H,21,22,24,25)
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n/an/a 23n/an/an/an/an/an/a



Sato Pharmaceutical Co., Ltd.

US Patent


Assay Description
It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...


US Patent US8987473 (2015)


BindingDB Entry DOI: 10.7270/Q23F4NCB
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM152054
PNG
(US8987473, 140)
Show SMILES CCc1nn(Cc2c(Cl)cccc2Cl)c2cc(CC(O)=O)ccc12
Show InChI InChI=1S/C18H16Cl2N2O2/c1-2-16-12-7-6-11(9-18(23)24)8-17(12)22(21-16)10-13-14(19)4-3-5-15(13)20/h3-8H,2,9-10H2,1H3,(H,23,24)
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n/an/a 24n/an/an/an/an/an/a



Sato Pharmaceutical Co., Ltd.

US Patent


Assay Description
It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...


US Patent US8987473 (2015)


BindingDB Entry DOI: 10.7270/Q23F4NCB
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM152015
PNG
(US8987473, 78)
Show SMILES CC1CN(Cc2c(C)cccc2C)c2cc(CC(O)=O)ccc12
Show InChI InChI=1/C20H23NO2/c1-13-5-4-6-14(2)18(13)12-21-11-15(3)17-8-7-16(9-19(17)21)10-20(22)23/h4-9,15H,10-12H2,1-3H3,(H,22,23)
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n/an/a 24n/an/an/an/an/an/a



Sato Pharmaceutical Co., Ltd.

US Patent


Assay Description
It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...


US Patent US8987473 (2015)


BindingDB Entry DOI: 10.7270/Q23F4NCB
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM290477
PNG
(3-[4-(4-Cyanonaphthalen-1-yl)isoquinolin-6-yl]buty...)
Show SMILES CC(CC(O)=O)c1ccc2cncc(-c3ccc(C#N)c4ccccc34)c2c1
Show InChI InChI=1/C24H18N2O2/c1-15(10-24(27)28)16-6-7-18-13-26-14-23(22(18)11-16)21-9-8-17(12-25)19-4-2-3-5-20(19)21/h2-9,11,13-15H,10H2,1H3,(H,27,28)
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n/an/a 24n/an/an/an/an/an/a



Shanghai Yingli Pharmaceutical Co., Ltd

US Patent


Assay Description
Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37 C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf...


US Patent US10100016 (2018)


Article DOI: 10.1021/jm0499458
BindingDB Entry DOI: 10.7270/Q2TH8PQZ
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM290468
PNG
(3-[4-(4-Cyanonaphthalen-1-yl)thieno[2,3-c]pyridin-...)
Show SMILES CC(Cl)(CC(O)=O)c1cc2c(cncc2s1)-c1ccc(C#N)c2ccccc12
Show InChI InChI=1/C22H15ClN2O2S/c1-22(23,9-21(26)27)20-8-17-18(11-25-12-19(17)28-20)16-7-6-13(10-24)14-4-2-3-5-15(14)16/h2-8,11-12H,9H2,1H3,(H,26,27)
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n/an/a 24n/an/an/an/an/an/a



Shanghai Yingli Pharmaceutical Co., Ltd

US Patent


Assay Description
Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37 C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf...


US Patent US10100016 (2018)


Article DOI: 10.1021/jm0499458
BindingDB Entry DOI: 10.7270/Q2TH8PQZ
More data for this
Ligand-Target Pair
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