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Compile Data Set for Download or QSAR

Found 111 hits Enz. Inhib. hit(s) with Target = 'Sulfonylurea receptor 2, Kir6.2'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50049750
PNG
((S)-3-(azetidin-2-ylmethoxy)pyridine | 3-((S)-1-Az...)
Show SMILES C(Oc1cccnc1)[C@@H]1CCN1
Show InChI InChI=1S/C9H12N2O/c1-2-9(6-10-4-1)12-7-8-3-5-11-8/h1-2,4,6,8,11H,3,5,7H2/t8-/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by PDSP Ki Database




Neuropharmacology 35: 725-34 (1996)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50357204
PNG
(CHEMBL1914835 | CHEMBL1963280)
Show SMILES OC(COc1ccccc1C(=O)CCc1ccccc1)CN1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C29H33NO3/c31-26(21-30-19-17-25(18-20-30)24-11-5-2-6-12-24)22-33-29-14-8-7-13-27(29)28(32)16-15-23-9-3-1-4-10-23/h1-14,25-26,31H,15-22H2
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n/an/a>5.00E+3n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of Kir6.2 by patch clamp assay


Citation and Details
More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50357205
PNG
(CHEMBL1914844 | CHEMBL1963594)
Show SMILES Cc1ccc(cc1)N1CCN(CC(O)COc2ccccc2C(=O)CCc2ccccc2)CC1
Show InChI InChI=1S/C29H34N2O3/c1-23-11-14-25(15-12-23)31-19-17-30(18-20-31)21-26(32)22-34-29-10-6-5-9-27(29)28(33)16-13-24-7-3-2-4-8-24/h2-12,14-15,26,32H,13,16-22H2,1H3
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n/an/a>5.00E+3n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of Kir6.2 by patch clamp assay


Citation and Details
More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50357207
PNG
(CHEMBL1915364 | CHEMBL1963307)
Show SMILES OC(COc1ccc(F)cc1C(=O)CCc1ccccc1)CN1CCN(CC1)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C35H37FN2O3/c36-30-17-19-34(32(24-30)33(40)18-16-27-10-4-1-5-11-27)41-26-31(39)25-37-20-22-38(23-21-37)35(28-12-6-2-7-13-28)29-14-8-3-9-15-29/h1-15,17,19,24,31,35,39H,16,18,20-23,25-26H2
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n/an/a>5.00E+3n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of Kir6.2 by patch clamp assay


Citation and Details
More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50127798
PNG
(CHEMBL50374 | Thiophene-2-carboxylic acid [2-(2,2,...)
Show SMILES OC(c1ccc2ccccc2c1NC(=O)c1cccs1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C18H11F6NO2S/c19-17(20,21)16(27,18(22,23)24)12-8-7-10-4-1-2-5-11(10)14(12)25-15(26)13-6-3-9-28-13/h1-9,27H,(H,25,26)
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n/an/an/an/a 12n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17


Bioorg Med Chem Lett 13: 1741-4 (2003)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50127799
PNG
(CHEMBL51071 | N-[2-(2,2,2-Trifluoro-1-hydroxy-1-tr...)
Show SMILES OC(c1ccc2ccccc2c1NC(=O)c1ccccc1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C20H13F6NO2/c21-19(22,23)18(29,20(24,25)26)15-11-10-12-6-4-5-9-14(12)16(15)27-17(28)13-7-2-1-3-8-13/h1-11,29H,(H,27,28)
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n/an/an/an/a 44n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17


Bioorg Med Chem Lett 13: 1741-4 (2003)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50127795
PNG
(4-Methoxy-N-[2-(2,2,2-trifluoro-1-hydroxy-1-triflu...)
Show SMILES COc1ccc(cc1)C(=O)Nc1c(ccc2ccccc12)C(O)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C21H15F6NO3/c1-31-14-9-6-13(7-10-14)18(29)28-17-15-5-3-2-4-12(15)8-11-16(17)19(30,20(22,23)24)21(25,26)27/h2-11,30H,1H3,(H,28,29)
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n/an/an/an/a 417n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17


Bioorg Med Chem Lett 13: 1741-4 (2003)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50127787
PNG
(2-Methoxy-N-[2-(2,2,2-trifluoro-1-hydroxy-1-triflu...)
Show SMILES COCC(=O)Nc1c(ccc2ccccc12)C(O)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C16H13F6NO3/c1-26-8-12(24)23-13-10-5-3-2-4-9(10)6-7-11(13)14(25,15(17,18)19)16(20,21)22/h2-7,25H,8H2,1H3,(H,23,24)
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n/an/an/an/a 213n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17


Bioorg Med Chem Lett 13: 1741-4 (2003)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50127796
PNG
(2-Methyl-N-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluo...)
Show SMILES CCC(C)C(=O)Nc1c(ccc2ccccc12)C(O)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C18H17F6NO2/c1-3-10(2)15(26)25-14-12-7-5-4-6-11(12)8-9-13(14)16(27,17(19,20)21)18(22,23)24/h4-10,27H,3H2,1-2H3,(H,25,26)
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n/an/an/an/a 1.77E+5n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17


Bioorg Med Chem Lett 13: 1741-4 (2003)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50127790
PNG
(3-Phenyl-N-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluo...)
Show SMILES OC(c1ccc2ccccc2c1NC(=O)CCc1ccccc1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C22H17F6NO2/c23-21(24,25)20(31,22(26,27)28)17-12-11-15-8-4-5-9-16(15)19(17)29-18(30)13-10-14-6-2-1-3-7-14/h1-9,11-12,31H,10,13H2,(H,29,30)
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n/an/an/an/a 1.75E+3n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17


Bioorg Med Chem Lett 13: 1741-4 (2003)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50127791
PNG
(4-Chloro-N-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluo...)
Show SMILES OC(c1ccc2ccccc2c1NC(=O)c1ccc(Cl)cc1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C20H12ClF6NO2/c21-13-8-5-12(6-9-13)17(29)28-16-14-4-2-1-3-11(14)7-10-15(16)18(30,19(22,23)24)20(25,26)27/h1-10,30H,(H,28,29)
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n/an/an/an/a 570n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17


Bioorg Med Chem Lett 13: 1741-4 (2003)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50127788
PNG
(3-Methyl-N-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluo...)
Show SMILES Cc1cccc(c1)C(=O)Nc1c(ccc2ccccc12)C(O)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C21H15F6NO2/c1-12-5-4-7-14(11-12)18(29)28-17-15-8-3-2-6-13(15)9-10-16(17)19(30,20(22,23)24)21(25,26)27/h2-11,30H,1H3,(H,28,29)
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n/an/an/an/a 23n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17


Bioorg Med Chem Lett 13: 1741-4 (2003)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50127784
PNG
(CHEMBL48801 | N-[2-(2,2,2-Trifluoro-1-hydroxy-1-tr...)
Show SMILES OC(c1ccc2ccccc2c1NC(=O)c1ccc(cc1)C(F)(F)F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C21H12F9NO2/c22-19(23,24)13-8-5-12(6-9-13)17(32)31-16-14-4-2-1-3-11(14)7-10-15(16)18(33,20(25,26)27)21(28,29)30/h1-10,33H,(H,31,32)
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n/an/an/an/a 160n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17


Bioorg Med Chem Lett 13: 1741-4 (2003)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50127789
PNG
(CHEMBL49191 | Cyclopentanecarboxylic acid [2-(2,2,...)
Show SMILES OC(c1ccc2ccccc2c1NC(=O)C1CCCC1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C19H17F6NO2/c20-18(21,22)17(28,19(23,24)25)14-10-9-11-5-3-4-8-13(11)15(14)26-16(27)12-6-1-2-7-12/h3-5,8-10,12,28H,1-2,6-7H2,(H,26,27)
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n/an/an/an/a 495n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17


Bioorg Med Chem Lett 13: 1741-4 (2003)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50127786
PNG
(CHEMBL49797 | N-[2-(2,2,2-Trifluoro-1-hydroxy-1-tr...)
Show SMILES CCCC(=O)Nc1c(ccc2ccccc12)C(O)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C17H15F6NO2/c1-2-5-13(25)24-14-11-7-4-3-6-10(11)8-9-12(14)15(26,16(18,19)20)17(21,22)23/h3-4,6-9,26H,2,5H2,1H3,(H,24,25)
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n/an/an/an/a 131n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17


Bioorg Med Chem Lett 13: 1741-4 (2003)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50127793
PNG
(CHEMBL48797 | Oxazole-5-carboxylic acid [2-(2,2,2-...)
Show SMILES OC(c1ccc2ccccc2c1NC(=O)c1cnco1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C17H10F6N2O3/c18-16(19,20)15(27,17(21,22)23)11-6-5-9-3-1-2-4-10(9)13(11)25-14(26)12-7-24-8-28-12/h1-8,27H,(H,25,26)
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n/an/an/an/a 24n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17


Bioorg Med Chem Lett 13: 1741-4 (2003)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50127801
PNG
(CHEMBL50760 | N-[2-(2,2,2-Trifluoro-1-hydroxy-1-tr...)
Show SMILES CCC(=O)Nc1c(ccc2ccccc12)C(O)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C16H13F6NO2/c1-2-12(24)23-13-10-6-4-3-5-9(10)7-8-11(13)14(25,15(17,18)19)16(20,21)22/h3-8,25H,2H2,1H3,(H,23,24)
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n/an/an/an/a 15n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17


Bioorg Med Chem Lett 13: 1741-4 (2003)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50127797
PNG
(3-Bromo-N-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluor...)
Show SMILES OC(c1ccc2ccccc2c1NC(=O)c1cccc(Br)c1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C20H12BrF6NO2/c21-13-6-3-5-12(10-13)17(29)28-16-14-7-2-1-4-11(14)8-9-15(16)18(30,19(22,23)24)20(25,26)27/h1-10,30H,(H,28,29)
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n/an/an/an/a 80n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17


Bioorg Med Chem Lett 13: 1741-4 (2003)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50127761
PNG
(CHEMBL49390 | N-[2-(2,2,2-Trifluoro-1-hydroxy-1-tr...)
Show SMILES OC(c1ccc2ccccc2c1NC(=O)c1ccc(OC(F)(F)F)cc1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C21H12F9NO3/c22-19(23,24)18(33,20(25,26)27)15-10-7-11-3-1-2-4-14(11)16(15)31-17(32)12-5-8-13(9-6-12)34-21(28,29)30/h1-10,33H,(H,31,32)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17


Bioorg Med Chem Lett 13: 1741-4 (2003)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50127762
PNG
(CHEMBL47170 | Cyclobutanecarboxylic acid [2-(2,2,2...)
Show SMILES OC(c1ccc2ccccc2c1NC(=O)C1CCC1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C18H15F6NO2/c19-17(20,21)16(27,18(22,23)24)13-9-8-10-4-1-2-7-12(10)14(13)25-15(26)11-5-3-6-11/h1-2,4,7-9,11,27H,3,5-6H2,(H,25,26)
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n/an/an/an/a 45n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17


Bioorg Med Chem Lett 13: 1741-4 (2003)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50127763
PNG
(4-Methyl-N-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluo...)
Show SMILES Cc1ccc(cc1)C(=O)Nc1c(ccc2ccccc12)C(O)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C21H15F6NO2/c1-12-6-8-14(9-7-12)18(29)28-17-15-5-3-2-4-13(15)10-11-16(17)19(30,20(22,23)24)21(25,26)27/h2-11,30H,1H3,(H,28,29)
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n/an/an/an/a 76n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17


Bioorg Med Chem Lett 13: 1741-4 (2003)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50127764
PNG
(3-Methyl-but-2-enoic acid [2-(2,2,2-trifluoro-1-hy...)
Show SMILES CC(C)=CC(=O)Nc1c(ccc2ccccc12)C(O)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C18H15F6NO2/c1-10(2)9-14(26)25-15-12-6-4-3-5-11(12)7-8-13(15)16(27,17(19,20)21)18(22,23)24/h3-9,27H,1-2H3,(H,25,26)
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n/an/an/an/a 46n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17


Bioorg Med Chem Lett 13: 1741-4 (2003)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50127765
PNG
(CHEMBL45645 | [2-(2,2,2-Trifluoro-1-hydroxy-1-trif...)
Show SMILES CC(C)OC(=O)Nc1c(ccc2ccccc12)C(O)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C17H15F6NO3/c1-9(2)27-14(25)24-13-11-6-4-3-5-10(11)7-8-12(13)15(26,16(18,19)20)17(21,22)23/h3-9,26H,1-2H3,(H,24,25)
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n/an/an/an/a 1.16E+3n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17


Bioorg Med Chem Lett 13: 1741-4 (2003)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50127766
PNG
(4-Fluoro-N-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluo...)
Show SMILES OC(c1ccc2ccccc2c1NC(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C20H12F7NO2/c21-13-8-5-12(6-9-13)17(29)28-16-14-4-2-1-3-11(14)7-10-15(16)18(30,19(22,23)24)20(25,26)27/h1-10,30H,(H,28,29)
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n/an/an/an/a 70n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17


Bioorg Med Chem Lett 13: 1741-4 (2003)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50127768
PNG
(CHEMBL299167 | N-[2-(2,2,2-Trifluoro-1-hydroxy-1-t...)
Show SMILES CC(=O)Nc1c(ccc2ccccc12)C(O)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C15H11F6NO2/c1-8(23)22-12-10-5-3-2-4-9(10)6-7-11(12)13(24,14(16,17)18)15(19,20)21/h2-7,24H,1H3,(H,22,23)
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n/an/an/an/a 18n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17


Bioorg Med Chem Lett 13: 1741-4 (2003)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50127767
PNG
(CHEMBL301591 | Quinoxaline-2-carboxylic acid [2-(2...)
Show SMILES OC(c1ccc2ccccc2c1NC(=O)c1cnc2ccccc2n1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C22H13F6N3O2/c23-21(24,25)20(33,22(26,27)28)14-10-9-12-5-1-2-6-13(12)18(14)31-19(32)17-11-29-15-7-3-4-8-16(15)30-17/h1-11,33H,(H,31,32)
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n/an/an/an/a 317n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17


Bioorg Med Chem Lett 13: 1741-4 (2003)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50127769
PNG
(4-Iodo-N-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluoro...)
Show SMILES OC(c1ccc2ccccc2c1NC(=O)c1ccc(I)cc1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C20H12F6INO2/c21-19(22,23)18(30,20(24,25)26)15-10-7-11-3-1-2-4-14(11)16(15)28-17(29)12-5-8-13(27)9-6-12/h1-10,30H,(H,28,29)
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n/an/an/an/a 154n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17


Bioorg Med Chem Lett 13: 1741-4 (2003)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50127770
PNG
(1-(6-Chloro-hexyl)-3-[2-(2,2,2-trifluoro-1-hydroxy...)
Show SMILES OC(c1ccc2ccccc2c1NC(=O)NCCCCCCCl)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C20H21ClF6N2O2/c21-11-5-1-2-6-12-28-17(30)29-16-14-8-4-3-7-13(14)9-10-15(16)18(31,19(22,23)24)20(25,26)27/h3-4,7-10,31H,1-2,5-6,11-12H2,(H2,28,29,30)
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n/an/an/an/a 4.84E+3n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17


Bioorg Med Chem Lett 13: 1741-4 (2003)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50127772
PNG
(2-Chloro-N-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluo...)
Show SMILES OC(c1ccc2ccccc2c1NC(=O)c1ccccc1Cl)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C20H12ClF6NO2/c21-15-8-4-3-7-13(15)17(29)28-16-12-6-2-1-5-11(12)9-10-14(16)18(30,19(22,23)24)20(25,26)27/h1-10,30H,(H,28,29)
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n/an/an/an/a 2.04E+3n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17


Bioorg Med Chem Lett 13: 1741-4 (2003)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50127771
PNG
(4-Methyl-pentanoic acid [2-(2,2,2-trifluoro-1-hydr...)
Show SMILES CC(C)CCC(=O)Nc1c(ccc2ccccc12)C(O)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C19H19F6NO2/c1-11(2)7-10-15(27)26-16-13-6-4-3-5-12(13)8-9-14(16)17(28,18(20,21)22)19(23,24)25/h3-6,8-9,11,28H,7,10H2,1-2H3,(H,26,27)
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n/an/an/an/a 49n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17


Bioorg Med Chem Lett 13: 1741-4 (2003)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50127773
PNG
(3,4-Dichloro-N-[2-(2,2,2-trifluoro-1-hydroxy-1-tri...)
Show SMILES OC(c1ccc2ccccc2c1NC(=O)c1ccc(Cl)c(Cl)c1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C20H11Cl2F6NO2/c21-14-8-6-11(9-15(14)22)17(30)29-16-12-4-2-1-3-10(12)5-7-13(16)18(31,19(23,24)25)20(26,27)28/h1-9,31H,(H,29,30)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17


Bioorg Med Chem Lett 13: 1741-4 (2003)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50127774
PNG
(3-Nitro-N-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluor...)
Show SMILES OC(c1ccc2ccccc2c1NC(=O)c1cccc(c1)[N+]([O-])=O)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C20H12F6N2O4/c21-19(22,23)18(30,20(24,25)26)15-9-8-11-4-1-2-7-14(11)16(15)27-17(29)12-5-3-6-13(10-12)28(31)32/h1-10,30H,(H,27,29)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17


Bioorg Med Chem Lett 13: 1741-4 (2003)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50127776
PNG
(1-(4-Chloro-phenyl)-3-[2-(2,2,2-trifluoro-1-hydrox...)
Show SMILES OC(c1ccc2ccccc2c1NC(=O)Nc1ccc(Cl)cc1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C20H13ClF6N2O2/c21-12-6-8-13(9-7-12)28-17(30)29-16-14-4-2-1-3-11(14)5-10-15(16)18(31,19(22,23)24)20(25,26)27/h1-10,31H,(H2,28,29,30)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17


Bioorg Med Chem Lett 13: 1741-4 (2003)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50127775
PNG
(CHEMBL298970 | N-[2-(2,2,2-Trifluoro-1-hydroxy-1-t...)
Show SMILES OC(c1ccc2ccccc2c1NC(=O)c1cccc(c1)C(F)(F)F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C21H12F9NO2/c22-19(23,24)13-6-3-5-12(10-13)17(32)31-16-14-7-2-1-4-11(14)8-9-15(16)18(33,20(25,26)27)21(28,29)30/h1-10,33H,(H,31,32)
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n/an/an/an/a 84n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17


Bioorg Med Chem Lett 13: 1741-4 (2003)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50127778
PNG
(3,5-Dichloro-N-[2-(2,2,2-trifluoro-1-hydroxy-1-tri...)
Show SMILES OC(c1ccc2ccccc2c1NC(=O)c1cc(Cl)cc(Cl)c1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C20H11Cl2F6NO2/c21-12-7-11(8-13(22)9-12)17(30)29-16-14-4-2-1-3-10(14)5-6-15(16)18(31,19(23,24)25)20(26,27)28/h1-9,31H,(H,29,30)
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n/an/an/an/a 306n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17


Bioorg Med Chem Lett 13: 1741-4 (2003)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50127777
PNG
(But-2-enoic acid [2-(2,2,2-trifluoro-1-hydroxy-1-t...)
Show SMILES C\C=C\C(=O)Nc1c(ccc2ccccc12)C(O)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C17H13F6NO2/c1-2-5-13(25)24-14-11-7-4-3-6-10(11)8-9-12(14)15(26,16(18,19)20)17(21,22)23/h2-9,26H,1H3,(H,24,25)/b5-2+
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17


Bioorg Med Chem Lett 13: 1741-4 (2003)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50127779
PNG
(2-Methyl-pentanoic acid [2-(2,2,2-trifluoro-1-hydr...)
Show SMILES CCCC(C)C(=O)Nc1c(ccc2ccccc12)C(O)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C19H19F6NO2/c1-3-6-11(2)16(27)26-15-13-8-5-4-7-12(13)9-10-14(15)17(28,18(20,21)22)19(23,24)25/h4-5,7-11,28H,3,6H2,1-2H3,(H,26,27)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17


Bioorg Med Chem Lett 13: 1741-4 (2003)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50127780
PNG
(Benzo[b]thiophene-2-carboxylic acid [2-(2,2,2-trif...)
Show SMILES OC(c1ccc2ccccc2c1NC(=O)c1cc2ccccc2s1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C22H13F6NO2S/c23-21(24,25)20(31,22(26,27)28)15-10-9-12-5-1-3-7-14(12)18(15)29-19(30)17-11-13-6-2-4-8-16(13)32-17/h1-11,31H,(H,29,30)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17


Bioorg Med Chem Lett 13: 1741-4 (2003)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50127781
PNG
(CHEMBL49701 | N-[5-Hydroxy-2-(2,2,2-trifluoro-1-hy...)
Show SMILES CC(=O)Nc1c(ccc2c(O)cccc12)C(O)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C15H11F6NO3/c1-7(23)22-12-9-3-2-4-11(24)8(9)5-6-10(12)13(25,14(16,17)18)15(19,20)21/h2-6,24-25H,1H3,(H,22,23)
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n/an/an/an/a 137n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17


Bioorg Med Chem Lett 13: 1741-4 (2003)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50127783
PNG
(CHEMBL49076 | N-[2-(2,2,2-Trifluoro-1-hydroxy-1-tr...)
Show SMILES OC(c1ccc2ccccc2c1NC(=O)c1cccnc1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C19H12F6N2O2/c20-18(21,22)17(29,19(23,24)25)14-8-7-11-4-1-2-6-13(11)15(14)27-16(28)12-5-3-9-26-10-12/h1-10,29H,(H,27,28)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17


Bioorg Med Chem Lett 13: 1741-4 (2003)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50127782
PNG
(2-Ethyl-N-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluor...)
Show SMILES CCC(CC)C(=O)Nc1c(ccc2ccccc12)C(O)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C19H19F6NO2/c1-3-11(4-2)16(27)26-15-13-8-6-5-7-12(13)9-10-14(15)17(28,18(20,21)22)19(23,24)25/h5-11,28H,3-4H2,1-2H3,(H,26,27)
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n/an/an/an/a 4.34E+3n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17


Bioorg Med Chem Lett 13: 1741-4 (2003)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50127785
PNG
(4-Bromo-N-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluor...)
Show SMILES OC(c1ccc2ccccc2c1NC(=O)c1ccc(Br)cc1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C20H12BrF6NO2/c21-13-8-5-12(6-9-13)17(29)28-16-14-4-2-1-3-11(14)7-10-15(16)18(30,19(22,23)24)20(25,26)27/h1-10,30H,(H,28,29)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17


Bioorg Med Chem Lett 13: 1741-4 (2003)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50127802
PNG
(3-Chloro-N-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluo...)
Show SMILES OC(c1ccc2ccccc2c1NC(=O)c1cccc(Cl)c1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C20H12ClF6NO2/c21-13-6-3-5-12(10-13)17(29)28-16-14-7-2-1-4-11(14)8-9-15(16)18(30,19(22,23)24)20(25,26)27/h1-10,30H,(H,28,29)
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n/an/an/an/a 98n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17


Bioorg Med Chem Lett 13: 1741-4 (2003)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50127803
PNG
(CHEMBL50501 | N-[4-Bromo-2-(2,2,2-trifluoro-1-hydr...)
Show SMILES CC(=O)Nc1c(cc(Br)c2ccccc12)C(O)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C15H10BrF6NO2/c1-7(24)23-12-9-5-3-2-4-8(9)11(16)6-10(12)13(25,14(17,18)19)15(20,21)22/h2-6,25H,1H3,(H,23,24)
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n/an/an/an/a 5.31E+3n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17


Bioorg Med Chem Lett 13: 1741-4 (2003)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50127800
PNG
(CHEMBL296840 | Cyclopropanecarboxylic acid [2-(2,2...)
Show SMILES OC(c1ccc2ccccc2c1NC(=O)C1CC1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C17H13F6NO2/c18-16(19,20)15(26,17(21,22)23)12-8-7-9-3-1-2-4-11(9)13(12)24-14(25)10-5-6-10/h1-4,7-8,10,26H,5-6H2,(H,24,25)
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n/an/an/an/a 751n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17


Bioorg Med Chem Lett 13: 1741-4 (2003)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50127792
PNG
(3-Fluoro-N-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluo...)
Show SMILES OC(c1ccc2ccccc2c1NC(=O)c1cccc(F)c1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C20H12F7NO2/c21-13-6-3-5-12(10-13)17(29)28-16-14-7-2-1-4-11(14)8-9-15(16)18(30,19(22,23)24)20(25,26)27/h1-10,30H,(H,28,29)
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n/an/an/an/a 44n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17


Bioorg Med Chem Lett 13: 1741-4 (2003)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50127794
PNG
(CHEMBL48848 | Furan-2-carboxylic acid [2-(2,2,2-tr...)
Show SMILES OC(c1ccc2ccccc2c1NC(=O)c1ccco1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C18H11F6NO3/c19-17(20,21)16(27,18(22,23)24)12-8-7-10-4-1-2-5-11(10)14(12)25-15(26)13-6-3-9-28-13/h1-9,27H,(H,25,26)
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n/an/an/an/a 9n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17


Bioorg Med Chem Lett 13: 1741-4 (2003)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50127809
PNG
(Biphenyl-4-carboxylic acid [2-(2,2,2-trifluoro-1-h...)
Show SMILES OC(c1ccc2ccccc2c1NC(=O)c1ccc(cc1)-c1ccccc1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C26H17F6NO2/c27-25(28,29)24(35,26(30,31)32)21-15-14-18-8-4-5-9-20(18)22(21)33-23(34)19-12-10-17(11-13-19)16-6-2-1-3-7-16/h1-15,35H,(H,33,34)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17


Bioorg Med Chem Lett 13: 1741-4 (2003)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50127808
PNG
(2,3-Dichloro-N-[2-(2,2,2-trifluoro-1-hydroxy-1-tri...)
Show SMILES OC(c1ccc2ccccc2c1NC(=O)c1cccc(Cl)c1Cl)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C20H11Cl2F6NO2/c21-14-7-3-6-12(15(14)22)17(30)29-16-11-5-2-1-4-10(11)8-9-13(16)18(31,19(23,24)25)20(26,27)28/h1-9,31H,(H,29,30)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17


Bioorg Med Chem Lett 13: 1741-4 (2003)

More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(HUMAN)
BDBM50127804
PNG
(CHEMBL49321 | N-[6-Hydroxy-2-(2,2,2-trifluoro-1-hy...)
Show SMILES CC(=O)Nc1c(ccc2cc(O)ccc12)C(O)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C15H11F6NO3/c1-7(23)22-12-10-4-3-9(24)6-8(10)2-5-11(12)13(25,14(16,17)18)15(19,20)21/h2-6,24-25H,1H3,(H,22,23)
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n/an/an/an/a 2.22E+3n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17


Bioorg Med Chem Lett 13: 1741-4 (2003)

More data for this
Ligand-Target Pair
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