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Compile Data Set for Download or QSAR

Found 250 hits Enz. Inhib. hit(s) with Target = 'Transcription Factor STAT3'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM28130
PNG
(4-[(2S)-2-{[(3S)-1-({[(1S)-1-(benzylcarbamoyl)-3-c...)
Show SMILES NC(=O)CC[C@H](NC(=O)CN1CCCC[C@H](NC(=O)[C@H](Cc2ccc(OP(O)(O)=O)cc2)NC(=O)OCc2ccccc2)C1=O)C(=O)NCc1ccccc1
Show InChI InChI=1S/C37H45N6O11P/c38-32(44)19-18-29(34(46)39-22-26-9-3-1-4-10-26)40-33(45)23-43-20-8-7-13-30(36(43)48)41-35(47)31(42-37(49)53-24-27-11-5-2-6-12-27)21-25-14-16-28(17-15-25)54-55(50,51)52/h1-6,9-12,14-17,29-31H,7-8,13,18-24H2,(H2,38,44)(H,39,46)(H,40,45)(H,41,47)(H,42,49)(H2,50,51,52)/t29-,30-,31-/m0/s1
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PubMed
190 -38.0n/an/an/an/an/a7.522



University of Michigan at Ann Arbor



Assay Description
The assay was based on the fluorescence polarization of the unbound small binding partner will be low, and its binding to a larger binding partner wi...


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM28128
PNG
(4-[(2S)-2-{[(2S)-1-[(2S)-2-{[(1S)-1-(benzylcarbamo...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)OCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)NCc1ccccc1
Show InChI InChI=1S/C40H51N6O11P/c1-26(2)22-33(39(51)46-21-9-14-34(46)38(50)43-31(19-20-35(41)47)36(48)42-24-28-10-5-3-6-11-28)44-37(49)32(45-40(52)56-25-29-12-7-4-8-13-29)23-27-15-17-30(18-16-27)57-58(53,54)55/h3-8,10-13,15-18,26,31-34H,9,14,19-25H2,1-2H3,(H2,41,47)(H,42,48)(H,43,50)(H,44,49)(H,45,52)(H2,53,54,55)/t31-,32-,33-,34-/m0/s1
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350 -36.5n/an/an/an/an/a7.522



University of Michigan at Ann Arbor



Assay Description
The assay was based on the fluorescence polarization of the unbound small binding partner will be low, and its binding to a larger binding partner wi...


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM28129
PNG
(4-[(2S)-2-{[(3S)-1-({[(1S)-1-(benzylcarbamoyl)-3-c...)
Show SMILES NC(=O)CC[C@H](NC(=O)CN1CCC[C@H](NC(=O)[C@H](Cc2ccc(OP(O)(O)=O)cc2)NC(=O)OCc2ccccc2)C1=O)C(=O)NCc1ccccc1
Show InChI InChI=1S/C36H43N6O11P/c37-31(43)18-17-28(33(45)38-21-25-8-3-1-4-9-25)39-32(44)22-42-19-7-12-29(35(42)47)40-34(46)30(41-36(48)52-23-26-10-5-2-6-11-26)20-24-13-15-27(16-14-24)53-54(49,50)51/h1-6,8-11,13-16,28-30H,7,12,17-23H2,(H2,37,43)(H,38,45)(H,39,44)(H,40,46)(H,41,48)(H2,49,50,51)/t28-,29-,30-/m0/s1
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PubMed
3.13E+3 -31.1n/an/an/an/an/a7.522



University of Michigan at Ann Arbor



Assay Description
The assay was based on the fluorescence polarization of the unbound small binding partner will be low, and its binding to a larger binding partner wi...


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM50337199
PNG
(4-((S)-3-((S)-1-(6-(Benzylcarbamoyl)-4'-carbamoylb...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)c1ccc(cc1)C#N)C(=O)Nc1ccc(C(=O)NCc2ccccc2)c(c1)-c1ccc(cc1)C(N)=O
Show InChI InChI=1S/C44H43N6O9P/c1-27(2)22-38(50-44(55)39(49-41(52)33-12-8-29(25-45)9-13-33)23-28-10-19-35(20-11-28)59-60(56,57)58)43(54)48-34-18-21-36(42(53)47-26-30-6-4-3-5-7-30)37(24-34)31-14-16-32(17-15-31)40(46)51/h3-21,24,27,38-39H,22-23,26H2,1-2H3,(H2,46,51)(H,47,53)(H,48,54)(H,49,52)(H,50,55)(H2,56,57,58)/t38-,39-/m0/s1
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5.00E+3n/an/an/an/an/an/an/an/a



University of Toronto

Curated by ChEMBL


Assay Description
Displacement of 5-carboxyfluorescein-GpYLPQTV-NH2 from mouse recombinant His-tagged STAT3-SH2 domain expressed in Escherichia coli BL21 (DE3) by fluo...


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20246
PNG
(4-[(2S)-2-{[(1S)-1-{[(6S,9S,12S)-12-{[(1S)-1-carba...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N[C@H]1CCCCn2cc(C[C@H](NC(=O)[C@@H](NC1=O)C(C)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)nn2
Show InChI InChI=1S/C41H57N10O12P/c1-23(2)18-32(46-39(57)33(43-25(4)53)20-27-13-15-29(16-14-27)63-64(60,61)62)38(56)44-30-12-8-9-17-51-22-28(49-50-51)21-34(47-41(59)35(24(3)52)48-37(30)55)40(58)45-31(36(42)54)19-26-10-6-5-7-11-26/h5-7,10-11,13-16,22-24,30-35,52H,8-9,12,17-21H2,1-4H3,(H2,42,54)(H,43,53)(H,44,56)(H,45,58)(H,46,57)(H,47,59)(H,48,55)(H2,60,61,62)/t24?,30-,31-,32-,33-,34-,35-/m0/s1
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PubMed
7.30E+3 -29.0n/an/an/an/an/a7.522



University of Michigan



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM50337198
PNG
((S)-3-(((S)-1-((5-(Benzylcarbamoyl)-4'-carbamoyl-[...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)c1ccc(cc1)C#N)C(=O)Nc1cc(cc(c1)-c1ccc(cc1)C(N)=O)C(=O)NCc1ccccc1
Show InChI InChI=1S/C44H43N6O9P/c1-27(2)20-38(50-44(55)39(49-42(53)33-12-8-29(25-45)9-13-33)21-28-10-18-37(19-11-28)59-60(56,57)58)43(54)48-36-23-34(31-14-16-32(17-15-31)40(46)51)22-35(24-36)41(52)47-26-30-6-4-3-5-7-30/h3-19,22-24,27,38-39H,20-21,26H2,1-2H3,(H2,46,51)(H,47,52)(H,48,54)(H,49,53)(H,50,55)(H2,56,57,58)/t38-,39-/m0/s1
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9.00E+3n/an/an/an/an/an/an/an/a



University of Toronto

Curated by ChEMBL


Assay Description
Displacement of 5-carboxyfluorescein-GpYLPQTV-NH2 from mouse recombinant His-tagged STAT3-SH2 domain expressed in Escherichia coli BL21 (DE3) by fluo...


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM50337205
PNG
(CHEMBL1684879 | Methyl 2'-(benzylcarbamoyl)-5'-((S...)
Show SMILES COC(=O)c1cccc(c1)-c1cc(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(OP(O)(O)=O)cc2)NC(=O)c2ccc(cc2)C#N)ccc1C(=O)NCc1ccccc1
Show InChI InChI=1S/C45H44N5O10P/c1-28(2)22-39(50-44(54)40(49-41(51)32-16-12-30(26-46)13-17-32)23-29-14-19-36(20-15-29)60-61(56,57)58)43(53)48-35-18-21-37(42(52)47-27-31-8-5-4-6-9-31)38(25-35)33-10-7-11-34(24-33)45(55)59-3/h4-21,24-25,28,39-40H,22-23,27H2,1-3H3,(H,47,52)(H,48,53)(H,49,51)(H,50,54)(H2,56,57,58)/t39-,40-/m0/s1
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1.00E+4n/an/an/an/an/an/an/an/a



University of Toronto

Curated by ChEMBL


Assay Description
Displacement of 5-carboxyfluorescein-GpYLPQTV-NH2 from mouse recombinant His-tagged STAT3-SH2 domain expressed in Escherichia coli BL21 (DE3) by fluo...


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM50337209
PNG
(4-((S)-3-(((S)-1-((6-(Benzylcarbamoyl)-4'-cyano-[1...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)c1ccc(cc1)C#N)C(=O)Nc1ccc(C(=O)NCc2ccccc2)c(c1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C44H41N6O8P/c1-28(2)22-39(50-44(54)40(49-41(51)34-16-10-31(26-46)11-17-34)23-29-12-19-36(20-13-29)58-59(55,56)57)43(53)48-35-18-21-37(42(52)47-27-32-6-4-3-5-7-32)38(24-35)33-14-8-30(25-45)9-15-33/h3-21,24,28,39-40H,22-23,27H2,1-2H3,(H,47,52)(H,48,53)(H,49,51)(H,50,54)(H2,55,56,57)/t39-,40-/m0/s1
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1.10E+4n/an/an/an/an/an/an/an/a



University of Toronto

Curated by ChEMBL


Assay Description
Displacement of 5-carboxyfluorescein-GpYLPQTV-NH2 from mouse recombinant His-tagged STAT3-SH2 domain expressed in Escherichia coli BL21 (DE3) by fluo...


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM50337206
PNG
(4-((S)-3-(((S)-1-((6-(Benzylcarbamoyl)-3'-cyano-[1...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)c1ccc(cc1)C#N)C(=O)Nc1ccc(C(=O)NCc2ccccc2)c(c1)-c1cccc(c1)C#N
Show InChI InChI=1S/C44H41N6O8P/c1-28(2)21-39(50-44(54)40(49-41(51)33-15-11-30(25-45)12-16-33)23-29-13-18-36(19-14-29)58-59(55,56)57)43(53)48-35-17-20-37(42(52)47-27-31-7-4-3-5-8-31)38(24-35)34-10-6-9-32(22-34)26-46/h3-20,22,24,28,39-40H,21,23,27H2,1-2H3,(H,47,52)(H,48,53)(H,49,51)(H,50,54)(H2,55,56,57)/t39-,40-/m0/s1
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1.30E+4n/an/an/an/an/an/an/an/a



University of Toronto

Curated by ChEMBL


Assay Description
Displacement of 5-carboxyfluorescein-GpYLPQTV-NH2 from mouse recombinant His-tagged STAT3-SH2 domain expressed in Escherichia coli BL21 (DE3) by fluo...


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM50353441
PNG
(CHEMBL1829786)
Show SMILES CN(CC(=O)N(Cc1ccc(cc1)C1CCCCC1)c1ccc(C(O)=O)c(O)c1)S(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C30H34N2O6S/c1-21-8-15-26(16-9-21)39(37,38)31(2)20-29(34)32(25-14-17-27(30(35)36)28(33)18-25)19-22-10-12-24(13-11-22)23-6-4-3-5-7-23/h8-18,23,33H,3-7,19-20H2,1-2H3,(H,35,36)
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1.50E+4n/an/an/an/an/an/an/an/a



University of Toronto Mississauga

Curated by ChEMBL


Assay Description
Inhibition of mouse STAT3 SH2 domain using fluorescent probe 5-carboxyfluorescein-GpYLPQTV-NH2 after 30 mins by fluorescence polarisation assay


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM50337207
PNG
(4-((S)-3-(((S)-1-((6-(Benzylcarbamoyl)-3'-carbamoy...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)c1ccc(cc1)C#N)C(=O)Nc1ccc(C(=O)NCc2ccccc2)c(c1)-c1cccc(c1)C(N)=O
Show InChI InChI=1S/C44H43N6O9P/c1-27(2)21-38(50-44(55)39(49-41(52)31-15-11-29(25-45)12-16-31)22-28-13-18-35(19-14-28)59-60(56,57)58)43(54)48-34-17-20-36(42(53)47-26-30-7-4-3-5-8-30)37(24-34)32-9-6-10-33(23-32)40(46)51/h3-20,23-24,27,38-39H,21-22,26H2,1-2H3,(H2,46,51)(H,47,53)(H,48,54)(H,49,52)(H,50,55)(H2,56,57,58)/t38-,39-/m0/s1
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1.50E+4n/an/an/an/an/an/an/an/a



University of Toronto

Curated by ChEMBL


Assay Description
Displacement of 5-carboxyfluorescein-GpYLPQTV-NH2 from mouse recombinant His-tagged STAT3-SH2 domain expressed in Escherichia coli BL21 (DE3) by fluo...


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM50337201
PNG
(4-((S)-3-(((S)-1-((5-(Benzylcarbamoyl)-3'-cyano-[1...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)c1ccc(cc1)C#N)C(=O)Nc1cc(cc(c1)-c1cccc(c1)C#N)C(=O)NCc1ccccc1
Show InChI InChI=1S/C44H41N6O8P/c1-28(2)19-39(50-44(54)40(49-42(52)33-15-11-30(25-45)12-16-33)21-29-13-17-38(18-14-29)58-59(55,56)57)43(53)48-37-23-35(34-10-6-9-32(20-34)26-46)22-36(24-37)41(51)47-27-31-7-4-3-5-8-31/h3-18,20,22-24,28,39-40H,19,21,27H2,1-2H3,(H,47,51)(H,48,53)(H,49,52)(H,50,54)(H2,55,56,57)/t39-,40-/m0/s1
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1.80E+4n/an/an/an/an/an/an/an/a



University of Toronto

Curated by ChEMBL


Assay Description
Displacement of 5-carboxyfluorescein-GpYLPQTV-NH2 from mouse recombinant His-tagged STAT3-SH2 domain expressed in Escherichia coli BL21 (DE3) by fluo...


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM50337200
PNG
(CHEMBL1681829 | Methyl 3'-(benzylcarbamoyl)-5'-((S...)
Show SMILES COC(=O)c1cccc(c1)-c1cc(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(OP(O)(O)=O)cc2)NC(=O)c2ccc(cc2)C#N)cc(c1)C(=O)NCc1ccccc1
Show InChI InChI=1S/C45H44N5O10P/c1-28(2)20-39(50-44(54)40(49-42(52)32-16-12-30(26-46)13-17-32)21-29-14-18-38(19-15-29)60-61(56,57)58)43(53)48-37-24-35(33-10-7-11-34(22-33)45(55)59-3)23-36(25-37)41(51)47-27-31-8-5-4-6-9-31/h4-19,22-25,28,39-40H,20-21,27H2,1-3H3,(H,47,51)(H,48,53)(H,49,52)(H,50,54)(H2,56,57,58)/t39-,40-/m0/s1
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2.30E+4n/an/an/an/an/an/an/an/a



University of Toronto

Curated by ChEMBL


Assay Description
Displacement of 5-carboxyfluorescein-GpYLPQTV-NH2 from mouse recombinant His-tagged STAT3-SH2 domain expressed in Escherichia coli BL21 (DE3) by fluo...


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM50337203
PNG
(CHEMBL1681826 | Methyl 3'-(benzylcarbamoyl)-5'-((S...)
Show SMILES COC(=O)c1ccc(cc1)-c1cc(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(OP(O)(O)=O)cc2)NC(=O)c2ccc(cc2)C#N)cc(c1)C(=O)NCc1ccccc1
Show InChI InChI=1S/C45H44N5O10P/c1-28(2)21-39(50-44(54)40(49-42(52)33-13-9-30(26-46)10-14-33)22-29-11-19-38(20-12-29)60-61(56,57)58)43(53)48-37-24-35(32-15-17-34(18-16-32)45(55)59-3)23-36(25-37)41(51)47-27-31-7-5-4-6-8-31/h4-20,23-25,28,39-40H,21-22,27H2,1-3H3,(H,47,51)(H,48,53)(H,49,52)(H,50,54)(H2,56,57,58)/t39-,40-/m0/s1
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2.50E+4n/an/an/an/an/an/an/an/a



University of Toronto

Curated by ChEMBL


Assay Description
Displacement of 5-carboxyfluorescein-GpYLPQTV-NH2 from mouse recombinant His-tagged STAT3-SH2 domain expressed in Escherichia coli BL21 (DE3) by fluo...


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20244
PNG
(4-[(2S)-2-{[(1S)-1-{[(1S)-5-amino-1-{[(1S,2R)-1-{[...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C42H66N9O12P/c1-25(2)22-34(50-41(58)35(46-27(4)53)24-29-16-18-30(19-17-29)63-64(60,61)62)40(57)47-32(15-9-11-21-44)39(56)51-36(26(3)52)42(59)48-31(14-8-10-20-43)38(55)49-33(37(45)54)23-28-12-6-5-7-13-28/h5-7,12-13,16-19,25-26,31-36,52H,8-11,14-15,20-24,43-44H2,1-4H3,(H2,45,54)(H,46,53)(H,47,57)(H,48,59)(H,49,55)(H,50,58)(H,51,56)(H2,60,61,62)/t26?,31-,32-,33-,34-,35-,36-/m0/s1
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PubMed
2.59E+4 -25.9n/an/an/an/an/a7.522



University of Michigan



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM50337208
PNG
(CHEMBL1684874 | Methyl 2'-(benzylcarbamoyl)-5'-((S...)
Show SMILES COC(=O)c1ccc(cc1)-c1cc(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(OP(O)(O)=O)cc2)NC(=O)c2ccc(cc2)C#N)ccc1C(=O)NCc1ccccc1
Show InChI InChI=1S/C45H44N5O10P/c1-28(2)23-39(50-44(54)40(49-41(51)33-13-9-30(26-46)10-14-33)24-29-11-20-36(21-12-29)60-61(56,57)58)43(53)48-35-19-22-37(42(52)47-27-31-7-5-4-6-8-31)38(25-35)32-15-17-34(18-16-32)45(55)59-3/h4-22,25,28,39-40H,23-24,27H2,1-3H3,(H,47,52)(H,48,53)(H,49,51)(H,50,54)(H2,56,57,58)/t39-,40-/m0/s1
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2.60E+4n/an/an/an/an/an/an/an/a



University of Toronto

Curated by ChEMBL


Assay Description
Displacement of 5-carboxyfluorescein-GpYLPQTV-NH2 from mouse recombinant His-tagged STAT3-SH2 domain expressed in Escherichia coli BL21 (DE3) by fluo...


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM50337204
PNG
(4-((S)-3-(((S)-1-((5-(Benzylcarbamoyl)-4'-cyano-[1...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)c1ccc(cc1)C#N)C(=O)Nc1cc(cc(c1)-c1ccc(cc1)C#N)C(=O)NCc1ccccc1
Show InChI InChI=1S/C44H41N6O8P/c1-28(2)20-39(50-44(54)40(49-42(52)34-16-10-31(26-46)11-17-34)21-29-12-18-38(19-13-29)58-59(55,56)57)43(53)48-37-23-35(33-14-8-30(25-45)9-15-33)22-36(24-37)41(51)47-27-32-6-4-3-5-7-32/h3-19,22-24,28,39-40H,20-21,27H2,1-2H3,(H,47,51)(H,48,53)(H,49,52)(H,50,54)(H2,55,56,57)/t39-,40-/m0/s1
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3.60E+4n/an/an/an/an/an/an/an/a



University of Toronto

Curated by ChEMBL


Assay Description
Displacement of 5-carboxyfluorescein-GpYLPQTV-NH2 from mouse recombinant His-tagged STAT3-SH2 domain expressed in Escherichia coli BL21 (DE3) by fluo...


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM50337202
PNG
(4-((S)-3-(((S)-1-((5-(Benzylcarbamoyl)-3'-carbamoy...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)c1ccc(cc1)C#N)C(=O)Nc1cc(cc(c1)-c1cccc(c1)C(N)=O)C(=O)NCc1ccccc1
Show InChI InChI=1S/C44H43N6O9P/c1-27(2)19-38(50-44(55)39(49-42(53)31-15-11-29(25-45)12-16-31)20-28-13-17-37(18-14-28)59-60(56,57)58)43(54)48-36-23-34(32-9-6-10-33(21-32)40(46)51)22-35(24-36)41(52)47-26-30-7-4-3-5-8-30/h3-18,21-24,27,38-39H,19-20,26H2,1-2H3,(H2,46,51)(H,47,52)(H,48,54)(H,49,53)(H,50,55)(H2,56,57,58)/t38-,39-/m0/s1
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3.80E+4n/an/an/an/an/an/an/an/a



University of Toronto

Curated by ChEMBL


Assay Description
Displacement of 5-carboxyfluorescein-GpYLPQTV-NH2 from mouse recombinant His-tagged STAT3-SH2 domain expressed in Escherichia coli BL21 (DE3) by fluo...


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20242
PNG
(4-[(2S)-2-{[(2S)-1-[(1R,2S,5S)-2-{[(1S)-1-(benzylc...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)CCc1ccccc1)C(=O)N1C[C@H]2C[C@H]2[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)NCc1ccccc1
Show InChI InChI=1S/C42H53N6O10P/c1-26(2)21-35(47-40(52)34(45-37(50)20-15-27-9-5-3-6-10-27)22-28-13-16-31(17-14-28)58-59(55,56)57)42(54)48-25-30-23-32(30)38(48)41(53)46-33(18-19-36(43)49)39(51)44-24-29-11-7-4-8-12-29/h3-14,16-17,26,30,32-35,38H,15,18-25H2,1-2H3,(H2,43,49)(H,44,51)(H,45,50)(H,46,53)(H,47,52)(H2,55,56,57)/t30-,32-,33+,34+,35+,38+/m1/s1
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n/an/a 125n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20193
PNG
(1, Ac-pTyr-Leu-Pro-Gln-Thr-Val-NH2 | 4-[(2S)-2-{[(...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](C(C)C)C(N)=O
Show InChI InChI=1S/C36H57N8O13P/c1-18(2)16-26(41-33(50)25(39-21(6)46)17-22-9-11-23(12-10-22)57-58(54,55)56)36(53)44-15-7-8-27(44)34(51)40-24(13-14-28(37)47)32(49)43-30(20(5)45)35(52)42-29(19(3)4)31(38)48/h9-12,18-20,24-27,29-30,45H,7-8,13-17H2,1-6H3,(H2,37,47)(H2,38,48)(H,39,46)(H,40,51)(H,41,50)(H,42,52)(H,43,49)(H2,54,55,56)/t20?,24-,25-,26-,27-,29-,30-/m0/s1
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n/an/a 150n/an/an/an/a7.822



The University of Texas at Houston



Assay Description
His10-Stat3 was expressed in Sf9 cells from a baculovirus encoding the recombinant protein. A nuclear extract of the Sf9 cells was incubated with 32P...


Bioorg Med Chem Lett 13: 633-6 (2003)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20211
PNG
(18, Ac-pTyr-Leu-cis-3,4-methanoPro-Gln-Thr-NH2-1 |...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1C[C@H]2C[C@H]2[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(N)=O
Show InChI InChI=1S/C32H48N7O12P/c1-15(2)11-24(37-30(45)23(35-17(4)41)12-18-5-7-20(8-6-18)51-52(48,49)50)32(47)39-14-19-13-21(19)27(39)31(46)36-22(9-10-25(33)42)29(44)38-26(16(3)40)28(34)43/h5-8,15-16,19,21-24,26-27,40H,9-14H2,1-4H3,(H2,33,42)(H2,34,43)(H,35,41)(H,36,46)(H,37,45)(H,38,44)(H2,48,49,50)/t16?,19-,21-,22+,23+,24+,26+,27+/m1/s1
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n/an/a 265n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20200
PNG
(4-[(2S)-2-{[(2S)-1-[(2S)-2-{[(1S)-3-carbamoyl-1-{[...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)CCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(N)=O
Show InChI InChI=1S/C38H54N7O12P/c1-22(2)20-29(38(53)45-19-7-10-30(45)37(52)42-27(16-17-31(39)47)35(50)44-33(23(3)46)34(40)49)43-36(51)28(41-32(48)18-13-24-8-5-4-6-9-24)21-25-11-14-26(15-12-25)57-58(54,55)56/h4-6,8-9,11-12,14-15,22-23,27-30,33,46H,7,10,13,16-21H2,1-3H3,(H2,39,47)(H2,40,49)(H,41,48)(H,42,52)(H,43,51)(H,44,50)(H2,54,55,56)/t23?,27-,28-,29-,30-,33-/m0/s1
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n/an/a 276n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20193
PNG
(1, Ac-pTyr-Leu-Pro-Gln-Thr-Val-NH2 | 4-[(2S)-2-{[(...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](C(C)C)C(N)=O
Show InChI InChI=1S/C36H57N8O13P/c1-18(2)16-26(41-33(50)25(39-21(6)46)17-22-9-11-23(12-10-22)57-58(54,55)56)36(53)44-15-7-8-27(44)34(51)40-24(13-14-28(37)47)32(49)43-30(20(5)45)35(52)42-29(19(3)4)31(38)48/h9-12,18-20,24-27,29-30,45H,7-8,13-17H2,1-6H3,(H2,37,47)(H2,38,48)(H,39,46)(H,40,51)(H,41,50)(H,42,52)(H,43,49)(H2,54,55,56)/t20?,24-,25-,26-,27-,29-,30-/m0/s1
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n/an/a 290n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20266
PNG
(4-[(2S)-2-{[(2S)-1-[(2S)-2-{[(1S)-3-carbamoyl-1-{[...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](C)C(N)=O
Show InChI InChI=1S/C34H53N8O13P/c1-17(2)15-25(40-31(48)24(38-20(5)44)16-21-8-10-22(11-9-21)55-56(52,53)54)34(51)42-14-6-7-26(42)32(49)39-23(12-13-27(35)45)30(47)41-28(19(4)43)33(50)37-18(3)29(36)46/h8-11,17-19,23-26,28,43H,6-7,12-16H2,1-5H3,(H2,35,45)(H2,36,46)(H,37,50)(H,38,44)(H,39,49)(H,40,48)(H,41,47)(H2,52,53,54)/t18-,19?,23-,24-,25-,26-,28-/m0/s1
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n/an/a 400n/an/an/an/a7.822



The University of Texas at Houston



Assay Description
His10-Stat3 was expressed in Sf9 cells from a baculovirus encoding the recombinant protein. A nuclear extract of the Sf9 cells was incubated with 32P...


Bioorg Med Chem Lett 13: 633-6 (2003)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20253
PNG
(LIFR (1001) derived peptide, 9 | Y(p)KPQMH)
Show SMILES CSCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O
Show InChI InChI=1S/C38H58N11O12PS/c1-22(50)44-30(18-23-8-10-25(11-9-23)61-62(58,59)60)36(55)47-28(6-3-4-15-39)38(57)49-16-5-7-31(49)37(56)46-26(12-13-32(40)51)34(53)45-27(14-17-63-2)35(54)48-29(33(41)52)19-24-20-42-21-43-24/h8-11,20-21,26-31H,3-7,12-19,39H2,1-2H3,(H2,40,51)(H2,41,52)(H,42,43)(H,44,50)(H,45,53)(H,46,56)(H,47,55)(H,48,54)(H2,58,59,60)/t26-,27-,28-,29-,30-,31-/m0/s1
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n/an/a 400n/an/an/an/a7.822



The University of Texas at Houston



Assay Description
His10-Stat3 was expressed in Sf9 cells from a baculovirus encoding the recombinant protein. A nuclear extract of the Sf9 cells was incubated with 32P...


Bioorg Med Chem Lett 13: 633-6 (2003)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20233
PNG
(4-[(2S)-2-{[(2S)-1-[(2S)-2-{[(1S)-1-(benzylcarbamo...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)NCc1ccccc1
Show InChI InChI=1S/C34H47N6O10P/c1-21(2)18-28(39-32(44)27(37-22(3)41)19-23-11-13-25(14-12-23)50-51(47,48)49)34(46)40-17-7-10-29(40)33(45)38-26(15-16-30(35)42)31(43)36-20-24-8-5-4-6-9-24/h4-6,8-9,11-14,21,26-29H,7,10,15-20H2,1-3H3,(H2,35,42)(H,36,43)(H,37,41)(H,38,45)(H,39,44)(H2,47,48,49)/t26-,27-,28-,29-/m0/s1
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n/an/a 409n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20210
PNG
(17, Ac-pTyr-Leu-4-hydroxy-Pro-Gln-Thr-NH2 | 4-[(2S...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(N)=O
Show InChI InChI=1S/C31H48N7O13P/c1-15(2)11-23(36-29(45)22(34-17(4)40)12-18-5-7-20(8-6-18)51-52(48,49)50)31(47)38-14-19(41)13-24(38)30(46)35-21(9-10-25(32)42)28(44)37-26(16(3)39)27(33)43/h5-8,15-16,19,21-24,26,39,41H,9-14H2,1-4H3,(H2,32,42)(H2,33,43)(H,34,40)(H,35,46)(H,36,45)(H,37,44)(H2,48,49,50)/t16?,19-,21+,22+,23+,24+,26+/m1/s1
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n/an/a 484n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20198
PNG
(4-[(2S)-2-{[(2S)-1-[(2S)-2-{[(1S)-3-carbamoyl-1-{[...)
Show SMILES CCC(=O)N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(N)=O
Show InChI InChI=1S/C32H50N7O12P/c1-5-26(42)35-22(16-19-8-10-20(11-9-19)51-52(48,49)50)30(45)37-23(15-17(2)3)32(47)39-14-6-7-24(39)31(46)36-21(12-13-25(33)41)29(44)38-27(18(4)40)28(34)43/h8-11,17-18,21-24,27,40H,5-7,12-16H2,1-4H3,(H2,33,41)(H2,34,43)(H,35,42)(H,36,46)(H,37,45)(H,38,44)(H2,48,49,50)/t18?,21-,22-,23-,24-,27-/m0/s1
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n/an/a 497n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20234
PNG
(4-[(2S)-2-{[(2S)-1-[(2S)-2-{[(1S)-3-carbamoyl-1-{[...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)c1ccccc1
Show InChI InChI=1S/C35H49N6O10P/c1-21(2)19-29(40-33(45)28(38-23(4)42)20-24-12-14-26(15-13-24)51-52(48,49)50)35(47)41-18-8-11-30(41)34(46)39-27(16-17-31(36)43)32(44)37-22(3)25-9-6-5-7-10-25/h5-7,9-10,12-15,21-22,27-30H,8,11,16-20H2,1-4H3,(H2,36,43)(H,37,44)(H,38,42)(H,39,46)(H,40,45)(H2,48,49,50)/t22-,27-,28-,29-,30-/m0/s1
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n/an/a 596n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20195
PNG
(2, Ac-pTyr-Leu-Pro-Gln-Thr-NH2 | 4-[(2S)-2-{[(2S)-...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(N)=O
Show InChI InChI=1S/C31H48N7O12P/c1-16(2)14-23(36-29(44)22(34-18(4)40)15-19-7-9-20(10-8-19)50-51(47,48)49)31(46)38-13-5-6-24(38)30(45)35-21(11-12-25(32)41)28(43)37-26(17(3)39)27(33)42/h7-10,16-17,21-24,26,39H,5-6,11-15H2,1-4H3,(H2,32,41)(H2,33,42)(H,34,40)(H,35,45)(H,36,44)(H,37,43)(H2,47,48,49)/t17?,21-,22-,23-,24-,26-/m0/s1
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n/an/a 600n/an/an/an/a7.822



The University of Texas at Houston



Assay Description
His10-Stat3 was expressed in Sf9 cells from a baculovirus encoding the recombinant protein. A nuclear extract of the Sf9 cells was incubated with 32P...


Bioorg Med Chem Lett 13: 633-6 (2003)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20205
PNG
(12, Ac-pTyr-Nle-Pro-Gln-Thr-NH2 | 4-[(2S)-2-{[(2S)...)
Show SMILES CCCC[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(N)=O
Show InChI InChI=1S/C31H48N7O12P/c1-4-5-7-22(36-29(44)23(34-18(3)40)16-19-9-11-20(12-10-19)50-51(47,48)49)31(46)38-15-6-8-24(38)30(45)35-21(13-14-25(32)41)28(43)37-26(17(2)39)27(33)42/h9-12,17,21-24,26,39H,4-8,13-16H2,1-3H3,(H2,32,41)(H2,33,42)(H,34,40)(H,35,45)(H,36,44)(H,37,43)(H2,47,48,49)/t17?,21-,22-,23-,24-,26-/m0/s1
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n/an/a 717n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20195
PNG
(2, Ac-pTyr-Leu-Pro-Gln-Thr-NH2 | 4-[(2S)-2-{[(2S)-...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(N)=O
Show InChI InChI=1S/C31H48N7O12P/c1-16(2)14-23(36-29(44)22(34-18(4)40)15-19-7-9-20(10-8-19)50-51(47,48)49)31(46)38-13-5-6-24(38)30(45)35-21(11-12-25(32)41)28(43)37-26(17(3)39)27(33)42/h7-10,16-17,21-24,26,39H,5-6,11-15H2,1-4H3,(H2,32,41)(H2,33,42)(H,34,40)(H,35,45)(H,36,44)(H,37,43)(H2,47,48,49)/t17?,21-,22-,23-,24-,26-/m0/s1
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n/an/a 739n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20236
PNG
((2S)-4-carbamoyl-2-{[(2S)-1-[(2S)-2-[(2S)-2-acetam...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(O)=O
Show InChI InChI=1S/C27H40N5O11P/c1-15(2)13-21(26(37)32-12-4-5-22(32)25(36)30-19(27(38)39)10-11-23(28)34)31-24(35)20(29-16(3)33)14-17-6-8-18(9-7-17)43-44(40,41)42/h6-9,15,19-22H,4-5,10-14H2,1-3H3,(H2,28,34)(H,29,33)(H,30,36)(H,31,35)(H,38,39)(H2,40,41,42)/t19-,20-,21-,22-/m0/s1
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n/an/a 748n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20199
PNG
(4-[(2S)-2-{[(benzyloxy)carbonyl]amino}-2-{[(2S)-1-...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)OCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(N)=O
Show InChI InChI=1S/C37H52N7O13P/c1-21(2)18-28(36(51)44-17-7-10-29(44)35(50)40-26(15-16-30(38)46)33(48)43-31(22(3)45)32(39)47)41-34(49)27(42-37(52)56-20-24-8-5-4-6-9-24)19-23-11-13-25(14-12-23)57-58(53,54)55/h4-6,8-9,11-14,21-22,26-29,31,45H,7,10,15-20H2,1-3H3,(H2,38,46)(H2,39,47)(H,40,50)(H,41,49)(H,42,52)(H,43,48)(H2,53,54,55)/t22?,26-,27-,28-,29-,31-/m0/s1
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n/an/a 750n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20265
PNG
(4-[(2S)-2-{[(2S)-1-[(2S)-2-{[(1S)-3-carbamoyl-1-{[...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(N)=O
Show InChI InChI=1S/C35H55N8O12P/c1-18(2)16-26(41-33(49)25(39-21(6)44)17-22-9-11-23(12-10-22)55-56(52,53)54)35(51)43-15-7-8-27(43)34(50)40-24(13-14-28(36)45)32(48)38-20(5)31(47)42-29(19(3)4)30(37)46/h9-12,18-20,24-27,29H,7-8,13-17H2,1-6H3,(H2,36,45)(H2,37,46)(H,38,48)(H,39,44)(H,40,50)(H,41,49)(H,42,47)(H2,52,53,54)/t20-,24-,25-,26-,27-,29-/m0/s1
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n/an/a 800n/an/an/an/a7.822



The University of Texas at Houston



Assay Description
His10-Stat3 was expressed in Sf9 cells from a baculovirus encoding the recombinant protein. A nuclear extract of the Sf9 cells was incubated with 32P...


Bioorg Med Chem Lett 13: 633-6 (2003)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20235
PNG
(4-[(2S)-2-{[(2S)-1-[(2S)-2-{[(1S)-3-carbamoyl-1-{[...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C)c1ccccc1
Show InChI InChI=1S/C35H49N6O10P/c1-21(2)19-29(40-33(45)28(38-23(4)42)20-24-12-14-26(15-13-24)51-52(48,49)50)35(47)41-18-8-11-30(41)34(46)39-27(16-17-31(36)43)32(44)37-22(3)25-9-6-5-7-10-25/h5-7,9-10,12-15,21-22,27-30H,8,11,16-20H2,1-4H3,(H2,36,43)(H,37,44)(H,38,42)(H,39,46)(H,40,45)(H2,48,49,50)/t22-,27+,28+,29+,30+/m1/s1
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n/an/a 801n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20197
PNG
(4, Benzoyl-pTyr-Leu -Pro-Gln-Thr-NH2 | 4-[(2S)-2-{...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)c1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(N)=O
Show InChI InChI=1S/C36H50N7O12P/c1-20(2)18-27(36(51)43-17-7-10-28(43)35(50)39-25(15-16-29(37)45)33(48)42-30(21(3)44)31(38)46)41-34(49)26(40-32(47)23-8-5-4-6-9-23)19-22-11-13-24(14-12-22)55-56(52,53)54/h4-6,8-9,11-14,20-21,25-28,30,44H,7,10,15-19H2,1-3H3,(H2,37,45)(H2,38,46)(H,39,50)(H,40,47)(H,41,49)(H,42,48)(H2,52,53,54)/t21?,25-,26-,27-,28-,30-/m0/s1
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n/an/a 814n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20196
PNG
(3, Ac-pTyr-Leu-Pro-Gln-NH2 | 4-[(2S)-2-{[(2S)-1-[(...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(N)=O
Show InChI InChI=1S/C27H41N6O10P/c1-15(2)13-21(27(39)33-12-4-5-22(33)26(38)31-19(24(29)36)10-11-23(28)35)32-25(37)20(30-16(3)34)14-17-6-8-18(9-7-17)43-44(40,41)42/h6-9,15,19-22H,4-5,10-14H2,1-3H3,(H2,28,35)(H2,29,36)(H,30,34)(H,31,38)(H,32,37)(H2,40,41,42)/t19-,20-,21-,22-/m0/s1
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n/an/a 856n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20232
PNG
(39, Ac-pTyr-Leu-Pro-Gln-NHMe | 4-[(2S)-2-{[(2S)-1-...)
Show SMILES CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O
Show InChI InChI=1S/C28H43N6O10P/c1-16(2)14-22(28(40)34-13-5-6-23(34)27(39)32-20(25(37)30-4)11-12-24(29)36)33-26(38)21(31-17(3)35)15-18-7-9-19(10-8-18)44-45(41,42)43/h7-10,16,20-23H,5-6,11-15H2,1-4H3,(H2,29,36)(H,30,37)(H,31,35)(H,32,39)(H,33,38)(H2,41,42,43)/t20-,21-,22-,23-/m0/s1
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n/an/a 882n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20204
PNG
(11, Ac-pTyr-Cha-Pro-Gln-Thr-NH2 | 4-[(2S)-2-{[(2S)...)
Show SMILES CC(O)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1CCCCC1)NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(N)=O
Show InChI InChI=1S/C34H52N7O12P/c1-19(42)29(30(36)45)40-31(46)24(14-15-28(35)44)38-33(48)27-9-6-16-41(27)34(49)26(18-21-7-4-3-5-8-21)39-32(47)25(37-20(2)43)17-22-10-12-23(13-11-22)53-54(50,51)52/h10-13,19,21,24-27,29,42H,3-9,14-18H2,1-2H3,(H2,35,44)(H2,36,45)(H,37,43)(H,38,48)(H,39,47)(H,40,46)(H2,50,51,52)/t19?,24-,25-,26-,27-,29-/m0/s1
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n/an/a 910n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20196
PNG
(3, Ac-pTyr-Leu-Pro-Gln-NH2 | 4-[(2S)-2-{[(2S)-1-[(...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(N)=O
Show InChI InChI=1S/C27H41N6O10P/c1-15(2)13-21(27(39)33-12-4-5-22(33)26(38)31-19(24(29)36)10-11-23(28)35)32-25(37)20(30-16(3)34)14-17-6-8-18(9-7-17)43-44(40,41)42/h6-9,15,19-22H,4-5,10-14H2,1-3H3,(H2,28,35)(H2,29,36)(H,30,34)(H,31,38)(H,32,37)(H2,40,41,42)/t19-,20-,21-,22-/m0/s1
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n/an/a 1.00E+3n/an/an/an/a7.822



The University of Texas at Houston



Assay Description
His10-Stat3 was expressed in Sf9 cells from a baculovirus encoding the recombinant protein. A nuclear extract of the Sf9 cells was incubated with 32P...


Bioorg Med Chem Lett 13: 633-6 (2003)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20254
PNG
(4-[(2S)-2-{[(2S)-5-carbamimidamido-1-[(2S)-2-{[(1S...)
Show SMILES CSCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(N)=O
Show InChI InChI=1S/C35H56N11O12PS/c1-19(30(50)43-23(29(37)49)14-17-60-3)41-31(51)24(12-13-28(36)48)44-33(53)27-7-5-16-46(27)34(54)25(6-4-15-40-35(38)39)45-32(52)26(42-20(2)47)18-21-8-10-22(11-9-21)58-59(55,56)57/h8-11,19,23-27H,4-7,12-18H2,1-3H3,(H2,36,48)(H2,37,49)(H,41,51)(H,42,47)(H,43,50)(H,44,53)(H,45,52)(H4,38,39,40)(H2,55,56,57)/t19-,23-,24-,25-,26-,27-/m0/s1
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n/an/a 1.00E+3n/an/an/an/a7.822



The University of Texas at Houston



Assay Description
His10-Stat3 was expressed in Sf9 cells from a baculovirus encoding the recombinant protein. A nuclear extract of the Sf9 cells was incubated with 32P...


Bioorg Med Chem Lett 13: 633-6 (2003)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20202
PNG
(4-[(2S)-2-{[(2S)-1-[(2S)-2-{[(1S)-3-carbamoyl-1-{[...)
Show SMILES CCC(C)[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(N)=O
Show InChI InChI=1S/C31H48N7O12P/c1-5-16(2)25(36-29(44)22(34-18(4)40)15-19-8-10-20(11-9-19)50-51(47,48)49)31(46)38-14-6-7-23(38)30(45)35-21(12-13-24(32)41)28(43)37-26(17(3)39)27(33)42/h8-11,16-17,21-23,25-26,39H,5-7,12-15H2,1-4H3,(H2,32,41)(H2,33,42)(H,34,40)(H,35,45)(H,36,44)(H,37,43)(H2,47,48,49)/t16?,17?,21-,22-,23-,25-,26-/m0/s1
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n/an/a 1.07E+3n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20241
PNG
(4-[(2S)-2-{[(2S)-1-[(2S)-2-{[(1S)-3-carbamoyl-1-{[...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N(C)[C@@H](C(C)O)C(N)=O
Show InChI InChI=1S/C32H50N7O12P/c1-17(2)15-24(37-29(44)23(35-19(4)41)16-20-8-10-21(11-9-20)51-52(48,49)50)32(47)39-14-6-7-25(39)30(45)36-22(12-13-26(33)42)31(46)38(5)27(18(3)40)28(34)43/h8-11,17-18,22-25,27,40H,6-7,12-16H2,1-5H3,(H2,33,42)(H2,34,43)(H,35,41)(H,36,45)(H,37,44)(H2,48,49,50)/t18?,22-,23-,24-,25-,27-/m0/s1
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Article
PubMed
n/an/a 1.22E+3n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20214
PNG
(21, Ac-pTyr-Leu-Pip-Gln-Thr-NH2 | 4-[(2S)-2-{[(2S)...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(N)=O
Show InChI InChI=1S/C32H50N7O12P/c1-17(2)15-24(37-30(45)23(35-19(4)41)16-20-8-10-21(11-9-20)51-52(48,49)50)32(47)39-14-6-5-7-25(39)31(46)36-22(12-13-26(33)42)29(44)38-27(18(3)40)28(34)43/h8-11,17-18,22-25,27,40H,5-7,12-16H2,1-4H3,(H2,33,42)(H2,34,43)(H,35,41)(H,36,46)(H,37,45)(H,38,44)(H2,48,49,50)/t18?,22-,23-,24-,25-,27-/m0/s1
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PubMed
n/an/a 1.24E+3n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20230
PNG
(37, Ac-pTyr-Leu-Pro-Cmpi-NH2 | 4-[(2S)-2-{[(2S)-1-...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N1CCN(CC(N)=O)CC1
Show InChI InChI=1S/C28H43N6O9P/c1-18(2)15-23(27(38)34-10-4-5-24(34)28(39)33-13-11-32(12-14-33)17-25(29)36)31-26(37)22(30-19(3)35)16-20-6-8-21(9-7-20)43-44(40,41)42/h6-9,18,22-24H,4-5,10-17H2,1-3H3,(H2,29,36)(H,30,35)(H,31,37)(H2,40,41,42)/t22-,23-,24-/m0/s1
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PubMed
n/an/a 1.40E+3n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20251
PNG
(4-[(2S)-2-{[(2S)-1-[(2S)-2-{[(1S)-1,3-dicarbamoylp...)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(N)=O
Show InChI InChI=1S/C26H39N6O10PS/c1-15(33)29-20(14-16-5-7-17(8-6-16)42-43(39,40)41)24(36)31-19(11-13-44-2)26(38)32-12-3-4-21(32)25(37)30-18(23(28)35)9-10-22(27)34/h5-8,18-21H,3-4,9-14H2,1-2H3,(H2,27,34)(H2,28,35)(H,29,33)(H,30,37)(H,31,36)(H2,39,40,41)/t18-,19-,20-,21-/m0/s1
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PubMed
n/an/a 1.50E+3n/an/an/an/a7.822



The University of Texas at Houston



Assay Description
His10-Stat3 was expressed in Sf9 cells from a baculovirus encoding the recombinant protein. A nuclear extract of the Sf9 cells was incubated with 32P...


Bioorg Med Chem Lett 13: 633-6 (2003)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20201
PNG
(4-[(2S)-2-{[(2S)-1-[(2S)-2-{[(1S)-3-carbamoyl-1-{[...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(N)=O
Show InChI InChI=1S/C30H46N7O12P/c1-15(2)24(35-28(43)21(33-17(4)39)14-18-7-9-19(10-8-18)49-50(46,47)48)30(45)37-13-5-6-22(37)29(44)34-20(11-12-23(31)40)27(42)36-25(16(3)38)26(32)41/h7-10,15-16,20-22,24-25,38H,5-6,11-14H2,1-4H3,(H2,31,40)(H2,32,41)(H,33,39)(H,34,44)(H,35,43)(H,36,42)(H2,46,47,48)/t16?,20-,21-,22-,24-,25-/m0/s1
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Article
PubMed
n/an/a 1.54E+3n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20262
PNG
(4-[(2S)-2-{[(2S)-1-[(2S)-2-{[(1S)-3-carbamoyl-1-{[...)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(C)O)C(N)=O
Show InChI InChI=1S/C33H51N8O13P/c1-16(2)26(28(35)45)39-32(49)27(18(4)42)40-29(46)22(12-13-25(34)44)38-31(48)24-7-6-14-41(24)33(50)17(3)36-30(47)23(37-19(5)43)15-20-8-10-21(11-9-20)54-55(51,52)53/h8-11,16-18,22-24,26-27,42H,6-7,12-15H2,1-5H3,(H2,34,44)(H2,35,45)(H,36,47)(H,37,43)(H,38,48)(H,39,49)(H,40,46)(H2,51,52,53)/t17-,18?,22-,23-,24-,26-,27-/m0/s1
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PubMed
n/an/a 1.60E+3n/an/an/an/a7.822



The University of Texas at Houston



Assay Description
His10-Stat3 was expressed in Sf9 cells from a baculovirus encoding the recombinant protein. A nuclear extract of the Sf9 cells was incubated with 32P...


Bioorg Med Chem Lett 13: 633-6 (2003)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20213
PNG
(20, Ac-pTyr-Leu-Azt-Gln-Thr-NH2 | 4-[(2S)-2-{[(2S)...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(N)=O
Show InChI InChI=1S/C30H46N7O12P/c1-15(2)13-22(35-28(43)21(33-17(4)39)14-18-5-7-19(8-6-18)49-50(46,47)48)30(45)37-12-11-23(37)29(44)34-20(9-10-24(31)40)27(42)36-25(16(3)38)26(32)41/h5-8,15-16,20-23,25,38H,9-14H2,1-4H3,(H2,31,40)(H2,32,41)(H,33,39)(H,34,44)(H,35,43)(H,36,42)(H2,46,47,48)/t16?,20-,21-,22-,23-,25-/m0/s1
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Article
PubMed
n/an/a 1.66E+3n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


Citation and Details
More data for this
Ligand-Target Pair
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