Compile Data Set for Download or QSAR

Found 1309 hits Enz. Inhib. hit(s) with Target = 'Transient receptor potential cation channel subfamily A member 1'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM50318511 (CHEMBL1085100 | dibenzo[b,f][1,4]oxazepine) Show SMILES O1c2ccccc2C=Nc2ccccc12 Show InChI InChI=1S/C13H9NO/c1-3-7-12-10(5-1)9-14-11-6-2-4-8-13(11)15-12/h1-9H	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as concentration required to incapacitate 50% of the population exposed to t...				J Med Chem 53: 7011-20 (2010)
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM50193602 (CHEMBL3907685) Show SMILES OC1(CCN(CC1)C(CNC(=O)C1(CCCC1)c1ccc(Cl)cc1)Cc1ccccc1)C(F)(F)F Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Temple University Curated by ChEMBL					Assay Description Inhibition of cinnamaldehyde-activated full length human TRPA1 channel expressed in 293T-Rex cells monitored at 5 sec interval by manual patch clamp ...				ACS Med Chem Lett 7: 658-9 (2016)
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM191653 (US9186360, 57) Show SMILES Cn1c2occ(CC(=O)Nc3nc(cs3)-c3cc(Cl)c(OCC(F)(F)F)c(Cl)c3)c2c(=O)n(C)c1=O Show InChI InChI=1S/C21H15Cl2F3N4O5S/c1-29-17(32)15-10(6-34-18(15)30(2)20(29)33)5-14(31)28-19-27-13(7-36-19)9-3-11(22)16(12(23)4-9)35-8-21(24,25)26/h3-4,6-7H,5,8H2,1-2H3,(H,27,28,31)	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.45	n/a	n/a	n/a	n/a	n/a	n/a
GLENMARK PHARMACEUTICALS S.A. US Patent					Assay Description The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...				Citation and Details
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM60874 (US9186360, 62) Show SMILES Cc1oc2n(C)c(=O)n(C)c(=O)c2c1CC(=O)Nc1nc(cs1)-c1cc(F)c(OCC(F)(F)F)c(F)c1 Show InChI InChI=1S/C22H17F5N4O5S/c1-9-11(16-18(33)30(2)21(34)31(3)19(16)36-9)6-15(32)29-20-28-14(7-37-20)10-4-12(23)17(13(24)5-10)35-8-22(25,26)27/h4-5,7H,6,8H2,1-3H3,(H,28,29,32)	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.68	n/a	n/a	n/a	n/a	n/a	n/a
GLENMARK PHARMACEUTICALS S.A. US Patent					Assay Description The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...				Citation and Details
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM50193601 (CHEMBL3903533) Show SMILES OC1(CCN(CC1)C(CNC(=O)C1(CC1)c1ccc(Cl)cc1)Cc1ccc(F)cc1)C(F)(F)F Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Temple University Curated by ChEMBL					Assay Description Inhibition of cinnamaldehyde-activated full length human TRPA1 channel expressed in 293T-Rex cells monitored at 5 sec interval by manual patch clamp ...				ACS Med Chem Lett 7: 658-9 (2016)
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM191709 (US9186360, 55) Show SMILES Cn1c2occ(CC(=O)Nc3nc(cs3)-c3cc(F)cc(c3)C(F)(F)F)c2c(=O)n(C)c1=O Show InChI InChI=1S/C20H14F4N4O4S/c1-27-16(30)15-10(7-32-17(15)28(2)19(27)31)5-14(29)26-18-25-13(8-33-18)9-3-11(20(22,23)24)6-12(21)4-9/h3-4,6-8H,5H2,1-2H3,(H,25,26,29)	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.15	n/a	n/a	n/a	n/a	n/a	n/a
GLENMARK PHARMACEUTICALS S.A. US Patent					Assay Description The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...				Citation and Details
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM191712 (US9186360, 59) Show SMILES Cn1c2occ(CC(=O)Nc3nc(cs3)-c3cccc(c3F)C(F)(F)F)c2c(=O)n(C)c1=O Show InChI InChI=1S/C20H14F4N4O4S/c1-27-16(30)14-9(7-32-17(14)28(2)19(27)31)6-13(29)26-18-25-12(8-33-18)10-4-3-5-11(15(10)21)20(22,23)24/h3-5,7-8H,6H2,1-2H3,(H,25,26,29)	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.21	n/a	n/a	n/a	n/a	n/a	n/a
GLENMARK PHARMACEUTICALS S.A. US Patent					Assay Description The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...				Citation and Details
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM191652 (US9186360, 51 | US9186360, 52) Show SMILES Cn1c2scc(CC(=O)Nc3nc(cs3)-c3ccc(F)c(c3F)C(F)(F)F)c2c(=O)n(C)c1=O Show InChI InChI=1S/C20H13F5N4O3S2/c1-28-16(31)13-8(6-33-17(13)29(2)19(28)32)5-12(30)27-18-26-11(7-34-18)9-3-4-10(21)14(15(9)22)20(23,24)25/h3-4,6-7H,5H2,1-2H3,(H,26,27,30)	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.49	n/a	n/a	n/a	n/a	n/a	n/a
GLENMARK PHARMACEUTICALS S.A. US Patent					Assay Description The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...				Citation and Details
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM191713 (US9186360, 61) Show SMILES Cc1oc2n(C)c(=O)n(C)c(=O)c2c1CC(=O)Nc1nc(cs1)-c1cc(F)cc(c1)C(F)(F)F Show InChI InChI=1S/C21H16F4N4O4S/c1-9-13(16-17(31)28(2)20(32)29(3)18(16)33-9)7-15(30)27-19-26-14(8-34-19)10-4-11(21(23,24)25)6-12(22)5-10/h4-6,8H,7H2,1-3H3,(H,26,27,30)	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.93	n/a	n/a	n/a	n/a	n/a	n/a
GLENMARK PHARMACEUTICALS S.A. US Patent					Assay Description The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...				Citation and Details
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Rattus norvegicus)	BDBM50362745 (CHEMBL1939822) Show SMILES COc1cccc(c1)C1NC(=S)N(C)C2=C1C(=O)c1ccccc21 Show InChI InChI=1S/C19H16N2O2S/c1-21-17-13-8-3-4-9-14(13)18(22)15(17)16(20-19(21)24)11-6-5-7-12(10-11)23-2/h3-10,16H,1-2H3,(H,20,24)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research& Development, Janssen Pharmaceutica N.V. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPA1 expressed in HEK293 cells assessed as inhibition of BITC-induced increase in intracellular calcium concentration by ...				Bioorg Med Chem Lett 22: 797-800 (2012)
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM191722 (US9186360, 71) Show SMILES Cc1oc2n(C)c(=O)n(C)c(=O)c2c1CC(=O)Nc1nc(cs1)-c1ccc(Cl)c(c1)C(F)(F)F Show InChI InChI=1S/C21H16ClF3N4O4S/c1-9-11(16-17(31)28(2)20(32)29(3)18(16)33-9)7-15(30)27-19-26-14(8-34-19)10-4-5-13(22)12(6-10)21(23,24)25/h4-6,8H,7H2,1-3H3,(H,26,27,30)	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.18	n/a	n/a	n/a	n/a	n/a	n/a
GLENMARK PHARMACEUTICALS S.A. US Patent					Assay Description The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...				Citation and Details
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM191656 (US9186360, 75) Show SMILES CC(C)COc1c(Cl)cc(cc1Cl)-c1csc(NC(=O)Cc2c(C)oc3n(C)c(=O)n(C)c(=O)c23)n1 Show InChI InChI=1S/C24H24Cl2N4O5S/c1-11(2)9-34-20-15(25)6-13(7-16(20)26)17-10-36-23(27-17)28-18(31)8-14-12(3)35-22-19(14)21(32)29(4)24(33)30(22)5/h6-7,10-11H,8-9H2,1-5H3,(H,27,28,31)	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.34	n/a	n/a	n/a	n/a	n/a	n/a
GLENMARK PHARMACEUTICALS S.A. US Patent					Assay Description The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...				Citation and Details
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM191710 (US9186360, 56) Show SMILES Cn1c2occ(CC(=O)Nc3nc(cs3)-c3cc(F)c(CCC(F)(F)F)c(F)c3)c2c(=O)n(C)c1=O Show InChI InChI=1S/C22H17F5N4O4S/c1-30-18(33)17-11(8-35-19(17)31(2)21(30)34)7-16(32)29-20-28-15(9-36-20)10-5-13(23)12(14(24)6-10)3-4-22(25,26)27/h5-6,8-9H,3-4,7H2,1-2H3,(H,28,29,32)	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.38	n/a	n/a	n/a	n/a	n/a	n/a
GLENMARK PHARMACEUTICALS S.A. US Patent					Assay Description The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...				Citation and Details
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM191654 (US9186360, 60) Show SMILES Cn1c2occ(CC(=O)Nc3nc(cs3)-c3cc(F)c(OCC(F)(F)F)c(Cl)c3)c2c(=O)n(C)c1=O Show InChI InChI=1S/C21H15ClF4N4O5S/c1-29-17(32)15-10(6-34-18(15)30(2)20(29)33)5-14(31)28-19-27-13(7-36-19)9-3-11(22)16(12(23)4-9)35-8-21(24,25)26/h3-4,6-7H,5,8H2,1-2H3,(H,27,28,31)	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.54	n/a	n/a	n/a	n/a	n/a	n/a
GLENMARK PHARMACEUTICALS S.A. US Patent					Assay Description The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...				Citation and Details
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM50327657 (2-chlorobenzylidenemalononitrile | CHEMBL1256101) Show SMILES Clc1ccccc1C=C(C#N)C#N Show InChI InChI=1S/C10H5ClN2/c11-10-4-2-1-3-9(10)5-8(6-12)7-13/h1-5H	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	3.60	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as concentration required to incapacitate 50% of the population exposed to t...				J Med Chem 53: 7011-20 (2010)
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM191655 (US9186360, 62 | US9186360, 66) Show SMILES Cc1oc2n(C)c(=O)n(C)c(=O)c2c1CC(=O)Nc1nc(cs1)-c1cc(F)c(OCC(C)(C)C)c(F)c1 Show InChI InChI=1S/C25H26F2N4O5S/c1-12-14(19-21(33)30(5)24(34)31(6)22(19)36-12)9-18(32)29-23-28-17(10-37-23)13-7-15(26)20(16(27)8-13)35-11-25(2,3)4/h7-8,10H,9,11H2,1-6H3,(H,28,29,32)	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.63	n/a	n/a	n/a	n/a	n/a	n/a
GLENMARK PHARMACEUTICALS S.A. US Patent					Assay Description The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...				Citation and Details
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM191705 (US9186360, 49) Show SMILES CCc1sc2n(C)c(=O)n(C)c(=O)c2c1CC(=O)Nc1nc(cs1)-c1cc(F)c(OCC(F)(F)F)c(F)c1 Show InChI InChI=1S/C23H19F5N4O4S2/c1-4-15-11(17-19(34)31(2)22(35)32(3)20(17)38-15)7-16(33)30-21-29-14(8-37-21)10-5-12(24)18(13(25)6-10)36-9-23(26,27)28/h5-6,8H,4,7,9H2,1-3H3,(H,29,30,33)	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.98	n/a	n/a	n/a	n/a	n/a	n/a
GLENMARK PHARMACEUTICALS S.A. US Patent					Assay Description The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...				Citation and Details
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Rattus norvegicus)	BDBM50362741 (CHEMBL1939826) Show SMILES COCCCOc1cccc(c1)[C@H]1NC(=S)N=C2C1C(=O)c1ccccc21 Show InChI InChI=1S/C21H20N2O3S/c1-25-10-5-11-26-14-7-4-6-13(12-14)18-17-19(23-21(27)22-18)15-8-2-3-9-16(15)20(17)24/h2-4,6-9,12,17-18H,5,10-11H2,1H3,(H,22,27)/t17?,18-/m1/s1	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research& Development, Janssen Pharmaceutica N.V. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPA1 expressed in HEK293 cells assessed as inhibition of BITC-induced increase in intracellular calcium concentration by ...				Bioorg Med Chem Lett 22: 797-800 (2012)
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM50193655 (CHEMBL3982480) Show SMILES OC1(CCN(CC1)C(CNC(=O)C1(CCCCC1)c1ccc(F)cc1)Cc1ccccc1)C(F)(F)F Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Temple University Curated by ChEMBL					Assay Description Inhibition of cinnamaldehyde-activated full length human TRPA1 channel expressed in 293T-Rex cells monitored at 5 sec interval by manual patch clamp ...				ACS Med Chem Lett 7: 658-9 (2016)
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM191725 (US9186360, 76) Show SMILES Cc1oc2n(C)c(=O)n(C)c(=O)c2c1CC(=O)Nc1nc(cs1)-c1ccc(c(F)c1F)C(F)(F)F Show InChI InChI=1S/C21H15F5N4O4S/c1-8-10(14-17(32)29(2)20(33)30(3)18(14)34-8)6-13(31)28-19-27-12(7-35-19)9-4-5-11(21(24,25)26)16(23)15(9)22/h4-5,7H,6H2,1-3H3,(H,27,28,31)	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.02	n/a	n/a	n/a	n/a	n/a	n/a
GLENMARK PHARMACEUTICALS S.A. US Patent					Assay Description The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...				Citation and Details
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM191723 (US9186360, 72) Show SMILES Cc1oc2n(C)c(=O)n(C)c(=O)c2c1CC(=O)Nc1nc(cs1)-c1cc(F)c(c(F)c1)C(F)(F)F Show InChI InChI=1S/C21H15F5N4O4S/c1-8-10(15-17(32)29(2)20(33)30(3)18(15)34-8)6-14(31)28-19-27-13(7-35-19)9-4-11(22)16(12(23)5-9)21(24,25)26/h4-5,7H,6H2,1-3H3,(H,27,28,31)	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.16	n/a	n/a	n/a	n/a	n/a	n/a
GLENMARK PHARMACEUTICALS S.A. US Patent					Assay Description The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...				Citation and Details
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM191731 (US9186360, 83) Show SMILES Cn1c2snc(CC(=O)Nc3nc(cs3)-c3cc(F)cc(c3)C(F)(F)F)c2c(=O)n(C)c1=O Show InChI InChI=1S/C19H13F4N5O3S2/c1-27-15(30)14-11(26-33-16(14)28(2)18(27)31)6-13(29)25-17-24-12(7-32-17)8-3-9(19(21,22)23)5-10(20)4-8/h3-5,7H,6H2,1-2H3,(H,24,25,29)	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.40	n/a	n/a	n/a	n/a	n/a	n/a
GLENMARK PHARMACEUTICALS S.A. US Patent					Assay Description The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...				Citation and Details
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM191715 (US9186360, 64) Show SMILES Cc1oc2n(C)c(=O)n(C)c(=O)c2c1CC(=O)Nc1nc(cs1)-c1ccc(F)c(c1F)C(F)(F)F Show InChI InChI=1S/C21H15F5N4O4S/c1-8-10(14-17(32)29(2)20(33)30(3)18(14)34-8)6-13(31)28-19-27-12(7-35-19)9-4-5-11(22)15(16(9)23)21(24,25)26/h4-5,7H,6H2,1-3H3,(H,27,28,31)	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.52	n/a	n/a	n/a	n/a	n/a	n/a
GLENMARK PHARMACEUTICALS S.A. US Patent					Assay Description The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...				Citation and Details
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM191719 (US9186360, 68) Show SMILES Cc1oc2n(C)c(=O)n(C)c(=O)c2c1CC(=O)Nc1nc(cs1)-c1ccc(F)c(OC(F)(F)F)c1 Show InChI InChI=1S/C21H16F4N4O5S/c1-9-11(16-17(31)28(2)20(32)29(3)18(16)33-9)7-15(30)27-19-26-13(8-35-19)10-4-5-12(22)14(6-10)34-21(23,24)25/h4-6,8H,7H2,1-3H3,(H,26,27,30)	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.84	n/a	n/a	n/a	n/a	n/a	n/a
GLENMARK PHARMACEUTICALS S.A. US Patent					Assay Description The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...				Citation and Details
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM191652 (US9186360, 51 | US9186360, 52) Show SMILES Cn1c2scc(CC(=O)Nc3nc(cs3)-c3ccc(F)c(c3F)C(F)(F)F)c2c(=O)n(C)c1=O Show InChI InChI=1S/C20H13F5N4O3S2/c1-28-16(31)13-8(6-33-17(13)29(2)19(28)32)5-12(30)27-18-26-11(7-34-18)9-3-4-10(21)14(15(9)22)20(23,24)25/h3-4,6-7H,5H2,1-2H3,(H,26,27,30)	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.84	n/a	n/a	n/a	n/a	n/a	n/a
GLENMARK PHARMACEUTICALS S.A. US Patent					Assay Description The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...				Citation and Details
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM191740 (US9186360, 99) Show SMILES Cn1c2oc(Cl)c(CC(=O)Nc3nc(cs3)-c3ccc(c(F)c3)C(F)(F)F)c2c(=O)n(C)c1=O Show InChI InChI=1S/C20H13ClF4N4O4S/c1-28-16(31)14-9(15(21)33-17(14)29(2)19(28)32)6-13(30)27-18-26-12(7-34-18)8-3-4-10(11(22)5-8)20(23,24)25/h3-5,7H,6H2,1-2H3,(H,26,27,30)	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.06	n/a	n/a	n/a	n/a	n/a	n/a
GLENMARK PHARMACEUTICALS S.A. US Patent					Assay Description The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...				Citation and Details
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM191741 (US9186360, 100) Show SMILES Cn1c2oc(Cl)c(CC(=O)Nc3nc(cs3)-c3cc(F)cc(c3)C(F)(F)F)c2c(=O)n(C)c1=O Show InChI InChI=1S/C20H13ClF4N4O4S/c1-28-16(31)14-11(15(21)33-17(14)29(2)19(28)32)6-13(30)27-18-26-12(7-34-18)8-3-9(20(23,24)25)5-10(22)4-8/h3-5,7H,6H2,1-2H3,(H,26,27,30)	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.15	n/a	n/a	n/a	n/a	n/a	n/a
GLENMARK PHARMACEUTICALS S.A. US Patent					Assay Description The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...				Citation and Details
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM191724 (US9186360, 74) Show SMILES Cc1oc2n(C)c(=O)n(C)c(=O)c2c1CC(=O)Nc1nc(cs1)-c1ccc(OCC(F)(F)F)c(Cl)c1 Show InChI InChI=1S/C22H18ClF3N4O5S/c1-10-12(17-18(32)29(2)21(33)30(3)19(17)35-10)7-16(31)28-20-27-14(8-36-20)11-4-5-15(13(23)6-11)34-9-22(24,25)26/h4-6,8H,7,9H2,1-3H3,(H,27,28,31)	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.29	n/a	n/a	n/a	n/a	n/a	n/a
GLENMARK PHARMACEUTICALS S.A. US Patent					Assay Description The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...				Citation and Details
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM191728 (US9186360, 79) Show SMILES Cn1c2snc(CC(=O)Nc3nc(cs3)-c3cccc(c3F)C(F)(F)F)c2c(=O)n(C)c1=O Show InChI InChI=1S/C19H13F4N5O3S2/c1-27-15(30)13-10(26-33-16(13)28(2)18(27)31)6-12(29)25-17-24-11(7-32-17)8-4-3-5-9(14(8)20)19(21,22)23/h3-5,7H,6H2,1-2H3,(H,24,25,29)	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.29	n/a	n/a	n/a	n/a	n/a	n/a
GLENMARK PHARMACEUTICALS S.A. US Patent					Assay Description The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...				Citation and Details
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM191666 (US9186360, 84) Show SMILES Cn1c2snc(CC(=O)Nc3nc(cs3)-c3ccc(c(F)c3F)C(F)(F)F)c2c(=O)n(C)c1=O Show InChI InChI=1S/C19H12F5N5O3S2/c1-28-15(31)12-9(27-34-16(12)29(2)18(28)32)5-11(30)26-17-25-10(6-33-17)7-3-4-8(19(22,23)24)14(21)13(7)20/h3-4,6H,5H2,1-2H3,(H,25,26,30)	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.35	n/a	n/a	n/a	n/a	n/a	n/a
GLENMARK PHARMACEUTICALS S.A. US Patent					Assay Description The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...				Citation and Details
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM191648 (US9186360, 33) Show SMILES Cn1c2cccc(CC(=O)Nc3nc(cs3)-c3cc(F)c(c(F)c3)C(F)(F)F)c2c(=O)n(C)c1=O Show InChI InChI=1S/C22H15F5N4O3S/c1-30-15-5-3-4-10(17(15)19(33)31(2)21(30)34)8-16(32)29-20-28-14(9-35-20)11-6-12(23)18(13(24)7-11)22(25,26)27/h3-7,9H,8H2,1-2H3,(H,28,29,32)	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.37	n/a	n/a	n/a	n/a	n/a	n/a
GLENMARK PHARMACEUTICALS S.A. US Patent					Assay Description The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...				Citation and Details
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM191726 (US9186360, 77) Show SMILES Cn1c2snc(CC(=O)Nc3nc(cs3)-c3ccc(F)c(c3F)C(F)(F)F)c2c(=O)n(C)c1=O Show InChI InChI=1S/C19H12F5N5O3S2/c1-28-15(31)12-9(27-34-16(12)29(2)18(28)32)5-11(30)26-17-25-10(6-33-17)7-3-4-8(20)13(14(7)21)19(22,23)24/h3-4,6H,5H2,1-2H3,(H,25,26,30)	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.60	n/a	n/a	n/a	n/a	n/a	n/a
GLENMARK PHARMACEUTICALS S.A. US Patent					Assay Description The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...				Citation and Details
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM50046740 (CHEMBL1939972 | US9186360, 90) Show SMILES COCCCOc1cccc(c1)C1NC(=S)NC2=C1C(=O)c1ccccc21 Show InChI InChI=1/C21H20N2O3S/c1-25-10-5-11-26-14-7-4-6-13(12-14)18-17-19(23-21(27)22-18)15-8-2-3-9-16(15)20(17)24/h2-4,6-9,12,18H,5,10-11H2,1H3,(H2,22,23,27)	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.61	n/a	n/a	n/a	n/a	n/a	n/a
GLENMARK PHARMACEUTICALS S.A. US Patent					Assay Description The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...				Citation and Details
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM191647 (US9186360, 32) Show SMILES Cn1c2cccc(CC(=O)Nc3nc(cs3)-c3cc(F)c(OCC(F)(F)F)c(F)c3)c2c(=O)n(C)c1=O Show InChI InChI=1S/C23H17F5N4O4S/c1-31-16-5-3-4-11(18(16)20(34)32(2)22(31)35)8-17(33)30-21-29-15(9-37-21)12-6-13(24)19(14(25)7-12)36-10-23(26,27)28/h3-7,9H,8,10H2,1-2H3,(H,29,30,33)	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.96	n/a	n/a	n/a	n/a	n/a	n/a
GLENMARK PHARMACEUTICALS S.A. US Patent					Assay Description The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...				Citation and Details
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM191657 (US9186360, 80) Show SMILES Cn1c2snc(CC(=O)Nc3nc(cs3)-c3ccc(OC(F)(F)F)c(Cl)c3)c2c(=O)n(C)c1=O Show InChI InChI=1S/C19H13ClF3N5O4S2/c1-27-15(30)14-10(26-34-16(14)28(2)18(27)31)6-13(29)25-17-24-11(7-33-17)8-3-4-12(9(20)5-8)32-19(21,22)23/h3-5,7H,6H2,1-2H3,(H,24,25,29)	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.28	n/a	n/a	n/a	n/a	n/a	n/a
GLENMARK PHARMACEUTICALS S.A. US Patent					Assay Description The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...				Citation and Details
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM191689 (US9186360, 28) Show SMILES Cn1c2cccc(CC(=O)Nc3nc(cs3)-c3ccc(c(F)c3F)C(F)(F)F)c2c(=O)n(C)c1=O Show InChI InChI=1S/C22H15F5N4O3S/c1-30-14-5-3-4-10(16(14)19(33)31(2)21(30)34)8-15(32)29-20-28-13(9-35-20)11-6-7-12(22(25,26)27)18(24)17(11)23/h3-7,9H,8H2,1-2H3,(H,28,29,32)	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.49	n/a	n/a	n/a	n/a	n/a	n/a
GLENMARK PHARMACEUTICALS S.A. US Patent					Assay Description The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...				Citation and Details
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM191716 (US9186360, 65) Show SMILES Cc1oc2n(C)c(=O)n(C)c(=O)c2c1CC(=O)Nc1nc(cs1)-c1ccc(cc1F)C(F)(F)F Show InChI InChI=1S/C21H16F4N4O4S/c1-9-12(16-17(31)28(2)20(32)29(3)18(16)33-9)7-15(30)27-19-26-14(8-34-19)11-5-4-10(6-13(11)22)21(23,24)25/h4-6,8H,7H2,1-3H3,(H,26,27,30)	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.65	n/a	n/a	n/a	n/a	n/a	n/a
GLENMARK PHARMACEUTICALS S.A. US Patent					Assay Description The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...				Citation and Details
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM191729 (US9186360, 81) Show SMILES Cn1c2snc(CC(=O)Nc3nc(cs3)-c3ccc(c(F)c3)C(F)(F)F)c2c(=O)n(C)c1=O Show InChI InChI=1S/C19H13F4N5O3S2/c1-27-15(30)14-11(26-33-16(14)28(2)18(27)31)6-13(29)25-17-24-12(7-32-17)8-3-4-9(10(20)5-8)19(21,22)23/h3-5,7H,6H2,1-2H3,(H,24,25,29)	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.74	n/a	n/a	n/a	n/a	n/a	n/a
GLENMARK PHARMACEUTICALS S.A. US Patent					Assay Description The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...				Citation and Details
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM191658 (US9186360, 86) Show SMILES Cn1c2nccc(CC(=O)Nc3nc(cs3)-c3cc(F)c(OCC(F)(F)F)c(F)c3)c2c(=O)n(C)c1=O Show InChI InChI=1S/C22H16F5N5O4S/c1-31-18-16(19(34)32(2)21(31)35)10(3-4-28-18)7-15(33)30-20-29-14(8-37-20)11-5-12(23)17(13(24)6-11)36-9-22(25,26)27/h3-6,8H,7,9H2,1-2H3,(H,29,30,33)	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.91	n/a	n/a	n/a	n/a	n/a	n/a
GLENMARK PHARMACEUTICALS S.A. US Patent					Assay Description The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...				Citation and Details
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM50318455 (AMG-9090 | CHEMBL1086371 | N-(2,2,2-trichloro-1-(4...) Show SMILES Clc1ccc(SC(NC(=O)c2ccccc2)C(Cl)(Cl)Cl)cc1 Show InChI InChI=1S/C15H11Cl4NOS/c16-11-6-8-12(9-7-11)22-14(15(17,18)19)20-13(21)10-4-2-1-3-5-10/h1-9,14H,(H,20,21)	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Ferrara University Curated by ChEMBL					Assay Description Antagonist activity at human TRPA1 channel assessed as inhibition of noxious cold-induced receptor activation				J Med Chem 53: 5085-107 (2010)
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM50193600 (CHEMBL3974466) Show SMILES FC(F)(F)C1CCN(CC1)C(CNC(=O)C1(CCCC1)c1ccc(Cl)cc1)Cc1ccccc1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Temple University Curated by ChEMBL					Assay Description Inhibition of cinnamaldehyde-activated full length human TRPA1 channel expressed in 293T-Rex cells monitored at 5 sec interval by manual patch clamp ...				ACS Med Chem Lett 7: 658-9 (2016)
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM191720 (US9186360, 69) Show SMILES Cc1oc2n(C)c(=O)n(C)c(=O)c2c1CC(=O)Nc1nc(cs1)-c1ccc(F)c(c1)C(F)(F)F Show InChI InChI=1S/C21H16F4N4O4S/c1-9-11(16-17(31)28(2)20(32)29(3)18(16)33-9)7-15(30)27-19-26-14(8-34-19)10-4-5-13(22)12(6-10)21(23,24)25/h4-6,8H,7H2,1-3H3,(H,26,27,30)	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.10	n/a	n/a	n/a	n/a	n/a	n/a
GLENMARK PHARMACEUTICALS S.A. US Patent					Assay Description The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...				Citation and Details
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM191663 (US9186360, 104) Show SMILES Cn1c2oc(Cl)c(CC(=O)Nc3nc(cs3)-c3ccc(c(F)c3F)C(F)(F)F)c2c(=O)n(C)c1=O Show InChI InChI=1S/C20H12ClF5N4O4S/c1-29-16(32)12-8(15(21)34-17(12)30(2)19(29)33)5-11(31)28-18-27-10(6-35-18)7-3-4-9(20(24,25)26)14(23)13(7)22/h3-4,6H,5H2,1-2H3,(H,27,28,31)	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.58	n/a	n/a	n/a	n/a	n/a	n/a
GLENMARK PHARMACEUTICALS S.A. US Patent					Assay Description The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...				Citation and Details
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM191742 (US9186360, 102) Show SMILES Cn1c2oc(Cl)c(CC(=O)Nc3nc(cs3)-c3ccc(OC(F)(F)F)c(F)c3)c2c(=O)n(C)c1=O Show InChI InChI=1S/C20H13ClF4N4O5S/c1-28-16(31)14-9(15(21)33-17(14)29(2)19(28)32)6-13(30)27-18-26-11(7-35-18)8-3-4-12(10(22)5-8)34-20(23,24)25/h3-5,7H,6H2,1-2H3,(H,26,27,30)	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.67	n/a	n/a	n/a	n/a	n/a	n/a
GLENMARK PHARMACEUTICALS S.A. US Patent					Assay Description The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...				Citation and Details
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM191730 (US9186360, 82) Show SMILES Cn1c2snc(CC(=O)Nc3nc(cs3)-c3ccc(OC(F)(F)F)c(F)c3)c2c(=O)n(C)c1=O Show InChI InChI=1S/C19H13F4N5O4S2/c1-27-15(30)14-10(26-34-16(14)28(2)18(27)31)6-13(29)25-17-24-11(7-33-17)8-3-4-12(9(20)5-8)32-19(21,22)23/h3-5,7H,6H2,1-2H3,(H,24,25,29)	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.04	n/a	n/a	n/a	n/a	n/a	n/a
GLENMARK PHARMACEUTICALS S.A. US Patent					Assay Description The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...				Citation and Details
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM191700 (US9186360, 44) Show SMILES Cn1c2c[nH]n(CC(=O)Nc3nc(cs3)-c3cc(Cl)c(OCC(C)(C)C)c(Cl)c3)c2c(=O)n(C)c1=O Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.36	n/a	n/a	n/a	n/a	n/a	n/a
GLENMARK PHARMACEUTICALS S.A. US Patent					Assay Description The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...				Citation and Details
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM191665 (US9186360, 73) Show SMILES Cc1oc2n(C)c(=O)n(C)c(=O)c2c1CC(=O)Nc1nc(cs1)-c1ccc(OC(F)(F)F)c(Cl)c1 Show InChI InChI=1S/C21H16ClF3N4O5S/c1-9-11(16-17(31)28(2)20(32)29(3)18(16)33-9)7-15(30)27-19-26-13(8-35-19)10-4-5-14(12(22)6-10)34-21(23,24)25/h4-6,8H,7H2,1-3H3,(H,26,27,30)	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.54	n/a	n/a	n/a	n/a	n/a	n/a
GLENMARK PHARMACEUTICALS S.A. US Patent					Assay Description The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...				Citation and Details
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM191732 (US9186360, 85) Show SMILES Cn1c2nccc(CC(=O)Nc3nc(cs3)-c3ccc(c(F)c3)C(F)(F)F)c2c(=O)n(C)c1=O Show InChI InChI=1S/C21H15F4N5O3S/c1-29-17-16(18(32)30(2)20(29)33)11(5-6-26-17)8-15(31)28-19-27-14(9-34-19)10-3-4-12(13(22)7-10)21(23,24)25/h3-7,9H,8H2,1-2H3,(H,27,28,31)	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.92	n/a	n/a	n/a	n/a	n/a	n/a
GLENMARK PHARMACEUTICALS S.A. US Patent					Assay Description The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...				Citation and Details
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM191714 (US9186360, 63) Show SMILES Cc1oc2n(C)c(=O)n(C)c(=O)c2c1CC(=O)Nc1nc(cs1)-c1ccc(Cl)c(OC(F)(F)F)c1 Show InChI InChI=1S/C21H16ClF3N4O5S/c1-9-11(16-17(31)28(2)20(32)29(3)18(16)33-9)7-15(30)27-19-26-13(8-35-19)10-4-5-12(22)14(6-10)34-21(23,24)25/h4-6,8H,7H2,1-3H3,(H,26,27,30)	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9.04	n/a	n/a	n/a	n/a	n/a	n/a
GLENMARK PHARMACEUTICALS S.A. US Patent					Assay Description The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...				Citation and Details
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Rattus norvegicus)	BDBM50157631 (CHEMBL3785736) Show SMILES Cn1cnc2ncn(Cc3nc(CCc4ccc(Cl)cc4)no3)c(=O)c12 Show InChI InChI=1S/C17H15ClN6O2/c1-23-9-19-16-15(23)17(25)24(10-20-16)8-14-21-13(22-26-14)7-4-11-2-5-12(18)6-3-11/h2-3,5-6,9-10H,4,7-8H2,1H3	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPA1 expressed in tetracycline-inducible T-REx expression system transfected CHO cells assessed as inhibition of hypo osm...				Citation and Details
					More data for this Ligand-Target Pair

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