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Compile Data Set for Download or QSAR

Found 932 hits Enz. Inhib. hit(s) with Target = 'Transient receptor potential cation channel subfamily M member 8'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM256293
PNG
(US9487488, 17)
Show SMILES Cc1cc(ccc1-c1nnn[nH]1)S(=O)(=O)N(Cc1ccc(OC(F)(F)F)cc1)c1ncc2ccccc2c1C1CC1
Show InChI InChI=1S/C28H23F3N6O3S/c1-17-14-22(12-13-23(17)26-33-35-36-34-26)41(38,39)37(16-18-6-10-21(11-7-18)40-28(29,30)31)27-25(19-8-9-19)24-5-3-2-4-20(24)15-32-27/h2-7,10-15,19H,8-9,16H2,1H3,(H,33,34,35,36)
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n/an/a 0.300n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...


US Patent US9487488 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM256277
PNG
(US9487488, 1)
Show SMILES FC(F)(F)Oc1ccc(CN(c2ncc3ccccc3c2C2CC2)S(=O)(=O)c2ccc(cc2)-c2nnn[nH]2)cc1
Show InChI InChI=1S/C27H21F3N6O3S/c28-27(29,30)39-21-11-5-17(6-12-21)16-36(26-24(18-7-8-18)23-4-2-1-3-20(23)15-31-26)40(37,38)22-13-9-19(10-14-22)25-32-34-35-33-25/h1-6,9-15,18H,7-8,16H2,(H,32,33,34,35)
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n/an/a 0.300n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...


US Patent US9487488 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM50335157
PNG
(3-[7-Trifluoromethyl-5-(2-trifluoromethyl-phenyl)-...)
Show SMILES FC(F)(F)c1ccccc1-c1cc(c2[nH]c(nc2c1)C1=NOC2(C1)CCCCC2)C(F)(F)F
Show InChI InChI=1S/C23H19F6N3O/c24-22(25,26)15-7-3-2-6-14(15)13-10-16(23(27,28)29)19-17(11-13)30-20(31-19)18-12-21(33-32-18)8-4-1-5-9-21/h2-3,6-7,10-11H,1,4-5,8-9,12H2,(H,30,31)
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n/an/a 0.413n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human TRPM8 expressed in HEK293 cells assessed as inhibition of cold-induced channel current by whole cell electrophysiology


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM256310
PNG
(US9487488, 34)
Show SMILES Cc1cc(ccc1-c1noc(=O)[nH]1)S(=O)(=O)N(Cc1ccc(OC(F)(F)F)cc1)c1ncc2ccccc2c1C1CC1
Show InChI InChI=1S/C29H23F3N4O5S/c1-17-14-22(12-13-23(17)26-34-28(37)41-35-26)42(38,39)36(16-18-6-10-21(11-7-18)40-29(30,31)32)27-25(19-8-9-19)24-5-3-2-4-20(24)15-33-27/h2-7,10-15,19H,8-9,16H2,1H3,(H,34,35,37)
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n/an/a 0.5n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...


US Patent US9487488 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM256299
PNG
(US9487488, 23)
Show SMILES Cc1cc(ccc1-c1ncn[nH]1)S(=O)(=O)N(Cc1ccc(OC(F)(F)F)cc1)c1ncc2ccccc2c1C1CC1
Show InChI InChI=1S/C29H24F3N5O3S/c1-18-14-23(12-13-24(18)27-34-17-35-36-27)41(38,39)37(16-19-6-10-22(11-7-19)40-29(30,31)32)28-26(20-8-9-20)25-5-3-2-4-21(25)15-33-28/h2-7,10-15,17,20H,8-9,16H2,1H3,(H,34,35,36)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...


US Patent US9487488 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151765
PNG
(US8987445, 201)
Show SMILES Cc1c(ncc2ccccc12)N(Cc1ccc(c(Cl)c1)C(F)(F)C1CC1)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C28H23ClF2N2O4S/c1-17-23-5-3-2-4-20(23)15-32-26(17)33(38(36,37)22-11-7-19(8-12-22)27(34)35)16-18-6-13-24(25(29)14-18)28(30,31)21-9-10-21/h2-8,11-15,21H,9-10,16H2,1H3,(H,34,35)
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n/an/a 0.600n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM256298
PNG
(US9487488, 22)
Show SMILES Cc1n[nH]c(n1)-c1ccc(cc1)S(=O)(=O)N(Cc1ccc(OC(F)(F)F)cc1)c1ncc2ccccc2c1C1CC1
Show InChI InChI=1S/C29H24F3N5O3S/c1-18-34-27(36-35-18)21-10-14-24(15-11-21)41(38,39)37(17-19-6-12-23(13-7-19)40-29(30,31)32)28-26(20-8-9-20)25-5-3-2-4-22(25)16-33-28/h2-7,10-16,20H,8-9,17H2,1H3,(H,34,35,36)
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n/an/a 0.600n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...


US Patent US9487488 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM256278
PNG
(US9487488, 2)
Show SMILES FC(F)(F)Oc1ccc(CN(c2ncc3ccccc3c2C2CC2)S(=O)(=O)c2ccc(nc2)-c2nnn[nH]2)cc1
Show InChI InChI=1S/C26H20F3N7O3S/c27-26(28,29)39-19-9-5-16(6-10-19)15-36(25-23(17-7-8-17)21-4-2-1-3-18(21)13-31-25)40(37,38)20-11-12-22(30-14-20)24-32-34-35-33-24/h1-6,9-14,17H,7-8,15H2,(H,32,33,34,35)
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n/an/a 0.700n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...


US Patent US9487488 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM256290
PNG
(US9487488, 14)
Show SMILES Cc1c(nc(C2CC2)c2ccccc12)N(Cc1ccc(OC(F)(F)F)cc1)S(=O)(=O)c1ccc(cc1)-c1nnn[nH]1
Show InChI InChI=1S/C28H23F3N6O3S/c1-17-23-4-2-3-5-24(23)25(19-8-9-19)32-27(17)37(16-18-6-12-21(13-7-18)40-28(29,30)31)41(38,39)22-14-10-20(11-15-22)26-33-35-36-34-26/h2-7,10-15,19H,8-9,16H2,1H3,(H,33,34,35,36)
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n/an/a 0.700n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...


US Patent US9487488 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM256314
PNG
(US9487488, 38)
Show SMILES Cc1cc(ccc1S(=O)(=O)N(Cc1ccc(OC(F)(F)F)cc1)c1ncc2ccccc2c1C1CC1)C(O)=O
Show InChI InChI=1S/C28H23F3N2O5S/c1-17-14-20(27(34)35)10-13-24(17)39(36,37)33(16-18-6-11-22(12-7-18)38-28(29,30)31)26-25(19-8-9-19)23-5-3-2-4-21(23)15-32-26/h2-7,10-15,19H,8-9,16H2,1H3,(H,34,35)
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n/an/a 0.700n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...


US Patent US9487488 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM256301
PNG
(US9487488, 25)
Show SMILES Cc1n[nH]c(n1)-c1ccc(cc1)S(=O)(=O)N(Cc1ccc(cn1)C(F)(F)F)c1ncc2ccccc2c1C1CC1
Show InChI InChI=1S/C28H23F3N6O2S/c1-17-34-26(36-35-17)19-8-12-23(13-9-19)40(38,39)37(16-22-11-10-21(15-32-22)28(29,30)31)27-25(18-6-7-18)24-5-3-2-4-20(24)14-33-27/h2-5,8-15,18H,6-7,16H2,1H3,(H,34,35,36)
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n/an/a 0.700n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...


US Patent US9487488 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151774
PNG
(US8987445, 210)
Show SMILES Fc1cc(CN(c2ncc3ccccc3c2C2CC2)S(=O)(=O)c2ccc(cc2)C(=O)O[Na])ccc1C(F)(F)C1CC1
Show InChI InChI=1S/C30H25F3N2O4S.Na/c31-26-15-18(5-14-25(26)30(32,33)22-10-11-22)17-35(40(38,39)23-12-8-20(9-13-23)29(36)37)28-27(19-6-7-19)24-4-2-1-3-21(24)16-34-28;/h1-5,8-9,12-16,19,22H,6-7,10-11,17H2,(H,36,37);/q;+1/p-1
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n/an/a 0.800n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM256303
PNG
(US9487488, 27)
Show SMILES Cc1n[nH]c(n1)-c1ccc(cc1C)S(=O)(=O)N(Cc1ccc(cn1)C(F)(F)F)c1ncc2ccccc2c1C1CC1
Show InChI InChI=1S/C29H25F3N6O2S/c1-17-13-23(11-12-24(17)27-35-18(2)36-37-27)41(39,40)38(16-22-10-9-21(15-33-22)29(30,31)32)28-26(19-7-8-19)25-6-4-3-5-20(25)14-34-28/h3-6,9-15,19H,7-8,16H2,1-2H3,(H,35,36,37)
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n/an/a 0.800n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...


US Patent US9487488 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151677
PNG
(US8987445, 104)
Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccc(OC(F)(F)F)cc1)c1ncc2ccccc2c1C1CC1
Show InChI InChI=1S/C27H21F3N2O5S/c28-27(29,30)37-21-11-5-17(6-12-21)16-32(38(35,36)22-13-9-19(10-14-22)26(33)34)25-24(18-7-8-18)23-4-2-1-3-20(23)15-31-25/h1-6,9-15,18H,7-8,16H2,(H,33,34)
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n/an/a 0.900n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM256294
PNG
(US9487488, 18)
Show SMILES FC(F)(F)c1ccc(CN(c2ncc3ccccc3c2C2CC2)S(=O)(=O)c2ccc(cc2)-c2nnn[nH]2)nc1
Show InChI InChI=1S/C26H20F3N7O2S/c27-26(28,29)19-9-10-20(30-14-19)15-36(25-23(16-5-6-16)22-4-2-1-3-18(22)13-31-25)39(37,38)21-11-7-17(8-12-21)24-32-34-35-33-24/h1-4,7-14,16H,5-6,15H2,(H,32,33,34,35)
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n/an/a 0.900n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...


US Patent US9487488 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151797
PNG
(US8987445, 233)
Show SMILES FC(F)(F)c1c(ncc2ccccc12)N(Cc1ccc(c(Cl)c1)C(F)(F)C1CC1)S(=O)(=O)c1ccc(cc1)C(=O)O[Na]
Show InChI InChI=1S/C28H20ClF5N2O4S.Na/c29-23-13-16(5-12-22(23)27(30,31)19-8-9-19)15-36(41(39,40)20-10-6-17(7-11-20)26(37)38)25-24(28(32,33)34)21-4-2-1-3-18(21)14-35-25;/h1-7,10-14,19H,8-9,15H2,(H,37,38);/q;+1/p-1
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Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM50036542
PNG
(CHEMBL3353600)
Show SMILES CC(C)(C)c1ccc(CN(c2ncc(cc2Cl)C(F)(F)F)S(=O)(=O)c2ccc(cc2)C(O)=O)cc1
Show InChI InChI=1S/C24H22ClF3N2O4S/c1-23(2,3)17-8-4-15(5-9-17)14-30(21-20(25)12-18(13-29-21)24(26,27)28)35(33,34)19-10-6-16(7-11-19)22(31)32/h4-13H,14H2,1-3H3,(H,31,32)
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n/an/a 0.960n/an/an/an/an/an/a



RaQualia Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influx


Bioorg Med Chem Lett 24: 5364-8 (2014)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM256302
PNG
(US9487488, 26)
Show SMILES Cc1cc(ccc1-c1ncn[nH]1)S(=O)(=O)N(Cc1ccc(cn1)C(F)(F)F)c1ncc2ccccc2c1C1CC1
Show InChI InChI=1S/C28H23F3N6O2S/c1-17-12-22(10-11-23(17)26-34-16-35-36-26)40(38,39)37(15-21-9-8-20(14-32-21)28(29,30)31)27-25(18-6-7-18)24-5-3-2-4-19(24)13-33-27/h2-5,8-14,16,18H,6-7,15H2,1H3,(H,34,35,36)
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n/an/a 1n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...


US Patent US9487488 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM256283
PNG
(US9487488, 7)
Show SMILES FC(F)(F)Oc1ccc(CN(c2ncc3ccccc3c2C2CC2)S(=O)(=O)c2ccc(cc2)-c2noc(=O)[nH]2)cc1
Show InChI InChI=1S/C28H21F3N4O5S/c29-28(30,31)39-21-11-5-17(6-12-21)16-35(26-24(18-7-8-18)23-4-2-1-3-20(23)15-32-26)41(37,38)22-13-9-19(10-14-22)25-33-27(36)40-34-25/h1-6,9-15,18H,7-8,16H2,(H,33,34,36)
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n/an/a 1n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...


US Patent US9487488 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM256328
PNG
(US9487488, 52)
Show SMILES OC(=O)c1ccc(cc1F)S(=O)(=O)N(Cc1ccc(OC(F)(F)F)cc1)c1ncc2ccccc2c1C1CC1
Show InChI InChI=1S/C27H20F4N2O5S/c28-23-13-20(11-12-22(23)26(34)35)39(36,37)33(15-16-5-9-19(10-6-16)38-27(29,30)31)25-24(17-7-8-17)21-4-2-1-3-18(21)14-32-25/h1-6,9-14,17H,7-8,15H2,(H,34,35)
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n/an/a 1n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...


US Patent US9487488 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151773
PNG
(US8987445, 209)
Show SMILES Cc1c(ncc2ccccc12)N(Cc1ccc(cc1)C(F)(F)C1(C)CC1)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C29H26F2N2O4S/c1-19-25-6-4-3-5-22(25)17-32-26(19)33(38(36,37)24-13-9-21(10-14-24)27(34)35)18-20-7-11-23(12-8-20)29(30,31)28(2)15-16-28/h3-14,17H,15-16,18H2,1-2H3,(H,34,35)
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Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151745
PNG
(US8987445, 181)
Show SMILES Cc1c(nc(C2CC2)c2ccccc12)N(Cc1ccc(c(Cl)c1)C(F)(F)C1CC1)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C31H27ClF2N2O4S/c1-18-24-4-2-3-5-25(24)28(20-7-8-20)35-29(18)36(41(39,40)23-13-9-21(10-14-23)30(37)38)17-19-6-15-26(27(32)16-19)31(33,34)22-11-12-22/h2-6,9-10,13-16,20,22H,7-8,11-12,17H2,1H3,(H,37,38)
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Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM256317
PNG
(US9487488, 41)
Show SMILES CNc1cc(ccc1C(O)=O)S(=O)(=O)N(Cc1ccc(OC(F)(F)F)cc1)c1ncc2ccccc2c1C1CC1
Show InChI InChI=1S/C28H24F3N3O5S/c1-32-24-14-21(12-13-23(24)27(35)36)40(37,38)34(16-17-6-10-20(11-7-17)39-28(29,30)31)26-25(18-8-9-18)22-5-3-2-4-19(22)15-33-26/h2-7,10-15,18,32H,8-9,16H2,1H3,(H,35,36)
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n/an/a 1.10n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...


US Patent US9487488 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM256285
PNG
(US9487488, 9)
Show SMILES FC(F)(F)Oc1ccc(CN(c2ncc3ccccc3c2C2CC2)S(=O)(=O)c2ccc(nc2)-c2noc(=O)[nH]2)cc1
Show InChI InChI=1S/C27H20F3N5O5S/c28-27(29,30)39-19-9-5-16(6-10-19)15-35(25-23(17-7-8-17)21-4-2-1-3-18(21)13-32-25)41(37,38)20-11-12-22(31-14-20)24-33-26(36)40-34-24/h1-6,9-14,17H,7-8,15H2,(H,33,34,36)
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n/an/a 1.10n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...


US Patent US9487488 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM256307
PNG
(US9487488, 31)
Show SMILES FC(F)(F)c1ccc(CN(c2ncc3ccccc3c2C2CC2)S(=O)(=O)c2ccc(cc2)-c2noc(=O)[nH]2)nc1
Show InChI InChI=1S/C27H20F3N5O4S/c28-27(29,30)19-9-10-20(31-14-19)15-35(25-23(16-5-6-16)22-4-2-1-3-18(22)13-32-25)40(37,38)21-11-7-17(8-12-21)24-33-26(36)39-34-24/h1-4,7-14,16H,5-6,15H2,(H,33,34,36)
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n/an/a 1.10n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...


US Patent US9487488 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM256306
PNG
(US9487488, 30)
Show SMILES Cc1n[nH]c(n1)-c1ccc(cn1)S(=O)(=O)N(Cc1ccc(OC(F)(F)F)cc1)c1ncc2ccccc2c1C1CC1
Show InChI InChI=1S/C28H23F3N6O3S/c1-17-34-26(36-35-17)24-13-12-22(15-32-24)41(38,39)37(16-18-6-10-21(11-7-18)40-28(29,30)31)27-25(19-8-9-19)23-5-3-2-4-20(23)14-33-27/h2-7,10-15,19H,8-9,16H2,1H3,(H,34,35,36)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...


US Patent US9487488 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151748
PNG
(US8987445, 184)
Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1cc2c(F)cc(F)cc2s1)c1ncc2ccccc2c1C1CC1
Show InChI InChI=1S/C28H20F2N2O4S2/c29-19-11-24(30)23-13-20(37-25(23)12-19)15-32(38(35,36)21-9-7-17(8-10-21)28(33)34)27-26(16-5-6-16)22-4-2-1-3-18(22)14-31-27/h1-4,7-14,16H,5-6,15H2,(H,33,34)
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Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM256280
PNG
(US9487488, 4)
Show SMILES FC(F)(F)Oc1ccc(CN(c2ncc3ccccc3c2C2CC2)S(=O)(=O)c2ccc(cn2)-n2nn[nH]c2=O)cc1
Show InChI InChI=1S/C26H20F3N7O4S/c27-26(28,29)40-20-10-5-16(6-11-20)15-35(24-23(17-7-8-17)21-4-2-1-3-18(21)13-31-24)41(38,39)22-12-9-19(14-30-22)36-25(37)32-33-34-36/h1-6,9-14,17H,7-8,15H2,(H,32,34,37)
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n/an/a 1.10n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...


US Patent US9487488 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM256297
PNG
(US9487488, 21)
Show SMILES Cc1n[nH]c(n1)-c1ccc(cc1)S(=O)(=O)N(Cc1ccc(OC(F)(F)F)cc1)c1ncc2ccccc2c1C(F)(F)F
Show InChI InChI=1S/C27H19F6N5O3S/c1-16-35-24(37-36-16)18-8-12-21(13-9-18)42(39,40)38(15-17-6-10-20(11-7-17)41-27(31,32)33)25-23(26(28,29)30)22-5-3-2-4-19(22)14-34-25/h2-14H,15H2,1H3,(H,35,36,37)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...


US Patent US9487488 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151749
PNG
(US8987445, 185)
Show SMILES FC(F)(C1CC1)c1ccc(CN(c2ncc3ccccc3c2C2CC2)S(=O)(=O)c2ccc(cc2)C(=O)O[Na])cc1Cl
Show InChI InChI=1S/C30H25ClF2N2O4S.Na/c31-26-15-18(5-14-25(26)30(32,33)22-10-11-22)17-35(40(38,39)23-12-8-20(9-13-23)29(36)37)28-27(19-6-7-19)24-4-2-1-3-21(24)16-34-28;/h1-5,8-9,12-16,19,22H,6-7,10-11,17H2,(H,36,37);/q;+1/p-1
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n/an/a 1.20n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM256300
PNG
(US9487488, 24)
Show SMILES FC(F)(F)c1ccc(CN(c2ncc3ccccc3c2C2CC2)S(=O)(=O)c2ccc(cc2)-c2ncn[nH]2)nc1
Show InChI InChI=1S/C27H21F3N6O2S/c28-27(29,30)20-9-10-21(31-14-20)15-36(26-24(17-5-6-17)23-4-2-1-3-19(23)13-32-26)39(37,38)22-11-7-18(8-12-22)25-33-16-34-35-25/h1-4,7-14,16-17H,5-6,15H2,(H,33,34,35)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...


US Patent US9487488 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151758
PNG
(US8987445, 194)
Show SMILES Cc1c(ncc2ccccc12)N(Cc1cc2c(F)cc(F)cc2s1)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C26H18F2N2O4S2/c1-15-21-5-3-2-4-17(21)13-29-25(15)30(36(33,34)20-8-6-16(7-9-20)26(31)32)14-19-12-22-23(28)10-18(27)11-24(22)35-19/h2-13H,14H2,1H3,(H,31,32)
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Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151655
PNG
(US8987445, 61)
Show SMILES Cc1c(ncc2ccccc12)N(Cc1ccc2c(CCC2(C)C)c1)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C29H28N2O4S/c1-19-25-7-5-4-6-23(25)17-30-27(19)31(36(34,35)24-11-9-21(10-12-24)28(32)33)18-20-8-13-26-22(16-20)14-15-29(26,2)3/h4-13,16-17H,14-15,18H2,1-3H3,(H,32,33)
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Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM248583
PNG
(US9434711, 496)
Show SMILES Cc1c(sc2ccccc12)N(Cc1ccc(OC(F)(F)F)cc1)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H18F3NO5S2/c1-15-20-4-2-3-5-21(20)34-22(15)28(14-16-6-10-18(11-7-16)33-24(25,26)27)35(31,32)19-12-8-17(9-13-19)23(29)30/h2-13H,14H2,1H3,(H,29,30)
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n/an/a 1.40n/an/an/an/an/an/a



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
For functional expression of TRPM8, the full-length cDNA encoding human and rat TRPM8 are subcloned into pCI-NEO mammalian expression vectors. The ex...


US Patent US9434711 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM256315
PNG
(US9487488, 39)
Show SMILES COCc1cc(ccc1C(O)=O)S(=O)(=O)N(Cc1ccc(OC(F)(F)F)cc1)c1ncc2ccccc2c1C1CC1
Show InChI InChI=1S/C29H25F3N2O6S/c1-39-17-21-14-23(12-13-25(21)28(35)36)41(37,38)34(16-18-6-10-22(11-7-18)40-29(30,31)32)27-26(19-8-9-19)24-5-3-2-4-20(24)15-33-27/h2-7,10-15,19H,8-9,16-17H2,1H3,(H,35,36)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...


US Patent US9487488 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM256312
PNG
(US9487488, 36)
Show SMILES Cc1cc(ccc1C(O)=O)S(=O)(=O)N(Cc1ccc(OC(F)(F)F)cc1)c1ncc2ccccc2c1C1CC1
Show InChI InChI=1S/C28H23F3N2O5S/c1-17-14-22(12-13-23(17)27(34)35)39(36,37)33(16-18-6-10-21(11-7-18)38-28(29,30)31)26-25(19-8-9-19)24-5-3-2-4-20(24)15-32-26/h2-7,10-15,19H,8-9,16H2,1H3,(H,34,35)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...


US Patent US9487488 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151766
PNG
(US8987445, 202)
Show SMILES Cc1cc2ccccc2nc1N(Cc1ccc(c(Cl)c1)C(F)(F)C1CC1)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C28H23ClF2N2O4S/c1-17-14-20-4-2-3-5-25(20)32-26(17)33(38(36,37)22-11-7-19(8-12-22)27(34)35)16-18-6-13-23(24(29)15-18)28(30,31)21-9-10-21/h2-8,11-15,21H,9-10,16H2,1H3,(H,34,35)
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Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM256318
PNG
(US9487488, 42)
Show SMILES Cc1cc(cc(F)c1C(O)=O)S(=O)(=O)N(Cc1ccc(OC(F)(F)F)cc1)c1ncc2ccccc2c1C1CC1
Show InChI InChI=1S/C28H22F4N2O5S/c1-16-12-21(13-23(29)24(16)27(35)36)40(37,38)34(15-17-6-10-20(11-7-17)39-28(30,31)32)26-25(18-8-9-18)22-5-3-2-4-19(22)14-33-26/h2-7,10-14,18H,8-9,15H2,1H3,(H,35,36)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...


US Patent US9487488 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151767
PNG
(US8987445, 203)
Show SMILES Cc1c(ncc2ccccc12)N(Cc1ccc(c(F)c1)C(F)(F)C1CC1)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C28H23F3N2O4S/c1-17-23-5-3-2-4-20(23)15-32-26(17)33(38(36,37)22-11-7-19(8-12-22)27(34)35)16-18-6-13-24(25(29)14-18)28(30,31)21-9-10-21/h2-8,11-15,21H,9-10,16H2,1H3,(H,34,35)
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n/an/a 1.5n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM256292
PNG
(US9487488, 16)
Show SMILES FC(F)(F)Oc1ccc(CN(c2ncc3ccccc3c2C(F)(F)F)S(=O)(=O)c2ccc(nc2)-c2nnn[nH]2)cc1
Show InChI InChI=1S/C24H15F6N7O3S/c25-23(26,27)20-18-4-2-1-3-15(18)11-32-22(20)37(13-14-5-7-16(8-6-14)40-24(28,29)30)41(38,39)17-9-10-19(31-12-17)21-33-35-36-34-21/h1-12H,13H2,(H,33,34,35,36)
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n/an/a 1.60n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...


US Patent US9487488 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151799
PNG
(US8987445, 235)
Show SMILES Fc1cc(CN(c2ncc3ccccc3c2C(F)(F)F)S(=O)(=O)c2ccc(cc2)C(=O)O[Na])ccc1C(F)(F)C1CC1
Show InChI InChI=1S/C28H20F6N2O4S.Na/c29-23-13-16(5-12-22(23)27(30,31)19-8-9-19)15-36(41(39,40)20-10-6-17(7-11-20)26(37)38)25-24(28(32,33)34)21-4-2-1-3-18(21)14-35-25;/h1-7,10-14,19H,8-9,15H2,(H,37,38);/q;+1/p-1
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n/an/a 1.60n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151786
PNG
(US8987445, 222)
Show SMILES COC(C)(c1ccc(CN(c2ncc3ccccc3c2C)S(=O)(=O)c2ccc(cc2)C(O)=O)cc1Cl)C(F)(F)F
Show InChI InChI=1/C28H24ClF3N2O5S/c1-17-22-7-5-4-6-20(22)15-33-25(17)34(40(37,38)21-11-9-19(10-12-21)26(35)36)16-18-8-13-23(24(29)14-18)27(2,39-3)28(30,31)32/h4-15H,16H2,1-3H3,(H,35,36)
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n/an/a 1.60n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151785
PNG
(US8987445, 221)
Show SMILES COC(c1ccc(CN(c2ncc3ccccc3c2C)S(=O)(=O)c2ccc(cc2)C(O)=O)cc1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C28H22F6N2O5S/c1-17-23-6-4-3-5-20(23)15-35-24(17)36(42(39,40)22-13-9-19(10-14-22)25(37)38)16-18-7-11-21(12-8-18)26(41-2,27(29,30)31)28(32,33)34/h3-15H,16H2,1-2H3,(H,37,38)
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n/an/a 1.70n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151753
PNG
(US8987445, 189)
Show SMILES Cc1c(ncc2ccccc12)N(Cc1ccc(cc1)C(F)(F)C1CCC1)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C29H26F2N2O4S/c1-19-26-8-3-2-5-22(26)17-32-27(19)33(38(36,37)25-15-11-21(12-16-25)28(34)35)18-20-9-13-24(14-10-20)29(30,31)23-6-4-7-23/h2-3,5,8-17,23H,4,6-7,18H2,1H3,(H,34,35)
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n/an/a 1.70n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM256282
PNG
(US9487488, 6)
Show SMILES FC(F)(F)Oc1ccc(CN(c2ncc3ccccc3c2C2CC2)S(=O)(=O)c2ccc(nc2)-c2ncn[nH]2)cc1
Show InChI InChI=1S/C27H21F3N6O3S/c28-27(29,30)39-20-9-5-17(6-10-20)15-36(26-24(18-7-8-18)22-4-2-1-3-19(22)13-32-26)40(37,38)21-11-12-23(31-14-21)25-33-16-34-35-25/h1-6,9-14,16,18H,7-8,15H2,(H,33,34,35)
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n/an/a 1.70n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...


US Patent US9487488 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151636
PNG
(US8987445, 23)
Show SMILES Cc1c(ncc2ccccc12)N(Cc1ccc(cc1)C(C)(C)C)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C28H28N2O4S/c1-19-25-8-6-5-7-22(25)17-29-26(19)30(18-20-9-13-23(14-10-20)28(2,3)4)35(33,34)24-15-11-21(12-16-24)27(31)32/h5-17H,18H2,1-4H3,(H,31,32)
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n/an/a 1.80n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM248583
PNG
(US9434711, 496)
Show SMILES Cc1c(sc2ccccc12)N(Cc1ccc(OC(F)(F)F)cc1)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H18F3NO5S2/c1-15-20-4-2-3-5-21(20)34-22(15)28(14-16-6-10-18(11-7-16)33-24(25,26)27)35(31,32)19-12-8-17(9-13-19)23(29)30/h2-13H,14H2,1H3,(H,29,30)
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
For functional expression of TRPM8, the full-length cDNA encoding human and rat TRPM8 are subcloned into pCI-NEO mammalian expression vectors. The ex...


US Patent US9434711 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151630
PNG
(US8987445, 10)
Show SMILES Cc1c(nc(C2CC2)c2ccccc12)N(Cc1ccc(OC(F)(F)F)cc1)S(=O)(=O)c1ccc(cc1)C(=O)O[Na]
Show InChI InChI=1S/C28H23F3N2O5S.Na/c1-17-23-4-2-3-5-24(23)25(19-8-9-19)32-26(17)33(16-18-6-12-21(13-7-18)38-28(29,30)31)39(36,37)22-14-10-20(11-15-22)27(34)35;/h2-7,10-15,19H,8-9,16H2,1H3,(H,34,35);/q;+1/p-1
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n/an/a 1.90n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM256291
PNG
(US9487488, 15)
Show SMILES FC(F)(F)Oc1ccc(CN(c2ncc3ccccc3c2C(F)(F)F)S(=O)(=O)c2ccc(cc2)-c2nnn[nH]2)cc1
Show InChI InChI=1S/C25H16F6N6O3S/c26-24(27,28)21-20-4-2-1-3-17(20)13-32-23(21)37(14-15-5-9-18(10-6-15)40-25(29,30)31)41(38,39)19-11-7-16(8-12-19)22-33-35-36-34-22/h1-13H,14H2,(H,33,34,35,36)
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n/an/a 2n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...


US Patent US9487488 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151678
PNG
(US8987445, 106)
Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccc(OC(F)(F)F)cc1)c1ncc2ccccc2c1C(F)(F)F
Show InChI InChI=1S/C25H16F6N2O5S/c26-24(27,28)21-20-4-2-1-3-17(20)13-32-22(21)33(14-15-5-9-18(10-6-15)38-25(29,30)31)39(36,37)19-11-7-16(8-12-19)23(34)35/h1-13H,14H2,(H,34,35)
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n/an/a 2n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
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