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Compile Data Set for Download or QSAR

Found 872 hits Enz. Inhib. hit(s) with Target = 'Transient receptor potential cation channel subfamily M member 8'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM50335157
PNG
(3-[7-Trifluoromethyl-5-(2-trifluoromethyl-phenyl)-...)
Show SMILES FC(F)(F)c1ccccc1-c1cc(c2[nH]c(nc2c1)C1=NOC2(C1)CCCCC2)C(F)(F)F
Show InChI InChI=1S/C23H19F6N3O/c24-22(25,26)15-7-3-2-6-14(15)13-10-16(23(27,28)29)19-17(11-13)30-20(31-19)18-12-21(33-32-18)8-4-1-5-9-21/h2-3,6-7,10-11H,1,4-5,8-9,12H2,(H,30,31)
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n/an/a 0.413n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human TRPM8 expressed in HEK293 cells assessed as inhibition of cold-induced channel current by whole cell electrophysiology


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151765
PNG
(US8987445, 201)
Show SMILES Cc1c(ncc2ccccc12)N(Cc1ccc(c(Cl)c1)C(F)(F)C1CC1)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C28H23ClF2N2O4S/c1-17-23-5-3-2-4-20(23)15-32-26(17)33(38(36,37)22-11-7-19(8-12-22)27(34)35)16-18-6-13-24(25(29)14-18)28(30,31)21-9-10-21/h2-8,11-15,21H,9-10,16H2,1H3,(H,34,35)
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n/an/a 0.600n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151774
PNG
(US8987445, 210)
Show SMILES Fc1cc(CN(c2ncc3ccccc3c2C2CC2)S(=O)(=O)c2ccc(cc2)C(=O)O[Na])ccc1C(F)(F)C1CC1
Show InChI InChI=1S/C30H25F3N2O4S.Na/c31-26-15-18(5-14-25(26)30(32,33)22-10-11-22)17-35(40(38,39)23-12-8-20(9-13-23)29(36)37)28-27(19-6-7-19)24-4-2-1-3-21(24)16-34-28;/h1-5,8-9,12-16,19,22H,6-7,10-11,17H2,(H,36,37);/q;+1/p-1
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n/an/a 0.800n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151797
PNG
(US8987445, 233)
Show SMILES FC(F)(F)c1c(ncc2ccccc12)N(Cc1ccc(c(Cl)c1)C(F)(F)C1CC1)S(=O)(=O)c1ccc(cc1)C(=O)O[Na]
Show InChI InChI=1S/C28H20ClF5N2O4S.Na/c29-23-13-16(5-12-22(23)27(30,31)19-8-9-19)15-36(41(39,40)20-10-6-17(7-11-20)26(37)38)25-24(28(32,33)34)21-4-2-1-3-18(21)14-35-25;/h1-7,10-14,19H,8-9,15H2,(H,37,38);/q;+1/p-1
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n/an/a 0.900n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151677
PNG
(US8987445, 104)
Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccc(OC(F)(F)F)cc1)c1ncc2ccccc2c1C1CC1
Show InChI InChI=1S/C27H21F3N2O5S/c28-27(29,30)37-21-11-5-17(6-12-21)16-32(38(35,36)22-13-9-19(10-14-22)26(33)34)25-24(18-7-8-18)23-4-2-1-3-20(23)15-31-25/h1-6,9-15,18H,7-8,16H2,(H,33,34)
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n/an/a 0.900n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM50036542
PNG
(CHEMBL3353600)
Show SMILES CC(C)(C)c1ccc(CN(c2ncc(cc2Cl)C(F)(F)F)S(=O)(=O)c2ccc(cc2)C(O)=O)cc1
Show InChI InChI=1S/C24H22ClF3N2O4S/c1-23(2,3)17-8-4-15(5-9-17)14-30(21-20(25)12-18(13-29-21)24(26,27)28)35(33,34)19-10-6-16(7-11-19)22(31)32/h4-13H,14H2,1-3H3,(H,31,32)
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PubMed
n/an/a 0.960n/an/an/an/an/an/a



RaQualia Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influx


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151773
PNG
(US8987445, 209)
Show SMILES Cc1c(ncc2ccccc12)N(Cc1ccc(cc1)C(F)(F)C1(C)CC1)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C29H26F2N2O4S/c1-19-25-6-4-3-5-22(25)17-32-26(19)33(38(36,37)24-13-9-21(10-14-24)27(34)35)18-20-7-11-23(12-8-20)29(30,31)28(2)15-16-28/h3-14,17H,15-16,18H2,1-2H3,(H,34,35)
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n/an/a 1n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151745
PNG
(US8987445, 181)
Show SMILES Cc1c(nc(C2CC2)c2ccccc12)N(Cc1ccc(c(Cl)c1)C(F)(F)C1CC1)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C31H27ClF2N2O4S/c1-18-24-4-2-3-5-25(24)28(20-7-8-20)35-29(18)36(41(39,40)23-13-9-21(10-14-23)30(37)38)17-19-6-15-26(27(32)16-19)31(33,34)22-11-12-22/h2-6,9-10,13-16,20,22H,7-8,11-12,17H2,1H3,(H,37,38)
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n/an/a 1n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151748
PNG
(US8987445, 184)
Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1cc2c(F)cc(F)cc2s1)c1ncc2ccccc2c1C1CC1
Show InChI InChI=1S/C28H20F2N2O4S2/c29-19-11-24(30)23-13-20(37-25(23)12-19)15-32(38(35,36)21-9-7-17(8-10-21)28(33)34)27-26(16-5-6-16)22-4-2-1-3-18(22)14-31-27/h1-4,7-14,16H,5-6,15H2,(H,33,34)
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n/an/a 1.10n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151749
PNG
(US8987445, 185)
Show SMILES FC(F)(C1CC1)c1ccc(CN(c2ncc3ccccc3c2C2CC2)S(=O)(=O)c2ccc(cc2)C(=O)O[Na])cc1Cl
Show InChI InChI=1S/C30H25ClF2N2O4S.Na/c31-26-15-18(5-14-25(26)30(32,33)22-10-11-22)17-35(40(38,39)23-12-8-20(9-13-23)29(36)37)28-27(19-6-7-19)24-4-2-1-3-21(24)16-34-28;/h1-5,8-9,12-16,19,22H,6-7,10-11,17H2,(H,36,37);/q;+1/p-1
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n/an/a 1.20n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151655
PNG
(US8987445, 61)
Show SMILES Cc1c(ncc2ccccc12)N(Cc1ccc2c(CCC2(C)C)c1)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C29H28N2O4S/c1-19-25-7-5-4-6-23(25)17-30-27(19)31(36(34,35)24-11-9-21(10-12-24)28(32)33)18-20-8-13-26-22(16-20)14-15-29(26,2)3/h4-13,16-17H,14-15,18H2,1-3H3,(H,32,33)
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n/an/a 1.30n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151758
PNG
(US8987445, 194)
Show SMILES Cc1c(ncc2ccccc12)N(Cc1cc2c(F)cc(F)cc2s1)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C26H18F2N2O4S2/c1-15-21-5-3-2-4-17(21)13-29-25(15)30(36(33,34)20-8-6-16(7-9-20)26(31)32)14-19-12-22-23(28)10-18(27)11-24(22)35-19/h2-13H,14H2,1H3,(H,31,32)
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n/an/a 1.30n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM248583
PNG
(US9434711, 496)
Show SMILES Cc1c(sc2ccccc12)N(Cc1ccc(OC(F)(F)F)cc1)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H18F3NO5S2/c1-15-20-4-2-3-5-21(20)34-22(15)28(14-16-6-10-18(11-7-16)33-24(25,26)27)35(31,32)19-12-8-17(9-13-19)23(29)30/h2-13H,14H2,1H3,(H,29,30)
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n/an/a 1.40n/an/an/an/an/an/a



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
For functional expression of TRPM8, the full-length cDNA encoding human and rat TRPM8 are subcloned into pCI-NEO mammalian expression vectors. The ex...


US Patent US9434711 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151766
PNG
(US8987445, 202)
Show SMILES Cc1cc2ccccc2nc1N(Cc1ccc(c(Cl)c1)C(F)(F)C1CC1)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C28H23ClF2N2O4S/c1-17-14-20-4-2-3-5-25(20)32-26(17)33(38(36,37)22-11-7-19(8-12-22)27(34)35)16-18-6-13-23(24(29)15-18)28(30,31)21-9-10-21/h2-8,11-15,21H,9-10,16H2,1H3,(H,34,35)
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n/an/a 1.40n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151767
PNG
(US8987445, 203)
Show SMILES Cc1c(ncc2ccccc12)N(Cc1ccc(c(F)c1)C(F)(F)C1CC1)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C28H23F3N2O4S/c1-17-23-5-3-2-4-20(23)15-32-26(17)33(38(36,37)22-11-7-19(8-12-22)27(34)35)16-18-6-13-24(25(29)14-18)28(30,31)21-9-10-21/h2-8,11-15,21H,9-10,16H2,1H3,(H,34,35)
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n/an/a 1.5n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151799
PNG
(US8987445, 235)
Show SMILES Fc1cc(CN(c2ncc3ccccc3c2C(F)(F)F)S(=O)(=O)c2ccc(cc2)C(=O)O[Na])ccc1C(F)(F)C1CC1
Show InChI InChI=1S/C28H20F6N2O4S.Na/c29-23-13-16(5-12-22(23)27(30,31)19-8-9-19)15-36(41(39,40)20-10-6-17(7-11-20)26(37)38)25-24(28(32,33)34)21-4-2-1-3-18(21)14-35-25;/h1-7,10-14,19H,8-9,15H2,(H,37,38);/q;+1/p-1
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n/an/a 1.60n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151786
PNG
(US8987445, 222)
Show SMILES COC(C)(c1ccc(CN(c2ncc3ccccc3c2C)S(=O)(=O)c2ccc(cc2)C(O)=O)cc1Cl)C(F)(F)F
Show InChI InChI=1/C28H24ClF3N2O5S/c1-17-22-7-5-4-6-20(22)15-33-25(17)34(40(37,38)21-11-9-19(10-12-21)26(35)36)16-18-8-13-23(24(29)14-18)27(2,39-3)28(30,31)32/h4-15H,16H2,1-3H3,(H,35,36)
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n/an/a 1.60n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151753
PNG
(US8987445, 189)
Show SMILES Cc1c(ncc2ccccc12)N(Cc1ccc(cc1)C(F)(F)C1CCC1)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C29H26F2N2O4S/c1-19-26-8-3-2-5-22(26)17-32-27(19)33(38(36,37)25-15-11-21(12-16-25)28(34)35)18-20-9-13-24(14-10-20)29(30,31)23-6-4-7-23/h2-3,5,8-17,23H,4,6-7,18H2,1H3,(H,34,35)
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n/an/a 1.70n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151785
PNG
(US8987445, 221)
Show SMILES COC(c1ccc(CN(c2ncc3ccccc3c2C)S(=O)(=O)c2ccc(cc2)C(O)=O)cc1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C28H22F6N2O5S/c1-17-23-6-4-3-5-20(23)15-35-24(17)36(42(39,40)22-13-9-19(10-14-22)25(37)38)16-18-7-11-21(12-8-18)26(41-2,27(29,30)31)28(32,33)34/h3-15H,16H2,1-2H3,(H,37,38)
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n/an/a 1.70n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151636
PNG
(US8987445, 23)
Show SMILES Cc1c(ncc2ccccc12)N(Cc1ccc(cc1)C(C)(C)C)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C28H28N2O4S/c1-19-25-8-6-5-7-22(25)17-29-26(19)30(18-20-9-13-23(14-10-20)28(2,3)4)35(33,34)24-15-11-21(12-16-24)27(31)32/h5-17H,18H2,1-4H3,(H,31,32)
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n/an/a 1.80n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM248583
PNG
(US9434711, 496)
Show SMILES Cc1c(sc2ccccc12)N(Cc1ccc(OC(F)(F)F)cc1)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H18F3NO5S2/c1-15-20-4-2-3-5-21(20)34-22(15)28(14-16-6-10-18(11-7-16)33-24(25,26)27)35(31,32)19-12-8-17(9-13-19)23(29)30/h2-13H,14H2,1H3,(H,29,30)
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n/an/a 1.80n/an/an/an/an/an/a



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
For functional expression of TRPM8, the full-length cDNA encoding human and rat TRPM8 are subcloned into pCI-NEO mammalian expression vectors. The ex...


US Patent US9434711 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151630
PNG
(US8987445, 10)
Show SMILES Cc1c(nc(C2CC2)c2ccccc12)N(Cc1ccc(OC(F)(F)F)cc1)S(=O)(=O)c1ccc(cc1)C(=O)O[Na]
Show InChI InChI=1S/C28H23F3N2O5S.Na/c1-17-23-4-2-3-5-24(23)25(19-8-9-19)32-26(17)33(16-18-6-12-21(13-7-18)38-28(29,30)31)39(36,37)22-14-10-20(11-15-22)27(34)35;/h2-7,10-15,19H,8-9,16H2,1H3,(H,34,35);/q;+1/p-1
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n/an/a 1.90n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151678
PNG
(US8987445, 106)
Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccc(OC(F)(F)F)cc1)c1ncc2ccccc2c1C(F)(F)F
Show InChI InChI=1S/C25H16F6N2O5S/c26-24(27,28)21-20-4-2-1-3-17(20)13-32-22(21)33(14-15-5-9-18(10-6-15)38-25(29,30)31)39(36,37)19-11-7-16(8-12-19)23(34)35/h1-13H,14H2,(H,34,35)
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n/an/a 2n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151743
PNG
(US8987445, 179)
Show SMILES Cc1c(ncc2ccccc12)N(C1CCc2cc(OC(F)(F)F)ccc12)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1/C27H21F3N2O5S/c1-16-22-5-3-2-4-19(22)15-31-25(16)32(38(35,36)21-10-6-17(7-11-21)26(33)34)24-13-8-18-14-20(9-12-23(18)24)37-27(28,29)30/h2-7,9-12,14-15,24H,8,13H2,1H3,(H,33,34)
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n/an/a 2.10n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151760
PNG
(US8987445, 196)
Show SMILES Cc1c(ncc2ccccc12)N(Cc1cc2c(Cl)cccc2s1)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C26H19ClN2O4S2/c1-16-21-6-3-2-5-18(21)14-28-25(16)29(15-19-13-22-23(27)7-4-8-24(22)34-19)35(32,33)20-11-9-17(10-12-20)26(30)31/h2-14H,15H2,1H3,(H,30,31)
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n/an/a 2.20n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151716
PNG
(US8987445, 151)
Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccc(OC(F)(F)F)cn1)c1ncc2ccccc2c1C1CC1
Show InChI InChI=1S/C26H20F3N3O5S/c27-26(28,29)37-20-10-9-19(30-14-20)15-32(38(35,36)21-11-7-17(8-12-21)25(33)34)24-23(16-5-6-16)22-4-2-1-3-18(22)13-31-24/h1-4,7-14,16H,5-6,15H2,(H,33,34)
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n/an/a 2.20n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151718
PNG
(US8987445, 154)
Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccc(OC(F)(F)F)cc1)c1ncc2ccccc2c1Br
Show InChI InChI=1S/C24H16BrF3N2O5S/c25-21-20-4-2-1-3-17(20)13-29-22(21)30(14-15-5-9-18(10-6-15)35-24(26,27)28)36(33,34)19-11-7-16(8-12-19)23(31)32/h1-13H,14H2,(H,31,32)
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n/an/a 2.30n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151643
PNG
(US8987445, 34)
Show SMILES COc1nc(N(Cc2ccc(OC(F)(F)F)cc2)S(=O)(=O)c2ccc(cc2)C(=O)O[Na])c(C)c2ccccc12
Show InChI InChI=1S/C26H21F3N2O6S.Na/c1-16-21-5-3-4-6-22(21)24(36-2)30-23(16)31(15-17-7-11-19(12-8-17)37-26(27,28)29)38(34,35)20-13-9-18(10-14-20)25(32)33;/h3-14H,15H2,1-2H3,(H,32,33);/q;+1/p-1
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n/an/a 2.5n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151783
PNG
(US8987445, 219)
Show SMILES COC(C)(c1ccc(CN(c2ncc3ccccc3c2C)S(=O)(=O)c2ccc(cc2)C(O)=O)cc1F)C(F)(F)F
Show InChI InChI=1/C28H24F4N2O5S/c1-17-22-7-5-4-6-20(22)15-33-25(17)34(40(37,38)21-11-9-19(10-12-21)26(35)36)16-18-8-13-23(24(29)14-18)27(2,39-3)28(30,31)32/h4-15H,16H2,1-3H3,(H,35,36)
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n/an/a 2.60n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151626
PNG
(US8987445, 2)
Show SMILES Cc1c(ncc2ccccc12)N(Cc1ccc(OC(F)(F)F)cc1)S(=O)(=O)c1ccc(cc1)C(=O)O[Na]
Show InChI InChI=1S/C25H19F3N2O5S.Na/c1-16-22-5-3-2-4-19(22)14-29-23(16)30(15-17-6-10-20(11-7-17)35-25(26,27)28)36(33,34)21-12-8-18(9-13-21)24(31)32;/h2-14H,15H2,1H3,(H,31,32);/q;+1/p-1
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n/an/a 2.70n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151789
PNG
(US8987445, 225)
Show SMILES CC(C)c1nc(N(Cc2ccc(OC(F)(F)F)cc2)S(=O)(=O)c2ccc(cc2)C(O)=O)c(C)c2ccccc12
Show InChI InChI=1S/C28H25F3N2O5S/c1-17(2)25-24-7-5-4-6-23(24)18(3)26(32-25)33(16-19-8-12-21(13-9-19)38-28(29,30)31)39(36,37)22-14-10-20(11-15-22)27(34)35/h4-15,17H,16H2,1-3H3,(H,34,35)
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n/an/a 2.80n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151734
PNG
(US8987445, 170)
Show SMILES Cc1c(ncc2ccccc12)N(Cc1ccc(CC2CC2)c(F)c1)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C28H25FN2O4S/c1-18-25-5-3-2-4-23(25)16-30-27(18)31(36(34,35)24-12-10-21(11-13-24)28(32)33)17-20-8-9-22(26(29)15-20)14-19-6-7-19/h2-5,8-13,15-16,19H,6-7,14,17H2,1H3,(H,32,33)
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n/an/a 2.90n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM50335157
PNG
(3-[7-Trifluoromethyl-5-(2-trifluoromethyl-phenyl)-...)
Show SMILES FC(F)(F)c1ccccc1-c1cc(c2[nH]c(nc2c1)C1=NOC2(C1)CCCCC2)C(F)(F)F
Show InChI InChI=1S/C23H19F6N3O/c24-22(25,26)15-7-3-2-6-14(15)13-10-16(23(27,28)29)19-17(11-13)30-20(31-19)18-12-21(33-32-18)8-4-1-5-9-21/h2-3,6-7,10-11H,1,4-5,8-9,12H2,(H,30,31)
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n/an/a 3n/an/an/an/an/an/a


TBA

Assay Description
Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation at 0.2 uM by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151768
PNG
(US8987445, 204)
Show SMILES Cc1cc2ccccc2nc1N(Cc1ccc(c(F)c1)C(F)(F)C1CC1)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C28H23F3N2O4S/c1-17-14-20-4-2-3-5-25(20)32-26(17)33(38(36,37)22-11-7-19(8-12-22)27(34)35)16-18-6-13-23(24(29)15-18)28(30,31)21-9-10-21/h2-8,11-15,21H,9-10,16H2,1H3,(H,34,35)
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n/an/a 3.10n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151702
PNG
(US8987445, 137)
Show SMILES Cc1cccc2cnc(N(Cc3ccc(OC(F)(F)F)cc3)S(=O)(=O)c3ccc(cc3)C(O)=O)c(C)c12
Show InChI InChI=1S/C26H21F3N2O5S/c1-16-4-3-5-20-14-30-24(17(2)23(16)20)31(15-18-6-10-21(11-7-18)36-26(27,28)29)37(34,35)22-12-8-19(9-13-22)25(32)33/h3-14H,15H2,1-2H3,(H,32,33)
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Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151644
PNG
(US8987445, 35)
Show SMILES FC(F)(F)Oc1ccc(CN(c2ncc3ccccc3c2Cl)S(=O)(=O)c2ccc(cc2)C(=O)O[Na])cc1
Show InChI InChI=1S/C24H16ClF3N2O5S.Na/c25-21-20-4-2-1-3-17(20)13-29-22(21)30(14-15-5-9-18(10-6-15)35-24(26,27)28)36(33,34)19-11-7-16(8-12-19)23(31)32;/h1-13H,14H2,(H,31,32);/q;+1/p-1
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Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151666
PNG
(US8987445, 84)
Show SMILES Cc1c(ncc2ccccc12)N(Cc1cc2ccccc2s1)S(=O)(=O)c1ccc(cc1)C(=O)O[Na]
Show InChI InChI=1S/C26H20N2O4S2.Na/c1-17-23-8-4-2-7-20(23)15-27-25(17)28(16-21-14-19-6-3-5-9-24(19)33-21)34(31,32)22-12-10-18(11-13-22)26(29)30;/h2-15H,16H2,1H3,(H,29,30);/q;+1/p-1
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Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM50036544
PNG
(CHEMBL3353601)
Show SMILES CC(C)(c1ccc(CN(c2ncc(cc2Cl)C(F)(F)F)S(=O)(=O)c2ccc(cc2)C(O)=O)cc1)C(F)(F)F
Show InChI InChI=1S/C24H19ClF6N2O4S/c1-22(2,24(29,30)31)16-7-3-14(4-8-16)13-33(20-19(25)11-17(12-32-20)23(26,27)28)38(36,37)18-9-5-15(6-10-18)21(34)35/h3-12H,13H2,1-2H3,(H,34,35)
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n/an/a 3.30n/an/an/an/an/an/a



RaQualia Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influx


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151787
PNG
(US8987445, 223)
Show SMILES COC1(CCc2cc(CN(c3ncc4ccccc4c3C)S(=O)(=O)c3ccc(cc3)C(O)=O)ccc12)C(F)(F)F
Show InChI InChI=1/C29H25F3N2O5S/c1-18-24-6-4-3-5-22(24)16-33-26(18)34(40(37,38)23-10-8-20(9-11-23)27(35)36)17-19-7-12-25-21(15-19)13-14-28(25,39-2)29(30,31)32/h3-12,15-16H,13-14,17H2,1-2H3,(H,35,36)
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Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151627
PNG
(US8987445, 4)
Show SMILES Cc1c(ncc2ccccc12)N(Cc1ccc(OC(F)(F)F)c(F)c1)S(=O)(=O)c1ccc(cc1)C(=O)O[Na]
Show InChI InChI=1S/C25H18F4N2O5S.Na/c1-15-20-5-3-2-4-18(20)13-30-23(15)31(37(34,35)19-9-7-17(8-10-19)24(32)33)14-16-6-11-22(21(26)12-16)36-25(27,28)29;/h2-13H,14H2,1H3,(H,32,33);/q;+1/p-1
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n/an/a 3.60n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151697
PNG
(US8987445, 132)
Show SMILES Cc1c(nc(C2CC2)c2ccccc12)N(Cc1ccc(F)c(c1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C28H22F4N2O4S/c1-16-21-4-2-3-5-22(21)25(18-7-8-18)33-26(16)34(15-17-6-13-24(29)23(14-17)28(30,31)32)39(37,38)20-11-9-19(10-12-20)27(35)36/h2-6,9-14,18H,7-8,15H2,1H3,(H,35,36)
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n/an/a 3.80n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151757
PNG
(US8987445, 193)
Show SMILES Cc1c(ncc2ccccc12)N(Cc1ccc(CC2(CC2)C(F)(F)F)cc1)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C29H25F3N2O4S/c1-19-25-5-3-2-4-23(25)17-33-26(19)34(39(37,38)24-12-10-22(11-13-24)27(35)36)18-21-8-6-20(7-9-21)16-28(14-15-28)29(30,31)32/h2-13,17H,14-16,18H2,1H3,(H,35,36)
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n/an/a 3.90n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151763
PNG
(US8987445, 199)
Show SMILES Cc1c(ncc2ccccc12)N(Cc1cc2cccc(Cl)c2s1)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C26H19ClN2O4S2/c1-16-22-7-3-2-5-19(22)14-28-25(16)29(15-20-13-18-6-4-8-23(27)24(18)34-20)35(32,33)21-11-9-17(10-12-21)26(30)31/h2-14H,15H2,1H3,(H,30,31)
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n/an/a 3.90n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151714
PNG
(US8987445, 149)
Show SMILES COc1c(ncc2ccccc12)N(Cc1ccc(OC(F)(F)F)cc1)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C25H19F3N2O6S/c1-35-22-21-5-3-2-4-18(21)14-29-23(22)30(15-16-6-10-19(11-7-16)36-25(26,27)28)37(33,34)20-12-8-17(9-13-20)24(31)32/h2-14H,15H2,1H3,(H,31,32)
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n/an/a 3.90n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM50426573
PNG
(CHEMBL2324349 | US9434711, 306)
Show SMILES Cc1c(sc2ccccc12)N(Cc1ccc(F)c(c1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H17F4NO4S2/c1-14-18-4-2-3-5-21(18)34-22(14)29(13-15-6-11-20(25)19(12-15)24(26,27)28)35(32,33)17-9-7-16(8-10-17)23(30)31/h2-12H,13H2,1H3,(H,30,31)
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n/an/a 4n/an/an/an/an/an/a



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
For functional expression of TRPM8, the full-length cDNA encoding human and rat TRPM8 are subcloned into pCI-NEO mammalian expression vectors. The ex...


US Patent US9434711 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM50331290
PNG
(CHEMBL1289953 | N-(3-aminopropyl)-2-(3-methylbenzy...)
Show SMILES Cc1cccc(COc2ccccc2C(=O)N(CCCN)Cc2cccs2)c1
Show InChI InChI=1S/C23H26N2O2S/c1-18-7-4-8-19(15-18)17-27-22-11-3-2-10-21(22)23(26)25(13-6-12-24)16-20-9-5-14-28-20/h2-5,7-11,14-15H,6,12-13,16-17,24H2,1H3
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n/an/a 4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of TRPM8 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM50426573
PNG
(CHEMBL2324349 | US9434711, 306)
Show SMILES Cc1c(sc2ccccc12)N(Cc1ccc(F)c(c1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H17F4NO4S2/c1-14-18-4-2-3-5-21(18)34-22(14)29(13-15-6-11-20(25)19(12-15)24(26,27)28)35(32,33)17-9-7-16(8-10-17)23(30)31/h2-12H,13H2,1H3,(H,30,31)
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n/an/a 4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of TRPM8 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50335157
PNG
(3-[7-Trifluoromethyl-5-(2-trifluoromethyl-phenyl)-...)
Show SMILES FC(F)(F)c1ccccc1-c1cc(c2[nH]c(nc2c1)C1=NOC2(C1)CCCCC2)C(F)(F)F
Show InChI InChI=1S/C23H19F6N3O/c24-22(25,26)15-7-3-2-6-14(15)13-10-16(23(27,28)29)19-17(11-13)30-20(31-19)18-12-21(33-32-18)8-4-1-5-9-21/h2-3,6-7,10-11H,1,4-5,8-9,12H2,(H,30,31)
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n/an/a 4n/an/an/an/an/an/a


TBA

Assay Description
Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation at 0.2 uM by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151746
PNG
(US8987445, 182)
Show SMILES Cc1cc2ccccc2nc1N(Cc1ccc(cc1)C(F)(F)C1CC1)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C28H24F2N2O4S/c1-18-16-21-4-2-3-5-25(21)31-26(18)32(37(35,36)24-14-8-20(9-15-24)27(33)34)17-19-6-10-22(11-7-19)28(29,30)23-12-13-23/h2-11,14-16,23H,12-13,17H2,1H3,(H,33,34)
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n/an/a 4n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151698
PNG
(US8987445, 133)
Show SMILES Cc1cc2cccc(Cl)c2nc1N(Cc1ccc(OC(F)(F)F)cc1)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C25H18ClF3N2O5S/c1-15-13-18-3-2-4-21(26)22(18)30-23(15)31(14-16-5-9-19(10-6-16)36-25(27,28)29)37(34,35)20-11-7-17(8-12-20)24(32)33/h2-13H,14H2,1H3,(H,32,33)
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n/an/a 4.30n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)

More data for this
Ligand-Target Pair
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