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Found 2701 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase BTK'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM206362
PNG
(US9260415, 113)
Show SMILES CN(CCOc1cccc(Nc2cc(cn(C)c2=O)-c2cc(F)cc(c2CO)-n2ncc3c4CCCCc4sc3c2=O)n1)C(=O)C=C
Show InChI InChI=1S/C34H33FN6O5S/c1-4-31(43)39(2)12-13-46-30-11-7-10-29(38-30)37-26-14-20(18-40(3)33(26)44)23-15-21(35)16-27(25(23)19-42)41-34(45)32-24(17-36-41)22-8-5-6-9-28(22)47-32/h4,7,10-11,14-18,42H,1,5-6,8-9,12-13,19H2,2-3H3,(H,37,38)
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0.146n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk, Kinase Assay that can be used to test Formula I compounds is as follows. A master mix minus B...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM206354
PNG
(US9260415, 105)
Show SMILES Cn1cc(cc(Nc2cccc(NCCNC(=O)C=C)n2)c1=O)-c1cc(F)cc(c1CO)-n1ncc2c3CCCCc3sc2c1=O
Show InChI InChI=1S/C33H32FN7O4S/c1-3-30(43)36-12-11-35-28-9-6-10-29(39-28)38-25-13-19(17-40(2)32(25)44)22-14-20(34)15-26(24(22)18-42)41-33(45)31-23(16-37-41)21-7-4-5-8-27(21)46-31/h3,6,9-10,13-17,42H,1,4-5,7-8,11-12,18H2,2H3,(H,36,43)(H2,35,38,39)
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0.248n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk, Kinase Assay that can be used to test Formula I compounds is as follows. A master mix minus B...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM50245852
PNG
(CHEMBL458333 | N3-(2,6-dimethylphenyl)-1-(3-methox...)
Show SMILES COC(C)(C)CCn1nc(Nc2c(C)cccc2C)c2cnc(Nc3ccc(OCCN4CCCC4)cc3)nc12
Show InChI InChI=1S/C31H41N7O2/c1-22-9-8-10-23(2)27(22)34-28-26-21-32-30(35-29(26)38(36-28)18-15-31(3,4)39-5)33-24-11-13-25(14-12-24)40-20-19-37-16-6-7-17-37/h8-14,21H,6-7,15-20H2,1-5H3,(H,34,36)(H,32,33,35)
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Similars

Article
PubMed
0.25n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of BTK (unknown origin)


Bioorg Med Chem Lett 18: 6352-6 (2008)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM206355
PNG
(US9260415, 106)
Show SMILES CC#CC(=O)NCCOc1cccc(Nc2cc(cn(C)c2=O)-c2cc(F)cc(c2CO)-n2ncc3c4CCCCc4sc3c2=O)n1
Show InChI InChI=1S/C34H31FN6O5S/c1-3-7-30(43)36-12-13-46-31-11-6-10-29(39-31)38-26-14-20(18-40(2)33(26)44)23-15-21(35)16-27(25(23)19-42)41-34(45)32-24(17-37-41)22-8-4-5-9-28(22)47-32/h6,10-11,14-18,42H,4-5,8-9,12-13,19H2,1-2H3,(H,36,43)(H,38,39)
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0.306n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk, Kinase Assay that can be used to test Formula I compounds is as follows. A master mix minus B...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM206360
PNG
(US9260415, 111)
Show SMILES CN(CCNC(=O)C=C)c1cccc(Nc2cc(cn(C)c2=O)-c2cc(F)cc(c2CO)-n2ncc3c4CCCCc4sc3c2=O)n1
Show InChI InChI=1S/C34H34FN7O4S/c1-4-31(44)36-12-13-40(2)30-11-7-10-29(39-30)38-26-14-20(18-41(3)33(26)45)23-15-21(35)16-27(25(23)19-43)42-34(46)32-24(17-37-42)22-8-5-6-9-28(22)47-32/h4,7,10-11,14-18,43H,1,5-6,8-9,12-13,19H2,2-3H3,(H,36,44)(H,38,39)
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0.494n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk, Kinase Assay that can be used to test Formula I compounds is as follows. A master mix minus B...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM206366
PNG
(US9260415, 117)
Show SMILES Cn1cc(cc(Nc2cccc(OCCNC(=O)C(=C)C#N)n2)c1=O)-c1cc(F)cc(c1CO)-n1ncc2c3CCCCc3sc2c1=O
Show InChI InChI=1S/C34H30FN7O5S/c1-19(15-36)32(44)37-10-11-47-30-9-5-8-29(40-30)39-26-12-20(17-41(2)33(26)45)23-13-21(35)14-27(25(23)18-43)42-34(46)31-24(16-38-42)22-6-3-4-7-28(22)48-31/h5,8-9,12-14,16-17,43H,1,3-4,6-7,10-11,18H2,2H3,(H,37,44)(H,39,40)
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0.576n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk, Kinase Assay that can be used to test Formula I compounds is as follows. A master mix minus B...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM206356
PNG
(US9260415, 107)
Show SMILES C[C@@H](COc1cccc(Nc2cc(cn(C)c2=O)-c2ccnc(N3CCn4c5CC(C)(C)Cc5cc4C3=O)c2CO)n1)NC(=O)C=C
Show InChI InChI=1/C35H39N7O5/c1-6-30(44)37-21(2)20-47-31-9-7-8-29(39-31)38-26-14-23(18-40(5)33(26)45)24-10-11-36-32(25(24)19-43)42-13-12-41-27(34(42)46)15-22-16-35(3,4)17-28(22)41/h6-11,14-15,18,21,43H,1,12-13,16-17,19-20H2,2-5H3,(H,37,44)(H,38,39)/t21-/s2
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0.612n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk, Kinase Assay that can be used to test Formula I compounds is as follows. A master mix minus B...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM206359
PNG
(US9260415, 110)
Show SMILES CN(CCNC(=O)C=C)c1cccc(Nc2cc(cn(C)c2=O)-c2ccnc(N3CCn4c5CC(C)(C)Cc5cc4C3=O)c2CO)n1
Show InChI InChI=1S/C35H40N8O4/c1-6-31(45)36-12-13-40(4)30-9-7-8-29(39-30)38-26-16-23(20-41(5)33(26)46)24-10-11-37-32(25(24)21-44)43-15-14-42-27(34(43)47)17-22-18-35(2,3)19-28(22)42/h6-11,16-17,20,44H,1,12-15,18-19,21H2,2-5H3,(H,36,45)(H,38,39)
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0.683n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk, Kinase Assay that can be used to test Formula I compounds is as follows. A master mix minus B...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM206350
PNG
(US9260415, 101)
Show SMILES Cn1cc(cc(Nc2cccc(OCCNC(=O)C=C)n2)c1=O)-c1ccnc(N2CCn3c4CC(C)(C)Cc4cc3C2=O)c1CO
Show InChI InChI=1S/C34H37N7O5/c1-5-29(43)35-11-14-46-30-8-6-7-28(38-30)37-25-15-22(19-39(4)32(25)44)23-9-10-36-31(24(23)20-42)41-13-12-40-26(33(41)45)16-21-17-34(2,3)18-27(21)40/h5-10,15-16,19,42H,1,11-14,17-18,20H2,2-4H3,(H,35,43)(H,37,38)
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0.792n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk, Kinase Assay that can be used to test Formula I compounds is as follows. A master mix minus B...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM206351
PNG
(US9260415, 102)
Show SMILES Cn1cc(cc(Nc2ccnc(n2)N2CCC(C2)C(=O)NCC#N)c1=O)-c1ccnc(N2CCn3c4CC(C)(C)Cc4cc3C2=O)c1CO
Show InChI InChI=1/C35H38N10O4/c1-35(2)16-22-15-27-33(49)45(13-12-44(27)28(22)17-35)30-25(20-46)24(4-8-37-30)23-14-26(32(48)42(3)18-23)40-29-5-9-39-34(41-29)43-11-6-21(19-43)31(47)38-10-7-36/h4-5,8-9,14-15,18,21,46H,6,10-13,16-17,19-20H2,1-3H3,(H,38,47)(H,39,40,41)
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0.864n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk, Kinase Assay that can be used to test Formula I compounds is as follows. A master mix minus B...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM206363
PNG
(US9260415, 114)
Show SMILES Cn1cc(cc(Nc2cccc(n2)N2CCC[C@@H](C2)NC(=O)C=C)c1=O)-c1ccnc(N2CCn3c4CC(C)(C)Cc4cc3C2=O)c1CO
Show InChI InChI=1/C37H42N8O4/c1-5-33(47)39-25-8-7-13-43(21-25)32-10-6-9-31(41-32)40-28-16-24(20-42(4)35(28)48)26-11-12-38-34(27(26)22-46)45-15-14-44-29(36(45)49)17-23-18-37(2,3)19-30(23)44/h5-6,9-12,16-17,20,25,46H,1,7-8,13-15,18-19,21-22H2,2-4H3,(H,39,47)(H,40,41)/t25-/s2
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0.888n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk, Kinase Assay that can be used to test Formula I compounds is as follows. A master mix minus B...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM206353
PNG
(US9260415, 104)
Show SMILES Cn1cc(cc(Nc2cccc(OCCNC(=O)C=C)n2)c1=O)-c1ccnc(c1CO)-n1ncc2cc(cc(F)c2c1=O)C(C)(C)C
Show InChI InChI=1S/C34H34FN7O5/c1-6-28(44)36-12-13-47-29-9-7-8-27(40-29)39-26-15-21(18-41(5)32(26)45)23-10-11-37-31(24(23)19-43)42-33(46)30-20(17-38-42)14-22(16-25(30)35)34(2,3)4/h6-11,14-18,43H,1,12-13,19H2,2-5H3,(H,36,44)(H,39,40)
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0.915n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk, Kinase Assay that can be used to test Formula I compounds is as follows. A master mix minus B...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM206367
PNG
(US9260415, 118)
Show SMILES Cn1cc(cc(Nc2cccc(OCCNC(=O)C(=C)C#N)n2)c1=O)-c1ccnc(N2CCn3c4CC(C)(C)Cc4cc3C2=O)c1CO
Show InChI InChI=1S/C35H36N8O5/c1-21(18-36)32(45)38-10-13-48-30-7-5-6-29(40-30)39-26-14-23(19-41(4)33(26)46)24-8-9-37-31(25(24)20-44)43-12-11-42-27(34(43)47)15-22-16-35(2,3)17-28(22)42/h5-9,14-15,19,44H,1,10-13,16-17,20H2,2-4H3,(H,38,45)(H,39,40)
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1.70n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk, Kinase Assay that can be used to test Formula I compounds is as follows. A master mix minus B...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM206361
PNG
(US9260415, 112)
Show SMILES CN(CCOc1cccc(Nc2cc(cn(C)c2=O)-c2ccnc(N3CCn4c5CC(C)(C)Cc5cc4C3=O)c2CO)n1)C(=O)C=C
Show InChI InChI=1S/C35H39N7O5/c1-6-31(44)39(4)14-15-47-30-9-7-8-29(38-30)37-26-16-23(20-40(5)33(26)45)24-10-11-36-32(25(24)21-43)42-13-12-41-27(34(42)46)17-22-18-35(2,3)19-28(22)41/h6-11,16-17,20,43H,1,12-15,18-19,21H2,2-5H3,(H,37,38)
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1.75n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk, Kinase Assay that can be used to test Formula I compounds is as follows. A master mix minus B...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM206364
PNG
(US9260415, 115)
Show SMILES Cn1cc(cc(Nc2cccc(n2)N2CCC[C@@H](C2)NC(=O)C=C)c1=O)-c1cc(F)cc(c1CO)-n1ncc2c3CCCCc3sc2c1=O
Show InChI InChI=1/C36H36FN7O4S/c1-3-33(46)39-23-8-7-13-43(19-23)32-12-6-11-31(41-32)40-28-14-21(18-42(2)35(28)47)25-15-22(37)16-29(27(25)20-45)44-36(48)34-26(17-38-44)24-9-4-5-10-30(24)49-34/h3,6,11-12,14-18,23,45H,1,4-5,7-10,13,19-20H2,2H3,(H,39,46)(H,40,41)/t23-/s2
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2.16n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk, Kinase Assay that can be used to test Formula I compounds is as follows. A master mix minus B...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM206365
PNG
(US9260415, 116)
Show SMILES CC#CC(=O)NCCOc1cccc(Nc2cc(cn(C)c2=O)-c2ccnc(N3CCn4c5CC(C)(C)Cc5cc4C3=O)c2CO)n1
Show InChI InChI=1S/C35H37N7O5/c1-5-7-30(44)36-12-15-47-31-9-6-8-29(39-31)38-26-16-23(20-40(4)33(26)45)24-10-11-37-32(25(24)21-43)42-14-13-41-27(34(42)46)17-22-18-35(2,3)19-28(22)41/h6,8-11,16-17,20,43H,12-15,18-19,21H2,1-4H3,(H,36,44)(H,38,39)
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2.37n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk, Kinase Assay that can be used to test Formula I compounds is as follows. A master mix minus B...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM206357
PNG
(US9260415, 108)
Show SMILES C[C@@H](COc1cccc(Nc2cc(cn(C)c2=O)-c2cc(F)cc(c2CO)-n2ncc3c4CCCCc4sc3c2=O)n1)NC(=O)C=C
Show InChI InChI=1/C34H33FN6O5S/c1-4-30(43)37-19(2)18-46-31-11-7-10-29(39-31)38-26-12-20(16-40(3)33(26)44)23-13-21(35)14-27(25(23)17-42)41-34(45)32-24(15-36-41)22-8-5-6-9-28(22)47-32/h4,7,10-16,19,42H,1,5-6,8-9,17-18H2,2-3H3,(H,37,43)(H,38,39)/t19-/s2
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2.57n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk, Kinase Assay that can be used to test Formula I compounds is as follows. A master mix minus B...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM206358
PNG
(US9260415, 109)
Show SMILES Cn1cc(cc(Nc2cccc(NCCNC(=O)C=C)n2)c1=O)-c1ccnc(N2CCn3c4CC(C)(C)Cc4cc3C2=O)c1CO
Show InChI InChI=1S/C34H38N8O4/c1-5-30(44)36-12-11-35-28-7-6-8-29(39-28)38-25-15-22(19-40(4)32(25)45)23-9-10-37-31(24(23)20-43)42-14-13-41-26(33(42)46)16-21-17-34(2,3)18-27(21)41/h5-10,15-16,19,43H,1,11-14,17-18,20H2,2-4H3,(H,36,44)(H2,35,38,39)
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4.33n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk, Kinase Assay that can be used to test Formula I compounds is as follows. A master mix minus B...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM209866
PNG
(PF-06651600)
Show SMILES C[C@H]1CC[C@H](CN1C(=O)C=C)Nc1ncnc2[nH]ccc12
Show InChI InChI=1/C15H19N5O/c1-3-13(21)20-8-11(5-4-10(20)2)19-15-12-6-7-16-14(12)17-9-18-15/h3,6-7,9-11H,1,4-5,8H2,2H3,(H2,16,17,18,19)/t10-,11+/s2
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62.3n/an/an/an/an/an/an/an/a



Pfizer Worldwide R&D



Assay Description
Assay buffer was 20 mM HEPES, pH 7.5, 10 mM MgCl2, 0.01% BSA, 1 mM DTT, 0.0005% Tween 20, and 2% DMSO. Inactivation kinetic reactions were performed ...


ACS Chem Biol 11: 3442-3451 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM50245904
PNG
(CHEMBL459044 | N-(2,6-dimethylphenyl)-4-(2-ethoxyp...)
Show SMILES CCOc1ccccc1Oc1nc(Nc2ccc(cc2)N2CCNCC2)ncc1C(=O)Nc1c(C)cccc1C
Show InChI InChI=1S/C31H34N6O3/c1-4-39-26-10-5-6-11-27(26)40-30-25(29(38)35-28-21(2)8-7-9-22(28)3)20-33-31(36-30)34-23-12-14-24(15-13-23)37-18-16-32-17-19-37/h5-15,20,32H,4,16-19H2,1-3H3,(H,35,38)(H,33,34,36)
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78n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of BTK (unknown origin)


Bioorg Med Chem Lett 18: 6352-6 (2008)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM50245853
PNG
(CHEMBL502156 | N3-(2,6-dimethylphenyl)-N6-(3-fluor...)
Show SMILES COC(C)(C)CCn1nc(Nc2c(C)cccc2C)c2cnc(Nc3ccc(OCCN4CCCC4)c(F)c3)nc12
Show InChI InChI=1S/C31H40FN7O2/c1-21-9-8-10-22(2)27(21)35-28-24-20-33-30(36-29(24)39(37-28)16-13-31(3,4)40-5)34-23-11-12-26(25(32)19-23)41-18-17-38-14-6-7-15-38/h8-12,19-20H,6-7,13-18H2,1-5H3,(H,35,37)(H,33,34,36)
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125n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of BTK (unknown origin)


Bioorg Med Chem Lett 18: 6352-6 (2008)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM50341519
PNG
((S)-3-(4-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl...)
Show SMILES CNc1cncc(n1)-c1c[nH]c(=O)c(NC(=O)c2ccc(cc2)N2CCC[C@H]2CN2CCCC2)c1
Show InChI InChI=1S/C26H31N7O2/c1-27-24-16-28-15-23(30-24)19-13-22(26(35)29-14-19)31-25(34)18-6-8-20(9-7-18)33-12-4-5-21(33)17-32-10-2-3-11-32/h6-9,13-16,21H,2-5,10-12,17H2,1H3,(H,27,30)(H,29,35)(H,31,34)/t21-/m0/s1
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>1.00E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of BTK


J Med Chem 54: 2341-50 (2011)

More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM165960
PNG
(US9688629, 204 | US9688629, 205 | US9688629, 206)
Show SMILES Cc1[nH]c2c(cc(F)c(-c3cccc4CCN(Cc34)C(=O)C=C)c2c1C)C(N)=O
Show InChI InChI=1S/C23H22FN3O2/c1-4-19(28)27-9-8-14-6-5-7-15(17(14)11-27)21-18(24)10-16(23(25)29)22-20(21)12(2)13(3)26-22/h4-7,10,26H,1,8-9,11H2,2-3H3,(H2,25,29)
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n/an/a 0.0400n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM165511
PNG
(US9688629, 167 | US9688629, 168)
Show SMILES Cc1[nH]c2c(cc(F)c(N3CC4CCN(C4C3)C(=O)C=C)c2c1C)C(N)=O
Show InChI InChI=1/C20H23FN4O2/c1-4-16(26)25-6-5-12-8-24(9-15(12)25)19-14(21)7-13(20(22)27)18-17(19)10(2)11(3)23-18/h4,7,12,15,23H,1,5-6,8-9H2,2-3H3,(H2,22,27)
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Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM165458
PNG
(US9688629, 136)
Show SMILES Cc1[nH]c2c(cc(F)c(N3CCC[C@@H](C3)NC(=O)C#CC3CC3)c2c1C)C(N)=O
Show InChI InChI=1/C22H25FN4O2/c1-12-13(2)25-20-16(22(24)29)10-17(23)21(19(12)20)27-9-3-4-15(11-27)26-18(28)8-7-14-5-6-14/h10,14-15,25H,3-6,9,11H2,1-2H3,(H2,24,29)(H,26,28)/t15-/s2
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Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM166569
PNG
(US9688629, 217 | US9688629, 218 | US9688629, 219)
Show SMILES Cc1[nH]c2c(cc(F)c(C3CCCN(C3)C(=O)C=C)c2c1C)C(N)=O
Show InChI InChI=1/C19H22FN3O2/c1-4-15(24)23-7-5-6-12(9-23)17-14(20)8-13(19(21)25)18-16(17)10(2)11(3)22-18/h4,8,12,22H,1,5-7,9H2,2-3H3,(H2,21,25)
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Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM255314
PNG
(US9481682, 63)
Show SMILES C[C@@H]1CC(=O)N2C[C@@H](CC[C@H]12)c1nc(-c2ccc(cc2)C(=O)Nc2cc(ccn2)C(F)(F)F)c2c(N)nccn12
Show InChI InChI=1/C28H26F3N7O2/c1-15-12-22(39)38-14-18(6-7-20(15)38)26-36-23(24-25(32)34-10-11-37(24)26)16-2-4-17(5-3-16)27(40)35-21-13-19(8-9-33-21)28(29,30)31/h2-5,8-11,13,15,18,20H,6-7,12,14H2,1H3,(H2,32,34)(H,33,35,40)/t15-,18-,20-/s2
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n/an/a 0.0580n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM165334
PNG
(US9688629, 128)
Show SMILES CCCC#CC(=O)N[C@H]1CCCN(C1)c1c(F)cc(C(N)=O)c2[nH]c(C)c(C)c12
Show InChI InChI=1/C22H27FN4O2/c1-4-5-6-9-18(28)26-15-8-7-10-27(12-15)21-17(23)11-16(22(24)29)20-19(21)13(2)14(3)25-20/h11,15,25H,4-5,7-8,10,12H2,1-3H3,(H2,24,29)(H,26,28)/t15-/s2
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Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM165330
PNG
(US9688629, 126)
Show SMILES CCC#CC(=O)N[C@H]1CCCN(C1)c1c(F)cc(C(N)=O)c2[nH]c(C)c(C)c12
Show InChI InChI=1/C21H25FN4O2/c1-4-5-8-17(27)25-14-7-6-9-26(11-14)20-16(22)10-15(21(23)28)19-18(20)12(2)13(3)24-19/h10,14,24H,4,6-7,9,11H2,1-3H3,(H2,23,28)(H,25,27)/t14-/s2
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Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM164877
PNG
(US9688629, 25)
Show SMILES CN(c1cccc(c1)-c1ccc(C(N)=O)c2[nH]c(C)c(C)c12)S(=O)(=O)C=C
Show InChI InChI=1S/C20H21N3O3S/c1-5-27(25,26)23(4)15-8-6-7-14(11-15)16-9-10-17(20(21)24)19-18(16)12(2)13(3)22-19/h5-11,22H,1H2,2-4H3,(H2,21,24)
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n/an/a 0.0700n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM255342
PNG
(US9481682, 92)
Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3cc(ccn3)C(F)(F)F)c12)[C@@H]1CC[C@H]2CCOC(=O)N2C1
Show InChI InChI=1/C27H24F3N7O3/c28-27(29,30)18-7-9-32-20(13-18)34-25(38)16-3-1-15(2-4-16)21-22-23(31)33-10-11-36(22)24(35-21)17-5-6-19-8-12-40-26(39)37(19)14-17/h1-4,7,9-11,13,17,19H,5-6,8,12,14H2,(H2,31,33)(H,32,34,38)/t17-,19+/s2
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM164805
PNG
(US9688629, 4)
Show SMILES Cc1[nH]c2c(ccc(-c3cccc(NS(=O)(=O)C=C)c3)c2c1C)C(N)=O
Show InChI InChI=1S/C19H19N3O3S/c1-4-26(24,25)22-14-7-5-6-13(10-14)15-8-9-16(19(20)23)18-17(15)11(2)12(3)21-18/h4-10,21-22H,1H2,2-3H3,(H2,20,23)
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Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM165523
PNG
(US9688629, 169 | US9688629, 170 | US9688629, 171 |...)
Show SMILES Cc1[nH]c2c(cc(F)c(-c3cccc4CN(CC(F)c34)C(=O)C=C)c2c1C)C(N)=O
Show InChI InChI=1/C23H21F2N3O2/c1-4-18(29)28-9-13-6-5-7-14(20(13)17(25)10-28)21-16(24)8-15(23(26)30)22-19(21)11(2)12(3)27-22/h4-8,17,27H,1,9-10H2,2-3H3,(H2,26,30)
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Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM255319
PNG
(US9481682, 68)
Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3cc(ccn3)C(F)(F)F)c12)[C@@H]1CC[C@H]2C[C@H](O)C(=O)N2C1
Show InChI InChI=1/C27H24F3N7O3/c28-27(29,30)17-7-8-32-20(11-17)34-25(39)15-3-1-14(2-4-15)21-22-23(31)33-9-10-36(22)24(35-21)16-5-6-18-12-19(38)26(40)37(18)13-16/h1-4,7-11,16,18-19,38H,5-6,12-13H2,(H2,31,33)(H,32,34,39)/t16-,18+,19+/s2
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM255263
PNG
(US9481682, 12)
Show SMILES Nc1nccn2c(nc(-c3ccc(cc3F)C(=O)Nc3cc(ccn3)C(F)(F)F)c12)[C@@H]1CC[C@H]2COC(=O)N2C1
Show InChI InChI=1/C26H21F4N7O3/c27-18-9-13(24(38)34-19-10-15(5-6-32-19)26(28,29)30)2-4-17(18)20-21-22(31)33-7-8-36(21)23(35-20)14-1-3-16-12-40-25(39)37(16)11-14/h2,4-10,14,16H,1,3,11-12H2,(H2,31,33)(H,32,34,38)/t14-,16+/s2
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM255316
PNG
(US9481682, 65)
Show SMILES C[C@H]1CC(=O)N2C[C@@H](CC[C@@H]12)c1nc(-c2ccc(cc2)C(=O)Nc2cc(ccn2)C(F)(F)F)c2c(N)nccn12
Show InChI InChI=1/C28H26F3N7O2/c1-15-12-22(39)38-14-18(6-7-20(15)38)26-36-23(24-25(32)34-10-11-37(24)26)16-2-4-17(5-3-16)27(40)35-21-13-19(8-9-33-21)28(29,30)31/h2-5,8-11,13,15,18,20H,6-7,12,14H2,1H3,(H2,32,34)(H,33,35,40)/t15-,18+,20-/s2
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM122415
PNG
(US8729078, I-25)
Show SMILES CN1CCn2nc(Nc3nn(cc3C(N)=O)-c3cccc(c3CO)-n3ncc4cc(cc(F)c4c3=O)C(C)(C)C)cc2C1
Show InChI InChI=1S/C30H32FN9O3/c1-30(2,3)18-10-17-13-33-40(29(43)26(17)22(31)11-18)24-7-5-6-23(21(24)16-41)39-15-20(27(32)42)28(36-39)34-25-12-19-14-37(4)8-9-38(19)35-25/h5-7,10-13,15,41H,8-9,14,16H2,1-4H3,(H2,32,42)(H,34,35,36)
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n/an/a 0.0900n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Plates assayed are 96-well polypropylene (Greiner) and 96-well 1.2 μm hydrophilic PVDF filter plates (Millipore). Concentrations reported here a...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM122417
PNG
(US8729078, I-27)
Show SMILES CC(C)(C)c1cc(F)c2c(cnn(-c3cccc(c3CO)-n3cc(C(N)=O)c(Nc4ccc(cc4)S(C)(=O)=O)n3)c2=O)c1
Show InChI InChI=1S/C30H29FN6O5S/c1-30(2,3)18-12-17-14-33-37(29(40)26(17)23(31)13-18)25-7-5-6-24(22(25)16-38)36-15-21(27(32)39)28(35-36)34-19-8-10-20(11-9-19)43(4,41)42/h5-15,38H,16H2,1-4H3,(H2,32,39)(H,34,35)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
Plates assayed are 96-well polypropylene (Greiner) and 96-well 1.2 μm hydrophilic PVDF filter plates (Millipore). Concentrations reported here a...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM164773
PNG
(US9688629, 173 | US9688629, 174)
Show SMILES CC#CC(=O)N1CCCC2CN(CC12)c1c(F)cc(C(N)=O)c2[nH]c(C)c(C)c12
Show InChI InChI=1/C22H25FN4O2/c1-4-6-18(28)27-8-5-7-14-10-26(11-17(14)27)21-16(23)9-15(22(24)29)20-19(21)12(2)13(3)25-20/h9,14,17,25H,5,7-8,10-11H2,1-3H3,(H2,24,29)
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Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM164717
PNG
(US9688629, 159 | US9688629, 160)
Show SMILES Cc1[nH]c2c(cc(F)c(N3CC4CCCN(C4C3)C(=O)C=C)c2c1C)C(N)=O
Show InChI InChI=1/C21H25FN4O2/c1-4-17(27)26-7-5-6-13-9-25(10-16(13)26)20-15(22)8-14(21(23)28)19-18(20)11(2)12(3)24-19/h4,8,13,16,24H,1,5-7,9-10H2,2-3H3,(H2,23,28)
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Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM165995
PNG
(US9688629, 207)
Show SMILES Cc1[nH]c2c(cc(F)c(-c3ccc4CCN(C(=O)C=C)c4c3)c2c1C)C(N)=O
Show InChI InChI=1S/C22H20FN3O2/c1-4-18(27)26-8-7-13-5-6-14(9-17(13)26)20-16(23)10-15(22(24)28)21-19(20)11(2)12(3)25-21/h4-6,9-10,25H,1,7-8H2,2-3H3,(H2,24,28)
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Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM164638
PNG
(BDBM166759 | US9688629, 123)
Show SMILES CC#CC(=O)N[C@H]1CCCN(C1)c1c(F)cc(C(N)=O)c2[nH]c(C)c(C)c12
Show InChI InChI=1/C20H23FN4O2/c1-4-6-16(26)24-13-7-5-8-25(10-13)19-15(21)9-14(20(22)27)18-17(19)11(2)12(3)23-18/h9,13,23H,5,7-8,10H2,1-3H3,(H2,22,27)(H,24,26)/t13-/s2
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Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM255334
PNG
(US9481682, 83)
Show SMILES CN1CC[C@@H]2CC[C@H](CN2C1=O)c1nc(-c2ccc(cc2)C(=O)Nc2cc(ccn2)C(F)(F)F)c2c(N)nccn12
Show InChI InChI=1/C28H27F3N8O2/c1-37-12-9-20-7-6-18(15-39(20)27(37)41)25-36-22(23-24(32)34-11-13-38(23)25)16-2-4-17(5-3-16)26(40)35-21-14-19(8-10-33-21)28(29,30)31/h2-5,8,10-11,13-14,18,20H,6-7,9,12,15H2,1H3,(H2,32,34)(H,33,35,40)/t18-,20+/s2
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM255295
PNG
(US9481682, 44)
Show SMILES Nc1nccn2c(nc(-c3ccc(cc3F)C(=O)Nc3cc(ccn3)C(F)(F)F)c12)[C@H]1CC[C@@H]2CCCC(=O)N2C1
Show InChI InChI=1/C28H25F4N7O2/c29-20-12-15(27(41)36-21-13-17(8-9-34-21)28(30,31)32)5-7-19(20)23-24-25(33)35-10-11-38(24)26(37-23)16-4-6-18-2-1-3-22(40)39(18)14-16/h5,7-13,16,18H,1-4,6,14H2,(H2,33,35)(H,34,36,41)/t16-,18-/s2
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM255282
PNG
(US9481682, 31)
Show SMILES C[C@H]1OC(=O)N2C[C@@H](CC[C@@H]12)c1nc(-c2ccc(cc2F)C(=O)Nc2cc(ccn2)C(F)(F)F)c2c(N)nccn12
Show InChI InChI=1/C27H23F4N7O3/c1-13-19-5-3-15(12-38(19)26(40)41-13)24-36-21(22-23(32)34-8-9-37(22)24)17-4-2-14(10-18(17)28)25(39)35-20-11-16(6-7-33-20)27(29,30)31/h2,4,6-11,13,15,19H,3,5,12H2,1H3,(H2,32,34)(H,33,35,39)/t13-,15-,19+/s2
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n/an/a 0.0960n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM255256
PNG
(US9481682, 4)
Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3cc(ccn3)C(F)(F)F)c12)[C@@H]1CC[C@H]2CCC(=O)N2C1
Show InChI InChI=1/C27H24F3N7O2/c28-27(29,30)18-9-10-32-20(13-18)34-26(39)16-3-1-15(2-4-16)22-23-24(31)33-11-12-36(23)25(35-22)17-5-6-19-7-8-21(38)37(19)14-17/h1-4,9-13,17,19H,5-8,14H2,(H2,31,33)(H,32,34,39)/t17-,19+/s2
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM259423
PNG
(US9512084, 22)
Show SMILES Cc1c(NC(=O)c2ccc(cc2F)C2CC2)cc(F)cc1-c1ncnc(N)c1OC[C@@H]1CCCN1C(=O)C=C
Show InChI InChI=1/C29H29F2N5O3/c1-3-25(37)36-10-4-5-20(36)14-39-27-26(33-15-34-28(27)32)22-12-19(30)13-24(16(22)2)35-29(38)21-9-8-18(11-23(21)31)17-6-7-17/h3,8-9,11-13,15,17,20H,1,4-7,10,14H2,2H3,(H,35,38)(H2,32,33,34)/t20-/s2
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n/an/a<0.100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM166831
PNG
(US9688629, 242)
Show SMILES Cc1[nH]c2c(cc(F)c(N3CCC[C@@H](C3)NC(=O)C#C)c2c1C)C(N)=O
Show InChI InChI=1/C19H21FN4O2/c1-4-15(25)23-12-6-5-7-24(9-12)18-14(20)8-13(19(21)26)17-16(18)10(2)11(3)22-17/h1,8,12,22H,5-7,9H2,2-3H3,(H2,21,26)(H,23,25)/t12-/s2
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Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM166785
PNG
(US9688629, 233)
Show SMILES Cc1[nH]c2c(cc(F)c(C3=CN(CCC3)C(=O)C=C)c2c1C)C(N)=O
Show InChI InChI=1S/C19H20FN3O2/c1-4-15(24)23-7-5-6-12(9-23)17-14(20)8-13(19(21)25)18-16(17)10(2)11(3)22-18/h4,8-9,22H,1,5-7H2,2-3H3,(H2,21,25)
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Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM164717
PNG
(US9688629, 159 | US9688629, 160)
Show SMILES Cc1[nH]c2c(cc(F)c(N3CC4CCCN(C4C3)C(=O)C=C)c2c1C)C(N)=O
Show InChI InChI=1/C21H25FN4O2/c1-4-17(27)26-7-5-6-13-9-25(10-16(13)26)20-15(22)8-14(21(23)28)19-18(20)11(2)12(3)24-19/h4,8,13,16,24H,1,5-7,9-10H2,2-3H3,(H2,23,28)
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Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


Citation and Details
More data for this
Ligand-Target Pair
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