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Compile Data Set for Download or QSAR

Found 6314 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK2'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232618
PNG
(US9346815, 164)
Show SMILES CN1CCN(CCCN2CCC(CC2)n2cc(NC(=O)c3c(N)nn4cccnc34)c(n2)-c2cc(Cl)ccc2OC(F)F)C1=O
Show InChI InChI=1S/C29H33ClF2N10O3/c1-38-14-15-40(29(38)44)10-3-9-39-12-6-19(7-13-39)42-17-21(24(36-42)20-16-18(30)4-5-22(20)45-28(31)32)35-27(43)23-25(33)37-41-11-2-8-34-26(23)41/h2,4-5,8,11,16-17,19,28H,3,6-7,9-10,12-15H2,1H3,(H2,33,37)(H,35,43)
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0.0600n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US9346815 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232751
PNG
(US9346815, 297)
Show SMILES N[C@H]1C[C@H](C1)n1cc(NC(=O)c2c(N)nn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1/C21H19ClF2N8O2/c22-10-2-3-15(34-21(23)24)13(6-10)17-14(9-32(29-17)12-7-11(25)8-12)28-20(33)16-18(26)30-31-5-1-4-27-19(16)31/h1-6,9,11-12,21H,7-8,25H2,(H2,26,30)(H,28,33)/t11-,12+
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0.0700n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US9346815 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232631
PNG
(US9346815, 177)
Show SMILES CS(=O)(=O)CCCN1CCC(CC1)n1cc(NC(=O)c2c(N)nn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C26H29ClF2N8O4S/c1-42(39,40)13-3-9-35-11-6-17(7-12-35)37-15-19(22(33-37)18-14-16(27)4-5-20(18)41-26(28)29)32-25(38)21-23(30)34-36-10-2-8-31-24(21)36/h2,4-5,8,10,14-15,17,26H,3,6-7,9,11-13H2,1H3,(H2,30,34)(H,32,38)
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0.0900n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US9346815 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232628
PNG
(US9346815, 174)
Show SMILES CC(C)CN1CCC(CC1)n1cc(NC(=O)c2c(N)nn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C26H29ClF2N8O2/c1-15(2)13-35-10-6-17(7-11-35)37-14-19(22(33-37)18-12-16(27)4-5-20(18)39-26(28)29)32-25(38)21-23(30)34-36-9-3-8-31-24(21)36/h3-5,8-9,12,14-15,17,26H,6-7,10-11,13H2,1-2H3,(H2,30,34)(H,32,38)
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0.0900n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US9346815 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM116315
PNG
(US8637526, 248)
Show SMILES Nc1ccn2ncc(C(=O)Nc3c[nH]nc3-c3cc(Cl)ccc3Cl)c2n1
Show InChI InChI=1S/C16H11Cl2N7O/c17-8-1-2-11(18)9(5-8)14-12(7-20-24-14)22-16(26)10-6-21-25-4-3-13(19)23-15(10)25/h1-7H,(H2,19,23)(H,20,24)(H,22,26)
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0.100n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
To determine the inhibition constants (Ki), compounds were diluted serially in DMSO and added to 50 kinase reactions containing 0.2 nM purified JAK2 ...


US Patent US8637526 (2014)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50355501
PNG
(INCB-018424 | RUXOLITINIB | RUXOLITINIB PHOSPHATE)
Show SMILES N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/m1/s1
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0.100n/an/an/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of human JAK2 (828-1132) expressed in baculovirus-infected Sf9 cells using EQEDEPEGDYFEWLE as substrate after 1 hr by HTRF assay


J Med Chem 56: 4521-36 (2013)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50355501
PNG
(INCB-018424 | RUXOLITINIB | RUXOLITINIB PHOSPHATE)
Show SMILES N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/m1/s1
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0.100n/an/an/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of JAK2 kinase domain using N-terminal 5-carboxyfluorescein-tagged Val-Ala-Leu-Val-Asp-Gly-Tyr-Phe-Arg-Leu-Thr-Thr as substrate after 30 m...


J Med Chem 55: 6176-93 (2012)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232720
PNG
(US9346815, 266)
Show SMILES Nc1nn2cccnc2c1C(=O)Nc1cn(CC(=O)N2CCC(CO)CC2)nc1-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C25H25ClF2N8O4/c26-15-2-3-18(40-25(27)28)16(10-15)21-17(31-24(39)20-22(29)33-36-7-1-6-30-23(20)36)11-35(32-21)12-19(38)34-8-4-14(13-37)5-9-34/h1-3,6-7,10-11,14,25,37H,4-5,8-9,12-13H2,(H2,29,33)(H,31,39)
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0.100n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US9346815 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50399014
PNG
(CHEMBL2178805)
Show SMILES Cc1ccc(Cl)cc1-c1nn(C)cc1NC(=O)c1cnn2ccc(N)nc12
Show InChI InChI=1S/C18H16ClN7O/c1-10-3-4-11(19)7-12(10)16-14(9-25(2)24-16)22-18(27)13-8-21-26-6-5-15(20)23-17(13)26/h3-9H,1-2H3,(H2,20,23)(H,22,27)
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0.100n/an/an/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of purified JAK2 incubated for 30 mins


J Med Chem 55: 10090-107 (2012)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232664
PNG
(US9346815, 210)
Show SMILES CCCCN(C)CC#Cc1nc(c(NC(=O)c2cnn3cccnc23)s1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C25H23ClF2N6O2S/c1-3-4-11-33(2)12-5-7-20-31-21(17-14-16(26)8-9-19(17)36-25(27)28)24(37-20)32-23(35)18-15-30-34-13-6-10-29-22(18)34/h6,8-10,13-15,25H,3-4,11-12H2,1-2H3,(H,32,35)
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0.100n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US9346815 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232602
PNG
(US9346815, 148)
Show SMILES CN(C)C(=O)CCCN1CCC(CC1)n1cc(NC(=O)c2c(N)nn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C28H32ClF2N9O3/c1-37(2)22(41)5-3-11-38-13-8-18(9-14-38)40-16-20(24(35-40)19-15-17(29)6-7-21(19)43-28(30)31)34-27(42)23-25(32)36-39-12-4-10-33-26(23)39/h4,6-7,10,12,15-16,18,28H,3,5,8-9,11,13-14H2,1-2H3,(H2,32,36)(H,34,42)
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0.100n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US9346815 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50399015
PNG
(CHEMBL2178804)
Show SMILES Cn1cc(NC(=O)c2cnn3ccc(N)nc23)c(n1)-c1cc(Cl)ccc1Cl
Show InChI InChI=1S/C17H13Cl2N7O/c1-25-8-13(15(24-25)10-6-9(18)2-3-12(10)19)22-17(27)11-7-21-26-5-4-14(20)23-16(11)26/h2-8H,1H3,(H2,20,23)(H,22,27)
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0.100n/an/an/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of purified JAK2 incubated for 30 mins


J Med Chem 55: 10090-107 (2012)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232744
PNG
(US9346815, 290)
Show SMILES Nc1nn2cccnc2c1C(=O)Nc1cn(CC(=O)N2CCOCC2)nc1-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C23H21ClF2N8O4/c24-13-2-3-16(38-23(25)26)14(10-13)19-15(11-33(30-19)12-17(35)32-6-8-37-9-7-32)29-22(36)18-20(27)31-34-5-1-4-28-21(18)34/h1-5,10-11,23H,6-9,12H2,(H2,27,31)(H,29,36)
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0.110n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US9346815 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232736
PNG
(US9346815, 282)
Show SMILES Nc1nn2cccnc2c1C(=O)Nc1cn(CC(=O)N2CCC(F)(F)C2)nc1-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C23H19ClF4N8O3/c24-12-2-3-15(39-22(25)26)13(8-12)18-14(9-35(32-18)10-16(37)34-7-4-23(27,28)11-34)31-21(38)17-19(29)33-36-6-1-5-30-20(17)36/h1-3,5-6,8-9,22H,4,7,10-11H2,(H2,29,33)(H,31,38)
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0.120n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US9346815 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232630
PNG
(US9346815, 176)
Show SMILES Nc1nn2cccnc2c1C(=O)Nc1cn(nc1-c1cc(Cl)ccc1OC(F)F)C1CCN(CCCO)CC1
Show InChI InChI=1S/C25H27ClF2N8O3/c26-15-3-4-19(39-25(27)28)17(13-15)21-18(14-36(32-21)16-5-10-34(11-6-16)8-2-12-37)31-24(38)20-22(29)33-35-9-1-7-30-23(20)35/h1,3-4,7,9,13-14,16,25,37H,2,5-6,8,10-12H2,(H2,29,33)(H,31,38)
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0.120n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US9346815 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232615
PNG
(US9346815, 161)
Show SMILES FC(F)Oc1ccc(Cl)cc1-c1nn(cc1NC(=O)c1cnn2cccnc12)C1CCN(CCCN2CCS(=O)(=O)CC2)CC1
Show InChI InChI=1S/C29H33ClF2N8O4S/c30-20-3-4-25(44-29(31)32)22(17-20)26-24(35-28(41)23-18-34-39-10-1-7-33-27(23)39)19-40(36-26)21-5-11-37(12-6-21)8-2-9-38-13-15-45(42,43)16-14-38/h1,3-4,7,10,17-19,21,29H,2,5-6,8-9,11-16H2,(H,35,41)
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0.130n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US9346815 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232627
PNG
(US9346815, 173)
Show SMILES CC(=O)N1CCC(CN2CCC(CC2)n2cc(NC(=O)c3c(N)nn4cccnc34)c(n2)-c2cc(Cl)ccc2OC(F)F)CC1
Show InChI InChI=1S/C30H34ClF2N9O3/c1-18(43)40-13-5-19(6-14-40)16-39-11-7-21(8-12-39)42-17-23(26(37-42)22-15-20(31)3-4-24(22)45-30(32)33)36-29(44)25-27(34)38-41-10-2-9-35-28(25)41/h2-4,9-10,15,17,19,21,30H,5-8,11-14,16H2,1H3,(H2,34,38)(H,36,44)
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0.130n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US9346815 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232725
PNG
(US9346815, 271)
Show SMILES Nc1nn2cccnc2c1C(=O)Nc1cn(CC(=O)N2CC[C@@H](O)C2)nc1-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1/C23H21ClF2N8O4/c24-12-2-3-16(38-23(25)26)14(8-12)19-15(10-33(30-19)11-17(36)32-7-4-13(35)9-32)29-22(37)18-20(27)31-34-6-1-5-28-21(18)34/h1-3,5-6,8,10,13,23,35H,4,7,9,11H2,(H2,27,31)(H,29,37)/t13-/s2
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0.130n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US9346815 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232511
PNG
(US9346815, 57)
Show SMILES Nc1nn2cccnc2c1C(=O)Nc1cn(CC(=O)N2C[C@@H]3CN(CC4CC4)C[C@@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1/C29H30ClF2N9O3/c30-19-4-5-22(44-29(31)32)20(8-19)25-21(35-28(43)24-26(33)37-41-7-1-6-34-27(24)41)14-40(36-25)15-23(42)39-12-17-10-38(9-16-2-3-16)11-18(17)13-39/h1,4-8,14,16-18,29H,2-3,9-13,15H2,(H2,33,37)(H,35,43)/t17-,18+
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0.130n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US9346815 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232600
PNG
(US9346815, 146)
Show SMILES Nc1nn2cccnc2c1C(=O)Nc1cn(nc1-c1cc(Cl)ccc1OC(F)F)C1CCN(CCCN2CCCC2=O)CC1
Show InChI InChI=1S/C29H32ClF2N9O3/c30-18-5-6-22(44-29(31)32)20(16-18)25-21(35-28(43)24-26(33)37-40-13-2-9-34-27(24)40)17-41(36-25)19-7-14-38(15-8-19)10-3-12-39-11-1-4-23(39)42/h2,5-6,9,13,16-17,19,29H,1,3-4,7-8,10-12,14-15H2,(H2,33,37)(H,35,43)
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0.130n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US9346815 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232629
PNG
(US9346815, 175)
Show SMILES CCOC(=O)CCCN1CCC(CC1)n1cc(NC(=O)c2c(N)nn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C28H31ClF2N8O4/c1-2-42-22(40)5-3-11-37-13-8-18(9-14-37)39-16-20(24(35-39)19-15-17(29)6-7-21(19)43-28(30)31)34-27(41)23-25(32)36-38-12-4-10-33-26(23)38/h4,6-7,10,12,15-16,18,28H,2-3,5,8-9,11,13-14H2,1H3,(H2,32,36)(H,34,41)
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0.130n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US9346815 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232601
PNG
(US9346815, 147)
Show SMILES Nc1nn2cccnc2c1C(=O)Nc1cn(nc1-c1cc(Cl)ccc1OC(F)F)C1CCN(CCCC(=O)N2CCOCC2)CC1
Show InChI InChI=1S/C30H34ClF2N9O4/c31-19-4-5-23(46-30(32)33)21(17-19)26-22(36-29(44)25-27(34)38-41-10-2-8-35-28(25)41)18-42(37-26)20-6-11-39(12-7-20)9-1-3-24(43)40-13-15-45-16-14-40/h2,4-5,8,10,17-18,20,30H,1,3,6-7,9,11-16H2,(H2,34,38)(H,36,44)
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0.140n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US9346815 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232619
PNG
(US9346815, 165)
Show SMILES NC(=O)CCN1CCC(CC1)n1cc(NC(=O)c2c(N)nn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C25H26ClF2N9O3/c26-14-2-3-18(40-25(27)28)16(12-14)21-17(32-24(39)20-22(30)34-36-8-1-7-31-23(20)36)13-37(33-21)15-4-9-35(10-5-15)11-6-19(29)38/h1-3,7-8,12-13,15,25H,4-6,9-11H2,(H2,29,38)(H2,30,34)(H,32,39)
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0.150n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US9346815 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232909
PNG
(US9346815, 455)
Show SMILES FC(F)Oc1ccc(Cl)cc1-c1nn(Cc2cn(nn2)C2CCN(CC2)C2CCOC2)cc1NC(=O)c1cnn2cccnc12
Show InChI InChI=1/C29H29ClF2N10O3/c30-18-2-3-25(45-29(31)32)22(12-18)26-24(35-28(43)23-13-34-41-8-1-7-33-27(23)41)16-40(37-26)14-19-15-42(38-36-19)20-4-9-39(10-5-20)21-6-11-44-17-21/h1-3,7-8,12-13,15-16,20-21,29H,4-6,9-11,14,17H2,(H,35,43)
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0.150n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US9346815 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232706
PNG
(US9346815, 252)
Show SMILES CN1C[C@H]2C[C@@H]1CN2C(=O)Cn1cc(NC(=O)c2c(N)nn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1/C25H24ClF2N9O3/c1-34-9-15-8-14(34)10-36(15)19(38)12-35-11-17(21(32-35)16-7-13(26)3-4-18(16)40-25(27)28)31-24(39)20-22(29)33-37-6-2-5-30-23(20)37/h2-7,11,14-15,25H,8-10,12H2,1H3,(H2,29,33)(H,31,39)/t14-,15-/s2
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0.150n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US9346815 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232626
PNG
(US9346815, 172)
Show SMILES CN1CCCC(CC1)n1cc(NC(=O)c2c(N)nn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1/C24H25ClF2N8O2/c1-33-9-2-4-15(7-11-33)35-13-17(20(31-35)16-12-14(25)5-6-18(16)37-24(26)27)30-23(36)19-21(28)32-34-10-3-8-29-22(19)34/h3,5-6,8,10,12-13,15,24H,2,4,7,9,11H2,1H3,(H2,28,32)(H,30,36)
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0.150n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US9346815 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232599
PNG
(US9346815, 145)
Show SMILES Nc1nn2cccnc2c1C(=O)Nc1cn(nc1-c1cc(Cl)ccc1OC(F)F)C1CCN(CCCNC(=O)c2ccccc2)CC1
Show InChI InChI=1S/C32H32ClF2N9O3/c33-21-8-9-25(47-32(34)35)23(18-21)27-24(39-31(46)26-28(36)41-43-15-5-12-37-29(26)43)19-44(40-27)22-10-16-42(17-11-22)14-4-13-38-30(45)20-6-2-1-3-7-20/h1-3,5-9,12,15,18-19,22,32H,4,10-11,13-14,16-17H2,(H2,36,41)(H,38,45)(H,39,46)
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0.160n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US9346815 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232625
PNG
(US9346815, 171)
Show SMILES Nc1nn2cccnc2c1C(=O)Nc1cn(nc1-c1cc(Cl)ccc1OC(F)F)C1CCCNCC1
Show InChI InChI=1/C23H23ClF2N8O2/c24-13-4-5-17(36-23(25)26)15(11-13)19-16(12-34(31-19)14-3-1-7-28-9-6-14)30-22(35)18-20(27)32-33-10-2-8-29-21(18)33/h2,4-5,8,10-12,14,23,28H,1,3,6-7,9H2,(H2,27,32)(H,30,35)
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0.170n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US9346815 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232604
PNG
(US9346815, 150)
Show SMILES CC(=O)NCCCN1CCC(CC1)n1cc(NC(=O)C(\C(N)=N)=C2\NC=CC=N2)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C27H32ClF2N9O3/c1-16(40)33-10-3-11-38-12-6-18(7-13-38)39-15-20(36-26(41)22(24(31)32)25-34-8-2-9-35-25)23(37-39)19-14-17(28)4-5-21(19)42-27(29)30/h2,4-5,8-9,14-15,18,27,34H,3,6-7,10-13H2,1H3,(H3,31,32)(H,33,40)(H,36,41)/b25-22-
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0.170n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US9346815 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232598
PNG
(US9346815, 144)
Show SMILES CC(=O)N1CCC(CC1)N1CCC(CC1)n1cc(NC(=O)c2c(N)nn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C29H32ClF2N9O3/c1-17(42)38-11-5-19(6-12-38)39-13-7-20(8-14-39)41-16-22(25(36-41)21-15-18(30)3-4-23(21)44-29(31)32)35-28(43)24-26(33)37-40-10-2-9-34-27(24)40/h2-4,9-10,15-16,19-20,29H,5-8,11-14H2,1H3,(H2,33,37)(H,35,43)
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0.170n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US9346815 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232576
PNG
(US9346815, 122)
Show SMILES CN(Cc1cccc(Br)c1)C1CCN(CC1)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C32H30BrClF2N8O3/c1-41(17-20-4-2-5-21(33)14-20)23-8-12-42(13-9-23)28(45)19-43-18-26(39-31(46)25-16-38-44-11-3-10-37-30(25)44)29(40-43)24-15-22(34)6-7-27(24)47-32(35)36/h2-7,10-11,14-16,18,23,32H,8-9,12-13,17,19H2,1H3,(H,39,46)
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0.170n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US9346815 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232616
PNG
(US9346815, 162)
Show SMILES NC(=O)CCCN1CCC(CC1)n1cc(NC(=O)c2c(N)nn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C26H28ClF2N9O3/c27-15-4-5-19(41-26(28)29)17(13-15)22-18(33-25(40)21-23(31)35-37-10-2-8-32-24(21)37)14-38(34-22)16-6-11-36(12-7-16)9-1-3-20(30)39/h2,4-5,8,10,13-14,16,26H,1,3,6-7,9,11-12H2,(H2,30,39)(H2,31,35)(H,33,40)
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0.180n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US9346815 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232597
PNG
(US9346815, 143)
Show SMILES Nc1nn2cccnc2c1C(=O)Nc1cn(nc1-c1cc(Cl)ccc1OC(F)F)C1CCN(CCCC(=O)N2CCCCC2)CC1
Show InChI InChI=1S/C31H36ClF2N9O3/c32-20-7-8-24(46-31(33)34)22(18-20)27-23(37-30(45)26-28(35)39-42-15-5-11-36-29(26)42)19-43(38-27)21-9-16-40(17-10-21)12-4-6-25(44)41-13-2-1-3-14-41/h5,7-8,11,15,18-19,21,31H,1-4,6,9-10,12-14,16-17H2,(H2,35,39)(H,37,45)
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0.180n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US9346815 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232730
PNG
(US9346815, 276)
Show SMILES OC1(CCN(CC1)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F)c1ccncc1
Show InChI InChI=1S/C29H25ClF2N8O4/c30-19-2-3-23(44-28(31)32)20(14-19)25-22(36-27(42)21-15-35-40-11-1-8-34-26(21)40)16-39(37-25)17-24(41)38-12-6-29(43,7-13-38)18-4-9-33-10-5-18/h1-5,8-11,14-16,28,43H,6-7,12-13,17H2,(H,36,42)
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0.180n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US9346815 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232621
PNG
(US9346815, 167)
Show SMILES Nc1nn2cccnc2c1C(=O)Nc1cn(nc1-c1cc(Cl)ccc1OC(F)F)C1CCN(CCCC(=O)NCc2ccccc2)CC1
Show InChI InChI=1S/C33H34ClF2N9O3/c34-22-9-10-26(48-33(35)36)24(18-22)29-25(40-32(47)28-30(37)42-44-15-5-13-38-31(28)44)20-45(41-29)23-11-16-43(17-12-23)14-4-8-27(46)39-19-21-6-2-1-3-7-21/h1-3,5-7,9-10,13,15,18,20,23,33H,4,8,11-12,14,16-17,19H2,(H2,37,42)(H,39,46)(H,40,47)
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0.180n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US9346815 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232754
PNG
(US9346815, 300)
Show SMILES CCN(Cc1ccnc(Cl)c1)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C27H22Cl2F2N8O3/c1-2-37(13-16-6-8-32-22(29)10-16)23(40)15-38-14-20(35-26(41)19-12-34-39-9-3-7-33-25(19)39)24(36-38)18-11-17(28)4-5-21(18)42-27(30)31/h3-12,14,27H,2,13,15H2,1H3,(H,35,41)
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0.180n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US9346815 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232638
PNG
(US9346815, 184)
Show SMILES CN1CCC(CC1)n1cc(NC(=O)c2c(N)nn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C23H23ClF2N8O2/c1-32-9-5-14(6-10-32)34-12-16(19(30-34)15-11-13(24)3-4-17(15)36-23(25)26)29-22(35)18-20(27)31-33-8-2-7-28-21(18)33/h2-4,7-8,11-12,14,23H,5-6,9-10H2,1H3,(H2,27,31)(H,29,35)
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0.180n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US9346815 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232752
PNG
(US9346815, 298)
Show SMILES CN[C@H]1C[C@H](C1)n1cc(NC(=O)c2c(N)nn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1/C22H21ClF2N8O2/c1-27-12-8-13(9-12)33-10-15(18(30-33)14-7-11(23)3-4-16(14)35-22(24)25)29-21(34)17-19(26)31-32-6-2-5-28-20(17)32/h2-7,10,12-13,22,27H,8-9H2,1H3,(H2,26,31)(H,29,34)/t12-,13+
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0.180n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US9346815 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232610
PNG
(US9346815, 156)
Show SMILES CCNC(=O)CCCN1CCC(CC1)n1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C28H31ClF2N8O3/c1-2-32-24(40)5-3-11-37-13-8-19(9-14-37)39-17-22(35-27(41)21-16-34-38-12-4-10-33-26(21)38)25(36-39)20-15-18(29)6-7-23(20)42-28(30)31/h4,6-7,10,12,15-17,19,28H,2-3,5,8-9,11,13-14H2,1H3,(H,32,40)(H,35,41)
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0.190n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US9346815 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232617
PNG
(US9346815, 163)
Show SMILES Nc1nn2cccnc2c1C(=O)Nc1cn(nc1-c1cc(Cl)ccc1OC(F)F)C1CCN(CCCN2CCNC2=O)CC1
Show InChI InChI=1S/C28H31ClF2N10O3/c29-17-3-4-21(44-27(30)31)19(15-17)23-20(35-26(42)22-24(32)37-40-11-1-7-33-25(22)40)16-41(36-23)18-5-12-38(13-6-18)9-2-10-39-14-8-34-28(39)43/h1,3-4,7,11,15-16,18,27H,2,5-6,8-10,12-14H2,(H2,32,37)(H,34,43)(H,35,42)
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0.190n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US9346815 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232606
PNG
(US9346815, 152)
Show SMILES FC(F)Oc1ccc(Cl)cc1-c1nn(cc1NC(=O)c1cnn2cccnc12)C1CCN(CCCC(=O)NC2CCOCC2)CC1
Show InChI InChI=1S/C31H35ClF2N8O4/c32-20-4-5-26(46-31(33)34)23(17-20)28-25(38-30(44)24-18-36-41-12-2-10-35-29(24)41)19-42(39-28)22-6-13-40(14-7-22)11-1-3-27(43)37-21-8-15-45-16-9-21/h2,4-5,10,12,17-19,21-22,31H,1,3,6-9,11,13-16H2,(H,37,43)(H,38,44)
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0.190n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US9346815 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232456
PNG
(US9346815, 2)
Show SMILES Nc1nn2cccnc2c1C(=O)Nc1cn(nc1-c1cc(Cl)ccc1OC(F)F)C1CCNCC1
Show InChI InChI=1S/C22H21ClF2N8O2/c23-12-2-3-16(35-22(24)25)14(10-12)18-15(11-33(30-18)13-4-7-27-8-5-13)29-21(34)17-19(26)31-32-9-1-6-28-20(17)32/h1-3,6,9-11,13,22,27H,4-5,7-8H2,(H2,26,31)(H,29,34)
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0.190n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US9346815 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232636
PNG
(US9346815, 182)
Show SMILES CN1CC[C@@H](C1)n1cc(NC(=O)c2c(N)nn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1/C22H21ClF2N8O2/c1-31-8-5-13(10-31)33-11-15(18(29-33)14-9-12(23)3-4-16(14)35-22(24)25)28-21(34)17-19(26)30-32-7-2-6-27-20(17)32/h2-4,6-7,9,11,13,22H,5,8,10H2,1H3,(H2,26,30)(H,28,34)/t13-/s2
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0.200n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US9346815 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232640
PNG
(US9346815, 186)
Show SMILES Nc1nn2cccnc2c1C(=O)Nc1cn(nc1-c1cc(Cl)ccc1OC(F)F)[C@H]1CCNC1
Show InChI InChI=1/C21H19ClF2N8O2/c22-11-2-3-15(34-21(23)24)13(8-11)17-14(10-32(29-17)12-4-6-26-9-12)28-20(33)16-18(25)30-31-7-1-5-27-19(16)31/h1-3,5,7-8,10,12,21,26H,4,6,9H2,(H2,25,30)(H,28,33)/t12-/s2
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0.200n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US9346815 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232724
PNG
(US9346815, 270)
Show SMILES Nc1nn2cccnc2c1C(=O)Nc1cn(CC(=O)N2CC[C@H](O)C2)nc1-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1/C23H21ClF2N8O4/c24-12-2-3-16(38-23(25)26)14(8-12)19-15(10-33(30-19)11-17(36)32-7-4-13(35)9-32)29-22(37)18-20(27)31-34-6-1-5-28-21(18)34/h1-3,5-6,8,10,13,23,35H,4,7,9,11H2,(H2,27,31)(H,29,37)/t13-/s2
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0.200n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US9346815 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232603
PNG
(US9346815, 149)
Show SMILES CNC(=O)CCCN1CCC(CC1)n1cc(NC(=O)c2c(N)nn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C27H30ClF2N9O3/c1-32-21(40)4-2-10-37-12-7-17(8-13-37)39-15-19(23(35-39)18-14-16(28)5-6-20(18)42-27(29)30)34-26(41)22-24(31)36-38-11-3-9-33-25(22)38/h3,5-6,9,11,14-15,17,27H,2,4,7-8,10,12-13H2,1H3,(H2,31,36)(H,32,40)(H,34,41)
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0.200n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US9346815 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232796
PNG
(US9346815, 342)
Show SMILES OC(=O)C1CCN(CC1)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C25H22ClF2N7O5/c26-15-2-3-19(40-25(27)28)16(10-15)21-18(31-23(37)17-11-30-35-7-1-6-29-22(17)35)12-34(32-21)13-20(36)33-8-4-14(5-9-33)24(38)39/h1-3,6-7,10-12,14,25H,4-5,8-9,13H2,(H,31,37)(H,38,39)
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0.200n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US9346815 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232781
PNG
(US9346815, 327)
Show SMILES Oc1cccc(CNCCn2cc(NC(=O)c3cnn4cccnc34)c(n2)-c2cc(Cl)ccc2OC(F)F)c1
Show InChI InChI=1S/C26H22ClF2N7O3/c27-17-5-6-22(39-26(28)29)19(12-17)23-21(33-25(38)20-14-32-36-9-2-7-31-24(20)36)15-35(34-23)10-8-30-13-16-3-1-4-18(37)11-16/h1-7,9,11-12,14-15,26,30,37H,8,10,13H2,(H,33,38)
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0.200n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US9346815 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232767
PNG
(US9346815, 313)
Show SMILES FC(F)Oc1ccc(Cl)cc1-c1nn(CCNCc2ccccc2)cc1NC(=O)c1cnn2cccnc12
Show InChI InChI=1S/C26H22ClF2N7O2/c27-18-7-8-22(38-26(28)29)19(13-18)23-21(33-25(37)20-15-32-36-11-4-9-31-24(20)36)16-35(34-23)12-10-30-14-17-5-2-1-3-6-17/h1-9,11,13,15-16,26,30H,10,12,14H2,(H,33,37)
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0.210n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US9346815 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232750
PNG
(US9346815, 296)
Show SMILES CN[C@@H]1CCC[C@@H](C1)n1cc(NC(=O)c2c(N)nn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1/C24H25ClF2N8O2/c1-29-14-4-2-5-15(11-14)35-12-17(20(32-35)16-10-13(25)6-7-18(16)37-24(26)27)31-23(36)19-21(28)33-34-9-3-8-30-22(19)34/h3,6-10,12,14-15,24,29H,2,4-5,11H2,1H3,(H2,28,33)(H,31,36)/t14-,15+/s2
PDB

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0.210n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US9346815 (2016)

More data for this
Ligand-Target Pair
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