BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1442 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase Kit (Kit)(D816V)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369302
PNG
(US10227357, Compound P-0616 | tert-butyl 4-[4-[4-[...)
Show SMILES CC(C)(C)OC(=O)N1CCC(=CC1)c1cc2ncnc(N3CCN(CC3)C(=O)NCc3ccc(F)cc3)c2s1
Show InChI InChI=1S/C28H33FN6O3S/c1-28(2,3)38-27(37)35-10-8-20(9-11-35)23-16-22-24(39-23)25(32-18-31-22)33-12-14-34(15-13-33)26(36)30-17-19-4-6-21(29)7-5-19/h4-8,16,18H,9-15,17H2,1-3H3,(H,30,36)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369305
PNG
(4-[6-(1,3-dimethylpyrazol-4-yl)thieno[3,2- d]pyrim...)
Show SMILES Cc1nn(C)cc1-c1cc2ncnc(N3CCN(CC3)C(=O)NCc3ccc(F)cc3)c2s1
Show InChI InChI=1S/C23H24FN7OS/c1-15-18(13-29(2)28-15)20-11-19-21(33-20)22(27-14-26-19)30-7-9-31(10-8-30)23(32)25-12-16-3-5-17(24)6-4-16/h3-6,11,13-14H,7-10,12H2,1-2H3,(H,25,32)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369306
PNG
(4-[6-(1,5-dimethylpyrazol-4-yl)thieno[3,2- d]pyrim...)
Show SMILES Cc1c(cnn1C)-c1cc2ncnc(N3CCN(CC3)C(=O)NCc3ccc(F)cc3)c2s1
Show InChI InChI=1S/C23H24FN7OS/c1-15-18(13-28-29(15)2)20-11-19-21(33-20)22(27-14-26-19)30-7-9-31(10-8-30)23(32)25-12-16-3-5-17(24)6-4-16/h3-6,11,13-14H,7-10,12H2,1-2H3,(H,25,32)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369309
PNG
(4-methyl-N-[4-(6-methylthieno[3,2- d]pyrimidin-4- ...)
Show SMILES Cc1cc2ncnc(-c3ccc(NS(=O)(=O)c4ccc(C)cc4)cc3)c2s1
Show InChI InChI=1S/C20H17N3O2S2/c1-13-3-9-17(10-4-13)27(24,25)23-16-7-5-15(6-8-16)19-20-18(21-12-22-19)11-14(2)26-20/h3-12,23H,1-2H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369310
PNG
(N-[(4-fluorophenyl)methyl]-4-[6-[1-(2- morpholinoe...)
Show SMILES Fc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3cc(sc23)-c2cnn(CCN3CCOCC3)c2)cc1
Show InChI InChI=1S/C27H31FN8O2S/c28-22-3-1-20(2-4-22)16-29-27(37)35-8-6-34(7-9-35)26-25-23(30-19-31-26)15-24(39-25)21-17-32-36(18-21)10-5-33-11-13-38-14-12-33/h1-4,15,17-19H,5-14,16H2,(H,29,37)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369319
PNG
(N-benzyl-4-[6-(4-fluorophenyl)thieno[3,2- d]pyrimi...)
Show SMILES Fc1ccc(cc1)-c1cc2ncnc(-c3ccc(cc3)S(=O)(=O)NCc3ccccc3)c2s1
Show InChI InChI=1S/C25H18FN3O2S2/c26-20-10-6-18(7-11-20)23-14-22-25(32-23)24(28-16-27-22)19-8-12-21(13-9-19)33(30,31)29-15-17-4-2-1-3-5-17/h1-14,16,29H,15H2
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369320
PNG
(N-[4-[6-(4-fluorophenyl)thieno[3,2- d]pyrimidin-4-...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1ncnc2cc(sc12)-c1ccc(F)cc1
Show InChI InChI=1S/C25H18FN3O2S2/c1-16-2-12-21(13-3-16)33(30,31)29-20-10-6-18(7-11-20)24-25-22(27-15-28-24)14-23(32-25)17-4-8-19(26)9-5-17/h2-15,29H,1H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369324
PNG
(N-(4-fluorophenyl)-4-thieno[3,2- d]pyrimidin-4-yl-...)
Show SMILES Fc1ccc(NC(=O)N2CCN(CC2)c2ncnc3ccsc23)cc1
Show InChI InChI=1S/C17H16FN5OS/c18-12-1-3-13(4-2-12)21-17(24)23-8-6-22(7-9-23)16-15-14(5-10-25-15)19-11-20-16/h1-5,10-11H,6-9H2,(H,21,24)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369325
PNG
(N-[(1S)-1-(3-chlorophenyl)ethyl]-2,2- dimethyl-4-(...)
Show SMILES C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(C)cc12)c1cccc(Cl)c1
Show InChI InChI=1/C22H27ClN6O/c1-14-10-18-19(26-14)24-13-25-20(18)28-8-9-29(22(3,4)12-28)21(30)27-15(2)16-6-5-7-17(23)11-16/h5-7,10-11,13,15H,8-9,12H2,1-4H3,(H,27,30)(H,24,25,26)/t15-/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369326
PNG
(N-[(1S)-1-(4-fluorophenyl)ethyl]-4-[6-(4- fluoroph...)
Show SMILES C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1/C27H28F2N6O/c1-17(18-4-8-20(28)9-5-18)32-26(36)35-13-12-34(15-27(35,2)3)25-22-14-23(33-24(22)30-16-31-25)19-6-10-21(29)11-7-19/h4-11,14,16-17H,12-13,15H2,1-3H3,(H,32,36)(H,30,31,33)/t17-/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369327
PNG
(N-[(1S)-1-(4-fluorophenypethyl]-4-[6-(2- methoxy-4...)
Show SMILES COc1cc(ccn1)-c1cc2c(ncnc2[nH]1)N1CCN(C(=O)N[C@@H](C)c2ccc(F)cc2)C(C)(C)C1
Show InChI InChI=1/C27H30FN7O2/c1-17(18-5-7-20(28)8-6-18)32-26(36)35-12-11-34(15-27(35,2)3)25-21-14-22(33-24(21)30-16-31-25)19-9-10-29-23(13-19)37-4/h5-10,13-14,16-17H,11-12,15H2,1-4H3,(H,32,36)(H,30,31,33)/t17-/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369331
PNG
((2R)-N-[(1S)-1-(3-chlorophenyl)ethyl]-2- methyl-4-...)
Show SMILES C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(C)cc12)c1cccc(Cl)c1
Show InChI InChI=1/C21H25ClN6O/c1-13-9-18-19(25-13)23-12-24-20(18)27-7-8-28(14(2)11-27)21(29)26-15(3)16-5-4-6-17(22)10-16/h4-6,9-10,12,14-15H,7-8,11H2,1-3H3,(H,26,29)(H,23,24,25)/t14-,15+/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369332
PNG
((2R)-N-[(1S)-1-[3- (difluoromethoxy)phenyl]ethyl]-...)
Show SMILES C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(C)cc12)c1cccc(OC(F)F)c1
Show InChI InChI=1/C22H26F2N6O2/c1-13-9-18-19(27-13)25-12-26-20(18)29-7-8-30(14(2)11-29)22(31)28-15(3)16-5-4-6-17(10-16)32-21(23)24/h4-6,9-10,12,14-15,21H,7-8,11H2,1-3H3,(H,28,31)(H,25,26,27)/t14-,15+/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369333
PNG
((2R)-N-[(1S)-1-(4-chloro-3-methoxy- phenyl)ethyl]-...)
Show SMILES COc1cc(ccc1Cl)[C@H](C)NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1
Show InChI InChI=1/C27H28ClFN6O2/c1-16-14-34(10-11-35(16)27(36)32-17(2)19-6-9-22(28)24(12-19)37-3)26-21-13-23(33-25(21)30-15-31-26)18-4-7-20(29)8-5-18/h4-9,12-13,15-17H,10-11,14H2,1-3H3,(H,32,36)(H,30,31,33)/t16-,17+/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369334
PNG
(N-[(1S)-1-(3-chlorophenyl)ethyl]-4-[6-(2- methoxy-...)
Show SMILES COc1cc(ccn1)-c1cc2c(ncnc2[nH]1)N1CCN(C(=O)N[C@@H](C)c2cccc(Cl)c2)C(C)(C)C1
Show InChI InChI=1/C27H30ClN7O2/c1-17(18-6-5-7-20(28)12-18)32-26(36)35-11-10-34(15-27(35,2)3)25-21-14-22(33-24(21)30-16-31-25)19-8-9-29-23(13-19)37-4/h5-9,12-14,16-17H,10-11,15H2,1-4H3,(H,32,36)(H,30,31,33)/t17-/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369335
PNG
(N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)cy...)
Show SMILES CCCc1ccc(cc1)S(=O)(=O)NC1CCC(=CC1)c1ncnc2[nH]c(C)cc12
Show InChI InChI=1/C22H26N4O2S/c1-3-4-16-5-11-19(12-6-16)29(27,28)26-18-9-7-17(8-10-18)21-20-13-15(2)25-22(20)24-14-23-21/h5-7,11-14,18,26H,3-4,8-10H2,1-2H3,(H,23,24,25)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369338
PNG
(N-[4-[6-(2-methoxy-4-pyridyl)-7H- pyrrolo[2,3-d]py...)
Show SMILES COc1cc(ccn1)-c1cc2c(ncnc2[nH]1)C1=CCC(CC1)NS(=O)(=O)c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1/C25H22F3N5O4S/c1-36-22-12-16(10-11-29-22)21-13-20-23(30-14-31-24(20)32-21)15-2-4-17(5-3-15)33-38(34,35)19-8-6-18(7-9-19)37-25(26,27)28/h2,6-14,17,33H,3-5H2,1H3,(H,30,31,32)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369343
PNG
(N-[1-[6-(1,3-dimethylpyrazol-4-yl)-7H- pyrrolo[2,3...)
Show SMILES Cc1nn(C)cc1-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C23H27N7O2S/c1-15-4-6-18(7-5-15)33(31,32)28-17-8-10-30(11-9-17)23-19-12-21(26-22(19)24-14-25-23)20-13-29(3)27-16(20)2/h4-7,12-14,17,28H,8-11H2,1-3H3,(H,24,25,26)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369344
PNG
(N-[1-[6-(2-methoxy-4-pyridyl)-7H- pyrrolo[2,3-d]py...)
Show SMILES COc1cc(ccn1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C24H26N6O3S/c1-16-3-5-19(6-4-16)34(31,32)29-18-8-11-30(12-9-18)24-20-14-21(28-23(20)26-15-27-24)17-7-10-25-22(13-17)33-2/h3-7,10,13-15,18,29H,8-9,11-12H2,1-2H3,(H,26,27,28)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369348
PNG
(N-[1-[6-(2,4-dimethylthiazol-5-yl)-7H- pyrrolo[2,3...)
Show SMILES Cc1nc(C)c(s1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C23H23F3N6O3S2/c1-13-20(36-14(2)29-13)19-11-18-21(30-19)27-12-28-22(18)32-9-7-15(8-10-32)31-37(33,34)17-5-3-16(4-6-17)35-23(24,25)26/h3-6,11-12,15,31H,7-10H2,1-2H3,(H,27,28,30)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369349
PNG
(5-ethyl-N-[1-[6-(1-methylpyrazol-4-yl)- 7H-pyrrolo...)
Show SMILES CCc1ccc(s1)S(=O)(=O)NC1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cnn(C)c1
Show InChI InChI=1S/C21H25N7O2S2/c1-3-16-4-5-19(31-16)32(29,30)26-15-6-8-28(9-7-15)21-17-10-18(14-11-24-27(2)12-14)25-20(17)22-13-23-21/h4-5,10-13,15,26H,3,6-9H2,1-2H3,(H,22,23,25)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369350
PNG
(4-chloro-N-[1-[6-(2-methoxy-4- pyridyl)-7H-pyrrolo...)
Show SMILES COc1cc(ccn1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H23ClN6O3S/c1-33-21-12-15(6-9-25-21)20-13-19-22(28-20)26-14-27-23(19)30-10-7-17(8-11-30)29-34(31,32)18-4-2-16(24)3-5-18/h2-6,9,12-14,17,29H,7-8,10-11H2,1H3,(H,26,27,28)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369351
PNG
(4-chloro-N-[1-[6-(1,3-dimethylpyrazol- 4-yl)-7H-py...)
Show SMILES Cc1nn(C)cc1-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H24ClN7O2S/c1-14-19(12-29(2)27-14)20-11-18-21(26-20)24-13-25-22(18)30-9-7-16(8-10-30)28-33(31,32)17-5-3-15(23)4-6-17/h3-6,11-13,16,28H,7-10H2,1-2H3,(H,24,25,26)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369352
PNG
(N-[1-[6-(1,3-dimethylpyrazol-4-yl)-7H- pyrrolo[2,3...)
Show SMILES Cc1nn(C)cc1-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C23H24F3N7O3S/c1-14-19(12-32(2)30-14)20-11-18-21(29-20)27-13-28-22(18)33-9-7-15(8-10-33)31-37(34,35)17-5-3-16(4-6-17)36-23(24,25)26/h3-6,11-13,15,31H,7-10H2,1-2H3,(H,27,28,29)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369353
PNG
(N-[1-[6-(cyclopenten-1-yl)-7H- pyrrolo[2,3-d]pyrim...)
Show SMILES FC(F)(F)Oc1ccc(cc1)S(=O)(=O)NC1CCN(CC1)c1ncnc2[nH]c(cc12)C1=CCCC1
Show InChI InChI=1S/C23H24F3N5O3S/c24-23(25,26)34-17-5-7-18(8-6-17)35(32,33)30-16-9-11-31(12-10-16)22-19-13-20(15-3-1-2-4-15)29-21(19)27-14-28-22/h3,5-8,13-14,16,30H,1-2,4,9-12H2,(H,27,28,29)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369355
PNG
(4-methyl-N-[3-methyl-1-[6-(1- methylpyrazol-4-yl)-...)
Show SMILES CC1CN(CCC1NS(=O)(=O)c1ccc(C)cc1)c1ncnc2[nH]c(cc12)-c1cnn(C)c1
Show InChI InChI=1/C23H27N7O2S/c1-15-4-6-18(7-5-15)33(31,32)28-20-8-9-30(12-16(20)2)23-19-10-21(17-11-26-29(3)13-17)27-22(19)24-14-25-23/h4-7,10-11,13-14,16,20,28H,8-9,12H2,1-3H3,(H,24,25,27)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369359
PNG
(4-ethyl-N-[1-[6-(1-methylpyrazol-4-yl)- 7H-pyrrolo...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)NC1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cnn(C)c1
Show InChI InChI=1S/C23H27N7O2S/c1-3-16-4-6-19(7-5-16)33(31,32)28-18-8-10-30(11-9-18)23-20-12-21(17-13-26-29(2)14-17)27-22(20)24-15-25-23/h4-7,12-15,18,28H,3,8-11H2,1-2H3,(H,24,25,27)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369362
PNG
(4-[6-(4-fluorophenyl)thieno[3,2- d]pyrimidin-4-yl]...)
Show SMILES CC(C)(NC(=O)N1CCC(=CC1)c1ncnc2cc(sc12)-c1ccc(F)cc1)c1ccccc1
Show InChI InChI=1S/C27H25FN4OS/c1-27(2,20-6-4-3-5-7-20)31-26(33)32-14-12-19(13-15-32)24-25-22(29-17-30-24)16-23(34-25)18-8-10-21(28)11-9-18/h3-12,16-17H,13-15H2,1-2H3,(H,31,33)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369363
PNG
(4-[6-(4,4-difluoro-1-piperidyl)thieno[3,2- d]pyrim...)
Show SMILES COc1cccc(c1)[C@H](C)NC(=O)N1CCN(CC1(C)C)c1ncnc2cc(sc12)N1CCC(F)(F)CC1
Show InChI InChI=1/C27H34F2N6O2S/c1-18(19-6-5-7-20(14-19)37-4)32-25(36)35-13-12-34(16-26(35,2)3)24-23-21(30-17-31-24)15-22(38-23)33-10-8-27(28,29)9-11-33/h5-7,14-15,17-18H,8-13,16H2,1-4H3,(H,32,36)/t18-/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369364
PNG
(US10227357, Compound P-0681 | ethyl 4-[4-[4-[[(1S)...)
Show SMILES CCOC(=O)N1CCN(CC1)c1cc2ncnc(N3CCN(C(=O)N[C@@H](C)c4cccc(OC)c4)C(C)(C)C3)c2s1
Show InChI InChI=1/C29H39N7O4S/c1-6-40-28(38)34-12-10-33(11-13-34)24-17-23-25(41-24)26(31-19-30-23)35-14-15-36(29(3,4)18-35)27(37)32-20(2)21-8-7-9-22(16-21)39-5/h7-9,16-17,19-20H,6,10-15,18H2,1-5H3,(H,32,37)/t20-/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369367
PNG
((2R)-N-[(1S)-1-(3-fluorophenyl)ethyl]-2- methyl-4-...)
Show SMILES C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(C)cc12)c1cccc(F)c1
Show InChI InChI=1/C21H25FN6O/c1-13-9-18-19(25-13)23-12-24-20(18)27-7-8-28(14(2)11-27)21(29)26-15(3)16-5-4-6-17(22)10-16/h4-6,9-10,12,14-15H,7-8,11H2,1-3H3,(H,26,29)(H,23,24,25)/t14-,15+/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369371
PNG
(4-[6-(4-cyanophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4...)
Show SMILES C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N)c1cccc(F)c1
Show InChI InChI=1/C28H28FN7O/c1-18(21-5-4-6-22(29)13-21)33-27(37)36-12-11-35(16-28(36,2)3)26-23-14-24(34-25(23)31-17-32-26)20-9-7-19(15-30)8-10-20/h4-10,13-14,17-18H,11-12,16H2,1-3H3,(H,33,37)(H,31,32,34)/t18-/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369372
PNG
(N-[(1S)-1-(3-chlorophenyl)ethyl]-4-[6-(4- cyanophe...)
Show SMILES C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N)c1cccc(Cl)c1
Show InChI InChI=1/C28H28ClN7O/c1-18(21-5-4-6-22(29)13-21)33-27(37)36-12-11-35(16-28(36,2)3)26-23-14-24(34-25(23)31-17-32-26)20-9-7-19(15-30)8-10-20/h4-10,13-14,17-18H,11-12,16H2,1-3H3,(H,33,37)(H,31,32,34)/t18-/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369373
PNG
((2R)-4-[6-(4-cyanophenyl)-7H-pyrrolo[2,3- d]pyrimi...)
Show SMILES C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N)c1ccc(F)cc1
Show InChI InChI=1/C27H26FN7O/c1-17-15-34(11-12-35(17)27(36)32-18(2)20-7-9-22(28)10-8-20)26-23-13-24(33-25(23)30-16-31-26)21-5-3-19(14-29)4-6-21/h3-10,13,16-18H,11-12,15H2,1-2H3,(H,32,36)(H,30,31,33)/t17-,18+/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369374
PNG
((2R)-N-[(1S)-1-(4-chlorophenyl)ethyl]-4-[6- (4-cya...)
Show SMILES C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N)c1ccc(Cl)cc1
Show InChI InChI=1/C27H26ClN7O/c1-17-15-34(11-12-35(17)27(36)32-18(2)20-7-9-22(28)10-8-20)26-23-13-24(33-25(23)30-16-31-26)21-5-3-19(14-29)4-6-21/h3-10,13,16-18H,11-12,15H2,1-2H3,(H,32,36)(H,30,31,33)/t17-,18+/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369375
PNG
((2R)-4-[6-(4-cyanophenyl)-7H-pyrrolo[2,3- d]pyrimi...)
Show SMILES COc1cccc(c1)[C@H](C)NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N
Show InChI InChI=1/C28H29N7O2/c1-18-16-34(11-12-35(18)28(36)32-19(2)22-5-4-6-23(13-22)37-3)27-24-14-25(33-26(24)30-17-31-27)21-9-7-20(15-29)8-10-21/h4-10,13-14,17-19H,11-12,16H2,1-3H3,(H,32,36)(H,30,31,33)/t18-,19+/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369376
PNG
((2R)-4-[6-(4-cyanophenyl)-7H-pyrrolo[2,3- d]pyrimi...)
Show SMILES C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N)c1cccc(F)c1
Show InChI InChI=1/C27H26FN7O/c1-17-15-34(10-11-35(17)27(36)32-18(2)21-4-3-5-22(28)12-21)26-23-13-24(33-25(23)30-16-31-26)20-8-6-19(14-29)7-9-20/h3-9,12-13,16-18H,10-11,15H2,1-2H3,(H,32,36)(H,30,31,33)/t17-,18+/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369377
PNG
((2R)-N-[(1S)-1-(3-chlorophenyl)ethyl]-4-[6- (4-cya...)
Show SMILES C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N)c1cccc(Cl)c1
Show InChI InChI=1/C27H26ClN7O/c1-17-15-34(10-11-35(17)27(36)32-18(2)21-4-3-5-22(28)12-21)26-23-13-24(33-25(23)30-16-31-26)20-8-6-19(14-29)7-9-20/h3-9,12-13,16-18H,10-11,15H2,1-2H3,(H,32,36)(H,30,31,33)/t17-,18+/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369378
PNG
((2R)-N-[(1S)-1-(4-fluorophenyl)ethyl]-4-[6- (2-met...)
Show SMILES COc1cc(ccn1)-c1cc2c(ncnc2[nH]1)N1CCN([C@H](C)C1)C(=O)N[C@@H](C)c1ccc(F)cc1
Show InChI InChI=1/C26H28FN7O2/c1-16-14-33(10-11-34(16)26(35)31-17(2)18-4-6-20(27)7-5-18)25-21-13-22(32-24(21)29-15-30-25)19-8-9-28-23(12-19)36-3/h4-9,12-13,15-17H,10-11,14H2,1-3H3,(H,31,35)(H,29,30,32)/t16-,17+/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369379
PNG
(4-[6-(4-cyanophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4...)
Show SMILES C[C@H](NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N)c1ccc(F)cc1
Show InChI InChI=1/C26H24FN7O/c1-17(19-6-8-21(27)9-7-19)31-26(35)34-12-10-33(11-13-34)25-22-14-23(32-24(22)29-16-30-25)20-4-2-18(15-28)3-5-20/h2-9,14,16-17H,10-13H2,1H3,(H,31,35)(H,29,30,32)/t17-/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369380
PNG
(N-[(1S)-1-(3-chlorophenyl)ethyl]-4-[6-(4- cyanophe...)
Show SMILES C[C@H](NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N)c1cccc(Cl)c1
Show InChI InChI=1/C26H24ClN7O/c1-17(20-3-2-4-21(27)13-20)31-26(35)34-11-9-33(10-12-34)25-22-14-23(32-24(22)29-16-30-25)19-7-5-18(15-28)6-8-19/h2-8,13-14,16-17H,9-12H2,1H3,(H,31,35)(H,29,30,32)/t17-/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369381
PNG
(4-[6-(4-cyanophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4...)
Show SMILES C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N)c1cccc(OC(F)F)c1
Show InChI InChI=1/C29H29F2N7O2/c1-18(21-5-4-6-22(13-21)40-27(30)31)35-28(39)38-12-11-37(16-29(38,2)3)26-23-14-24(36-25(23)33-17-34-26)20-9-7-19(15-32)8-10-20/h4-10,13-14,17-18,27H,11-12,16H2,1-3H3,(H,35,39)(H,33,34,36)/t18-/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369382
PNG
((2R)-4-[6-(4-cyanophenyl)-7H-pyrrolo[2,3- d]pyrimi...)
Show SMILES C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N)c1cccc(OC(F)F)c1
Show InChI InChI=1/C28H27F2N7O2/c1-17-15-36(10-11-37(17)28(38)34-18(2)21-4-3-5-22(12-21)39-27(29)30)26-23-13-24(35-25(23)32-16-33-26)20-8-6-19(14-31)7-9-20/h3-9,12-13,16-18,27H,10-11,15H2,1-2H3,(H,34,38)(H,32,33,35)/t17-,18+/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369383
PNG
(N-[(1S)-1-(4-chlorophenyl)ethyl]-4-[6-(4- fluoroph...)
Show SMILES C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1ccc(Cl)cc1
Show InChI InChI=1/C27H28ClFN6O/c1-17(18-4-8-20(28)9-5-18)32-26(36)35-13-12-34(15-27(35,2)3)25-22-14-23(33-24(22)30-16-31-25)19-6-10-21(29)11-7-19/h4-11,14,16-17H,12-13,15H2,1-3H3,(H,32,36)(H,30,31,33)/t17-/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369384
PNG
((2R)-N-[(1S)-1-(3-chlorophenyl)ethyl]-4-[6- (4-flu...)
Show SMILES C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1cccc(Cl)c1
Show InChI InChI=1/C26H26ClFN6O/c1-16-14-33(10-11-34(16)26(35)31-17(2)19-4-3-5-20(27)12-19)25-22-13-23(32-24(22)29-15-30-25)18-6-8-21(28)9-7-18/h3-9,12-13,15-17H,10-11,14H2,1-2H3,(H,31,35)(H,29,30,32)/t16-,17+/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369385
PNG
(N-[(1S)-1-(4-chlorophenyl)ethyl]-4-[6-(4- cyanophe...)
Show SMILES C[C@H](NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N)c1ccc(Cl)cc1
Show InChI InChI=1/C26H24ClN7O/c1-17(19-6-8-21(27)9-7-19)31-26(35)34-12-10-33(11-13-34)25-22-14-23(32-24(22)29-16-30-25)20-4-2-18(15-28)3-5-20/h2-9,14,16-17H,10-13H2,1H3,(H,31,35)(H,29,30,32)/t17-/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369386
PNG
(4-[6-(4-fluorophenyl)thieno[3,2- d]pyrimidin-4-yl]...)
Show SMILES CC(NC(=O)N1CCN(CC1)c1ncnc2cc(sc12)-c1ccc(F)cc1)c1ccc(C)s1
Show InChI InChI=1/C24H24FN5OS2/c1-15-3-8-20(32-15)16(2)28-24(31)30-11-9-29(10-12-30)23-22-19(26-14-27-23)13-21(33-22)17-4-6-18(25)7-5-17/h3-8,13-14,16H,9-12H2,1-2H3,(H,28,31)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369387
PNG
(5-[6-(1,3-dimethylpyrazol-4-yl)thieno[3,2- d]pyrim...)
Show SMILES C[C@@H](NC(=O)N1CC2CCC1CN2c1ncnc2cc(sc12)-c1cn(C)nc1C)c1ccc(F)cc1
Show InChI InChI=1/C26H28FN7OS/c1-15(17-4-6-18(27)7-5-17)30-26(35)34-12-19-8-9-20(34)11-33(19)25-24-22(28-14-29-25)10-23(36-24)21-13-32(3)31-16(21)2/h4-7,10,13-15,19-20H,8-9,11-12H2,1-3H3,(H,30,35)/t15-,19?,20?/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369388
PNG
(4-[6-(4-fluorophenyl)thieno[3,2- d]pyrimidin-4-yl]...)
Show SMILES Fc1ccc(cc1)-c1cc2ncnc(N3CCN(CC3)C(=O)NCc3cccs3)c2s1
Show InChI InChI=1S/C22H20FN5OS2/c23-16-5-3-15(4-6-16)19-12-18-20(31-19)21(26-14-25-18)27-7-9-28(10-8-27)22(29)24-13-17-2-1-11-30-17/h1-6,11-12,14H,7-10,13H2,(H,24,29)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369389
PNG
(N-[(1S)-1-(4-chlorophenyl)ethyl]-4-[6-(2- methoxy-...)
Show SMILES COc1cc(ccn1)-c1cc2c(ncnc2[nH]1)N1CCN(C(=O)N[C@@H](C)c2ccc(Cl)cc2)C(C)(C)C1
Show InChI InChI=1/C27H30ClN7O2/c1-17(18-5-7-20(28)8-6-18)32-26(36)35-12-11-34(15-27(35,2)3)25-21-14-22(33-24(21)30-16-31-25)19-9-10-29-23(13-19)37-4/h5-10,13-14,16-17H,11-12,15H2,1-4H3,(H,32,36)(H,30,31,33)/t17-/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 1442 total )  |  Next  |  Last  >>
Jump to: