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Compile Data Set for Download or QSAR

Found 316 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase Kit (Kit)(V560G/D816V)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175493
PNG
(US9688680, 93)
Show SMILES C[C@H](O)Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CC(C1)C(=O)NCc1ccc(C)cc1
Show InChI InChI=1/C24H27N7O2/c1-16-3-5-18(6-4-16)8-25-24(33)21-11-29(12-21)23-22-7-19(14-31(22)28-15-26-23)20-9-27-30(13-20)10-17(2)32/h3-7,9,13-15,17,21,32H,8,10-12H2,1-2H3,(H,25,33)/t17-/s2
PDB

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US Patent
n/an/a<10n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175667
PNG
(US9688680, 213)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2ccc(cc2)C2(O)CCOC2)cc1
Show InChI InChI=1/C28H29N5O3/c1-19-2-4-20(5-3-19)13-29-27(34)23-14-32(15-23)26-25-12-22(16-33(25)31-18-30-26)21-6-8-24(9-7-21)28(35)10-11-36-17-28/h2-9,12,16,18,23,35H,10-11,13-15,17H2,1H3,(H,29,34)
PDB

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US Patent
n/an/a<10n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175550
PNG
(US9688680, 108)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2ccc(cc2)C2(N)CC2)cc1
Show InChI InChI=1S/C27H28N6O/c1-18-2-4-19(5-3-18)13-29-26(34)22-14-32(15-22)25-24-12-21(16-33(24)31-17-30-25)20-6-8-23(9-7-20)27(28)10-11-27/h2-9,12,16-17,22H,10-11,13-15,28H2,1H3,(H,29,34)
PDB

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US Patent
n/an/a<10n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175559
PNG
(US9688680, 111)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2ccc(cc2)C(C)(C)N)cc1
Show InChI InChI=1S/C27H30N6O/c1-18-4-6-19(7-5-18)13-29-26(34)22-14-32(15-22)25-24-12-21(16-33(24)31-17-30-25)20-8-10-23(11-9-20)27(2,3)28/h4-12,16-17,22H,13-15,28H2,1-3H3,(H,29,34)
PDB

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US Patent
n/an/a<10n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175566
PNG
(US9688680, 117)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2ccc(cc2)C(C)(C)O)cc1
Show InChI InChI=1S/C27H29N5O2/c1-18-4-6-19(7-5-18)13-28-26(33)22-14-31(15-22)25-24-12-21(16-32(24)30-17-29-25)20-8-10-23(11-9-20)27(2,3)34/h4-12,16-17,22,34H,13-15H2,1-3H3,(H,28,33)
PDB

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US Patent
n/an/a<10n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175576
PNG
(US9688680, 125)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2ccc(cc2)C(O)CO)cc1
Show InChI InChI=1/C26H27N5O3/c1-17-2-4-18(5-3-17)11-27-26(34)22-12-30(13-22)25-23-10-21(14-31(23)29-16-28-25)19-6-8-20(9-7-19)24(33)15-32/h2-10,14,16,22,24,32-33H,11-13,15H2,1H3,(H,27,34)
PDB

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UniChem
US Patent
n/an/a<10n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175577
PNG
(US9688680, 126)
Show SMILES CCC(=O)N1CCC(=CC1)c1cc2c(ncnn2c1)N1CC(C1)C(=O)NCc1ccc(C)cc1
Show InChI InChI=1S/C26H30N6O2/c1-3-24(33)30-10-8-20(9-11-30)21-12-23-25(28-17-29-32(23)16-21)31-14-22(15-31)26(34)27-13-19-6-4-18(2)5-7-19/h4-8,12,16-17,22H,3,9-11,13-15H2,1-2H3,(H,27,34)
PDB

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UniChem
US Patent
n/an/a<10n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175223
PNG
(US9688680, 10)
Show SMILES C[C@H](NCC1CN(C1)c1ncnn2cc(cc12)-c1cnn(C)c1)c1ccc(C)cc1
Show InChI InChI=1/C23H27N7/c1-16-4-6-19(7-5-16)17(2)24-9-18-11-29(12-18)23-22-8-20(14-30(22)27-15-25-23)21-10-26-28(3)13-21/h4-8,10,13-15,17-18,24H,9,11-12H2,1-3H3/t17-/s2
PDB

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US Patent
n/an/a<10n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175447
PNG
(US9688680, 47)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2cnn(c2)C2CC2)cc1
Show InChI InChI=1S/C24H25N7O/c1-16-2-4-17(5-3-16)9-25-24(32)20-11-29(12-20)23-22-8-18(13-31(22)28-15-26-23)19-10-27-30(14-19)21-6-7-21/h2-5,8,10,13-15,20-21H,6-7,9,11-12H2,1H3,(H,25,32)
PDB

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PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175449
PNG
(US9688680, 49)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2cnn3CCCc23)cc1
Show InChI InChI=1S/C24H25N7O/c1-16-4-6-17(7-5-16)10-25-24(32)19-12-29(13-19)23-22-9-18(14-31(22)28-15-26-23)20-11-27-30-8-2-3-21(20)30/h4-7,9,11,14-15,19H,2-3,8,10,12-13H2,1H3,(H,25,32)
PDB

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US Patent
n/an/a<10n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175454
PNG
(US9688680, 54)
Show SMILES CC(C)n1cc(cn1)-c1cc2c(ncnn2c1)N1CC(C1)C(=O)NCc1ccc(C)cc1
Show InChI InChI=1S/C24H27N7O/c1-16(2)30-14-20(10-27-30)19-8-22-23(26-15-28-31(22)13-19)29-11-21(12-29)24(32)25-9-18-6-4-17(3)5-7-18/h4-8,10,13-16,21H,9,11-12H2,1-3H3,(H,25,32)
PDB

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PC sid
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US Patent
n/an/a<10n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175479
PNG
(US9688680, 79)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2cnn(c2)C2CCC2)cc1
Show InChI InChI=1S/C25H27N7O/c1-17-5-7-18(8-6-17)10-26-25(33)21-12-30(13-21)24-23-9-19(14-32(23)29-16-27-24)20-11-28-31(15-20)22-3-2-4-22/h5-9,11,14-16,21-22H,2-4,10,12-13H2,1H3,(H,26,33)
PDB

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n/an/a<10n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175485
PNG
(US9688680, 85)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2cnn(c2)C(C)(C)C)cc1
Show InChI InChI=1S/C25H29N7O/c1-17-5-7-18(8-6-17)10-26-24(33)21-12-30(13-21)23-22-9-19(14-31(22)29-16-27-23)20-11-28-32(15-20)25(2,3)4/h5-9,11,14-16,21H,10,12-13H2,1-4H3,(H,26,33)
PDB

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PC sid
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US Patent
n/an/a<10n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175678
PNG
(US9688680, 223)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2cnn(C[C@@H]3CNCCO3)c2)cc1
Show InChI InChI=1/C26H30N8O2/c1-18-2-4-19(5-3-18)9-28-26(35)22-12-32(13-22)25-24-8-20(15-34(24)31-17-29-25)21-10-30-33(14-21)16-23-11-27-6-7-36-23/h2-5,8,10,14-15,17,22-23,27H,6-7,9,11-13,16H2,1H3,(H,28,35)/t23-/s2
PDB

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US Patent
n/an/a<10n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175679
PNG
(US9688680, 224)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)C2=CCN(CC2)C(=O)C(C)(C)C)cc1
Show InChI InChI=1S/C28H34N6O2/c1-19-5-7-20(8-6-19)14-29-26(35)23-15-33(16-23)25-24-13-22(17-34(24)31-18-30-25)21-9-11-32(12-10-21)27(36)28(2,3)4/h5-9,13,17-18,23H,10-12,14-16H2,1-4H3,(H,29,35)
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175684
PNG
(US9688680, 229)
Show SMILES CC(C)OC(=O)N1CCC(=CC1)c1cc2c(ncnn2c1)N1CC(C1)C(=O)NCc1ccc(C)cc1
Show InChI InChI=1S/C27H32N6O3/c1-18(2)36-27(35)31-10-8-21(9-11-31)22-12-24-25(29-17-30-33(24)16-22)32-14-23(15-32)26(34)28-13-20-6-4-19(3)5-7-20/h4-8,12,16-18,23H,9-11,13-15H2,1-3H3,(H,28,34)
PDB

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n/an/a<10n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175707
PNG
(US9688680, 252)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2ccc(cc2)C(=O)N2CCCC2)cc1
Show InChI InChI=1S/C29H30N6O2/c1-20-4-6-21(7-5-20)15-30-28(36)25-16-34(17-25)27-26-14-24(18-35(26)32-19-31-27)22-8-10-23(11-9-22)29(37)33-12-2-3-13-33/h4-11,14,18-19,25H,2-3,12-13,15-17H2,1H3,(H,30,36)
PDB

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n/an/a<10n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175720
PNG
(US9688680, 265)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)C2=CCN(CC2)C(=O)N2CCCC2)cc1
Show InChI InChI=1S/C28H33N7O2/c1-20-4-6-21(7-5-20)15-29-27(36)24-16-34(17-24)26-25-14-23(18-35(25)31-19-30-26)22-8-12-33(13-9-22)28(37)32-10-2-3-11-32/h4-8,14,18-19,24H,2-3,9-13,15-17H2,1H3,(H,29,36)
PDB

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US Patent
n/an/a<10n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175722
PNG
(US9688680, 267)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)C2=CCN(CC2)C(=O)OC(C)(C)C)cc1
Show InChI InChI=1S/C28H34N6O3/c1-19-5-7-20(8-6-19)14-29-26(35)23-15-33(16-23)25-24-13-22(17-34(24)31-18-30-25)21-9-11-32(12-10-21)27(36)37-28(2,3)4/h5-9,13,17-18,23H,10-12,14-16H2,1-4H3,(H,29,35)
PDB

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PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175740
PNG
(US9688680, 285)
Show SMILES CC[C@H](NC(=O)C1CN(C1)c1ncnn2cc(cc12)-c1cnn(c1)[C@@H](C)[C@@H](C)O)c1ccc(Cl)cc1
Show InChI InChI=1/C26H30ClN7O2/c1-4-23(18-5-7-22(27)8-6-18)31-26(36)21-11-32(12-21)25-24-9-19(13-34(24)30-15-28-25)20-10-29-33(14-20)16(2)17(3)35/h5-10,13-17,21,23,35H,4,11-12H2,1-3H3,(H,31,36)/t16-,17+,23-/s2
PDB

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US Patent
n/an/a<10n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175742
PNG
(US9688680, 287)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2ccc(cc2)C(C)(O)C(F)(F)F)cc1
Show InChI InChI=1/C27H26F3N5O2/c1-17-3-5-18(6-4-17)12-31-25(36)21-13-34(14-21)24-23-11-20(15-35(23)33-16-32-24)19-7-9-22(10-8-19)26(2,37)27(28,29)30/h3-11,15-16,21,37H,12-14H2,1-2H3,(H,31,36)
PDB

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US Patent
n/an/a<10n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175743
PNG
(US9688680, 288)
Show SMILES CC(C)(O)c1ccc(cc1)-c1cc2c(ncnn2c1)N1CC(C1)NC(=O)Cc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C26H25Cl2N5O2/c1-26(2,35)19-6-3-16(4-7-19)18-9-23-25(29-15-30-33(23)12-18)32-13-21(14-32)31-24(34)10-17-5-8-20(27)11-22(17)28/h3-9,11-12,15,21,35H,10,13-14H2,1-2H3,(H,31,34)
PDB

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US Patent
n/an/a<10n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175745
PNG
(US9688680, 290)
Show SMILES Cc1ccc(cc1)[C@H](CCO)NC(=O)C1CN(C1)c1ncnn2cc(cc12)-c1ccc(OC(C)(C)C)cc1
Show InChI InChI=1/C30H35N5O3/c1-20-5-7-22(8-6-20)26(13-14-36)33-29(37)24-16-34(17-24)28-27-15-23(18-35(27)32-19-31-28)21-9-11-25(12-10-21)38-30(2,3)4/h5-12,15,18-19,24,26,36H,13-14,16-17H2,1-4H3,(H,33,37)/t26-/s2
PDB

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US Patent
n/an/a<10n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175585
PNG
(US9688680, 134)
Show SMILES COC(=O)N1CCC(=CC1)c1cc2c(ncnn2c1)N1CC(C1)C(=O)NCc1ccc(C)cc1
Show InChI InChI=1S/C25H28N6O3/c1-17-3-5-18(6-4-17)12-26-24(32)21-13-30(14-21)23-22-11-20(15-31(22)28-16-27-23)19-7-9-29(10-8-19)25(33)34-2/h3-7,11,15-16,21H,8-10,12-14H2,1-2H3,(H,26,32)
PDB

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US Patent
n/an/a<10n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175609
PNG
(US9688680, 158)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2ccc(cc2)C2(O)CCC2)cc1
Show InChI InChI=1S/C28H29N5O2/c1-19-3-5-20(6-4-19)14-29-27(34)23-15-32(16-23)26-25-13-22(17-33(25)31-18-30-26)21-7-9-24(10-8-21)28(35)11-2-12-28/h3-10,13,17-18,23,35H,2,11-12,14-16H2,1H3,(H,29,34)
PDB

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US Patent
n/an/a<10n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175613
PNG
(US9688680, 162)
Show SMILES CN(C)C(=O)c1ccc(cc1)-c1cc2c(ncnn2c1)N1CC(C1)C(=O)NCc1ccc(C)cc1
Show InChI InChI=1S/C27H28N6O2/c1-18-4-6-19(7-5-18)13-28-26(34)23-14-32(15-23)25-24-12-22(16-33(24)30-17-29-25)20-8-10-21(11-9-20)27(35)31(2)3/h4-12,16-17,23H,13-15H2,1-3H3,(H,28,34)
PDB

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US Patent
n/an/a<10n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175620
PNG
(US9688680, 169)
Show SMILES CCC(C)(O)c1ccc(cc1)-c1cc2c(ncnn2c1)N1CC(C1)C(=O)NCc1ccc(C)cc1
Show InChI InChI=1/C28H31N5O2/c1-4-28(3,35)24-11-9-21(10-12-24)22-13-25-26(30-18-31-33(25)17-22)32-15-23(16-32)27(34)29-14-20-7-5-19(2)6-8-20/h5-13,17-18,23,35H,4,14-16H2,1-3H3,(H,29,34)
PDB

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US Patent
n/an/a<10n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175621
PNG
(US9688680, 170)
Show SMILES C[C@H](NC(=O)C1CN(C1)c1ncnn2cc(cc12)-c1ccc(cc1)C(C)(C)O)c1ccc(C)cc1
Show InChI InChI=1/C28H31N5O2/c1-18-5-7-20(8-6-18)19(2)31-27(34)23-14-32(15-23)26-25-13-22(16-33(25)30-17-29-26)21-9-11-24(12-10-21)28(3,4)35/h5-13,16-17,19,23,35H,14-15H2,1-4H3,(H,31,34)/t19-/s2
PDB

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n/an/a<10n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175624
PNG
(US9688680, 173)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)C2=CCN(CC2)C(=O)C2CC2)cc1
Show InChI InChI=1S/C27H30N6O2/c1-18-2-4-19(5-3-18)13-28-26(34)23-14-32(15-23)25-24-12-22(16-33(24)30-17-29-25)20-8-10-31(11-9-20)27(35)21-6-7-21/h2-5,8,12,16-17,21,23H,6-7,9-11,13-15H2,1H3,(H,28,34)
PDB

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US Patent
n/an/a<10n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175627
PNG
(US9688680, 176)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2cnn(CC3(C)COC3)c2)cc1
Show InChI InChI=1S/C26H29N7O2/c1-18-3-5-19(6-4-18)8-27-25(34)22-10-31(11-22)24-23-7-20(13-33(23)30-17-28-24)21-9-29-32(12-21)14-26(2)15-35-16-26/h3-7,9,12-13,17,22H,8,10-11,14-16H2,1-2H3,(H,27,34)
PDB

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US Patent
n/an/a<10n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175637
PNG
(US9688680, 185)
Show SMILES CN(C)C(=O)N1CCC(=CC1)c1cc2c(ncnn2c1)N1CC(C1)C(=O)NCc1ccc(C)cc1
Show InChI InChI=1S/C26H31N7O2/c1-18-4-6-19(7-5-18)13-27-25(34)22-14-32(15-22)24-23-12-21(16-33(23)29-17-28-24)20-8-10-31(11-9-20)26(35)30(2)3/h4-8,12,16-17,22H,9-11,13-15H2,1-3H3,(H,27,34)
PDB

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US Patent
n/an/a<10n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175640
PNG
(US9688680, 188)
Show SMILES CCOC(=O)N1CCC(=CC1)c1cc2c(ncnn2c1)N1CC(C1)C(=O)NCc1ccc(C)cc1
Show InChI InChI=1S/C26H30N6O3/c1-3-35-26(34)30-10-8-20(9-11-30)21-12-23-24(28-17-29-32(23)16-21)31-14-22(15-31)25(33)27-13-19-6-4-18(2)5-7-19/h4-8,12,16-17,22H,3,9-11,13-15H2,1-2H3,(H,27,33)
PDB

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US Patent
n/an/a<10n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175642
PNG
(US9688680, 190)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2ccc(cc2)S(C)(=O)=O)cc1
Show InChI InChI=1S/C25H25N5O3S/c1-17-3-5-18(6-4-17)12-26-25(31)21-13-29(14-21)24-23-11-20(15-30(23)28-16-27-24)19-7-9-22(10-8-19)34(2,32)33/h3-11,15-16,21H,12-14H2,1-2H3,(H,26,31)
PDB

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US Patent
n/an/a<10n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175661
PNG
(US9688680, 207)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)C2=CCN(CC2)S(C)(=O)=O)cc1
Show InChI InChI=1S/C24H28N6O3S/c1-17-3-5-18(6-4-17)12-25-24(31)21-13-28(14-21)23-22-11-20(15-30(22)27-16-26-23)19-7-9-29(10-8-19)34(2,32)33/h3-7,11,15-16,21H,8-10,12-14H2,1-2H3,(H,25,31)
PDB

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US Patent
n/an/a<10n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175664
PNG
(US9688680, 210)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2ccc(cc2)C(C)(O)C2CC2)cc1
Show InChI InChI=1/C29H31N5O2/c1-19-3-5-20(6-4-19)14-30-28(35)23-15-33(16-23)27-26-13-22(17-34(26)32-18-31-27)21-7-9-24(10-8-21)29(2,36)25-11-12-25/h3-10,13,17-18,23,25,36H,11-12,14-16H2,1-2H3,(H,30,35)
PDB

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n/an/a<10n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175665
PNG
(US9688680, 211)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2ccc(cc2)C2(O)CCCC2)cc1
Show InChI InChI=1S/C29H31N5O2/c1-20-4-6-21(7-5-20)15-30-28(35)24-16-33(17-24)27-26-14-23(18-34(26)32-19-31-27)22-8-10-25(11-9-22)29(36)12-2-3-13-29/h4-11,14,18-19,24,36H,2-3,12-13,15-17H2,1H3,(H,30,35)
PDB

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n/an/a<10n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175536
PNG
(US9688680, 107)
Show SMILES CC(C)(O)c1ccc(cc1)-c1cc2c(ncnn2c1)N1CC(C1)C(=O)Nc1ccc(cc1)C#N
Show InChI InChI=1S/C26H24N6O2/c1-26(2,34)21-7-5-18(6-8-21)19-11-23-24(28-16-29-32(23)15-19)31-13-20(14-31)25(33)30-22-9-3-17(12-27)4-10-22/h3-11,15-16,20,34H,13-14H2,1-2H3,(H,30,33)
PDB

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n/an/a<10n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175487
PNG
(US9688680, 87)
Show SMILES CC(=O)N1CCC(=CC1)c1cc2c(ncnn2c1)N1CC(C1)C(=O)NCc1ccc(C)cc1
Show InChI InChI=1S/C25H28N6O2/c1-17-3-5-19(6-4-17)12-26-25(33)22-13-30(14-22)24-23-11-21(15-31(23)28-16-27-24)20-7-9-29(10-8-20)18(2)32/h3-7,11,15-16,22H,8-10,12-14H2,1-2H3,(H,26,33)
PDB

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n/an/a 55n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175488
PNG
(US9688680, 88)
Show SMILES CNCC1(CN(C1)c1ncnn2cc(cc12)-c1cnn(C)c1)C(=O)NCc1ccc(C)cc1
Show InChI InChI=1S/C24H28N8O/c1-17-4-6-18(7-5-17)9-26-23(33)24(13-25-2)14-31(15-24)22-21-8-19(12-32(21)29-16-27-22)20-10-28-30(3)11-20/h4-8,10-12,16,25H,9,13-15H2,1-3H3,(H,26,33)
PDB

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n/an/a 55n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175489
PNG
(US9688680, 89)
Show SMILES CC(C)n1cc(c(N)n1)-c1cc2c(ncnn2c1)N1CC(C1)C(=O)NCc1ccc(C)cc1
Show InChI InChI=1S/C24H28N8O/c1-15(2)31-13-20(22(25)29-31)18-8-21-23(27-14-28-32(21)12-18)30-10-19(11-30)24(33)26-9-17-6-4-16(3)5-7-17/h4-8,12-15,19H,9-11H2,1-3H3,(H2,25,29)(H,26,33)
PDB

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n/an/a 55n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175490
PNG
(US9688680, 90)
Show SMILES Cc1ccc(cc1)[C@H](CCN)NC(=O)C1CN(C1)c1ncnn2cc(cc12)-c1cnn(C)c1
Show InChI InChI=1/C24H28N8O/c1-16-3-5-17(6-4-16)21(7-8-25)29-24(33)20-12-31(13-20)23-22-9-18(14-32(22)28-15-26-23)19-10-27-30(2)11-19/h3-6,9-11,14-15,20-21H,7-8,12-13,25H2,1-2H3,(H,29,33)/t21-/s2
PDB

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UniChem
US Patent
n/an/a 55n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175492
PNG
(US9688680, 92)
Show SMILES COc1ccc(cc1F)-c1cc2c(ncnn2c1)N1CC(C1)C(=O)NCc1ccc(C)cc1
Show InChI InChI=1S/C25H24FN5O2/c1-16-3-5-17(6-4-16)11-27-25(32)20-12-30(13-20)24-22-10-19(14-31(22)29-15-28-24)18-7-8-23(33-2)21(26)9-18/h3-10,14-15,20H,11-13H2,1-2H3,(H,27,32)
PDB

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PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175494
PNG
(US9688680, 94)
Show SMILES Cc1ccc(cc1)[C@H](CCO)NC(=O)C1CN(C1)c1ncnn2cc(cc12)-c1cnn(C)c1
Show InChI InChI=1/C24H27N7O2/c1-16-3-5-17(6-4-16)21(7-8-32)28-24(33)20-12-30(13-20)23-22-9-18(14-31(22)27-15-25-23)19-10-26-29(2)11-19/h3-6,9-11,14-15,20-21,32H,7-8,12-13H2,1-2H3,(H,28,33)/t21-/s2
PDB

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PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175495
PNG
(US9688680, 95)
Show SMILES CC(C)n1cc(cn1)-c1cc2c(ncnn2c1)N1CC(C1)C(=O)N[C@@H](C)c1ccc(F)cc1
Show InChI InChI=1/C24H26FN7O/c1-15(2)31-13-19(9-27-31)18-8-22-23(26-14-28-32(22)12-18)30-10-20(11-30)24(33)29-16(3)17-4-6-21(25)7-5-17/h4-9,12-16,20H,10-11H2,1-3H3,(H,29,33)/t16-/s2
PDB

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PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175473
PNG
(US9688680, 73 | US9688680, 99)
Show SMILES CC[C@H](NC(=O)C1CN(C1)c1ncnn2cc(cc12)-c1cnn(C)c1)c1ccc(Cl)cc1
Show InChI InChI=1/C23H24ClN7O/c1-3-20(15-4-6-19(24)7-5-15)28-23(32)18-11-30(12-18)22-21-8-16(13-31(21)27-14-25-22)17-9-26-29(2)10-17/h4-10,13-14,18,20H,3,11-12H2,1-2H3,(H,28,32)/t20-/s2
PDB

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PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175529
PNG
(US9688680, 105)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2ccc3C(=O)NCc3c2)cc1
Show InChI InChI=1S/C26H24N6O2/c1-16-2-4-17(5-3-16)10-27-25(33)21-12-31(13-21)24-23-9-20(14-32(23)30-15-29-24)18-6-7-22-19(8-18)11-28-26(22)34/h2-9,14-15,21H,10-13H2,1H3,(H,27,33)(H,28,34)
PDB

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UniChem
US Patent
n/an/a 55n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175530
PNG
(US9688680, 106)
Show SMILES CC(C)Oc1ccc(cc1)-c1cc2c(ncnn2c1)N1CC(C1)C(=O)Nc1ccc(cc1)C#N
Show InChI InChI=1S/C26H24N6O2/c1-17(2)34-23-9-5-19(6-10-23)20-11-24-25(28-16-29-32(24)15-20)31-13-21(14-31)26(33)30-22-7-3-18(12-27)4-8-22/h3-11,15-17,21H,13-14H2,1-2H3,(H,30,33)
PDB

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PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175555
PNG
(US9688680, 109)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2ccc(OC3CC3)cc2)cc1
Show InChI InChI=1S/C27H27N5O2/c1-18-2-4-19(5-3-18)13-28-27(33)22-14-31(15-22)26-25-12-21(16-32(25)30-17-29-26)20-6-8-23(9-7-20)34-24-10-11-24/h2-9,12,16-17,22,24H,10-11,13-15H2,1H3,(H,28,33)
PDB

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PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175562
PNG
(US9688680, 113)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2ccc3OCCOc3c2)cc1
Show InChI InChI=1S/C26H25N5O3/c1-17-2-4-18(5-3-17)12-27-26(32)21-13-30(14-21)25-22-10-20(15-31(22)29-16-28-25)19-6-7-23-24(11-19)34-9-8-33-23/h2-7,10-11,15-16,21H,8-9,12-14H2,1H3,(H,27,32)
PDB

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PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(V560G/D816V)


(Homo sapiens (Human))
BDBM175564
PNG
(US9688680, 115)
Show SMILES CC(C)Oc1ccc(cc1)-c1cc2c(ncnn2c1)N1CC(C1)C(=O)NCc1ccc(C)cc1
Show InChI InChI=1S/C27H29N5O2/c1-18(2)34-24-10-8-21(9-11-24)22-12-25-26(29-17-30-32(25)16-22)31-14-23(15-31)27(33)28-13-20-6-4-19(3)5-7-20/h4-12,16-18,23H,13-15H2,1-3H3,(H,28,33)
PDB

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PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
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