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Compile Data Set for Download or QSAR

Found 127 hits Enz. Inhib. hit(s) with Target = 'Voltage-dependent calcium channel gamma-2 subunit'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM311805
PNG
(7-(4-Fluorophenyl)-8-(7-chloro-1H-indazol-5-yl)-2-...)
Show SMILES Fc1ccc(cc1)-c1ccn2nc(nc2c1-c1cc(Cl)c2[nH]ncc2c1)C(F)(F)F
Show InChI InChI=1S/C20H10ClF4N5/c21-15-8-11(7-12-9-26-28-17(12)15)16-14(10-1-3-13(22)4-2-10)5-6-30-18(16)27-19(29-30)20(23,24)25/h1-9H,(H,26,28)
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n/an/a 0.0100n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2SB47TC
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM311771
PNG
(2-Cyclopentyl-7-(4-fluorophenyl)-8-(7-methyl-1H-in...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccn2nc(nc12)C1CCCC1)-c1ccc(F)cc1
Show InChI InChI=1S/C25H22FN5/c1-15-12-18(13-19-14-27-29-23(15)19)22-21(16-6-8-20(26)9-7-16)10-11-31-25(22)28-24(30-31)17-4-2-3-5-17/h6-14,17H,2-5H2,1H3,(H,27,29)
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US Patent
n/an/a 0.0160n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2SB47TC
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM292056
PNG
(2-Cyclobutyl-3-(7-methyl-1H-indazol-5-yl)-5-(trifl...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1n(nc2ccc(nc12)C(F)(F)F)C1CCC1
Show InChI InChI=1S/C19H16F3N5/c1-10-7-11(8-12-9-23-25-16(10)12)18-17-14(26-27(18)13-3-2-4-13)5-6-15(24-17)19(20,21)22/h5-9,13H,2-4H2,1H3,(H,23,25)
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US Patent
n/an/a 0.0200n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)


Article DOI: 10.1021/jm049354h
BindingDB Entry DOI: 10.7270/Q2MW2K56
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM292057
PNG
(3-(7-Chloro-1H-indazol-5-yl)-2-cyclobutyl-5-(trifl...)
Show SMILES FC(F)(F)c1ccc2nn(C3CCC3)c(-c3cc(Cl)c4[nH]ncc4c3)c2n1
Show InChI InChI=1S/C18H13ClF3N5/c19-12-7-9(6-10-8-23-25-15(10)12)17-16-13(26-27(17)11-2-1-3-11)4-5-14(24-16)18(20,21)22/h4-8,11H,1-3H2,(H,23,25)
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US Patent
n/an/a 0.0200n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)


Article DOI: 10.1021/jm049354h
BindingDB Entry DOI: 10.7270/Q2MW2K56
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM311766
PNG
(2-Cyclobutyl-7-(4-fluorophenyl)-8-(7-methyl-1H-ind...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccn2nc(nc12)C1CCC1)-c1ccc(F)cc1
Show InChI InChI=1S/C24H20FN5/c1-14-11-17(12-18-13-26-28-22(14)18)21-20(15-5-7-19(25)8-6-15)9-10-30-24(21)27-23(29-30)16-3-2-4-16/h5-13,16H,2-4H2,1H3,(H,26,28)
PDB

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US Patent
n/an/a 0.0250n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2SB47TC
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM311848
PNG
(8-(7-Chloro-1H-indazol-5-yl)-2-isopropyl-7-(triflu...)
Show SMILES CC(C)c1cn2ccc(c(-c3cc(Cl)c4[nH]ncc4c3)c2n1)C(F)(F)F
Show InChI InChI=1S/C18H14ClF3N4/c1-9(2)14-8-26-4-3-12(18(20,21)22)15(17(26)24-14)10-5-11-7-23-25-16(11)13(19)6-10/h3-9H,1-2H3,(H,23,25)
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n/an/a 0.0250n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2SB47TC
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM311811
PNG
(7-Isopropyl-8-(7-methyl-1H-indazol-5-yl)-2-(triflu...)
Show SMILES CC(C)c1ccn2nc(nc2c1-c1cc(C)c2[nH]ncc2c1)C(F)(F)F
Show InChI InChI=1S/C18H16F3N5/c1-9(2)13-4-5-26-16(23-17(25-26)18(19,20)21)14(13)11-6-10(3)15-12(7-11)8-22-24-15/h4-9H,1-3H3,(H,22,24)
PDB

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US Patent
n/an/a 0.0320n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2SB47TC
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM311806
PNG
(7-(4-Fluorophenyl)-8-(7-methyl-1H-indazol-5-yl)-2-...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccn2nc(nc12)C(F)(F)F)-c1ccc(F)cc1
Show InChI InChI=1S/C21H13F4N5/c1-11-8-13(9-14-10-26-28-18(11)14)17-16(12-2-4-15(22)5-3-12)6-7-30-19(17)27-20(29-30)21(23,24)25/h2-10H,1H3,(H,26,28)
PDB

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US Patent
n/an/a 0.0320n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2SB47TC
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM311808
PNG
(2-(Difluoromethyl)-7-(4-fluorophenyl)-8-(7-methyl-...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccn2nc(nc12)C(F)F)-c1ccc(F)cc1
Show InChI InChI=1S/C21H14F3N5/c1-11-8-13(9-14-10-25-27-18(11)14)17-16(12-2-4-15(22)5-3-12)6-7-29-21(17)26-20(28-29)19(23)24/h2-10,19H,1H3,(H,25,27)
PDB

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US Patent
n/an/a 0.0320n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2SB47TC
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM292055
PNG
(7-Chloro-5-(2-cyclobutyl-5-(trifluoromethyl)-2H-py...)
Show SMILES FC(F)(F)c1ccc2nn(C3CCC3)c(-c3cc4CC(=O)Nc4c(Cl)c3)c2n1
Show InChI InChI=1S/C19H14ClF3N4O/c20-12-7-10(6-9-8-15(28)25-16(9)12)18-17-13(26-27(18)11-2-1-3-11)4-5-14(24-17)19(21,22)23/h4-7,11H,1-3,8H2,(H,25,28)
PDB

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US Patent
n/an/a 0.0320n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)


Article DOI: 10.1021/jm049354h
BindingDB Entry DOI: 10.7270/Q2MW2K56
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM311847
PNG
(5-(2,7-Bis(trifluoromethyl)imidazo[1,2-a]pyridin-8...)
Show SMILES FC(F)(F)c1cn2ccc(c(-c3cc(Cl)c4[nH]ncc4c3)c2n1)C(F)(F)F
Show InChI InChI=1S/C16H7ClF6N4/c17-10-4-7(3-8-5-24-26-13(8)10)12-9(15(18,19)20)1-2-27-6-11(16(21,22)23)25-14(12)27/h1-6H,(H,24,26)
PDB

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US Patent
n/an/a 0.0500n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2SB47TC
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM292054
PNG
(5-(2-Cyclobutyl-5-(trifluoromethyl)-2H-pyrazolo[4,...)
Show SMILES Cc1cc(cc2CC(=O)Nc12)-c1n(nc2ccc(nc12)C(F)(F)F)C1CCC1
Show InChI InChI=1S/C20H17F3N4O/c1-10-7-12(8-11-9-16(28)25-17(10)11)19-18-14(26-27(19)13-3-2-4-13)5-6-15(24-18)20(21,22)23/h5-8,13H,2-4,9H2,1H3,(H,25,28)
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n/an/a 0.0500n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)


Article DOI: 10.1021/jm049354h
BindingDB Entry DOI: 10.7270/Q2MW2K56
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM292053
PNG
(3-(7-Chloro-1H-indazol-5-yl)-2-isopropyl-5-(triflu...)
Show SMILES CC(C)n1nc2ccc(nc2c1-c1cc(Cl)c2[nH]ncc2c1)C(F)(F)F
Show InChI InChI=1S/C17H13ClF3N5/c1-8(2)26-16(9-5-10-7-22-24-14(10)11(18)6-9)15-12(25-26)3-4-13(23-15)17(19,20)21/h3-8H,1-2H3,(H,22,24)
PDB

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n/an/a 0.0630n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)


Article DOI: 10.1021/jm049354h
BindingDB Entry DOI: 10.7270/Q2MW2K56
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM311768
PNG
(7-Cyclopentyl-8-(7-methyl-1H-indazol-5-yl)-2-(trif...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccn2nc(nc12)C(F)(F)F)C1CCCC1
Show InChI InChI=1S/C20H18F3N5/c1-11-8-13(9-14-10-24-26-17(11)14)16-15(12-4-2-3-5-12)6-7-28-18(16)25-19(27-28)20(21,22)23/h6-10,12H,2-5H2,1H3,(H,24,26)
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n/an/a 0.0790n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2SB47TC
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM311810
PNG
(2-Cyclopropyl-7-(4-fluorophenyl)-8-(7-methyl-1H-in...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccn2nc(nc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C23H18FN5/c1-13-10-16(11-17-12-25-27-21(13)17)20-19(14-4-6-18(24)7-5-14)8-9-29-23(20)26-22(28-29)15-2-3-15/h4-12,15H,2-3H2,1H3,(H,25,27)
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US Patent
n/an/a 0.0790n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2SB47TC
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM311828
PNG
(8-(7-Chloro-1H-indazol-5-yl)-2-isopropyl-7-(triflu...)
Show SMILES CC(C)c1cn2cnc(c(-c3cc(Cl)c4[nH]ncc4c3)c2n1)C(F)(F)F
Show InChI InChI=1S/C17H13ClF3N5/c1-8(2)12-6-26-7-22-15(17(19,20)21)13(16(26)24-12)9-3-10-5-23-25-14(10)11(18)4-9/h3-8H,1-2H3,(H,23,25)
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n/an/a 0.100n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2SB47TC
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM311849
PNG
(2-Isopropyl-8-(7-methyl-1H-indazol-5-yl)-7-(triflu...)
Show SMILES CC(C)c1cn2ccc(c(-c3cc(C)c4[nH]ncc4c3)c2n1)C(F)(F)F
Show InChI InChI=1S/C19H17F3N4/c1-10(2)15-9-26-5-4-14(19(20,21)22)16(18(26)24-15)12-6-11(3)17-13(7-12)8-23-25-17/h4-10H,1-3H3,(H,23,25)
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n/an/a 0.100n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2SB47TC
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM292061
PNG
(5-(Difluoromethyl)-2-isopropyl-3-(7-methyl-1H-inda...)
Show SMILES CC(C)n1nc2ccc(nc2c1-c1cc(C)c2[nH]ncc2c1)C(F)F
Show InChI InChI=1S/C18H17F2N5/c1-9(2)25-17(11-6-10(3)15-12(7-11)8-21-23-15)16-13(24-25)4-5-14(22-16)18(19)20/h4-9,18H,1-3H3,(H,21,23)
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n/an/a 0.100n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)


Article DOI: 10.1021/jm049354h
BindingDB Entry DOI: 10.7270/Q2MW2K56
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM311829
PNG
(8-(7-Chloro-1H-indazol-5-yl)-2-cyclopropyl-7-(trif...)
Show SMILES FC(F)(F)c1ncn2cc(nc2c1-c1cc(Cl)c2[nH]ncc2c1)C1CC1
Show InChI InChI=1S/C17H11ClF3N5/c18-11-4-9(3-10-5-23-25-14(10)11)13-15(17(19,20)21)22-7-26-6-12(8-1-2-8)24-16(13)26/h3-8H,1-2H2,(H,23,25)
PDB

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UniChem
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US Patent
n/an/a 0.126n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2SB47TC
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM292037
PNG
(2-Cyclopentyl-3-(7-methyl-1H-indazol-5-yl)-5-(trif...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1n(nc2ccc(nc12)C(F)(F)F)C1CCCC1
Show InChI InChI=1S/C20H18F3N5/c1-11-8-12(9-13-10-24-26-17(11)13)19-18-15(6-7-16(25-18)20(21,22)23)27-28(19)14-4-2-3-5-14/h6-10,14H,2-5H2,1H3,(H,24,26)
PDB

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Article
US Patent
n/an/a 0.126n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)


Article DOI: 10.1021/jm049354h
BindingDB Entry DOI: 10.7270/Q2MW2K56
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM311799
PNG
(8-(7-Chloro-1H-indazol-5-yl)-2-isopropyl-7-(triflu...)
Show SMILES CC(C)c1nc2c(-c3cc(Cl)c4[nH]ncc4c3)c(ccn2n1)C(F)(F)F
Show InChI InChI=1S/C17H13ClF3N5/c1-8(2)15-23-16-13(11(17(19,20)21)3-4-26(16)25-15)9-5-10-7-22-24-14(10)12(18)6-9/h3-8H,1-2H3,(H,22,24)
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n/an/a 0.126n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2SB47TC
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM311843
PNG
(3-Chloro-8-(7-chloro-1H-indazol-5-yl)-2-cyclopropy...)
Show SMILES FC(F)(F)c1ncn2c(Cl)c(nc2c1-c1cc(Cl)c2[nH]ncc2c1)C1CC1
Show InChI InChI=1S/C17H10Cl2F3N5/c18-10-4-8(3-9-5-24-26-12(9)10)11-14(17(20,21)22)23-6-27-15(19)13(7-1-2-7)25-16(11)27/h3-7H,1-2H2,(H,24,26)
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n/an/a 0.126n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2SB47TC
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM311845
PNG
(5-(2,7-Bis(trifluoromethyl)imidazo[1,2-a]pyridin-8...)
Show SMILES FC(F)(F)c1cn2ccc(c(-c3cc4CC(=O)Nc4c(Cl)c3)c2n1)C(F)(F)F
Show InChI InChI=1S/C17H8ClF6N3O/c18-10-4-7(3-8-5-12(28)26-14(8)10)13-9(16(19,20)21)1-2-27-6-11(17(22,23)24)25-15(13)27/h1-4,6H,5H2,(H,26,28)
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n/an/a 0.158n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2SB47TC
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM311792
PNG
(8-(7-Chloro-1H-indazol-5-yl)-2-cyclopropyl-7-(trif...)
Show SMILES FC(F)(F)c1ccn2nc(nc2c1-c1cc(Cl)c2[nH]ncc2c1)C1CC1
Show InChI InChI=1S/C17H11ClF3N5/c18-12-6-9(5-10-7-22-24-14(10)12)13-11(17(19,20)21)3-4-26-16(13)23-15(25-26)8-1-2-8/h3-8H,1-2H2,(H,22,24)
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n/an/a 0.158n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2SB47TC
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM292065
PNG
(5,7-Bis(difluoromethyl)-2-isopropyl-3-(7-methyl-1H...)
Show SMILES CC(C)n1nc2c(cc(nc2c1-c1cc(C)c2[nH]ncc2c1)C(F)F)C(F)F
Show InChI InChI=1S/C19H17F4N5/c1-8(2)28-17(10-4-9(3)14-11(5-10)7-24-26-14)16-15(27-28)12(18(20)21)6-13(25-16)19(22)23/h4-8,18-19H,1-3H3,(H,24,26)
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n/an/a 0.158n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)


Article DOI: 10.1021/jm049354h
BindingDB Entry DOI: 10.7270/Q2MW2K56
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM311833
PNG
(8-(7-Chloro-1H-indazol-5-yl)-7-isopropyl-2-(triflu...)
Show SMILES CC(C)c1ncn2cc(nc2c1-c1cc(Cl)c2[nH]ncc2c1)C(F)(F)F
Show InChI InChI=1S/C17H13ClF3N5/c1-8(2)14-13(9-3-10-5-23-25-15(10)11(18)4-9)16-24-12(17(19,20)21)6-26(16)7-22-14/h3-8H,1-2H3,(H,23,25)
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n/an/a 0.158n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2SB47TC
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM311793
PNG
(2-Cyclopropyl-8-(7-methyl-1H-indazol-5-yl)-7-(trif...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccn2nc(nc12)C1CC1)C(F)(F)F
Show InChI InChI=1S/C18H14F3N5/c1-9-6-11(7-12-8-22-24-15(9)12)14-13(18(19,20)21)4-5-26-17(14)23-16(25-26)10-2-3-10/h4-8,10H,2-3H2,1H3,(H,22,24)
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n/an/a 0.200n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2SB47TC
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM311781
PNG
(8-(7-Chloro-1H-indazol-5-yl)-2,7-bis(trifluorometh...)
Show SMILES FC(F)(F)c1nc2c(-c3cc(Cl)c4[nH]ncc4c3)c(ccn2n1)C(F)(F)F
Show InChI InChI=1S/C15H6ClF6N5/c16-9-4-6(3-7-5-23-25-11(7)9)10-8(14(17,18)19)1-2-27-12(10)24-13(26-27)15(20,21)22/h1-5H,(H,23,25)
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n/an/a 0.251n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2SB47TC
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM311767
PNG
(6-(7-(4-Fluorophenyl)-2-(trifluoromethyl)-[1,2,4]t...)
Show SMILES Fc1ccc(cc1)-c1ccn2nc(nc2c1-c1ccc2[nH]c(=O)sc2c1)C(F)(F)F
Show InChI InChI=1S/C20H10F4N4OS/c21-12-4-1-10(2-5-12)13-7-8-28-17(26-18(27-28)20(22,23)24)16(13)11-3-6-14-15(9-11)30-19(29)25-14/h1-9H,(H,25,29)
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n/an/a 0.251n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2SB47TC
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM311850
PNG
(2-Cyclopropyl-8-(7-methyl-1H-indazol-5-yl)-7-(trif...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccn2cc(nc12)C1CC1)C(F)(F)F
Show InChI InChI=1S/C19H15F3N4/c1-10-6-12(7-13-8-23-25-17(10)13)16-14(19(20,21)22)4-5-26-9-15(11-2-3-11)24-18(16)26/h4-9,11H,2-3H2,1H3,(H,23,25)
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n/an/a 0.251n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2SB47TC
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM292051
PNG
(7-Chloro-5-(2-isopropyl-5-(trifluoromethyl)-2H-pyr...)
Show SMILES CC(C)n1nc2ccc(nc2c1-c1cc2CC(=O)Nc2c(Cl)c1)C(F)(F)F
Show InChI InChI=1S/C18H14ClF3N4O/c1-8(2)26-17(10-5-9-7-14(27)24-15(9)11(19)6-10)16-12(25-26)3-4-13(23-16)18(20,21)22/h3-6,8H,7H2,1-2H3,(H,24,27)
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n/an/a 0.251n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)


Article DOI: 10.1021/jm049354h
BindingDB Entry DOI: 10.7270/Q2MW2K56
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM292052
PNG
(2-Isopropyl-3-(7-methyl-1H-indazol-5-yl)-5-(triflu...)
Show SMILES CC(C)n1nc2ccc(nc2c1-c1cc(C)c2[nH]ncc2c1)C(F)(F)F
Show InChI InChI=1S/C18H16F3N5/c1-9(2)26-17(11-6-10(3)15-12(7-11)8-22-24-15)16-13(25-26)4-5-14(23-16)18(19,20)21/h4-9H,1-3H3,(H,22,24)
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n/an/a 0.251n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)


Article DOI: 10.1021/jm049354h
BindingDB Entry DOI: 10.7270/Q2MW2K56
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM311830
PNG
(2-Cyclopropyl-8-(7-methyl-1H-indazol-5-yl)-7-(trif...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ncn2cc(nc12)C1CC1)C(F)(F)F
Show InChI InChI=1S/C18H14F3N5/c1-9-4-11(5-12-6-23-25-15(9)12)14-16(18(19,20)21)22-8-26-7-13(10-2-3-10)24-17(14)26/h4-8,10H,2-3H2,1H3,(H,23,25)
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n/an/a 0.251n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2SB47TC
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM292045
PNG
(3-(7-Chloro-1H-indazol-5-yl)-2-methyl-5-(trifluoro...)
Show SMILES Cn1nc2ccc(nc2c1-c1cc(Cl)c2[nH]ncc2c1)C(F)(F)F
Show InChI InChI=1S/C15H9ClF3N5/c1-24-14(7-4-8-6-20-22-12(8)9(16)5-7)13-10(23-24)2-3-11(21-13)15(17,18)19/h2-6H,1H3,(H,20,22)
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n/an/a 0.316n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)


Article DOI: 10.1021/jm049354h
BindingDB Entry DOI: 10.7270/Q2MW2K56
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM311783
PNG
(5-(2,7-Bis(trifluoromethyl)-[1,2,4]triazolo[1,5-a]...)
Show SMILES FC(F)(F)c1nc2c(-c3cc4CC(=O)Nc4c(Cl)c3)c(ccn2n1)C(F)(F)F
Show InChI InChI=1S/C16H7ClF6N4O/c17-9-4-6(3-7-5-10(28)24-12(7)9)11-8(15(18,19)20)1-2-27-13(11)25-14(26-27)16(21,22)23/h1-4H,5H2,(H,24,28)
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n/an/a 0.316n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2SB47TC
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM311775
PNG
(8-(7-Chloro-1H-indazol-5-yl)-2,7-bis(trifluorometh...)
Show SMILES FC(F)(F)c1nc2c(-c3cc(Cl)c4[nH]ncc4c3)c(ncn2n1)C(F)(F)F
Show InChI InChI=1S/C14H5ClF6N6/c15-7-2-5(1-6-3-23-25-9(6)7)8-10(13(16,17)18)22-4-27-11(8)24-12(26-27)14(19,20)21/h1-4H,(H,23,25)
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n/an/a 0.316n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2SB47TC
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM311769
PNG
(7-(Azetidin-1-yl)-8-(7-methyl-1H-indazol-5-yl)-2-(...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccn2nc(nc12)C(F)(F)F)N1CCC1
Show InChI InChI=1S/C18H15F3N6/c1-10-7-11(8-12-9-22-24-15(10)12)14-13(26-4-2-5-26)3-6-27-16(14)23-17(25-27)18(19,20)21/h3,6-9H,2,4-5H2,1H3,(H,22,24)
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n/an/a 0.316n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2SB47TC
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM311754
PNG
(8-(7-Chloro-1H-indazol-5-yl)-2-(difluoromethyl)-7-...)
Show SMILES FC(F)c1nc2c(-c3cc(Cl)c4[nH]ncc4c3)c(ccn2n1)C(F)(F)F
Show InChI InChI=1S/C15H7ClF5N5/c16-9-4-6(3-7-5-22-24-11(7)9)10-8(15(19,20)21)1-2-26-14(10)23-13(25-26)12(17)18/h1-5,12H,(H,22,24)
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n/an/a 0.316n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2SB47TC
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM311844
PNG
(8-(7-Chloro-1H-indazol-5-yl)-2-cyclopropyl-3-fluor...)
Show SMILES Fc1c(nc2c(-c3cc(Cl)c4[nH]ncc4c3)c(ncn12)C(F)(F)F)C1CC1
Show InChI InChI=1S/C17H10ClF4N5/c18-10-4-8(3-9-5-24-26-12(9)10)11-14(17(20,21)22)23-6-27-15(19)13(7-1-2-7)25-16(11)27/h3-7H,1-2H2,(H,24,26)
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n/an/a 0.316n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2SB47TC
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM311834
PNG
(8-(7-Chloro-1H-indazol-5-yl)-2-(difluoromethyl)-7-...)
Show SMILES CC(C)c1ncn2cc(nc2c1-c1cc(Cl)c2[nH]ncc2c1)C(F)F
Show InChI InChI=1S/C17H14ClF2N5/c1-8(2)14-13(9-3-10-5-22-24-15(10)11(18)4-9)17-23-12(16(19)20)6-25(17)7-21-14/h3-8,16H,1-2H3,(H,22,24)
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n/an/a 0.316n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2SB47TC
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM311831
PNG
(7-Chloro-5-[2-cyclopropyl-7-(trifluoromethyl)imida...)
Show SMILES FC(F)(F)c1ncn2cc(nc2c1-c1cc2CC(=O)Nc2c(Cl)c1)C1CC1
Show InChI InChI=1S/C18H12ClF3N4O/c19-11-4-9(3-10-5-13(27)25-15(10)11)14-16(18(20,21)22)23-7-26-6-12(8-1-2-8)24-17(14)26/h3-4,6-8H,1-2,5H2,(H,25,27)
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n/an/a 0.316n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2SB47TC
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM311824
PNG
(5-(2,7-Bis(trifluoromethyl)imidazo[1,2-a]pyridin-8...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccn2cc(nc12)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C17H10F6N4/c1-8-4-9(5-10-6-24-26-14(8)10)13-11(16(18,19)20)2-3-27-7-12(17(21,22)23)25-15(13)27/h2-7H,1H3,(H,24,26)
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US Patent
n/an/a 0.316n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2SB47TC
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM311785
PNG
(8-(7-Chloro-1H-indazol-5-yl)-7-(difluoromethyl)-2-...)
Show SMILES FC(F)c1ccn2nc(nc2c1-c1cc(Cl)c2[nH]ncc2c1)C(F)(F)F
Show InChI InChI=1S/C15H7ClF5N5/c16-9-4-6(3-7-5-22-24-11(7)9)10-8(12(17)18)1-2-26-13(10)23-14(25-26)15(19,20)21/h1-5,12H,(H,22,24)
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US Patent
n/an/a 0.398n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2SB47TC
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM292062
PNG
(7-Chloro-5-(5-(difluoromethyl)-2-isopropyl-2H-pyra...)
Show SMILES CC(C)n1nc2ccc(nc2c1-c1cc2CC(=O)Nc2c(Cl)c1)C(F)F
Show InChI InChI=1S/C18H15ClF2N4O/c1-8(2)25-17(16-12(24-25)3-4-13(22-16)18(20)21)10-5-9-7-14(26)23-15(9)11(19)6-10/h3-6,8,18H,7H2,1-2H3,(H,23,26)
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n/an/a 0.398n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)


Article DOI: 10.1021/jm049354h
BindingDB Entry DOI: 10.7270/Q2MW2K56
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM311796
PNG
(8-(7-Chloro-1H-indazol-5-yl)-2-ethyl-7-(trifluorom...)
Show SMILES CCc1nc2c(-c3cc(Cl)c4[nH]ncc4c3)c(ccn2n1)C(F)(F)F
Show InChI InChI=1S/C16H11ClF3N5/c1-2-12-22-15-13(10(16(18,19)20)3-4-25(15)24-12)8-5-9-7-21-23-14(9)11(17)6-8/h3-7H,2H2,1H3,(H,21,23)
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n/an/a 0.398n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2SB47TC
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM311851
PNG
(2-Ethyl-8-(7-methyl-1H-indazol-5-yl)-7-(trifluorom...)
Show SMILES CCc1cn2ccc(c(-c3cc(C)c4[nH]ncc4c3)c2n1)C(F)(F)F
Show InChI InChI=1S/C18H15F3N4/c1-3-13-9-25-5-4-14(18(19,20)21)15(17(25)23-13)11-6-10(2)16-12(7-11)8-22-24-16/h4-9H,3H2,1-2H3,(H,22,24)
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US Patent
n/an/a 0.398n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2SB47TC
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM292050
PNG
(5-(2-Isopropyl-5-(trifluoromethyl)-2H-pyrazolo[4,3...)
Show SMILES CC(C)n1nc2ccc(nc2c1-c1cc2CC(=O)Nc2c(C)c1)C(F)(F)F
Show InChI InChI=1S/C19H17F3N4O/c1-9(2)26-18(12-6-10(3)16-11(7-12)8-15(27)24-16)17-13(25-26)4-5-14(23-17)19(20,21)22/h4-7,9H,8H2,1-3H3,(H,24,27)
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n/an/a 0.398n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)


Article DOI: 10.1021/jm049354h
BindingDB Entry DOI: 10.7270/Q2MW2K56
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM311776
PNG
(8-(7-Chloro-1H-indazol-5-yl)-2-(difluoromethyl)-7-...)
Show SMILES FC(F)c1nc2c(-c3cc(Cl)c4[nH]ncc4c3)c(ncn2n1)C(F)(F)F
Show InChI InChI=1S/C14H6ClF5N6/c15-7-2-5(1-6-3-22-24-9(6)7)8-10(14(18,19)20)21-4-26-13(8)23-12(25-26)11(16)17/h1-4,11H,(H,22,24)
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US Patent
n/an/a 0.398n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2SB47TC
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM292049
PNG
(3-(7-Chloro-1H-indazol-5-yl)-2-ethyl-5-(trifluorom...)
Show SMILES CCn1nc2ccc(nc2c1-c1cc(Cl)c2[nH]ncc2c1)C(F)(F)F
Show InChI InChI=1S/C16H11ClF3N5/c1-2-25-15(8-5-9-7-21-23-13(9)10(17)6-8)14-11(24-25)3-4-12(22-14)16(18,19)20/h3-7H,2H2,1H3,(H,21,23)
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US Patent
n/an/a 0.398n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)


Article DOI: 10.1021/jm049354h
BindingDB Entry DOI: 10.7270/Q2MW2K56
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))
BDBM311846
PNG
(5-(2,7-Bis(trifluoromethyl)imidazo[1,2-a]pyridin-8...)
Show SMILES Cc1cc(cc2CC(=O)Nc12)-c1c(ccn2cc(nc12)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C18H11F6N3O/c1-8-4-9(5-10-6-13(28)26-15(8)10)14-11(17(19,20)21)2-3-27-7-12(18(22,23)24)25-16(14)27/h2-5,7H,6H2,1H3,(H,26,28)
PDB

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US Patent
n/an/a 0.398n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2SB47TC
More data for this
Ligand-Target Pair
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