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Compile Data Set for Download or QSAR

Found 1069 hits Enz. Inhib. hit(s) with Target = 'alpha-Glucosidase (α-Glucosidase)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50147013
PNG
(CHEMBL3764559)
Show SMILES [Cl-].OC[C@H](O)[C@@H](O)[C@@H](OCc1ccccc1[N+]([O-])=O)[C@H](O)C[S+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1/C18H28NO10S.ClH/c20-5-12(22)17(26)18(29-7-10-3-1-2-4-11(10)19(27)28)14(24)9-30-8-13(23)16(25)15(30)6-21;/h1-4,12-18,20-26H,5-9H2;1H/q+1;/p-1/t12-,13+,14+,15+,16-,17+,18-,30?;/s2
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0.0900n/an/an/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Competitive inhibition of rat intestinal sucrase using sucrose as substrate incubated for 30 mins by Lineweaver-Burk plot analysis


Citation and Details
More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50147016
PNG
(CHEMBL3763300)
Show SMILES [Cl-].OC[C@H](O)[C@@H](O)[C@@H](OCc1ccccc1Cl)[C@H](O)C[S+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1/C18H28ClO8S.ClH/c19-11-4-2-1-3-10(11)7-27-18(17(26)12(22)5-20)14(24)9-28-8-13(23)16(25)15(28)6-21;/h1-4,12-18,20-26H,5-9H2;1H/q+1;/p-1/t12-,13+,14+,15+,16-,17+,18-,28?;/s2
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0.100n/an/an/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Competitive inhibition of rat intestinal sucrase using sucrose as substrate incubated for 30 mins by Lineweaver-Burk plot analysis


Citation and Details
More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50147107
PNG
(CHEMBL3763319)
Show SMILES [Cl-].OC[C@H](O)[C@@H](O)[C@@H](OCc1ccccc1C(F)(F)F)[C@H](O)C[S+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1/C19H28F3O8S.ClH/c20-19(21,22)11-4-2-1-3-10(11)7-30-18(17(29)12(25)5-23)14(27)9-31-8-13(26)16(28)15(31)6-24;/h1-4,12-18,23-29H,5-9H2;1H/q+1;/p-1/t12-,13+,14+,15+,16-,17+,18-,31?;/s2
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0.110n/an/an/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Competitive inhibition of rat intestinal sucrase using sucrose as substrate incubated for 30 mins by Lineweaver-Burk plot analysis


Citation and Details
More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50291029
PNG
((2R,3R,4R,5S)-2-Hydroxymethyl-1-((E)-3-trimethylsi...)
Show SMILES C[Si](C)(C)\C=C\CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H25NO4Si/c1-18(2,3)6-4-5-13-7-10(15)12(17)11(16)9(13)8-14/h4,6,9-12,14-17H,5,7-8H2,1-3H3/b6-4+/t9-,10+,11-,12-/m1/s1
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0.150n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for the inhibition constant against rat small intestinal sucrase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50147158
PNG
(CHEMBL3764745)
Show SMILES [Cl-].OC[C@H](O)[C@@H](O)[C@@H](OCc1cccc(c1)C(F)(F)F)[C@H](O)C[S+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1/C19H28F3O8S.ClH/c20-19(21,22)11-3-1-2-10(4-11)7-30-18(17(29)12(25)5-23)14(27)9-31-8-13(26)16(28)15(31)6-24;/h1-4,12-18,23-29H,5-9H2;1H/q+1;/p-1/t12-,13+,14+,15+,16-,17+,18-,31?;/s2
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0.180n/an/an/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Competitive inhibition of rat intestinal sucrase using sucrose as substrate incubated for 30 mins by Lineweaver-Burk plot analysis


Citation and Details
More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50147159
PNG
(CHEMBL3764813)
Show SMILES [Cl-].OC[C@H](O)[C@@H](O)[C@@H](OCc1ccc(cc1)C(F)(F)F)[C@H](O)C[S+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1/C19H28F3O8S.ClH/c20-19(21,22)11-3-1-10(2-4-11)7-30-18(17(29)12(25)5-23)14(27)9-31-8-13(26)16(28)15(31)6-24;/h1-4,12-18,23-29H,5-9H2;1H/q+1;/p-1/t12-,13+,14+,15+,16-,17+,18-,31?;/s2
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0.400n/an/an/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Competitive inhibition of rat intestinal sucrase using sucrose as substrate incubated for 30 mins by Lineweaver-Burk plot analysis


Citation and Details
More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50291026
PNG
((2R,3R,4R,5S)-1-[(E)-3-(Dimethyl-phenyl-silanyl)-a...)
Show SMILES C[Si](C)(\C=C\CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO)c1ccccc1
Show InChI InChI=1S/C17H27NO4Si/c1-23(2,13-7-4-3-5-8-13)10-6-9-18-11-15(20)17(22)16(21)14(18)12-19/h3-8,10,14-17,19-22H,9,11-12H2,1-2H3/b10-6+/t14-,15+,16-,17-/m1/s1
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3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for the inhibition constant against rat small intestinal sucrase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50291031
PNG
((2R,3R,4R,5S)-2-Hydroxymethyl-1-(3-trimethylsilany...)
Show SMILES C[Si](C)(C)CCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H27NO4Si/c1-18(2,3)6-4-5-13-7-10(15)12(17)11(16)9(13)8-14/h9-12,14-17H,4-8H2,1-3H3/t9-,10+,11-,12-/m1/s1
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8n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for the inhibition constant against rat small intestinal sucrase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50291023
PNG
((2R,3R,4R,5S)-1-[(E)-3-(tert-Butyl-dimethyl-silany...)
Show SMILES CC(C)(C)[Si](C)(C)\C=C\CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C15H31NO4Si/c1-15(2,3)21(4,5)8-6-7-16-9-12(18)14(20)13(19)11(16)10-17/h6,8,11-14,17-20H,7,9-10H2,1-5H3/b8-6+/t11-,12+,13-,14-/m1/s1
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10n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for the inhibition constant against rat small intestinal sucrase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50291021
PNG
((2R,3R,4R,5S)-2-Hydroxymethyl-1-(4-trimethylsilany...)
Show SMILES C[Si](C)(C)CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C13H29NO4Si/c1-19(2,3)7-5-4-6-14-8-11(16)13(18)12(17)10(14)9-15/h10-13,15-18H,4-9H2,1-3H3/t10-,11+,12-,13-/m1/s1
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16n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for the inhibition constant against rat small intestinal sucrase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50291034
PNG
((2R,3R,4R,5S)-2-Hydroxymethyl-1-(5-trimethylsilany...)
Show SMILES C[Si](C)(C)CCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C14H31NO4Si/c1-20(2,3)8-6-4-5-7-15-9-12(17)14(19)13(18)11(15)10-16/h11-14,16-19H,4-10H2,1-3H3/t11-,12+,13-,14-/m1/s1
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16n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for the inhibition constant against rat small intestinal isomaltase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50291020
PNG
((2R,3R,4R,5S)-1-[3-(Dimethyl-phenyl-silanyl)-propy...)
Show SMILES C[Si](C)(CCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO)c1ccccc1
Show InChI InChI=1S/C17H29NO4Si/c1-23(2,13-7-4-3-5-8-13)10-6-9-18-11-15(20)17(22)16(21)14(18)12-19/h3-5,7-8,14-17,19-22H,6,9-12H2,1-2H3/t14-,15+,16-,17-/m1/s1
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17n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for the inhibition constant against rat small intestinal sucrase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50291030
PNG
((2R,3R,4R,5S)-1-[4-(Dimethyl-phenyl-silanyl)-butyl...)
Show SMILES C[Si](C)(CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO)c1ccccc1
Show InChI InChI=1S/C18H31NO4Si/c1-24(2,14-8-4-3-5-9-14)11-7-6-10-19-12-16(21)18(23)17(22)15(19)13-20/h3-5,8-9,15-18,20-23H,6-7,10-13H2,1-2H3/t15-,16+,17-,18-/m1/s1
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18n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for the inhibition constant against rat small intestinal isomaltase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM18353
PNG
((2R,3R,4R,5S)-2-(hydroxymethyl)-1-methylpiperidine...)
Show SMILES CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C7H15NO4/c1-8-2-5(10)7(12)6(11)4(8)3-9/h4-7,9-12H,2-3H2,1H3/t4-,5+,6-,7-/m1/s1
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20n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for the inhibition constant against rat small intestinal sucrase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM18351
PNG
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Show SMILES OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
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24n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for the inhibition constant against rat small intestinal sucrase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50291020
PNG
((2R,3R,4R,5S)-1-[3-(Dimethyl-phenyl-silanyl)-propy...)
Show SMILES C[Si](C)(CCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO)c1ccccc1
Show InChI InChI=1S/C17H29NO4Si/c1-23(2,13-7-4-3-5-8-13)10-6-9-18-11-15(20)17(22)16(21)14(18)12-19/h3-5,7-8,14-17,19-22H,6,9-12H2,1-2H3/t14-,15+,16-,17-/m1/s1
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27n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for the inhibition constant against rat small intestinal isomaltase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50291034
PNG
((2R,3R,4R,5S)-2-Hydroxymethyl-1-(5-trimethylsilany...)
Show SMILES C[Si](C)(C)CCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C14H31NO4Si/c1-20(2,3)8-6-4-5-7-15-9-12(17)14(19)13(18)11(15)10-16/h11-14,16-19H,4-10H2,1-3H3/t11-,12+,13-,14-/m1/s1
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33n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for the inhibition constant against rat small intestinal sucrase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50291030
PNG
((2R,3R,4R,5S)-1-[4-(Dimethyl-phenyl-silanyl)-butyl...)
Show SMILES C[Si](C)(CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO)c1ccccc1
Show InChI InChI=1S/C18H31NO4Si/c1-24(2,14-8-4-3-5-9-14)11-7-6-10-19-12-16(21)18(23)17(22)15(19)13-20/h3-5,8-9,15-18,20-23H,6-7,10-13H2,1-2H3/t15-,16+,17-,18-/m1/s1
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39n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for the inhibition constant against rat small intestinal sucrase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50291021
PNG
((2R,3R,4R,5S)-2-Hydroxymethyl-1-(4-trimethylsilany...)
Show SMILES C[Si](C)(C)CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C13H29NO4Si/c1-19(2,3)7-5-4-6-14-8-11(16)13(18)12(17)10(14)9-15/h10-13,15-18H,4-9H2,1-3H3/t10-,11+,12-,13-/m1/s1
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40n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for the inhibition constant against rat small intestinal isomaltase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50291026
PNG
((2R,3R,4R,5S)-1-[(E)-3-(Dimethyl-phenyl-silanyl)-a...)
Show SMILES C[Si](C)(\C=C\CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO)c1ccccc1
Show InChI InChI=1S/C17H27NO4Si/c1-23(2,13-7-4-3-5-8-13)10-6-9-18-11-15(20)17(22)16(21)14(18)12-19/h3-8,10,14-17,19-22H,9,11-12H2,1-2H3/b10-6+/t14-,15+,16-,17-/m1/s1
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50n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for the inhibition constant against rat small intestinal isomaltase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50242818
PNG
(1-Oxo-1lambda-4-thia-cyclotridecan-3,4,5,6,8,10,11...)
Show SMILES OC1CC(O)C(O)C(O)CS(=O)CC(O)C(O)C(O)C(O)C1
Show InChI InChI=1S/C12H24O9S/c13-5-1-6(14)10(18)8(16)3-22(21)4-9(17)12(20)11(19)7(15)2-5/h5-20H,1-4H2
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52n/an/an/an/an/an/an/an/a



Fuji-Sangyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal sucrase


J Nat Prod 71: 981-4 (2008)

More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50291032
PNG
((2R,3R,4R,5S)-2-Hydroxymethyl-1-(3-trimethylsilany...)
Show SMILES C[Si](C)(C)c1cccc(CN2C[C@H](O)[C@@H](O)[C@H](O)[C@H]2CO)c1
Show InChI InChI=1S/C16H27NO4Si/c1-22(2,3)12-6-4-5-11(7-12)8-17-9-14(19)16(21)15(20)13(17)10-18/h4-7,13-16,18-21H,8-10H2,1-3H3/t13-,14+,15-,16-/m1/s1
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55n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for the inhibition constant against rat small intestinal sucrase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50291027
PNG
((2R,3R,4R,5S)-2-Hydroxymethyl-1-(4-trimethylsilany...)
Show SMILES C[Si](C)(C)c1ccc(CN2C[C@H](O)[C@@H](O)[C@H](O)[C@H]2CO)cc1
Show InChI InChI=1S/C16H27NO4Si/c1-22(2,3)12-6-4-11(5-7-12)8-17-9-14(19)16(21)15(20)13(17)10-18/h4-7,13-16,18-21H,8-10H2,1-3H3/t13-,14+,15-,16-/m1/s1
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64n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for the inhibition constant against rat small intestinal sucrase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50291029
PNG
((2R,3R,4R,5S)-2-Hydroxymethyl-1-((E)-3-trimethylsi...)
Show SMILES C[Si](C)(C)\C=C\CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H25NO4Si/c1-18(2,3)6-4-5-13-7-10(15)12(17)11(16)9(13)8-14/h4,6,9-12,14-17H,5,7-8H2,1-3H3/b6-4+/t9-,10+,11-,12-/m1/s1
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100n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for the inhibition constant against rat small intestinal isomaltase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50291028
PNG
((2R,3R,4R,5S)-1-(Dimethyl-propyl-silanylmethyl)-2-...)
Show SMILES CCC[Si](C)(C)CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H27NO4Si/c1-4-5-18(2,3)8-13-6-10(15)12(17)11(16)9(13)7-14/h9-12,14-17H,4-8H2,1-3H3/t9-,10+,11-,12-/m1/s1
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110n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for the inhibition constant against rat small intestinal sucrase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50291031
PNG
((2R,3R,4R,5S)-2-Hydroxymethyl-1-(3-trimethylsilany...)
Show SMILES C[Si](C)(C)CCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H27NO4Si/c1-18(2,3)6-4-5-13-7-10(15)12(17)11(16)9(13)8-14/h9-12,14-17H,4-8H2,1-3H3/t9-,10+,11-,12-/m1/s1
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120n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for the inhibition constant against rat small intestinal isomaltase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50291022
PNG
((2R,3R,4R,5S)-2-Hydroxymethyl-1-trimethylsilanylme...)
Show SMILES C[Si](C)(C)CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C10H23NO4Si/c1-16(2,3)6-11-4-8(13)10(15)9(14)7(11)5-12/h7-10,12-15H,4-6H2,1-3H3/t7-,8+,9-,10-/m1/s1
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150n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for the inhibition constant against rat small intestinal sucrase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50291033
PNG
((2R,3R,4R,5S)-1-[(Dimethyl-phenyl-silanyl)-methyl]...)
Show SMILES C[Si](C)(CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO)c1ccccc1
Show InChI InChI=1S/C15H25NO4Si/c1-21(2,11-6-4-3-5-7-11)10-16-8-13(18)15(20)14(19)12(16)9-17/h3-7,12-15,17-20H,8-10H2,1-2H3/t12-,13+,14-,15-/m1/s1
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160n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for the inhibition constant against rat small intestinal sucrase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50330955
PNG
((1S,2S)-3-[(2R,3S,4S)-3,4-dihydroxy-2-(hydroxymeth...)
Show SMILES OC[C@H](OS([O-])(=O)=O)[C@H](O)C[S@@+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C9H18O9S2/c10-1-7(18-20(15,16)17)5(12)3-19-4-6(13)9(14)8(19)2-11/h5-14H,1-4H2/t5-,6-,7+,8-,9+,19-/m1/s1
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200n/an/an/an/an/an/an/an/a



Fuji-Sangyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal sucrase


J Nat Prod 71: 981-4 (2008)

More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50291025
PNG
((2R,3R,4R,5S)-2-Hydroxymethyl-1-((E)-4-trimethylsi...)
Show SMILES C[Si](C)(C)\C=C\CCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C13H27NO4Si/c1-19(2,3)7-5-4-6-14-8-11(16)13(18)12(17)10(14)9-15/h5,7,10-13,15-18H,4,6,8-9H2,1-3H3/b7-5+/t10-,11+,12-,13-/m1/s1
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220n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for the inhibition constant against rat small intestinal sucrase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50291035
PNG
((2R,3R,4R,5S)-2-Hydroxymethyl-1-((Z)-3-trimethylsi...)
Show SMILES C[Si](C)(C)\C=C/CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H25NO4Si/c1-18(2,3)6-4-5-13-7-10(15)12(17)11(16)9(13)8-14/h4,6,9-12,14-17H,5,7-8H2,1-3H3/b6-4-/t9-,10+,11-,12-/m1/s1
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350n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for the inhibition constant against rat small intestinal sucrase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50291023
PNG
((2R,3R,4R,5S)-1-[(E)-3-(tert-Butyl-dimethyl-silany...)
Show SMILES CC(C)(C)[Si](C)(C)\C=C\CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C15H31NO4Si/c1-15(2,3)21(4,5)8-6-7-16-9-12(18)14(20)13(19)11(16)10-17/h6,8,11-14,17-20H,7,9-10H2,1-5H3/b8-6+/t11-,12+,13-,14-/m1/s1
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390n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for the inhibition constant against rat small intestinal isomaltase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50316179
PNG
((1S,2R,3R,4S)-1-{(1S)-2-[(2R,3S,4S)-3,4-dihydroxy-...)
Show SMILES OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](OS([O-])(=O)=O)[C@H](O)C[S+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H24O12S2/c13-1-5(15)10(19)11(20)12(24-26(21,22)23)7(17)4-25-3-6(16)9(18)8(25)2-14/h5-20H,1-4H2/t5-,6+,7+,8+,9-,10+,11+,12+,25?/m0/s1
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420n/an/an/an/an/an/an/an/a



Fuji-Sangyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal sucrase


J Nat Prod 71: 981-4 (2008)

More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50291035
PNG
((2R,3R,4R,5S)-2-Hydroxymethyl-1-((Z)-3-trimethylsi...)
Show SMILES C[Si](C)(C)\C=C/CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H25NO4Si/c1-18(2,3)6-4-5-13-7-10(15)12(17)11(16)9(13)8-14/h4,6,9-12,14-17H,5,7-8H2,1-3H3/b6-4-/t9-,10+,11-,12-/m1/s1
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640n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for the inhibition constant against rat small intestinal isomaltase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50291027
PNG
((2R,3R,4R,5S)-2-Hydroxymethyl-1-(4-trimethylsilany...)
Show SMILES C[Si](C)(C)c1ccc(CN2C[C@H](O)[C@@H](O)[C@H](O)[C@H]2CO)cc1
Show InChI InChI=1S/C16H27NO4Si/c1-22(2,3)12-6-4-11(5-7-12)8-17-9-14(19)16(21)15(20)13(17)10-18/h4-7,13-16,18-21H,8-10H2,1-3H3/t13-,14+,15-,16-/m1/s1
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830n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for the inhibition constant against rat small intestinal isomaltase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50330955
PNG
((1S,2S)-3-[(2R,3S,4S)-3,4-dihydroxy-2-(hydroxymeth...)
Show SMILES OC[C@H](OS([O-])(=O)=O)[C@H](O)C[S@@+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C9H18O9S2/c10-1-7(18-20(15,16)17)5(12)3-19-4-6(13)9(14)8(19)2-11/h5-14H,1-4H2/t5-,6-,7+,8-,9+,19-/m1/s1
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1.10E+3n/an/an/an/an/an/an/an/a



Fuji-Sangyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal isomaltase


J Nat Prod 71: 981-4 (2008)

More data for this
Ligand-Target Pair
Alpha-glucosidase MAL12


(Saccharomyces cerevisiae)
BDBM84968
PNG
(Urea derivative, 12)
Show SMILES Oc1ccc(\C=C\c2ccc(NC(=O)Nc3ccc(F)cc3F)cc2)cc1O
Show InChI InChI=1S/C21H16F2N2O3/c22-15-6-9-18(17(23)12-15)25-21(28)24-16-7-3-13(4-8-16)1-2-14-5-10-19(26)20(27)11-14/h1-12,26-27H,(H2,24,25,28)/b2-1+
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3.20E+3n/a 8.40E+3n/an/an/an/an/an/a



Gyeongsang National University



Assay Description
All enzymatic activities were determined by using the appropriate substrate (p-nitrophenyl-alpha-D-glucopyranoside, p-nitrophenyl-beta-D-gulcopyranos...


Chembiochem 11: 2125-31 (2010)

More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50291022
PNG
((2R,3R,4R,5S)-2-Hydroxymethyl-1-trimethylsilanylme...)
Show SMILES C[Si](C)(C)CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C10H23NO4Si/c1-16(2,3)6-11-4-8(13)10(15)9(14)7(11)5-12/h7-10,12-15H,4-6H2,1-3H3/t7-,8+,9-,10-/m1/s1
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3.30E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for the inhibition constant against rat small intestinal isomaltase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50291033
PNG
((2R,3R,4R,5S)-1-[(Dimethyl-phenyl-silanyl)-methyl]...)
Show SMILES C[Si](C)(CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO)c1ccccc1
Show InChI InChI=1S/C15H25NO4Si/c1-21(2,11-6-4-3-5-7-11)10-16-8-13(18)15(20)14(19)12(16)9-17/h3-7,12-15,17-20H,8-10H2,1-2H3/t12-,13+,14-,15-/m1/s1
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3.50E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for the inhibition constant against rat small intestinal isomaltase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50291024
PNG
((2R,3R,4R,5S)-2-Hydroxymethyl-1-(2-trimethylsilany...)
Show SMILES C[Si](C)(C)c1ccccc1CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C16H27NO4Si/c1-22(2,3)14-7-5-4-6-11(14)8-17-9-13(19)16(21)15(20)12(17)10-18/h4-7,12-13,15-16,18-21H,8-10H2,1-3H3/t12-,13+,15-,16-/m1/s1
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4.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for the inhibition constant against rat small intestinal isomaltase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50373981
PNG
(CHEMBL403239)
Show SMILES Nc1c(O)cccc1O
Show InChI InChI=1S/C6H7NO2/c7-6-4(8)2-1-3-5(6)9/h1-3,8-9H,7H2
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4.20E+3n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of sucrose hydrolyzing activity of rat intestinal alpha glucosidase


Bioorg Med Chem Lett 18: 812-5 (2008)

More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50316179
PNG
((1S,2R,3R,4S)-1-{(1S)-2-[(2R,3S,4S)-3,4-dihydroxy-...)
Show SMILES OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](OS([O-])(=O)=O)[C@H](O)C[S+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H24O12S2/c13-1-5(15)10(19)11(20)12(24-26(21,22)23)7(17)4-25-3-6(16)9(18)8(25)2-14/h5-20H,1-4H2/t5-,6+,7+,8+,9-,10+,11+,12+,25?/m0/s1
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4.20E+3n/an/an/an/an/an/an/an/a



Fuji-Sangyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal isomaltase


J Nat Prod 71: 981-4 (2008)

More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50242818
PNG
(1-Oxo-1lambda-4-thia-cyclotridecan-3,4,5,6,8,10,11...)
Show SMILES OC1CC(O)C(O)C(O)CS(=O)CC(O)C(O)C(O)C(O)C1
Show InChI InChI=1S/C12H24O9S/c13-5-1-6(14)10(18)8(16)3-22(21)4-9(17)12(20)11(19)7(15)2-5/h5-20H,1-4H2
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4.20E+3n/an/an/an/an/an/an/an/a



Fuji-Sangyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal isomaltase


J Nat Prod 71: 981-4 (2008)

More data for this
Ligand-Target Pair
Alpha-glucosidase MAL12


(Saccharomyces cerevisiae)
BDBM84969
PNG
(Urea derivative, 13)
Show SMILES Oc1ccc(\C=C\c2ccc(NC(=O)Nc3ccc(Cl)cc3)cc2)cc1O
Show InChI InChI=1S/C21H17ClN2O3/c22-16-6-10-18(11-7-16)24-21(27)23-17-8-3-14(4-9-17)1-2-15-5-12-19(25)20(26)13-15/h1-13,25-26H,(H2,23,24,27)/b2-1+
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4.60E+3n/a 1.43E+4n/an/an/an/an/an/a



Gyeongsang National University



Assay Description
All enzymatic activities were determined by using the appropriate substrate (p-nitrophenyl-alpha-D-glucopyranoside, p-nitrophenyl-beta-D-gulcopyranos...


Chembiochem 11: 2125-31 (2010)

More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM50341204
PNG
((Z)-3-butylidenephthalide | CHEMBL1765390)
Show SMILES CCC\C=C1\OC(=O)c2ccccc12
Show InChI InChI=1S/C12H12O2/c1-2-3-8-11-9-6-4-5-7-10(9)12(13)14-11/h4-8H,2-3H2,1H3/b11-8+
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MMDB

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4.86E+3n/an/an/an/an/an/an/an/a



Universidad Nacional Aut£noma de M£xico

Curated by ChEMBL


Assay Description
Mixed type inhibition of baker's yeast alpha-glucosidase by Dixon plot analysis


J Nat Prod 76: 468-83 (2013)

More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50291028
PNG
((2R,3R,4R,5S)-1-(Dimethyl-propyl-silanylmethyl)-2-...)
Show SMILES CCC[Si](C)(C)CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H27NO4Si/c1-4-5-18(2,3)8-13-6-10(15)12(17)11(16)9(13)7-14/h9-12,14-17H,4-8H2,1-3H3/t9-,10+,11-,12-/m1/s1
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7.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for the inhibition constant against rat small intestinal isomaltase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
Alpha-glucosidase MAL12


(Saccharomyces cerevisiae)
BDBM84967
PNG
(Urea derivative, 11)
Show SMILES Oc1ccc(\C=C\c2ccc(NC(=O)Nc3ccc(F)cc3)cc2)cc1O
Show InChI InChI=1S/C21H17FN2O3/c22-16-6-10-18(11-7-16)24-21(27)23-17-8-3-14(4-9-17)1-2-15-5-12-19(25)20(26)13-15/h1-13,25-26H,(H2,23,24,27)/b2-1+
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7.20E+3n/a 1.98E+4n/an/an/an/an/an/a



Gyeongsang National University



Assay Description
All enzymatic activities were determined by using the appropriate substrate (p-nitrophenyl-alpha-D-glucopyranoside, p-nitrophenyl-beta-D-gulcopyranos...


Chembiochem 11: 2125-31 (2010)

More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50291024
PNG
((2R,3R,4R,5S)-2-Hydroxymethyl-1-(2-trimethylsilany...)
Show SMILES C[Si](C)(C)c1ccccc1CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C16H27NO4Si/c1-22(2,3)14-7-5-4-6-11(14)8-17-9-13(19)16(21)15(20)12(17)10-18/h4-7,12-13,15-16,18-21H,8-10H2,1-3H3/t12-,13+,15-,16-/m1/s1
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8.50E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for the inhibition constant against rat small intestinal sucrase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
Alpha-glucosidase MAL12


(Saccharomyces cerevisiae)
BDBM84972
PNG
(Urea derivative, 16)
Show SMILES Oc1ccc(\C=C\c2ccc(NC(=O)Nc3ccc(F)cc3F)cc2)cc1
Show InChI InChI=1S/C21H16F2N2O2/c22-16-7-12-20(19(23)13-16)25-21(27)24-17-8-3-14(4-9-17)1-2-15-5-10-18(26)11-6-15/h1-13,26H,(H2,24,25,27)/b2-1+
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9.40E+3n/a 1.85E+4n/an/an/an/an/an/a



Gyeongsang National University



Assay Description
All enzymatic activities were determined by using the appropriate substrate (p-nitrophenyl-alpha-D-glucopyranoside, p-nitrophenyl-beta-D-gulcopyranos...


Chembiochem 11: 2125-31 (2010)

More data for this
Ligand-Target Pair
Alpha-glucosidase MAL12


(Saccharomyces cerevisiae)
BDBM84963
PNG
(Urea derivative, 7)
Show SMILES COc1ccc(NC(=O)Nc2ccc(\C=C\c3ccc(O)c(O)c3)cc2)cc1
Show InChI InChI=1S/C22H20N2O4/c1-28-19-11-9-18(10-12-19)24-22(27)23-17-7-4-15(5-8-17)2-3-16-6-13-20(25)21(26)14-16/h2-14,25-26H,1H3,(H2,23,24,27)/b3-2+
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1.05E+4n/a 1.95E+4n/an/an/an/an/an/a



Gyeongsang National University



Assay Description
All enzymatic activities were determined by using the appropriate substrate (p-nitrophenyl-alpha-D-glucopyranoside, p-nitrophenyl-beta-D-gulcopyranos...


Chembiochem 11: 2125-31 (2010)

More data for this
Ligand-Target Pair
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