BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 36 hits Enz. Inhib. hit(s) with Target = 'cAMP-dependent protein kinase catalytic subunit gamma'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP-dependent protein kinase catalytic subunit gamma


(Homo sapiens (Human))
BDBM50228843
PNG
(CHEMBL436718)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)CCNCCNS(=O)(=O)c1cccc2cnccc12)C(O)=O
Show InChI InChI=1S/C53H94N28O12S/c54-48(55)68-18-2-9-32(41(84)77-34(11-4-20-70-50(58)59)43(86)79-36(13-6-22-72-52(62)63)45(88)81-37(47(90)91)14-7-23-73-53(64)65)76-42(85)33(10-3-19-69-49(56)57)78-44(87)35(12-5-21-71-51(60)61)80-46(89)38(29-82)75-40(83)17-25-66-26-27-74-94(92,93)39-15-1-8-30-28-67-24-16-31(30)39/h1,8,15-16,24,28,32-38,66,74,82H,2-7,9-14,17-23,25-27,29H2,(H,75,83)(H,76,85)(H,77,84)(H,78,87)(H,79,86)(H,80,89)(H,81,88)(H,90,91)(H4,54,55,68)(H4,56,57,69)(H4,58,59,70)(H4,60,61,71)(H4,62,63,72)(H4,64,65,73)/t32-,33-,34-,35-,36-,37-,38-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
4n/an/an/an/an/an/an/an/a



URA CNRS 1309

Curated by ChEMBL


Assay Description
Displacement of ATP from protein kinase A (PKA)


J Med Chem 34: 73-8 (1991)


Article DOI: 10.1021/jm00105a012
BindingDB Entry DOI: 10.7270/Q2J38VS9
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit gamma


(Homo sapiens (Human))
BDBM50228839
PNG
(CHEMBL415414)
Show SMILES C[C@H](NC(=O)[C@H](C)NS(=O)(=O)c1cccc2cnccc12)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C54H94N28O13S/c1-28(74-41(85)29(2)82-96(94,95)39-17-3-10-30-26-67-25-18-31(30)39)40(84)81-38(27-83)47(91)79-35(14-7-22-71-52(61)62)45(89)77-33(12-5-20-69-50(57)58)43(87)75-32(11-4-19-68-49(55)56)42(86)76-34(13-6-21-70-51(59)60)44(88)78-36(15-8-23-72-53(63)64)46(90)80-37(48(92)93)16-9-24-73-54(65)66/h3,10,17-18,25-26,28-29,32-38,82-83H,4-9,11-16,19-24,27H2,1-2H3,(H,74,85)(H,75,87)(H,76,86)(H,77,89)(H,78,88)(H,79,91)(H,80,90)(H,81,84)(H,92,93)(H4,55,56,68)(H4,57,58,69)(H4,59,60,70)(H4,61,62,71)(H4,63,64,72)(H4,65,66,73)/t28-,29-,32-,33-,34-,35-,36-,37-,38-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
170n/an/an/an/an/an/an/an/a



URA CNRS 1309

Curated by ChEMBL


Assay Description
Displacement of ATP from protein kinase A (PKA)


J Med Chem 34: 73-8 (1991)


Article DOI: 10.1021/jm00105a012
BindingDB Entry DOI: 10.7270/Q2J38VS9
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit gamma


(Homo sapiens (Human))
BDBM50216682
PNG
(1-(5-Isoquinolinesulfonyl)-2-methylpiperazine | 1-...)
Show SMILES CC1CNCCN1S(=O)(=O)c1cccc2cnccc12
Show InChI InChI=1S/C14H17N3O2S/c1-11-9-16-7-8-17(11)20(18,19)14-4-2-3-12-10-15-6-5-13(12)14/h2-6,10-11,16H,7-9H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

CHEBI
CHEMBL
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
3.00E+3n/an/an/an/an/an/an/an/a



URA CNRS 1309

Curated by ChEMBL


Assay Description
Displacement of ATP from protein kinase A (PKA)


J Med Chem 34: 73-8 (1991)


Article DOI: 10.1021/jm00105a012
BindingDB Entry DOI: 10.7270/Q2J38VS9
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit gamma


(Homo sapiens (Human))
BDBM50223628
PNG
(CHEMBL1161622)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)NC(CNC(=O)CSP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(=O)N[C@@H](CC(C)C)C(=O)NCC(O)=O
Show InChI InChI=1S/C46H80N19O22P3S/c1-21(2)13-27(39(73)55-16-32(68)69)63-43(77)29(15-54-31(67)18-91-90(82,83)87-89(80,81)86-88(78,79)84-17-30-34(70)35(71)44(85-30)65-20-58-33-36(47)56-19-57-37(33)65)64-38(72)23(5)59-40(74)25(9-7-11-52-45(48)49)61-41(75)26(10-8-12-53-46(50)51)62-42(76)28(14-22(3)4)60-24(6)66/h19-23,25-30,34-35,44,70-71H,7-18H2,1-6H3,(H,54,67)(H,55,73)(H,59,74)(H,60,66)(H,61,75)(H,62,76)(H,63,77)(H,64,72)(H,68,69)(H,78,79)(H,80,81)(H,82,83)(H2,47,56,57)(H4,48,49,52)(H4,50,51,53)/t23-,25-,26-,27-,28-,29?,30+,34+,35+,44+/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
3.80E+3n/an/an/an/an/an/an/an/a



Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of protein kinase A expressed in Escherichia coli


Bioorg Med Chem Lett 14: 2951-4 (2004)


Article DOI: 10.1016/j.bmcl.2004.03.039
BindingDB Entry DOI: 10.7270/Q2CR5WJF
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit gamma


(Homo sapiens (Human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

CHEBI
CHEMBL
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a<1n/an/an/an/an/an/a



Hanyang University

Curated by ChEMBL


Assay Description
Inhibition of PKA (unknown origin) after 40 mins by scintillation counting analysis


Eur J Med Chem 102: 600-10 (2015)


Article DOI: 10.1016/j.ejmech.2015.08.031
BindingDB Entry DOI: 10.7270/Q2XG9SXV
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit gamma


(Homo sapiens (Human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

CHEBI
CHEMBL
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

PubMed
n/an/a 1.30n/an/an/an/an/an/a



Beijing Normal University

Curated by ChEMBL


Assay Description
Inhibition of human PKAcg using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate by [gamma-33P]-ATP assay


Bioorg Med Chem 26: 1740-1750 (2018)

More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit gamma


(Homo sapiens (Human))
BDBM50228843
PNG
(CHEMBL436718)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)CCNCCNS(=O)(=O)c1cccc2cnccc12)C(O)=O
Show InChI InChI=1S/C53H94N28O12S/c54-48(55)68-18-2-9-32(41(84)77-34(11-4-20-70-50(58)59)43(86)79-36(13-6-22-72-52(62)63)45(88)81-37(47(90)91)14-7-23-73-53(64)65)76-42(85)33(10-3-19-69-49(56)57)78-44(87)35(12-5-21-71-51(60)61)80-46(89)38(29-82)75-40(83)17-25-66-26-27-74-94(92,93)39-15-1-8-30-28-67-24-16-31(30)39/h1,8,15-16,24,28,32-38,66,74,82H,2-7,9-14,17-23,25-27,29H2,(H,75,83)(H,76,85)(H,77,84)(H,78,87)(H,79,86)(H,80,89)(H,81,88)(H,90,91)(H4,54,55,68)(H4,56,57,69)(H4,58,59,70)(H4,60,61,71)(H4,62,63,72)(H4,64,65,73)/t32-,33-,34-,35-,36-,37-,38-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3n/an/an/an/an/an/a



URA CNRS 1309

Curated by ChEMBL


Assay Description
Inhibition of cAMP-dependent protein kinase (PKA).


J Med Chem 34: 73-8 (1991)


Article DOI: 10.1021/jm00105a012
BindingDB Entry DOI: 10.7270/Q2J38VS9
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit gamma


(Homo sapiens (Human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

CHEBI
CHEMBL
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

n/an/a 6.5n/an/an/an/an/an/a


TBA

Assay Description
In vitro inhibition of Protein Kinase A


Citation and Details

BindingDB Entry DOI: 10.7270/Q2HM5BN1
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit gamma


(Homo sapiens (Human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

CHEBI
CHEMBL
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 6.80n/an/an/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Inhibition of human PKAcg using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate by [gamma-33P]-ATP assay


Eur J Med Chem 161: 456-467 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.052
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit gamma


(Homo sapiens (Human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

CHEBI
CHEMBL
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

n/an/a 8.20n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of protein kinase A


Citation and Details

BindingDB Entry DOI: 10.7270/Q2HX1FVJ
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit gamma


(Homo sapiens (Human))
BDBM50280450
PNG
(18-hydroxy-3-methoxy-2-methyl-4-methylamino-(2R,3S...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4[C@H](O)NC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O4/c1-28-25(35-3)15(29-2)12-18(36-28)31-16-10-6-4-8-13(16)19-21-22(27(34)30-26(21)33)20-14-9-5-7-11-17(14)32(28)24(20)23(19)31/h4-11,15,18,25,27,29,34H,12H2,1-3H3,(H,30,33)/t15-,18-,25-,27+,28+/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

n/an/a 42n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of protein kinase A


Citation and Details

BindingDB Entry DOI: 10.7270/Q2HX1FVJ
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit gamma


(Homo sapiens (Human))
BDBM50280450
PNG
(18-hydroxy-3-methoxy-2-methyl-4-methylamino-(2R,3S...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4[C@H](O)NC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O4/c1-28-25(35-3)15(29-2)12-18(36-28)31-16-10-6-4-8-13(16)19-21-22(27(34)30-26(21)33)20-14-9-5-7-11-17(14)32(28)24(20)23(19)31/h4-11,15,18,25,27,29,34H,12H2,1-3H3,(H,30,33)/t15-,18-,25-,27+,28+/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

n/an/a 250n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of protein kinase A


Citation and Details

BindingDB Entry DOI: 10.7270/Q2HX1FVJ
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit gamma


(Homo sapiens (Human))
BDBM50228839
PNG
(CHEMBL415414)
Show SMILES C[C@H](NC(=O)[C@H](C)NS(=O)(=O)c1cccc2cnccc12)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C54H94N28O13S/c1-28(74-41(85)29(2)82-96(94,95)39-17-3-10-30-26-67-25-18-31(30)39)40(84)81-38(27-83)47(91)79-35(14-7-22-71-52(61)62)45(89)77-33(12-5-20-69-50(57)58)43(87)75-32(11-4-19-68-49(55)56)42(86)76-34(13-6-21-70-51(59)60)44(88)78-36(15-8-23-72-53(63)64)46(90)80-37(48(92)93)16-9-24-73-54(65)66/h3,10,17-18,25-26,28-29,32-38,82-83H,4-9,11-16,19-24,27H2,1-2H3,(H,74,85)(H,75,87)(H,76,86)(H,77,89)(H,78,88)(H,79,91)(H,80,90)(H,81,84)(H,92,93)(H4,55,56,68)(H4,57,58,69)(H4,59,60,70)(H4,61,62,71)(H4,63,64,72)(H4,65,66,73)/t28-,29-,32-,33-,34-,35-,36-,37-,38-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 300n/an/an/an/an/an/a



URA CNRS 1309

Curated by ChEMBL


Assay Description
Inhibition of cAMP-dependent protein kinase (PKA).


J Med Chem 34: 73-8 (1991)


Article DOI: 10.1021/jm00105a012
BindingDB Entry DOI: 10.7270/Q2J38VS9
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit gamma


(Homo sapiens (Human))
BDBM50228847
PNG
(CHEMBL407100)
Show SMILES C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NS(=O)(=O)c1cccc2cnccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C48H80N22O13S/c1-24(62-37(73)25(2)64-39(75)27(4)70-84(82,83)35-15-5-10-28-22-57-21-16-29(28)35)36(72)63-26(3)38(74)69-34(23-71)43(79)67-31(12-7-18-59-46(51)52)41(77)65-30(11-6-17-58-45(49)50)40(76)66-32(13-8-19-60-47(53)54)42(78)68-33(44(80)81)14-9-20-61-48(55)56/h5,10,15-16,21-22,24-27,30-34,70-71H,6-9,11-14,17-20,23H2,1-4H3,(H,62,73)(H,63,72)(H,64,75)(H,65,77)(H,66,76)(H,67,79)(H,68,78)(H,69,74)(H,80,81)(H4,49,50,58)(H4,51,52,59)(H4,53,54,60)(H4,55,56,61)/t24-,25-,26-,27-,30-,31-,32-,33-,34-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.20E+3n/an/an/an/an/an/a



URA CNRS 1309

Curated by ChEMBL


Assay Description
Inhibition of cAMP-dependent protein kinase (PKA).


J Med Chem 34: 73-8 (1991)


Article DOI: 10.1021/jm00105a012
BindingDB Entry DOI: 10.7270/Q2J38VS9
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit gamma


(Homo sapiens (Human))
BDBM50228838
PNG
(CHEMBL428973)
Show SMILES C[C@H](NC(=O)[C@H](C)NS(=O)(=O)c1cccc2cnccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C42H70N20O10S/c1-22(57-34(65)24(3)62-73(71,72)31-14-4-9-25-21-51-20-15-26(25)31)32(63)56-23(2)33(64)58-27(10-5-16-52-39(43)44)35(66)59-28(11-6-17-53-40(45)46)36(67)60-29(12-7-18-54-41(47)48)37(68)61-30(38(69)70)13-8-19-55-42(49)50/h4,9,14-15,20-24,27-30,62H,5-8,10-13,16-19H2,1-3H3,(H,56,63)(H,57,65)(H,58,64)(H,59,66)(H,60,67)(H,61,68)(H,69,70)(H4,43,44,52)(H4,45,46,53)(H4,47,48,54)(H4,49,50,55)/t22-,23-,24-,27-,28-,29-,30-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.20E+3n/an/an/an/an/an/a



URA CNRS 1309

Curated by ChEMBL


Assay Description
Inhibition of cAMP-dependent protein kinase (PKA).


J Med Chem 34: 73-8 (1991)


Article DOI: 10.1021/jm00105a012
BindingDB Entry DOI: 10.7270/Q2J38VS9
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit gamma


(Homo sapiens (Human))
BDBM50228846
PNG
(CHEMBL265876)
Show SMILES C[C@H](NC(=O)[C@H](C)NS(=O)(=O)c1cccc2cnccc12)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C42H70N20O11S/c1-22(56-33(65)23(2)62-74(72,73)31-13-3-8-24-20-51-19-14-25(24)31)32(64)61-30(21-63)37(69)59-27(10-5-16-53-40(45)46)35(67)57-26(9-4-15-52-39(43)44)34(66)58-28(11-6-17-54-41(47)48)36(68)60-29(38(70)71)12-7-18-55-42(49)50/h3,8,13-14,19-20,22-23,26-30,62-63H,4-7,9-12,15-18,21H2,1-2H3,(H,56,65)(H,57,67)(H,58,66)(H,59,69)(H,60,68)(H,61,64)(H,70,71)(H4,43,44,52)(H4,45,46,53)(H4,47,48,54)(H4,49,50,55)/t22-,23-,26-,27-,28-,29-,30-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.20E+3n/an/an/an/an/an/a



URA CNRS 1309

Curated by ChEMBL


Assay Description
Inhibition of cAMP-dependent protein kinase (PKA).


J Med Chem 34: 73-8 (1991)


Article DOI: 10.1021/jm00105a012
BindingDB Entry DOI: 10.7270/Q2J38VS9
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit gamma


(Homo sapiens (Human))
BDBM15211
PNG
(CHEMBL104264 | H-89 | H89 | HT-89 (H-89) | N-(2-{[...)
Show SMILES Brc1ccc(\C=C\CNCCNS(=O)(=O)c2cccc3cnccc23)cc1
Show InChI InChI=1S/C20H20BrN3O2S/c21-18-8-6-16(7-9-18)3-2-11-22-13-14-24-27(25,26)20-5-1-4-17-15-23-12-10-19(17)20/h1-10,12,15,22,24H,11,13-14H2/b3-2+
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

CHEBI
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.20E+3n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of PKA-mediated phosphorylation of kemptide at 100 uM


Bioorg Med Chem Lett 16: 5360-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.078
BindingDB Entry DOI: 10.7270/Q2NG4TD5
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit gamma


(Homo sapiens (Human))
BDBM50228841
PNG
(CHEMBL351282)
Show SMILES COC(=O)CCNCCNS(=O)(=O)c1cccc2cnccc12
Show InChI InChI=1S/C15H19N3O4S/c1-22-15(19)6-8-16-9-10-18-23(20,21)14-4-2-3-12-11-17-7-5-13(12)14/h2-5,7,11,16,18H,6,8-10H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



URA CNRS 1309

Curated by ChEMBL


Assay Description
Inhibition of cAMP-dependent protein kinase (PKA).


J Med Chem 34: 73-8 (1991)


Article DOI: 10.1021/jm00105a012
BindingDB Entry DOI: 10.7270/Q2J38VS9
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit gamma


(Homo sapiens (Human))
BDBM50011236
PNG
(CHEMBL344314 | Isoquinoline-5-sulfonic acid (2-ami...)
Show SMILES NCCNS(=O)(=O)c1cccc2cnccc12
Show InChI InChI=1S/C11H13N3O2S/c12-5-7-14-17(15,16)11-3-1-2-9-8-13-6-4-10(9)11/h1-4,6,8,14H,5,7,12H2
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



URA CNRS 1309

Curated by ChEMBL


Assay Description
Inhibition of cAMP-dependent protein kinase (PKA).


J Med Chem 34: 73-8 (1991)


Article DOI: 10.1021/jm00105a012
BindingDB Entry DOI: 10.7270/Q2J38VS9
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit gamma


(Homo sapiens (Human))
BDBM50216682
PNG
(1-(5-Isoquinolinesulfonyl)-2-methylpiperazine | 1-...)
Show SMILES CC1CNCCN1S(=O)(=O)c1cccc2cnccc12
Show InChI InChI=1S/C14H17N3O2S/c1-11-9-16-7-8-17(11)20(18,19)14-4-2-3-12-10-15-6-5-13(12)14/h2-6,10-11,16H,7-9H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

CHEBI
CHEMBL
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 3.50E+3n/an/an/an/an/an/a



URA CNRS 1309

Curated by ChEMBL


Assay Description
Inhibition of cAMP-dependent protein kinase (PKA).


J Med Chem 34: 73-8 (1991)


Article DOI: 10.1021/jm00105a012
BindingDB Entry DOI: 10.7270/Q2J38VS9
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit gamma


(Homo sapiens (Human))
BDBM15203
PNG
(5-(piperazine-1-sulfonyl)isoquinoline | CHEMBL7577...)
Show SMILES O=S(=O)(N1CCNCC1)c1cccc2cnccc12
Show InChI InChI=1S/C13H15N3O2S/c17-19(18,16-8-6-14-7-9-16)13-3-1-2-11-10-15-5-4-12(11)13/h1-5,10,14H,6-9H2
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 6.00E+3n/an/an/an/an/an/a



URA CNRS 1309

Curated by ChEMBL


Assay Description
Inhibition of cAMP-dependent protein kinase (PKA).


J Med Chem 34: 73-8 (1991)


Article DOI: 10.1021/jm00105a012
BindingDB Entry DOI: 10.7270/Q2J38VS9
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit gamma


(Homo sapiens (Human))
BDBM50135286
PNG
(CHEMBL3745885)
Show SMILES Cn1c2nc(Nc3ccc4[nH]ccc4c3)ncc2cc(c1=O)S(=O)(=O)c1ccc(F)cc1F
Show InChI InChI=1S/C22H15F2N5O3S/c1-29-20-13(9-19(21(29)30)33(31,32)18-5-2-14(23)10-16(18)24)11-26-22(28-20)27-15-3-4-17-12(8-15)6-7-25-17/h2-11,25H,1H3,(H,26,27,28)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Icahn School of Medicine at Mount Sinai

Curated by ChEMBL


Assay Description
Inhibition of human PKAcgamma using [KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK] as substrate


Bioorg Med Chem 24: 521-44 (2016)


Article DOI: 10.1016/j.bmc.2015.11.045
BindingDB Entry DOI: 10.7270/Q24Q7WT8
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit gamma


(Homo sapiens (Human))
BDBM2581
PNG
(3,13,23-triazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^...)
Show SMILES O=C1NCc2c1c1c3ccccc3[nH]c1c1[nH]c3ccccc3c21
Show InChI InChI=1S/C20H13N3O/c24-20-17-12(9-21-20)15-10-5-1-3-7-13(10)22-18(15)19-16(17)11-6-2-4-8-14(11)23-19/h1-8,22-23H,9H2,(H,21,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

CHEMBL
DrugBank
PC cid
PC sid
PDB
UniChem

Patents


Similars

n/an/a 2.57E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of protein kinase A


Citation and Details

BindingDB Entry DOI: 10.7270/Q2HX1FVJ
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit gamma


(Homo sapiens (Human))
BDBM50054426
PNG
(7-hydroxy-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyr...)
Show SMILES OC1NC(=O)c2c1c1c3ccccc3[nH]c1c1[nH]c3ccccc3c21
Show InChI InChI=1S/C20H13N3O2/c24-19-15-13-9-5-1-3-7-11(9)21-17(13)18-14(16(15)20(25)23-19)10-6-2-4-8-12(10)22-18/h1-8,19,21-22,24H,(H,23,25)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

n/an/a 3.40E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of protein kinase A


Citation and Details

BindingDB Entry DOI: 10.7270/Q2HX1FVJ
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit gamma


(Homo sapiens (Human))
BDBM2672
PNG
(3,13,23-triazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^...)
Show SMILES O=C1NC(=O)c2c1c1c3ccccc3[nH]c1c1[nH]c3ccccc3c21
Show InChI InChI=1S/C20H11N3O2/c24-19-15-13-9-5-1-3-7-11(9)21-17(13)18-14(16(15)20(25)23-19)10-6-2-4-8-12(10)22-18/h1-8,21-22H,(H,23,24,25)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

n/an/a 6.00E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of protein kinase A


Citation and Details

BindingDB Entry DOI: 10.7270/Q2HX1FVJ
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit gamma


(Homo sapiens (Human))
BDBM50228842
PNG
(CHEMBL437640)
Show SMILES C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NS(=O)(=O)c1ccc(N(C)C)c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C51H86N22O13S/c1-26(64-40(76)27(2)66-42(78)29(4)72-87(85,86)38-20-19-37(73(5)6)30-13-7-8-14-31(30)38)39(75)65-28(3)41(77)71-36(25-74)46(82)69-33(16-10-22-61-49(54)55)44(80)67-32(15-9-21-60-48(52)53)43(79)68-34(17-11-23-62-50(56)57)45(81)70-35(47(83)84)18-12-24-63-51(58)59/h7-8,13-14,19-20,26-29,32-36,72,74H,9-12,15-18,21-25H2,1-6H3,(H,64,76)(H,65,75)(H,66,78)(H,67,80)(H,68,79)(H,69,82)(H,70,81)(H,71,77)(H,83,84)(H4,52,53,60)(H4,54,55,61)(H4,56,57,62)(H4,58,59,63)/t26-,27-,28-,29-,32-,33-,34-,35-,36-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>7.50E+4n/an/an/an/an/an/a



URA CNRS 1309

Curated by ChEMBL


Assay Description
Inhibition of cAMP-dependent protein kinase (PKA).


J Med Chem 34: 73-8 (1991)


Article DOI: 10.1021/jm00105a012
BindingDB Entry DOI: 10.7270/Q2J38VS9
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit gamma


(Homo sapiens (Human))
BDBM50228845
PNG
(CHEMBL410778)
Show SMILES C[C@H](NC(=O)[C@H](C)NS(=O)(=O)c1ccc(N(C)C)c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C45H76N20O10S/c1-24(59-37(68)26(3)64-76(74,75)34-19-18-33(65(4)5)27-12-6-7-13-28(27)34)35(66)58-25(2)36(67)60-29(14-8-20-54-42(46)47)38(69)61-30(15-9-21-55-43(48)49)39(70)62-31(16-10-22-56-44(50)51)40(71)63-32(41(72)73)17-11-23-57-45(52)53/h6-7,12-13,18-19,24-26,29-32,64H,8-11,14-17,20-23H2,1-5H3,(H,58,66)(H,59,68)(H,60,67)(H,61,69)(H,62,70)(H,63,71)(H,72,73)(H4,46,47,54)(H4,48,49,55)(H4,50,51,56)(H4,52,53,57)/t24-,25-,26-,29-,30-,31-,32-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>7.50E+4n/an/an/an/an/an/a



URA CNRS 1309

Curated by ChEMBL


Assay Description
Inhibition of cAMP-dependent protein kinase (PKA).


J Med Chem 34: 73-8 (1991)


Article DOI: 10.1021/jm00105a012
BindingDB Entry DOI: 10.7270/Q2J38VS9
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit gamma


(Homo sapiens (Human))
BDBM50228844
PNG
(CHEMBL263188)
Show SMILES C[C@H](NC(=O)[C@H](C)NS(=O)(=O)c1ccc(N(C)C)c2ccccc12)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C45H76N20O11S/c1-24(58-36(68)25(2)64-77(75,76)34-18-17-33(65(3)4)26-11-5-6-12-27(26)34)35(67)63-32(23-66)40(72)61-29(14-8-20-55-43(48)49)38(70)59-28(13-7-19-54-42(46)47)37(69)60-30(15-9-21-56-44(50)51)39(71)62-31(41(73)74)16-10-22-57-45(52)53/h5-6,11-12,17-18,24-25,28-32,64,66H,7-10,13-16,19-23H2,1-4H3,(H,58,68)(H,59,70)(H,60,69)(H,61,72)(H,62,71)(H,63,67)(H,73,74)(H4,46,47,54)(H4,48,49,55)(H4,50,51,56)(H4,52,53,57)/t24-,25-,28-,29-,30-,31-,32-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>7.50E+4n/an/an/an/an/an/a



URA CNRS 1309

Curated by ChEMBL


Assay Description
Inhibition of cAMP-dependent protein kinase (PKA).


J Med Chem 34: 73-8 (1991)


Article DOI: 10.1021/jm00105a012
BindingDB Entry DOI: 10.7270/Q2J38VS9
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit gamma


(Homo sapiens (Human))
BDBM50469778
PNG
(CHEMBL116963)
Show SMILES N=c1ccc(nn1CCCCCCCCCCC(=O)Nc1ccc(nn1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C31H36N6O/c32-29-22-20-28(26-17-11-8-12-18-26)36-37(29)24-14-6-4-2-1-3-5-13-19-31(38)33-30-23-21-27(34-35-30)25-15-9-7-10-16-25/h7-12,15-18,20-23,32H,1-6,13-14,19,24H2,(H,33,35,38)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Northwestern University

Curated by ChEMBL


Assay Description
Inhibition of Protein kinase A


Bioorg Med Chem Lett 13: 3465-70 (2003)


Article DOI: 10.1016/s0960-894x(03)00733-9
BindingDB Entry DOI: 10.7270/Q2V69N9R
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit gamma


(Homo sapiens (Human))
BDBM50469776
PNG
(CHEMBL117443)
Show SMILES Cc1ccc(=N)n(CCCCCCCCCCC(=O)Nc2ccc(nn2)-c2ccccc2)n1
Show InChI InChI=1S/C26H34N6O/c1-21-16-18-24(27)32(31-21)20-12-7-5-3-2-4-6-11-15-26(33)28-25-19-17-23(29-30-25)22-13-9-8-10-14-22/h8-10,13-14,16-19,27H,2-7,11-12,15,20H2,1H3,(H,28,30,33)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Northwestern University

Curated by ChEMBL


Assay Description
Inhibition of Protein kinase A


Bioorg Med Chem Lett 13: 3465-70 (2003)


Article DOI: 10.1016/s0960-894x(03)00733-9
BindingDB Entry DOI: 10.7270/Q2V69N9R
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit gamma


(Homo sapiens (Human))
BDBM50469777
PNG
(CHEMBL115531)
Show SMILES N=c1cc2CCc3ccccc3-c2nn1CCCCCCCCCCC(=O)Nc1ccc(nn1)-c1ccccc1
Show InChI InChI=1S/C33H38N6O/c34-30-24-27-20-19-25-14-11-12-17-28(25)33(27)38-39(30)23-13-6-4-2-1-3-5-10-18-32(40)35-31-22-21-29(36-37-31)26-15-8-7-9-16-26/h7-9,11-12,14-17,21-22,24,34H,1-6,10,13,18-20,23H2,(H,35,37,40)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Northwestern University

Curated by ChEMBL


Assay Description
Inhibition of Protein kinase A


Bioorg Med Chem Lett 13: 3465-70 (2003)


Article DOI: 10.1016/s0960-894x(03)00733-9
BindingDB Entry DOI: 10.7270/Q2V69N9R
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit gamma


(Homo sapiens (Human))
BDBM50054421
PNG
(1,11-dichloro-6,7,12,13-tetrahydro-5H-indolo[2,3-a...)
Show SMILES Clc1cccc2c1[nH]c1c3[nH]c4c(Cl)cccc4c3c3C(=O)NC(=O)c3c21
Show InChI InChI=1S/C20H9Cl2N3O2/c21-9-5-1-3-7-11-13-14(20(27)25-19(13)26)12-8-4-2-6-10(22)16(8)24-18(12)17(11)23-15(7)9/h1-6,23-24H,(H,25,26,27)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEBI
CHEMBL
PC cid
PC sid
UniChem

Similars

n/an/a>1.00E+5n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of protein kinase A


Citation and Details

BindingDB Entry DOI: 10.7270/Q2HX1FVJ
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit gamma


(Homo sapiens (Human))
BDBM50074289
PNG
((4-Methyl-6-phenyl-pyridazin-3-yl)-(2-morpholin-4-...)
Show SMILES Cc1cc(nnc1NCCN1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C17H22N4O/c1-14-13-16(15-5-3-2-4-6-15)19-20-17(14)18-7-8-21-9-11-22-12-10-21/h2-6,13H,7-12H2,1H3,(H,18,20)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

CHEMBL
DrugBank
MCE
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Northwestern University

Curated by ChEMBL


Assay Description
Inhibition of Protein kinase A


Bioorg Med Chem Lett 13: 3465-70 (2003)


Article DOI: 10.1016/s0960-894x(03)00733-9
BindingDB Entry DOI: 10.7270/Q2V69N9R
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit gamma


(Homo sapiens (Human))
BDBM50476034
PNG
(CHEMBL218747)
Show SMILES CCc1cccc2c1CNc1c(CCc3ccccc3)cccc1\C=C2\COc1ccccc1NC(C)=O
Show InChI InChI=1S/C34H34N2O2/c1-3-26-13-10-16-30-29(23-38-33-18-8-7-17-32(33)36-24(2)37)21-28-15-9-14-27(34(28)35-22-31(26)30)20-19-25-11-5-4-6-12-25/h4-18,21,35H,3,19-20,22-23H2,1-2H3,(H,36,37)/b29-21-
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.22E+5n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of PKA-mediated phosphorylation of kemptide at 100 uM


Bioorg Med Chem Lett 16: 5360-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.078
BindingDB Entry DOI: 10.7270/Q2NG4TD5
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit gamma


(Homo sapiens (Human))
BDBM50505542
PNG
(CHEMBL4576489)
Show SMILES CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)CCOCCOCCOCCNC(=O)CCC1=[N+]2C(C=C1)=Cc1c(C)cc(C)n1[B-]2(F)F
Show InChI InChI=1S/C50H56BF2N7O7/c1-30-26-31(2)59-39(30)27-33-15-14-32(60(33)51(59,52)53)16-17-41(61)54-18-20-64-22-24-66-25-23-65-21-19-56(4)40-28-42-57-37-12-8-6-10-34(37)44-45-36(29-55-49(45)62)43-35-11-7-9-13-38(35)58(47(43)46(44)57)50(3,67-42)48(40)63-5/h6-15,26-27,40,42,48H,16-25,28-29H2,1-5H3,(H,54,61)(H,55,62)/t40-,42-,48-,50+/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 154n/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Binding affinity to recombinant full-length N-terminal His-FLAG-GST-tagged PRKACG (unknown origin) expressed in baculovirus infected Sf9 insect cells...


Bioorg Med Chem Lett 29: (2019)


Article DOI: 10.1016/j.bmcl.2019.126641
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit gamma


(Homo sapiens (Human))
BDBM50505541
PNG
(CHEMBL4465866)
Show SMILES CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)NCCOCCOCCOCCNC(=O)CCC1=[N+]2C(C=C1)=Cc1c(C)cc(C)n1[B-]2(F)F
Show InChI InChI=1S/C49H54BF2N7O7/c1-29-25-30(2)58-39(29)26-32-14-13-31(59(32)50(58,51)52)15-16-40(60)54-18-20-64-22-24-65-23-21-63-19-17-53-36-27-41-56-37-11-7-5-9-33(37)43-44-35(28-55-48(44)61)42-34-10-6-8-12-38(34)57(46(42)45(43)56)49(3,66-41)47(36)62-4/h5-14,25-26,36,41,47,53H,15-24,27-28H2,1-4H3,(H,54,60)(H,55,61)/t36-,41-,47-,49+/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 148n/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Binding affinity to recombinant full-length N-terminal His-FLAG-GST-tagged PRKACG (unknown origin) expressed in baculovirus infected Sf9 insect cells...


Bioorg Med Chem Lett 29: (2019)


Article DOI: 10.1016/j.bmcl.2019.126641
More data for this
Ligand-Target Pair