Compile Data Set for Download or QSAR
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Found 24 Enz. Inhib. hit(s) with all data for entry = 9253
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM453207(1-(5-fluoro-2-methoxy-4-(4,4,4-trifluoro-3,3- dime...)
Affinity DataIC50:  1.20nMAssay Description:HEK 293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro automated ele...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM453206(1-(4-((4,4-difluorocyclohexyl)ethynyl)-5-fluoro-2-...)
Affinity DataIC50:  3.30nMAssay Description:HEK 293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro automated ele...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM217959(US10729684, Example 10 | US9212182, 643)
Affinity DataIC50:  4.53nMAssay Description:HEK 293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro automated ele...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM453211(1-(5-fluoro-2-methoxy-4-(((1R,2S)-2- (trifluoromet...)
Affinity DataIC50:  5.5nMAssay Description:HEK 293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro automated ele...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM453210(1-(5-fluoro-2-methoxy-4-(((1R,2S)-2- (trifluoromet...)
Affinity DataIC50:  6.80nMAssay Description:HEK 293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro automated ele...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM453209(1-(5-fluoro-2-methoxy-4-(((1R,2S)-2-(trifluorometh...)
Affinity DataIC50:  7nMAssay Description:HEK 293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro automated ele...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM453208(1-(4-(cyclopentylethynyl)-2-methoxyphenyl)-N-3- is...)
Affinity DataIC50:  7.5nMAssay Description:HEK 293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro automated ele...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM453214(1-(5-chloro-4-(cyclopentylethynyl)-2- methoxypheny...)
Affinity DataIC50:  7.80nMAssay Description:HEK 293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro automated ele...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM453212(1-(5-fluoro-2-methoxy-4-(((1R,2R)-2- (trifluoromet...)
Affinity DataIC50:  8nMAssay Description:HEK 293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro automated ele...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM217977(US10729684, Example 9 | US9212182, 645)
Affinity DataIC50:  8.95nMAssay Description:HEK 293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro automated ele...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM453215(1-(4-(((1R)-3,3-difluorocyclohexyl)ethynyl)-5-fluo...)
Affinity DataIC50:  9.73nMAssay Description:HEK 293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro automated ele...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM453213(1-(5-fluoro-2-methoxy-4-((1- (trifluoromethyl)cycl...)
Affinity DataIC50:  10nMAssay Description:HEK 293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro automated ele...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM217959(US10729684, Example 10 | US9212182, 643)
Affinity DataIC50:  17.3nMAssay Description:HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM453213(1-(5-fluoro-2-methoxy-4-((1- (trifluoromethyl)cycl...)
Affinity DataIC50:  18.6nMAssay Description:HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM217977(US10729684, Example 9 | US9212182, 645)
Affinity DataIC50:  19.3nMAssay Description:HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM453207(1-(5-fluoro-2-methoxy-4-(4,4,4-trifluoro-3,3- dime...)
Affinity DataIC50:  27.8nMAssay Description:HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM453215(1-(4-(((1R)-3,3-difluorocyclohexyl)ethynyl)-5-fluo...)
Affinity DataIC50:  33.8nMAssay Description:HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM453206(1-(4-((4,4-difluorocyclohexyl)ethynyl)-5-fluoro-2-...)
Affinity DataIC50:  44.6nMAssay Description:HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM453208(1-(4-(cyclopentylethynyl)-2-methoxyphenyl)-N-3- is...)
Affinity DataIC50:  49.7nMAssay Description:HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM453209(1-(5-fluoro-2-methoxy-4-(((1R,2S)-2-(trifluorometh...)
Affinity DataIC50:  57.8nMAssay Description:HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM453212(1-(5-fluoro-2-methoxy-4-(((1R,2R)-2- (trifluoromet...)
Affinity DataIC50:  62nMAssay Description:HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM453214(1-(5-chloro-4-(cyclopentylethynyl)-2- methoxypheny...)
Affinity DataIC50:  66.7nMAssay Description:HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM453211(1-(5-fluoro-2-methoxy-4-(((1R,2S)-2- (trifluoromet...)
Affinity DataIC50:  139nMAssay Description:HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM453210(1-(5-fluoro-2-methoxy-4-(((1R,2S)-2- (trifluoromet...)
Affinity DataIC50:  210nMAssay Description:HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent