Compile Data Set for Download or QSAR
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Found 11 Enz. Inhib. hit(s) with all data for entry = 5882
TargetKappa-type opioid receptor(Homo sapiens (Human))
The Mclean Hospital

US Patent
LigandPNGBDBM50266418((2S,4aR,6aR,7R,9S,10aS,10bR)-methyl 9-acetoxy-2-((...)
Affinity DataKi:  20nMAssay Description:In vitro binding assay: The affinities of compounds for opioid receptors were determined by competitive inhibition of [3H]diprenorphine binding to ka...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
The Mclean Hospital

US Patent
LigandPNGBDBM50266390((2S,4aR,6aR,7R,9S,10aS,10bR)-methyl 9-acetoxy-6a,1...)
Affinity DataKi:  38nMAssay Description:In vitro binding assay: The affinities of compounds for opioid receptors were determined by competitive inhibition of [3H]diprenorphine binding to ka...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
The Mclean Hospital

US Patent
LigandPNGBDBM98547(US8492564, 6)
Affinity DataKi:  41nMAssay Description:In vitro binding assay: The affinities of compounds for opioid receptors were determined by competitive inhibition of [3H]diprenorphine binding to ka...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
The Mclean Hospital

US Patent
LigandPNGBDBM98546(US8492564, 7)
Affinity DataKi:  55nMAssay Description:In vitro binding assay: The affinities of compounds for opioid receptors were determined by competitive inhibition of [3H]diprenorphine binding to ka...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
The Mclean Hospital

US Patent
LigandPNGBDBM50266417((2S,4aR,6aR,7R,9S,10aS,10bR)-methyl 9-acetoxy-6a,1...)
Affinity DataKi:  83nMAssay Description:In vitro binding assay: The affinities of compounds for opioid receptors were determined by competitive inhibition of [3H]diprenorphine binding to ka...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
The Mclean Hospital

US Patent
LigandPNGBDBM50266445((2S,4aR,6aR,7R,9S,10aS,10bR)-2-isopropyl 7-methyl ...)
Affinity DataKi:  109nMAssay Description:In vitro binding assay: The affinities of compounds for opioid receptors were determined by competitive inhibition of [3H]diprenorphine binding to ka...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
The Mclean Hospital

US Patent
LigandPNGBDBM50266419((2S,4aR,6aR,7R,9S,10aS,10bR)-dimethyl 9-acetoxy-6a...)
Affinity DataKi:  154nMAssay Description:In vitro binding assay: The affinities of compounds for opioid receptors were determined by competitive inhibition of [3H]diprenorphine binding to ka...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
The Mclean Hospital

US Patent
LigandPNGBDBM50266420((2S,4aR,6aR,7R,9S,10aS,10bR)-2-ethyl 7-methyl 9-ac...)
Affinity DataKi:  196nMAssay Description:In vitro binding assay: The affinities of compounds for opioid receptors were determined by competitive inhibition of [3H]diprenorphine binding to ka...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
The Mclean Hospital

US Patent
LigandPNGBDBM50266388((2S,4aR,6aR,7R,9S,10aS,10bR)-methyl 9-acetoxy-2-(e...)
Affinity DataKi:  497nMAssay Description:In vitro binding assay: The affinities of compounds for opioid receptors were determined by competitive inhibition of [3H]diprenorphine binding to ka...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
The Mclean Hospital

US Patent
LigandPNGBDBM50266387((2S,4aR,6aR,7R,9S,10aS,10bR)-methyl 9-acetoxy-2-(m...)
Affinity DataKi:  498nMAssay Description:In vitro binding assay: The affinities of compounds for opioid receptors were determined by competitive inhibition of [3H]diprenorphine binding to ka...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
The Mclean Hospital

US Patent
LigandPNGBDBM50266389((2S,4aR,6aR,7R,9S,10aS,10bR)-methyl 9-acetoxy-2-(a...)
Affinity DataKi:  555nMAssay Description:In vitro binding assay: The affinities of compounds for opioid receptors were determined by competitive inhibition of [3H]diprenorphine binding to ka...More data for this Ligand-Target Pair
In DepthDetails US Patent