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Found 7 Enz. Inhib. hit(s) with all data for entry = 6951
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM19187((2S)-2-[({4-[(3-fluorophenyl)methoxy]phenyl}methyl...)
Affinity DataIC50:  100nMpH: 7.4Assay Description:The enzyme activity was assessed with a radioenzymatic assay using the substrate 14C-phenylethylamine (PEA) specific for MAO-B.The mitochondrial pell...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM161094(US9051240, (S)-(+)-2-[4-(2-Fluorobenzyloxy)-benzyl...)
Affinity DataIC50:  200nMpH: 7.4Assay Description:The enzyme activity was assessed with a radioenzymatic assay using the substrate 14C-phenylethylamine (PEA) specific for MAO-B.The mitochondrial pell...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM161089(US9051240, 2-[2-(3-Butoxyphenyl)-ethylamino]-N-met...)
Affinity DataIC50:  1.10E+5nMpH: 7.4Assay Description:The enzyme activity was assessed with a radioenzymatic assay using the substrate 14C-phenylethylamine (PEA) specific for MAO-B.The mitochondrial pell...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM161090(US9051240, 2-[2-(3-Butoxyphenyl)-ethylamino]-N,N-d...)
Affinity DataIC50:  2.31E+5nMpH: 7.4Assay Description:The enzyme activity was assessed with a radioenzymatic assay using the substrate 14C-phenylethylamine (PEA) specific for MAO-B.The mitochondrial pell...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM161093(US9051240, 2-[2-(3-Butoxyphenyl)-ethylamino]-N,N-d...)
Affinity DataIC50: >3.00E+5nMpH: 7.4Assay Description:The enzyme activity was assessed with a radioenzymatic assay using the substrate 14C-phenylethylamine (PEA) specific for MAO-B.The mitochondrial pell...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM161091(US9051240, 2-[2-(3-Butoxy-2,6-difluorophenyl)-ethy...)
Affinity DataIC50: >3.00E+5nMpH: 7.4Assay Description:The enzyme activity was assessed with a radioenzymatic assay using the substrate 14C-phenylethylamine (PEA) specific for MAO-B.The mitochondrial pell...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM161092(US9051240, 2-[2-(3-Butoxy-4-methoxyphenyl)-ethylam...)
Affinity DataIC50: >3.00E+5nMpH: 7.4Assay Description:The enzyme activity was assessed with a radioenzymatic assay using the substrate 14C-phenylethylamine (PEA) specific for MAO-B.The mitochondrial pell...More data for this Ligand-Target Pair
In DepthDetails US Patent