Found 5 Enz. Inhib. hit(s) for PDB: 1HVK 
Affinity DataKi: 0.0110nM ΔG°: -63.6kJ/molepH: 4.7 T: 2°CAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay using the internally quenched fluorogenic substrate DABCYL-GABA-Ser-Gln-Tyr-P...More data for this Ligand-Target Pair
3D Structure (crystal)TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Universidad De Santiago De Compostela
Universidad De Santiago De Compostela
Affinity DataKi: 1.30nM ΔG°: -52.8kJ/molepH: 4.7 T: 2°CAssay Description:The inhibition constants Ki were determined by monitoring the inhibition of hydrolysis of the chromogenic substrate using a Hewlett-Packard 8452A spe...More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587,V571A](Human immunodeficiency virus type 1)
Universidad De Santiago De Compostela
Universidad De Santiago De Compostela
Affinity DataKi: 9nM ΔG°: -47.8kJ/molepH: 4.7 T: 2°CAssay Description:The inhibition constants Ki were determined by monitoring the inhibition of hydrolysis of the chromogenic substrate using a Hewlett-Packard 8452A spe...More data for this Ligand-Target Pair
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Universidade Federal De Lavras
Curated by ChEMBL
Universidade Federal De Lavras
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of HIV1 protease expressed in Escherichia coli K12 assessed as inhibition of enzyme activityMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Harvard University
Curated by ChEMBL
Harvard University
Curated by ChEMBL
Affinity DataKd: 0.0759nMAssay Description:Affinity for HIV ProteaseMore data for this Ligand-Target Pair
