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Found 6 Enz. Inhib. hit(s) for PDB: 1LD8
LigandPNGBDBM14010((20R)-19,20,21,22-Tetrahydro-19-oxo-5H-18,20-ethan...)
Affinity DataIC50:  1.60nMpH: 7.5 T: 2°CAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
LigandPNGBDBM14009((20S)-19,20,21,22-Tetrahydro-19-oxo-5H-18,20-ethan...)
Affinity DataIC50:  3.5nMpH: 7.5 T: 2°CAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
LigandPNGBDBM14009((20S)-19,20,21,22-Tetrahydro-19-oxo-5H-18,20-ethan...)
Affinity DataIC50:  3.5nMAssay Description:In vitro inhibitory activity to reduce the human farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
LigandPNGBDBM14009((20S)-19,20,21,22-Tetrahydro-19-oxo-5H-18,20-ethan...)
Affinity DataIC50:  650nMAssay Description:The enzymatic reaction between [3H]GGPP and a biotinylated peptide was carried out in the presence of 5 mM ATP and varying concentrations of inhibit...More data for this Ligand-Target Pair
LigandPNGBDBM14010((20R)-19,20,21,22-Tetrahydro-19-oxo-5H-18,20-ethan...)
Affinity DataIC50:  3.90E+3nMAssay Description:The enzymatic reaction between [3H]GGPP and a biotinylated peptide was carried out in the presence of 5 mM ATP and varying concentrations of inhibit...More data for this Ligand-Target Pair
LigandPNGBDBM50366477(CHEMBL69330)
Affinity DataKd:  2nMAssay Description:Binding affinity to FTase (unknown origin)More data for this Ligand-Target Pair