Affinity Data by PDB ID

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PDB code 1YDS

Identical Ligands in BindingDB

Found 2 hits Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Cyclic AMP-dependent protein kinase (PKA) (339/350 = 97%)^† (Oryctolagus cuniculus (Rabbit))	BDBM15210 (CHEMBL148333 \| H-8 \| Lopac-M-9656 \| N-(2-methylami...) Show SMILES CNCCNS(=O)(=O)c1cccc2cnccc12 Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL GoogleScholar	Purchase CHEBI CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Institute for Biochemistry Curated by ChEMBL					Assay Description Inhibitory constant against cAPK (PKA)				J Biol Chem 271: 26157-64 (1996) Article DOI: 10.1074/jbc.271.42.26157 BindingDB Entry DOI: 10.7270/Q2BR8T3M
Institute for Biochemistry Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP-Dependent Protein Kinase (PKA) (348/350 > 99%)^† (Bos taurus (bovine))	BDBM15210 (CHEMBL148333 \| H-8 \| Lopac-M-9656 \| N-(2-methylami...) Show SMILES CNCCNS(=O)(=O)c1cccc2cnccc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar	Purchase CHEBI CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	5.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
UK Centre for Cancer Therapeutics					Assay Description The recombinant alpha catalytic subunit of bovine PKA was assayed with a peptide substrate and test compound in the presence of 40 uM ATP/ [gamma-33P...				Bioorg Med Chem 14: 1255-73 (2006) Article DOI: 10.1016/j.bmc.2005.09.055 BindingDB Entry DOI: 10.7270/Q2FN14F2
UK Centre for Cancer Therapeutics					More data for this Ligand-Target Pair				3D Structure (crystal)

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_* indicates data uncertainty>20%
* 0.9 Tanimoto similarity
† Identities from BLAST output