Found 23 Enz. Inhib. hit(s) for PDB: 1YET 
Affinity DataIC50: <10nMAssay Description:Inhibition of HSP90 in human MDA-kb2 cells assessed as reduction in glucocorticoid receptor-dependent luciferase expression after 18 hrs by firefly l...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 14nMAssay Description:Inhibition of fluorescein isothiocyanate labeled geldanamycin binding to N-terminal domain of full length human recombinant Hsp90alpha expressed in E...More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of FITC-geldanamycin binding to N-terminal domain of recombinant full-length HSP90alpha (unknown origin) after 16 hrs by fluorescence pola...More data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of geldanamycin-based probe binding to HSP90 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMpH: 7.3 T: 2°CAssay Description:Compounds were assayed over a threefold dilution series in a 96-well plate format to determine IC50 values. The reaction was allowed to proceed with ...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Binding affinity to Hsp90 by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Inhibition of HSP90alpha (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of HSP90alpha after 3 hrs by fluorescence polarization binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Binding affinity to HSP90alpha after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of Hsp90alpha after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 74nMAssay Description:Displacement of GM-BODIPY from human full length HSP90 alpha expressed in baculovirus-infected Sf9 cells after 16 hrs by fluorescence polarization as...More data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Displacement of GA-FITC from human recombinant HSP90alpha ATP-binding site by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of steady-state expression of Raf-1 in MCF-7 breast cancer cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 272nMAssay Description:Inhibition of recombinant Homo sapiens (human) Hsp90 alpha ATPase activity assessed as inorganic phosphate release by malachite green colorimetric me...More data for this Ligand-Target Pair
Affinity DataIC50: 348nMAssay Description:Inhibition of HSP90 using VER-00045864 probe by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 780nMAssay Description:Inhibition of GA-FITC binding to human recombinant Hsp90alpha incubated for 5 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKd: 670nMAssay Description:Binding affinity to human recombinant HSP90More data for this Ligand-Target Pair
Affinity DataKd: 1.22E+3nMAssay Description:The compound was tested for binding affinity against yeast Heat shock protein HSP 90More data for this Ligand-Target Pair
Affinity DataKd: 775nMAssay Description:The compound was tested for binding affinity against isolated N-domain of Heat shock protein HSP 90More data for this Ligand-Target Pair
Affinity DataKd: 1.00E+3nMAssay Description:Binding affinity to Hsp90 N-domainMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataEC50: 35nMAssay Description:Displacement of GM-BODIPY from Hsp90More data for this Ligand-Target Pair
Affinity DataKd: 714nMAssay Description:Binding affinity to N-terminal FLAG-tagged human recombinant HSP90alpha expressed in Escherichia coli BL21(DE3) by microscale thermophoresis assayMore data for this Ligand-Target Pair
Affinity DataKd: 152nMAssay Description:Binding affinity to N-terminal FLAG-tagged human recombinant HSP90beta expressed in Escherichia coli BL21(DE3) by microscale thermophoresis assayMore data for this Ligand-Target Pair
