Compile Data Set for Download or QSAR
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Found 4 Enz. Inhib. hit(s) for PDB: 2C3I
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM11835(1-(3-{6-[(cyclopropylmethyl)amino]imidazo[1,2-a]py...)
Affinity DataIC50:  61nMAssay Description:Inhibition of Pim1 (unknown origin) assessed as [32P] incorporation preincubated for 15 mins before ATP substrate addition by coupled spectrophotomet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM11835(1-(3-{6-[(cyclopropylmethyl)amino]imidazo[1,2-a]py...)
Affinity DataIC50:  61nMAssay Description:Inhibitory activity against PIM1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM11835(1-(3-{6-[(cyclopropylmethyl)amino]imidazo[1,2-a]py...)
Affinity DataIC50:  120nMpH: 7.5 T: 2°CAssay Description:Phosphorylation reactions were monitored using a coupled-enzyme assay in which ADP production was coupled to NADH oxidation by pyruvate kinase and la...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM11835(1-(3-{6-[(cyclopropylmethyl)amino]imidazo[1,2-a]py...)
Affinity DataKd:  25nMAssay Description:Binding affinity to non phosphorylated PIM1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed