Compile Data Set for Download or QSAR
maximum 50k data
Found 5 Enz. Inhib. hit(s) for PDB: 2V8X
TargetEukaryotic translation initiation factor 4E(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50316305(((2R,3S,4R,5R)-5-(2-amino-7-benzyl-6-oxo-1H-purin-...)
Affinity DataIC50:  1.55E+4nMAssay Description:Competitive inhibition of [3H]m7-GTP binding to human FLAG-His6 tagged eIF4E expressed in Escherichia coli by scintillation proximity assayMore data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 4E(Oryctolagus cuniculus)
Amgen

Curated by ChEMBL
LigandPNGBDBM50316305(((2R,3S,4R,5R)-5-(2-amino-7-benzyl-6-oxo-1H-purin-...)
Affinity DataIC50:  2.68E+4nMAssay Description:Inhibition of eIF4E in rabbit reticulocyte cell lysate assessed as inhibition of cap-dependent translation after 90 mins by luciferase reporter gene ...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 4E(Mus musculus)
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50316305(((2R,3S,4R,5R)-5-(2-amino-7-benzyl-6-oxo-1H-purin-...)
Affinity DataKd:  790nMAssay Description:Binding affinity to mouse eIF4E expressed in Escherichia coli by fluorescence time-synchronized titration method in absence of KKRYDREFLLGFQFIFAMore data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 4E(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50249977(CHEMBL1234304)
Affinity DataKd:  800nMAssay Description:Binding affinity to eIF4E (unknown origin) by fluorescence titration assayMore data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 4E(Mus musculus)
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50316305(((2R,3S,4R,5R)-5-(2-amino-7-benzyl-6-oxo-1H-purin-...)
Affinity DataKd:  1.32E+3nMAssay Description:Binding affinity to mouse eIF4E expressed in Escherichia coli by fluorescence time-synchronized titration method in presence of KKRYDREFLLGFQFIFAMore data for this Ligand-Target Pair