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Found 4 Enz. Inhib. hit(s) for PDB: 2ZDZ
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM16753(2-[2-(2-chlorophenyl)-5-[4-(4-acetylphenoxy)phenyl...)
Affinity DataIC50:  160nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM16753(2-[2-(2-chlorophenyl)-5-[4-(4-acetylphenoxy)phenyl...)
Affinity DataIC50:  700nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM16753(2-[2-(2-chlorophenyl)-5-[4-(4-acetylphenoxy)phenyl...)
Affinity DataIC50:  700nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM16753(2-[2-(2-chlorophenyl)-5-[4-(4-acetylphenoxy)phenyl...)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of BACE1 assessed as reduction of total cellular amyloid beta formation by ELISAMore data for this Ligand-Target Pair