Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SARS Coronavirus Coronavirus Papain-Like Protease (315/315 = 100%)† (Human SARS coronavirus (SARS-CoV)) | BDBM31524![]() (5-amino-2-methyl-N-[(1R)-1-(naphthalen-1-yl)ethyl]...) | PDB MMDB DrugBank GoogleScholar | Purchase DrugBank MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 230 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Illinois at Chicago | Assay Description done in a single pass in black 384-well plates (Matrix Technologies). The SARS-PLpro enzyme (20 nM final concentration) was prepared in an assay buff... | ACS Chem Biol 10: 1456-65 (2015) Article DOI: 10.1021/cb500917m BindingDB Entry DOI: 10.7270/Q2086426 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Papain-like protease (PLpro) (315/315 = 100%)† (Human SARS coronavirus (SARS-CoV)) | BDBM31523![]() (Compound 6 | Naphthalene and Benzamide Derivative,...) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 560 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bonn | Assay Description This is a review article. | Med Res Rev (2020) Article DOI: 10.1002/med.21724 BindingDB Entry DOI: 10.7270/Q2JS9ST6 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
SARS Coronavirus Coronavirus Papain-Like Protease (315/315 = 100%)† (Human SARS coronavirus (SARS-CoV)) | BDBM31523![]() (Compound 6 | Naphthalene and Benzamide Derivative,...) | PDB MMDB DrugBank GoogleScholar | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 560 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Purdue University | Assay Description IC50 values for all inhibitors were determined using a 96-well plate based assay. Reactions were performed in buffer containing RLRGG-AMC, 2% DMSO, a... | J Med Chem 52: 5228-40 (2009) Article DOI: 10.1021/jm900611t BindingDB Entry DOI: 10.7270/Q2P8497Z | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Papain-like protease (PLpro) (315/315 = 100%)† (Human SARS coronavirus (SARS-CoV)) | BDBM31524![]() (5-amino-2-methyl-N-[(1R)-1-(naphthalen-1-yl)ethyl]...) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar | Purchase DrugBank MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bonn | Assay Description This is a review article. | Med Res Rev (2020) Article DOI: 10.1002/med.21724 BindingDB Entry DOI: 10.7270/Q2JS9ST6 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
SARS Coronavirus Coronavirus Papain-Like Protease (315/315 = 100%)† (Human SARS coronavirus (SARS-CoV)) | BDBM31524![]() (5-amino-2-methyl-N-[(1R)-1-(naphthalen-1-yl)ethyl]...) | PDB MMDB DrugBank GoogleScholar | Purchase DrugBank MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 2.64E+3 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Purdue University | Assay Description IC50 values for all inhibitors were determined using a 96-well plate based assay. Reactions were performed in buffer containing RLRGG-AMC, 2% DMSO, a... | J Med Chem 52: 5228-40 (2009) Article DOI: 10.1021/jm900611t BindingDB Entry DOI: 10.7270/Q2P8497Z | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |