Compile Data Set for Download or QSAR
maximum 50k data
Found 23 Enz. Inhib. hit(s) for PDB: 3FQS
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM60665(BDBM50249542 | US9145414, R406 | US9212178, R406)
Affinity DataKi:  30nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM60665(BDBM50249542 | US9145414, R406 | US9212178, R406)
Affinity DataIC50:  5.5nMpH: 7.4 T: 2°CAssay Description:The in vitro inhibitory activity of the compound against Aurora B kinase activity was assayed with reference to a method described in patent public...More data for this Ligand-Target Pair
In DepthDetails US PatentDrugBank

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM60665(BDBM50249542 | US9145414, R406 | US9212178, R406)
Affinity DataIC50:  23.6nMT: 2°CAssay Description:Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...More data for this Ligand-Target Pair
In DepthDetails US PatentDrugBank

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM60665(BDBM50249542 | US9145414, R406 | US9212178, R406)
Affinity DataIC50:  41nMAssay Description:Inhibition of SYK in human mast cell cultures assessed as reduction in Anti-IgG-stimulated FcgammaR-mediated leukotriene LTC4 production by fluoresce...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM60665(BDBM50249542 | US9145414, R406 | US9212178, R406)
Affinity DataIC50:  41nMAssay Description:Inhibition of recombinant Syk (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM60665(BDBM50249542 | US9145414, R406 | US9212178, R406)
Affinity DataIC50:  64nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM60665(BDBM50249542 | US9145414, R406 | US9212178, R406)
Affinity DataIC50:  68nMAssay Description:Inhibition of Syk (unknown origin) using 4 uM peptide assessed as product formation after 60 mins incubation by microfluidic mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM60665(BDBM50249542 | US9145414, R406 | US9212178, R406)
Affinity DataIC50:  457nMAssay Description:Inhibition of Syk in anti IgM-stimulated human Ramos cells assessed as BLNK phosphorylation by cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM60665(BDBM50249542 | US9145414, R406 | US9212178, R406)
Affinity DataIC50:  3.35E+3nMAssay Description:Inhibition of Syk in human whole blood assessed as inhibition of P-SLP76 in CD14+ monocytes by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM60665(BDBM50249542 | US9145414, R406 | US9212178, R406)
Affinity DataEC50:  335nMAssay Description:Inhibition of Syk in alphaIgM-stimulated human B cells assessed as CD86 expression after 1 hr incubation by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM60665(BDBM50249542 | US9145414, R406 | US9212178, R406)
Affinity DataEC50:  53nMAssay Description:Inhibition of Syk in antihuman IgM-stimulated human Ramos cells assessed as decrease in BCR-mediated BLNK phosphorylation by cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM60665(BDBM50249542 | US9145414, R406 | US9212178, R406)
Affinity DataKd:  19nMAssay Description:Binding constant for SYK kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM60665(BDBM50249542 | US9145414, R406 | US9212178, R406)
Affinity DataEC50:  10nMAssay Description:Inhibition of SYK in OVA-challenged and IgE-sensitized cells assessed as reduction in TNFalpha releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM60665(BDBM50249542 | US9145414, R406 | US9212178, R406)
Affinity DataEC50:  10nMAssay Description:Inhibition of SYK in OVA-challenged and IgE-sensitized cells assessed as reduction in IL13 releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM60665(BDBM50249542 | US9145414, R406 | US9212178, R406)
Affinity DataEC50:  10nMAssay Description:Inhibition of SYK in OVA-challenged and IgE-sensitized cells assessed as reduction in IL6 releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM60665(BDBM50249542 | US9145414, R406 | US9212178, R406)
Affinity DataEC50:  10nMAssay Description:Inhibition of SYK in OVA-challenged and IgE-sensitized cells assessed as reduction in IL2 releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM60665(BDBM50249542 | US9145414, R406 | US9212178, R406)
Affinity DataEC50:  48nMAssay Description:Inhibition of SYK in human B-cells cells assessed as reduction in FcepsilonR1/FcgammaR-mediated signaling responsesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM60665(BDBM50249542 | US9145414, R406 | US9212178, R406)
Affinity DataEC50:  33nMAssay Description:Inhibition of SYK in human neutrophils cells assessed as reduction in FcepsilonR1/FcgammaR-mediated signaling responsesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM60665(BDBM50249542 | US9145414, R406 | US9212178, R406)
Affinity DataEC50:  171nMAssay Description:Inhibition of SYK in human THP1 cells assessed as reduction in FcepsilonR1/FcgammaR-mediated signaling responsesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM60665(BDBM50249542 | US9145414, R406 | US9212178, R406)
Affinity DataEC50:  111nMAssay Description:Inhibition of SYK in human macrophages assessed as reduction in FcepsilonR1/FcgammaR-mediated signaling responsesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM60665(BDBM50249542 | US9145414, R406 | US9212178, R406)
Affinity DataEC50:  56nMAssay Description:Inhibition of SYK in cultured human mesangial cells assessed as reduction in FcepsilonR1/FcgammaR-mediated signaling responsesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM60665(BDBM50249542 | US9145414, R406 | US9212178, R406)
Affinity DataEC50:  151nMAssay Description:Inhibition of Syk in alphaIgM-stimulated human B cells assessed as cell proliferation after 1 hr incubation by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM60665(BDBM50249542 | US9145414, R406 | US9212178, R406)
Affinity DataEC50:  3.66E+3nMAssay Description:Inhibition of Syk in goat antihuman IgE-induced CD63 expression in human whole blood by FACS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank