Compile Data Set for Download or QSAR
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Found 4 Enz. Inhib. hit(s) for PDB: 3JX4
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Northwestern University

US Patent
LigandPNGBDBM50330883(CHEMBL1233715 | CHEMBL1277952 | N1-((3R,4S)-4-((6-...)
Affinity DataKi:  17.7nMAssay Description:Recombinant NOS isozymes over-expressed in E. coli were utilized. (Ji, H., et al., Discovery of highly potent and selective inhibitors of neuronal ni...More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50330883(CHEMBL1233715 | CHEMBL1277952 | N1-((3R,4S)-4-((6-...)
Affinity DataKi:  1.61E+7nMAssay Description:Inhibition of rat recombinant nNOSMore data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50279361((+/-)-N1-(4-((6-amino-4-methylpyridin-2-yl)methyl)...)
Affinity DataIC50:  100nMAssay Description:Inhibition of wild type rat nNOS by hemoglobin capture assayMore data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Northwestern University

US Patent
LigandPNGBDBM50279361((+/-)-N1-(4-((6-amino-4-methylpyridin-2-yl)methyl)...)
Affinity DataIC50:  700nMAssay Description:Inhibition of human nNOS by hemoglobin capture assayMore data for this Ligand-Target Pair