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Found 6 Enz. Inhib. hit(s) for PDB: 4DEG
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50302905(7-methoxy-N-((6-(3-methylisothiazol-5-yl)-[1,2,4]t...)
Affinity DataKi:  3.20nM ΔG°:  -48.8kJ/molepH: 8.0 T: 2°CAssay Description:A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50302905(7-methoxy-N-((6-(3-methylisothiazol-5-yl)-[1,2,4]t...)
Affinity DataIC50:  3nMAssay Description:Inhibition of HGF-mediated human c-Met autophosphorylation expressed in human PC3 cells after 1 hr by electrochemiluminescent immunoassayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50302905(7-methoxy-N-((6-(3-methylisothiazol-5-yl)-[1,2,4]t...)
Affinity DataIC50:  5nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50302905(7-methoxy-N-((6-(3-methylisothiazol-5-yl)-[1,2,4]t...)
Affinity DataIC50:  6nMAssay Description:Inhibition of recombinant MET (unknown origin) using gastrin peptide as substrate preincubated for 30 mins followed by substrate addition incubated f...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50302905(7-methoxy-N-((6-(3-methylisothiazol-5-yl)-[1,2,4]t...)
Affinity DataIC50:  6nMAssay Description:Inhibition of C-Met (unknown origin) using polu (Glu,Tyr)4:1 substrate after 30 mins incubation by multi-well spectrophotometryMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50302905(7-methoxy-N-((6-(3-methylisothiazol-5-yl)-[1,2,4]t...)
Affinity DataIC50:  6nMAssay Description:Inhibition of recombinant MET (unknown origin) using gastrin peptide as substrate preincubated for 30 mins followed by substrate addition incubated f...More data for this Ligand-Target Pair