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Found 22 Enz. Inhib. hit(s) for PDB: 4FYR
TargetAminopeptidase N(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  800nMAssay Description:Inhibition of recombinant human C-terminal His10-tagged APN (Lys69 to Lys967 residues) using Ala-AMC as substrate measured for 30 mins by fluorescenc...More data for this Ligand-Target Pair
TargetAminopeptidase N(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of aminopeptidase NMore data for this Ligand-Target Pair
TargetAminopeptidase N(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of aminopeptidase N (unknown origin)More data for this Ligand-Target Pair
TargetAminopeptidase N(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  2.62E+3nMAssay Description:Inhibitory activity against aminopeptidase N assayed by the L-Ala-MCA method.More data for this Ligand-Target Pair
TargetAminopeptidase N(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibitory activity against mammalian Aminopeptidase N (APN)More data for this Ligand-Target Pair
TargetAminopeptidase N(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of human aminopeptidase N by Dixon plot analysisMore data for this Ligand-Target Pair
TargetAminopeptidase N(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibitory concentration against aminopeptidase NMore data for this Ligand-Target Pair
TargetAminopeptidase N(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of APN in human ES2 cell surface assessed as inhibition of L-Leu-p-nitroanilide substrate hydrolysis incubated for 5 mins before substrate...More data for this Ligand-Target Pair
TargetAminopeptidase N(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  1.63E+4nMAssay Description:Inhibition of CD13 on surface of human ES2 cells using L-leucine-p-nitroanilide as substrate after 1 hrMore data for this Ligand-Target Pair
TargetAminopeptidase N(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  1.94E+4nMAssay Description:Inhibition of Aminopeptidase M.More data for this Ligand-Target Pair
TargetAminopeptidase N(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  2.01E+4nMAssay Description:Inhibition of APN in human ES2 cells preincubated for 5 mins before L-leu-p-nitroanilide substrate addition for 1 hr by photometryMore data for this Ligand-Target Pair
TargetAminopeptidase N(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  2.01E+4nMAssay Description:Inhibition of aminopeptidase N in human ES2 cells using L-leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured a...More data for this Ligand-Target Pair
TargetAminopeptidase N(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  2.29E+4nMAssay Description:Inhibition of APN in human HL60 cells assessed as hydrolysis of L-Leu-p-nitroanilide by spectrophotometryMore data for this Ligand-Target Pair
TargetAminopeptidase N(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  2.97E+4nMAssay Description:Inhibition of aminopeptidase-N in human ES2 cells using L-leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured a...More data for this Ligand-Target Pair
TargetAminopeptidase N(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  2.97E+4nMAssay Description:Inhibition of aminopeptidase N in human ES2 cells assessed as L-Leu-p-nitroanilide hydrolysisMore data for this Ligand-Target Pair
TargetAminopeptidase N(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  3.44E+4nMAssay Description:Inhibition of CD13 on surface of human PLC/PRF/5 cells using L-leucine-p-nitroanilide as substrate after 1 hrMore data for this Ligand-Target Pair
TargetAminopeptidase N(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  3.55E+4nMAssay Description:Inhibition of APN in human ES2 cells using L-Leu-pnitroanilide as substrate pretreated for 5 mins followed by substrate addition measured after 1 hrMore data for this Ligand-Target Pair
TargetAminopeptidase N(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibition of APN in human ES-2 cells using L-Leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 1 hr by...More data for this Ligand-Target Pair
TargetAminopeptidase N(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibition of APN in human ES2 cell surface using L-Leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 1...More data for this Ligand-Target Pair
TargetAminopeptidase N(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  5.47E+4nMAssay Description:Inhibition of APN in human PLC/PRF/5 cells using L-Leu-pnitroanilide as substrate pretreated for 5 mins followed by substrate addition measured after...More data for this Ligand-Target Pair
TargetAminopeptidase N(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50: >3.24E+5nMAssay Description:Inhibitory activity against aminopeptidase N (APN) in human acute lymphoblastic leukemia MOLT-4 cell lineMore data for this Ligand-Target Pair
TargetAminopeptidase N(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50: >4.71E+5nMAssay Description:Inhibitory activity against aminopeptidase N (APN) in human acute lymphoblastic leukemia MOLT-4 cell lineMore data for this Ligand-Target Pair