Affinity Data by PDB ID

PDB code 4HDB

Found 2 hits Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Protease (89/99 = 90%)^† (Human immunodeficiency virus 1 (HIV-1))	BDBM50489369 (CHEMBL1232930 \| GRL-0519) Show SMILES Show InChI	PDB UniProtKB/TrEMBL GoogleScholar	PC cid PC sid PDB UniChem	Article PubMed	0.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Georgia State University Curated by ChEMBL					Assay Description Inhibition of HIV-1 wildtype protease using Abz-Thr-Ile-Nle-p-nitro-Phe-Gln-Arg-NH2 as substrate incubated for 5 mins prior to substrate addition mea...				J Med Chem 56: 1074-83 (2013) Article DOI: 10.1021/jm301519z BindingDB Entry DOI: 10.7270/Q2542RH4
Georgia State University Curated by ChEMBL					More data for this Ligand-Target Pair
Protease (89/99 = 90%)^† (Human immunodeficiency virus 1 (HIV-1))	BDBM50489369 (CHEMBL1232930 \| GRL-0519) Show SMILES Show InChI	PDB UniProtKB/TrEMBL GoogleScholar	PC cid PC sid PDB UniChem	Article PubMed	5.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of HIV1 protease				J Med Chem 56: 6792-802 (2013) Article DOI: 10.1021/jm400768f BindingDB Entry DOI: 10.7270/Q2K07764
Purdue University Curated by ChEMBL					More data for this Ligand-Target Pair

_* indicates data uncertainty>20%
* 0.9 Tanimoto similarity
† Identities from BLAST output