TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Affinity DataIC50: 3.20nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Affinity DataIC50: 8.10nMAssay Description:Inhibition of human PARP1 using [3H]NAD as substrate after 1 min by microplate scintillation counting analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Affinity DataIC50: 11.7nMAssay Description:Inhibition of PARP1 was assessed using the Universal Chemiluminescent PARPKit. Luminescence readings were normalized to controls and fit to a sigmoid...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of full length recombinant human His6-tagged PARP1 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of full length recombinant human His6-tagged PARP1 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of GST-tagged recombinant human PARP-1 expressed in Escherichia coli after 30 mins by fluorescence-based assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Affinity DataIC50: 32nMAssay Description:Inhibition of recombinant human GST-fused PARP-1 expressed in Escherichia coli after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Affinity DataIC50: 35nMAssay Description:Inhibition of human PARP1 catalytic activity after 10 mins by ELISAMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Affinity DataIC50: 132nMAssay Description:Inhibition of recombinant human His6-tagged PARP1 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins foll...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Affinity DataIC50: 132nMAssay Description:Inhibition of recombinant human His6-tagged PARP1 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins foll...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Affinity DataEC50: 200nMAssay Description:Inhibition of PARP1 in human Jurkat cells assessed as reduction of cell viability after 96 hrs by MTS assay in presence of 100 uM of temozolomideMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Affinity DataEC50: 3.10E+4nMAssay Description:Inhibition of PARP1 in human Jurkat cells assessed as reduction of cell viability after 96 hrs by MTS assayMore data for this Ligand-Target Pair